8,547 research outputs found
Differential Subordinations Involving Generalized Bessel Functions
In this paper our aim is to present some subordination and superordination
results, by using an operator, which involves the normalized form of the
generalized Bessel functions of first kind. These results are obtained by
investigating some appropriate classes of admissible functions. We obtain also
some sandwich-type results and we point out various known or new special cases
of our main results.Comment: 15 pages, accepted in Bulletin of the Malaysian Mathematical Sciences
Societ
Cultivating community economies: tools for building a liveable world
One chapter allowed - 18mth embargoAmid the failure of traditional politics and policies to address our fundamental challenges, an increasing number of thoughtful proposals and real-world models suggest new possibilities, this book convenes an essential conversation about ..
Machine Learning in Astronomy: A Case Study in Quasar-Star Classification
We present the results of various automated classification methods, based on
machine learning (ML), of objects from data releases 6 and 7 (DR6 and DR7) of
the Sloan Digital Sky Survey (SDSS), primarily distinguishing stars from
quasars. We provide a careful scrutiny of approaches available in the
literature and have highlighted the pitfalls in those approaches based on the
nature of data used for the study. The aim is to investigate the
appropriateness of the application of certain ML methods. The manuscript argues
convincingly in favor of the efficacy of asymmetric AdaBoost to classify
photometric data. The paper presents a critical review of existing study and
puts forward an application of asymmetric AdaBoost, as an offspring of that
exercise.Comment: 10 pages, 8 figure
A Golf Programme for People with Severe and Enduring Mental Health Problems
This article reports a pioneering golf programme for people with severe and enduring mental health problems. Following a discussion of the problems and possibilities of golf as a form of physical activity for this group, we outline the structure, organisation, and ethos of the golf programme. Through an analysis of qualitative case study data collected during the programme, we discuss the response to the programme from service users and mental health professionals. We conclude by highlighting aspects of the programme which were critical to its success and offering suggestions for further initiatives in this area
Author Correction: Differentiating central nervous system infection from disease infiltration in hematological malignancy.
Blood transcriptional biomarkers for active pulmonary tuberculosis in a high-burden setting: a prospective, observational, diagnostic accuracy study.
BACKGROUND: Blood transcriptional signatures are candidates for non-sputum triage or confirmatory tests of tuberculosis. Prospective head-to-head comparisons of their diagnostic accuracy in real-world settings are necessary to assess their clinical use. We aimed to compare the diagnostic accuracy of candidate transcriptional signatures identified by systematic review, in a setting with a high burden of tuberculosis and HIV. METHODS: We did a prospective observational study nested within a diagnostic accuracy study of sputum Xpert MTB/RIF (Xpert) and Xpert MTB/RIF Ultra (Ultra) tests for pulmonary tuberculosis. We recruited consecutive symptomatic adults aged 18 years or older self-presenting to a tuberculosis clinic in Cape Town, South Africa. Participants provided blood for RNA sequencing, and sputum samples for liquid culture and molecular testing using Xpert and Ultra. We assessed the diagnostic accuracy of candidate blood transcriptional signatures for active tuberculosis (including those intended to distinguish active tuberculosis from other diseases) identified by systematic review, compared with culture or Xpert MTB/RIF positivity as the standard reference. In our primary analysis, patients with tuberculosis were defined as those with either a positive liquid culture or Xpert result. Patients with missing blood RNA or sputum results were excluded. Our primary objective was to benchmark the diagnostic accuracy of candidate transcriptional signatures against the WHO target product profile (TPP) for a tuberculosis triage test. FINDINGS: Between Feb 12, 2016, and July 18, 2017, we obtained paired sputum and RNA sequencing data from 181 participants, 54 (30%) of whom had confirmed pulmonary tuberculosis. Of 27 eligible signatures identified by systematic review, four achieved the highest diagnostic accuracy with similar area under the receiver operating characteristic curves (Sweeney3: 90¡6% [95% CI 85¡6-95¡6]; Kaforou25: 86¡9% [80¡9-92¡9]; Roe3: 86¡9% [80¡3-93¡5]; and BATF2: 86¡8% [80¡6-93¡1]), independent of age, sex, HIV status, previous tuberculosis, or sputum smear result. At test thresholds that gave 70% specificity (the minimum WHO TPP specificity for a triage test), these four signatures achieved sensitivities between 83¡3% (95% CI 71¡3-91¡0) and 90¡7% (80¡1-96¡0). No signature met the optimum criteria, of 95% sensitivity and 80% specificity proposed by WHO for a triage test, or the minimum criteria (of 65% sensitivity and 98% specificity) for a confirmatory test, but all four correctly identified Ultra-positive, culture-negative patients. INTERPRETATION: Selected blood transcriptional signatures met the minimum WHO benchmarks for a tuberculosis triage test but not for a confirmatory test. Further development of the signatures is warranted to investigate their possible effects on clinical and health economic outcomes as part of a triage strategy, or when used as add-on confirmatory test in conjunction with the highly sensitive Ultra test for Mycobacterium tuberculosis DNA. FUNDING: Royal Society Newton Advanced Fellowship, Wellcome Trust, National Institute of Health Research, and UK Medical Research Council
Identifying component modules
A computer-based system for modelling component dependencies and identifying component modules is presented. A variation of the Dependency Structure Matrix (DSM) representation was used to model component dependencies. The system utilises a two-stage approach towards facilitating the identification of a hierarchical modular structure. The first stage calculates a value for a clustering criterion that may be used to group component dependencies together. A Genetic Algorithm is described to optimise the order of the components within the DSM with the focus of minimising the value of the clustering criterion to identify the most significant component groupings (modules) within the product structure. The second stage utilises a 'Module Strength Indicator' (MSI) function to determine a value representative of the degree of modularity of the component groupings. The application of this function to the DSM produces a 'Module Structure Matrix' (MSM) depicting the relative modularity of available component groupings within it. The approach enabled the identification of hierarchical modularity in the product structure without the requirement for any additional domain specific knowledge within the system. The system supports design by providing mechanisms to explicitly represent and utilise component and dependency knowledge to facilitate the nontrivial task of determining near-optimal component modules and representing product modularity
Sperm death and dumping in Drosophila
Mating with more than one male is the norm for females of many species. In addition to generating competition between the ejaculates of different males, multiple mating may allow females to bias sperm use. In Drosophila melanogaster, the last male to inseminate a female sires approximately 80% of subsequent progeny. Both sperm displacement, where resident sperm are removed from storage by the incoming ejaculate of the copulating male, and sperm incapacitation, where incoming seminal fluids supposedly interfere with resident sperm, have been implicated in this pattern of sperm use. But the idea of incapacitation is problematic because there are no known mechanisms by which an individual could damage rival sperm and not their own. Females also influence the process of sperm use, but exactly how is unclear. Here we show that seminal fluids do not kill rival sperm and that any 'incapacitation' is probably due to sperm ageing during sperm storage. We also show that females release stored sperm from the reproductive tract (sperm dumping) after copulation with a second male and that this requires neither incoming sperm nor seminal fluids. Instead, males may cause stored sperm to be dumped or females may differentially eject sperm from the previous mating
Reference to the index of the correspondence of Walter Stone and Edmund Morris Miller, 1948 - 1964.
Edmund Morris Miller (1881-1964) scholar, Professor of Philosophy and Psychology and Librarian at the University of Tasmania, had extensive correspondence with Walter Stone, publisher and book collector of Sydney and publisher of Biblionews , between 1948 and 1964 about book collecting and Australian literature. Letters include references to J.K. Morris (d. 1958) ,Henry Kendall and Rev. Thornton Reed's thesis on Kendall, Fred. Bloomfield, Roderick Quinn, C.J. Brennan, W.E. Fitzhenry (editor of The Bulletin ), M. Gilmour and to The Tasmanian, Launceston's first newspaper (9). Morris Miller sometimes enclosed copies of his letters to others, including J.K. Morris (1951), and there are also letters from W.E. Fitzhenry of The Bulletin sent by Morris. Miller to Stone for his files
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