9,295 research outputs found

    Increased Adenine Nucleotide Degradation in Skeletal Muscle Atrophy

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    Adenine nucleotides (AdNs: ATP, ADP, AMP) are essential biological compounds that facilitate many necessary cellular processes by providing chemical energy, mediating intracellular signaling, and regulating protein metabolism and solubilization. A dramatic reduction in total AdNs is observed in atrophic skeletal muscle across numerous disease states and conditions, such as cancer, diabetes, chronic kidney disease, heart failure, COPD, sepsis, muscular dystrophy, denervation, disuse, and sarcopenia. The reduced AdNs in atrophic skeletal muscle are accompanied by increased expression/activities of AdN degrading enzymes and the accumulation of degradation products (IMP, hypoxanthine, xanthine, uric acid), suggesting that the lower AdN content is largely the result of increased nucleotide degradation. Furthermore, this characteristic decrease of AdNs suggests that increased nucleotide degradation contributes to the general pathophysiology of skeletal muscle atrophy. In view of the numerous energetic, and non-energetic, roles of AdNs in skeletal muscle, investigations into the physiological consequences of AdN degradation may provide valuable insight into the mechanisms of muscle atrophy

    “Miss, I Am Not Being Fully Prepared”: Student - Teachers’ Concerns About Their Preparation at a Teacher Training Institution in Jamaica

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    The issue of teacher preparation continues to occupy academic discourse relating to student outcomes and student achievement (Stronge, Ward & Grant, 2011). Research has supported the view that there is an inextricable connection between student outcomes, quality of teaching and teachers, and teacher preparation (Darling-Hammond 2005; Grover 2002). Similarly, theories about students’ self efficacy beliefs (e.g. Bandura, 1977; Dweck, 2000) and Institutional Habitus (Bourdieu, 1977) have been advanced in relation to students’ study experience, motivation and coping mechanisms. Using data from a focus group comprising 30 third year students enrolled in a four year teacher training pogramme in Jamaica, this paper discusses student-teachers’ concerns about their training. The main findings from this small scale exploratory study indicated that student teachers’ concerns were about the quality of teaching and teachers, curriculum organisation, content and delivery, and resources

    Are Attitudes Towards Economic Risk Heritable? Analyses Using the Australian Twin Study of Gambling

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    This study employs multiple regression models based on DeFries and Fulker (1985), and a large sample of twins, to assess heritability in attitudes towards economic risk, and the extent to which this heritability differs between males and females. Consistent with Cesarini, Dawes, Johannesson, Lichtenstein and Wallace (2009), it is found that attitudes towards risk are moderately heritable, with about 20 percent of the variation in these attitudes across individuals being linked to genetic differences. This value is less than one-half the estimates reported by Zyphur, Narayanan, Arvey and Alexander (2009) and Zhong, Chew, Set, Zhang, Xue, Sham, Ebstein and Israel (2009). While females are more risk averse than males, there is no evidence that heritability in attitudes towards risk differs between males and females. Even though heritability is shown to be important to economic risk taking, the analyses suggest that multivariate studies of the determinants of attitudes towards risk which to not take heritability into consideration still provide reliable estimates of the partial effects of other key variables, such as gender and educational attainment.risk, heritability, gender

    Connection between the elastic GEp/GMp and P to Delta form factors

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    It is suggested that the falloff in Qsq of the P to Delta magnetic form factor GM* is related to the recently observed falloff of the elastic electric form factor GEp/GMp. Calculation is carried out in the framework of a GPD mechanism

    A Logistic Regression Model For The Enhancement Of Student Retention: The Identification Of At-Risk Freshmen

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    A logistic regression model will be developed to provide early identification of freshmen at risk of attrition.  The early identification is accomplished literally within a couple of weeks after freshman orientation.  The dependent variable of interest is persistence, and it is a binary, nominal variable.  Students who proceed from freshman matriculation to graduation without ever having dropped out are labeled persistors.  Freshman matriculates who leave college either temporarily or permanently are classified as dropouts.  The independent variables employed to predict attrition include demographics, high school experiences, and attitudes, opinions, and values as reported on a survey administered during freshman orientation.  The model and its results will be presented along with a brief description of the institutional intervention program designed to enhance student persistence

    Adjustable microchip ring trap for cold atoms and molecules

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    We describe the design and function of a circular magnetic waveguide produced from wires on a microchip for atom interferometry using deBroglie waves. The guide is a two-dimensional magnetic minimum for trapping weak-field seeking states of atoms or molecules with a magnetic dipole moment. The design consists of seven circular wires sharing a common radius. We describe the design, the time-dependent currents of the wires and show that it is possible to form a circular waveguide with adjustable height and gradient while minimizing perturbation resulting from leads or wire crossings. This maximal area geometry is suited for rotation sensing with atom interferometry via the Sagnac effect using either cold atoms, molecules and Bose-condensed systems
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