Public Confidence in the Judiciary: Some Notes and Reflections

Persons with intellectual disability have been found to perform more poorly on tasks, demanding the use of executive functions like planning, than their peers. This study investigated difficulties with planning, and how problems with planning ability can be supported by using cognitive artifacts to help performance on activities in everyday life, for adolescents with intellectual disability. The approach taken is one of situated cognition, where the natural environment plays a big role, to see if the same difficulties arise as results from traditional research has shown. The traditional view focuses a lot on executive functions, and experimental studies in controlled settings and often suggests interventions and practice of certain functions to get better abilities. Another way is to focus on the use of cognitive artifact, to support problematic abilities, and to get a well-rounded understanding of how the problems actually appear in everyday life, the alternative view of situated cognition is a way to go. The data was gathered through interviews and surveys with the individual’s parents and analyzed through categorization and a repeated measures ANOVA, with a bonferroni corrected post hoc test. Results show several problematic areas, and that there is a difference in how problematic these areas are estimated to be when it comes to planning in everyday situations. It is discussed how the natural contexts helps knowing what planning really means for the group, as well as how it can help finding properties in cognitive artifacts that can help raise the level of independence in planning related tasks

Complementary transcriptomic, lipidomic, and targeted functional genetic analyses in cultured Drosophila cells highlight the role of glycerophospholipid metabolism in Flock House virus RNA replication

Abstract Background Cellular membranes are crucial host components utilized by positive-strand RNA viruses for replication of their genomes. Published studies have suggested that the synthesis and distribution of membrane lipids are particularly important for the assembly and function of positive-strand RNA virus replication complexes. However, the impact of specific lipid metabolism pathways in this process have not been well defined, nor have potential changes in lipid expression associated with positive-strand RNA virus replication been examined in detail. Results In this study we used parallel and complementary global and targeted approaches to examine the impact of lipid metabolism on the replication of the well-studied model alphanodavirus Flock House virus (FHV). We found that FHV RNA replication in cultured Drosophila S2 cells stimulated the transcriptional upregulation of several lipid metabolism genes, and was also associated with increased phosphatidylcholine accumulation with preferential increases in lipid molecules with longer and unsaturated acyl chains. Furthermore, targeted RNA interference-mediated downregulation of candidate glycerophospholipid metabolism genes revealed a functional role of several genes in virus replication. In particular, we found that downregulation of Cct1 or Cct2, which encode essential enzymes for phosphatidylcholine biosynthesis, suppressed FHV RNA replication. Conclusion These results indicate that glycerophospholipid metabolism, and in particular phosphatidylcholine biosynthesis, plays an important role in FHV RNA replication. Furthermore, they provide a framework in which to further explore the impact of specific steps in lipid metabolism on FHV replication, and potentially identify novel cellular targets for the development of drugs to inhibit positive-strand RNA viruses.http://deepblue.lib.umich.edu/bitstream/2027.42/78268/1/1471-2164-11-183.xmlhttp://deepblue.lib.umich.edu/bitstream/2027.42/78268/2/1471-2164-11-183-S3.XLShttp://deepblue.lib.umich.edu/bitstream/2027.42/78268/3/1471-2164-11-183-S2.XLShttp://deepblue.lib.umich.edu/bitstream/2027.42/78268/4/1471-2164-11-183.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/78268/5/1471-2164-11-183-S4.XLShttp://deepblue.lib.umich.edu/bitstream/2027.42/78268/6/1471-2164-11-183-S1.XLSPeer Reviewe

All My Sons

Like his Death of a Salesman, Miller\u27s All My Sons deals with failure and tragedy within a family. It was presented by the John Carroll University Little Theatre Society in January of 1951.https://collected.jcu.edu/plays/1117/thumbnail.jp

The Emerging Law of the Internet

The consequences of living in a totally global environment have been given new meaning with the Internet. Any piece of information about anyone of us can move anywhere in the world in two seconds. … It [the Internet] can only be dealt with on an international basis. Today’s students will become the regulators of cyberspace tomorrow