The October 27-28, 1986, FIRE cirrus case study: Cloud microstructure

Using aircraft in-situ measurements, the microphysics of cirrus clouds observed on 28 Oct. 1986 during FIRE were examined. Results are presented as one component of a coordinated study of the cirrus on the day. The study contributes to the understanding of cold clouds by: (1) providing microphysical data to supplement satellite and aircraft data for investigating cirrus cloud radiative effects; (2) providing more complete information on ice particle evolution and cloud forcing mechanisms than has been available through the use of instrumentation with higher resolution and more accurate calibration; (3) expanding the knowledge of the particle characteristics in cold liquid water clouds, through improved instrumentation and by making use of sensors on other platforms, such as lidar; and (4) by estimating the ice nucleus concentrations active at low temperatures in the upper troposphere from the concentrations of ice particles in colloidally stable liquid water clouds

The nature of emotional support and counselling provision for people with sight loss in the United Kingdom

People with sight loss in the United Kingdom are known to have lower levels of emotional wellbeing and to be at higher risk of depression. Consequently ‘having someone to talk to’ is an important priority for people with visual impairment. An on-line survey of the provision of emotional support and counselling for people affected by sight loss across the UK was undertaken. The survey was distributed widely and received 182 responses. There were more services offering ‘emotional support’, in the form of listening and information and advice giving, than offered ‘counselling’. Services were delivered by providers with differing qualifications in a variety of formats. Waiting times were fairly short and clients presented with a wide range of issues. Funding came from a range of sources, but many felt their funding was vulnerable. Conclusions have been drawn about the need for a national standardised framework for the provision of emotional support and counselling services for blind and partially sighted people in the U

A comparison of broad iron emission lines in archival data of neutron star low-mass X-ray binaries

Relativistic X-ray disk-lines have been found in multiple neutron star low-mass X-ray binaries, in close analogy with black holes across the mass-scale. These lines have tremendous diagnostic power and have been used to constrain stellar radii and magnetic fields, often finding values that are consistent with independent timing techniques. Here, we compare CCD-based data from Suzaku with Fe K line profiles from archival data taken with gas-based spectrometers. In general, we find good consistency between the gas-based line profiles from EXOSAT, BeppoSAX and RXTE and the CCD data from Suzaku, demonstrating that the broad profiles seen are intrinsic to the line and not broad due to instrumental issues. However, we do find that when fitting with a Gaussian line profile, the width of the Gaussian can depend on the continuum model in instruments with low spectral resolution, though when the different models fit equally well the line widths generally agree. We also demonstrate that three BeppoSAX observations show evidence for asymmetric lines, with a relativistic disk-line model providing a significantly better fit than a Gaussian. We test this by using the posterior predictive p-value method, and bootstrapping of the spectra to show that such deviations from a Gaussian are unlikely to be observed by chance.Comment: 13 pages, 9 figures, accepted to Ap

Matched-filter study and energy budget suggest no detectable gravitational-wave 'extended emission' from GW170817

Van Putten & Della Valle (2018) have reported a possible detection of gravitational-wave 'extended emission' from a neutron star remnant of GW170817. Starting from the time-frequency evolution and total emitted energy of their reported candidate, we show that such an emission is not compatible with the current understanding of neutron stars. We explore the additional required physical assumptions to make a full waveform model, for example, taking the optimistic emission from a spining-down neutron star with fixed quadrupolar deformation, and study whether even an ideal single-template matched-filter analysis could detect an ideal, fully phase-coherent signal. We find that even in the most optimistic case an increase in energy and extreme parameters would be required for a confident detection with LIGO sensitivity as of 2018-08-17. The argument also holds for other waveform models following a similar time-frequency track and overall energy budget. Single-template matched filtering on the LIGO data around GW170817, and on data with added simulated signals, verifies the expected sensitivity scaling and the overall statistical expectation.Comment: 9 pages, 6 figures, updated version as accepted by MNRA

miR-34a-/- mice are susceptible to diet-induced obesity

Objective: MicroRNA (miR)−34a regulates inflammatory pathways, and increased transcripts have been observed in serum and subcutaneous adipose of subjects who have obesity and type 2 diabetes. Therefore, the role of miR-34a in adipose tissue inflammation and lipid metabolism in murine diet-induced obesity was investigated. Methods: Wild-type (WT) and miR-34a−/− mice were fed chow or high-fat diet (HFD) for 24 weeks. WT and miR-34a−/− bone marrow-derived macrophages were cultured in vitro with macrophage colony-stimulating factor (M-CSF). Brown and white preadipocytes were cultured from the stromal vascular fraction (SVF) of intrascapular brown and epididymal white adipose tissue (eWAT), with rosiglitazone. Results: HFD-fed miR-34a−/− mice were significantly heavier with a greater increase in eWAT weight than WT. miR-34a−/− eWAT had a smaller adipocyte area, which significantly increased with HFD. miR-34a−/− eWAT showed basal increases in Cd36, Hmgcr, Lxrα, Pgc1α, and Fasn. miR-34a−/− intrascapular brown adipose tissue had basal reductions in c/ebpα and c/ebpβ, with in vitro miR-34a−/− white adipocytes showing increased lipid content. An F4/80high macrophage population was present in HFD miR-34a−/− eWAT, with increased IL-10 transcripts and serum IL-5 protein. Finally, miR-34a−/− bone marrow-derived macrophages showed an ablated CXCL1 response to tumor necrosis factor-α. Conclusions: These findings suggest a multifactorial role of miR-34a in controlling susceptibility to obesity, by regulating inflammatory and metabolic pathways

Genome Assembly Improvement and Mapping Convergently Evolved Skeletal Traits in Sticklebacks with Genotyping-by-Sequencing.

Marine populations of the threespine stickleback (Gasterosteus aculeatus) have repeatedly colonized and rapidly adapted to freshwater habitats, providing a powerful system to map the genetic architecture of evolved traits. Here, we developed and applied a binned genotyping-by-sequencing (GBS) method to build dense genome-wide linkage maps of sticklebacks using two large marine by freshwater F2 crosses of more than 350 fish each. The resulting linkage maps significantly improve the genome assembly by anchoring 78 new scaffolds to chromosomes, reorienting 40 scaffolds, and rearranging scaffolds in 4 locations. In the revised genome assembly, 94.6% of the assembly was anchored to a chromosome. To assess linkage map quality, we mapped quantitative trait loci (QTL) controlling lateral plate number, which mapped as expected to a 200-kb genomic region containing Ectodysplasin, as well as a chromosome 7 QTL overlapping a previously identified modifier QTL. Finally, we mapped eight QTL controlling convergently evolved reductions in gill raker length in the two crosses, which revealed that this classic adaptive trait has a surprisingly modular and nonparallel genetic basis