3,038 research outputs found
Tradition and Prudence in Locke's Exceptions to Toleration
Why did Locke exclude Catholics and atheists from toleration? Not, I contend, because he was trapped by his context, but because his prudential approach and practica ljudgments led him to traditiona ltexts. I make this argumentfirst by outlining the connections among prudential exceptionality, practical judgments, and traditional texts. I then describe important continuities betweenc onventional English understandings of the relationship between state and religion and Locke's writings on toleration, discuss Locke's conception of rights, and illustrate his use of prudential exceptions and distinctions. I conclude by arguing that Locke's problems are relevant to assessingc ontemporary liberal discussions of tolerationa nd the separation of state and religion that lean heavily on practical justification
Do pharmacy practice standards effectively describe behaviour? Reviewing practice standards using a behavioural specificity framework
BACKGROUND: Guidelines and practice standards exist to communicate the conduct and behaviour expected of health care professionals and ensure consistent quality practice. It is important that they describe behaviours explicitly so they can be interpreted, enacted and measured with ease. The AACTT framework specifies behaviour in terms of the: Action to be performed, Actor who performs the action, Context where the action occurs, Target who the action is performed with/for and Time when the action is performed (AACTT). It provides the most up to date framework for specifying behaviours and is particularly relevant to complex behavioural problems that involve sequences of behaviours performed by different people. Behavioural specificity within pharmacy practice standards has not been explored. AIM: To determine if behaviours described in the Professional Practice Standards for Australian Pharmacists specify Action, Actor, Context, Target and Time. METHODS: Two researchers independently reviewed the scope and structure of the practice standards and one extracted action statements (behaviours) verbatim. Through an iterative process, the researchers modified and developed the existing AACTT definitions to operationalise them for application to review of the action statements in the practice standards. The operational definitions, decision criteria and curated examples were combined in a codebook. The definitions were consistently applied through a directed content analysis approach to evaluate all extracted action statements by one researcher. For consistency 20% was independently checked for agreement by a second researcher. RESULTS: A novel codebook to apply AACTT criteria to evaluate practice standards was developed. Application of this codebook identified 768 independent behaviours. Of these, 300 (39%) described at least one discrete observable action, none specified an actor, 25 (3%) specified context, 131 (17%) specified target and 88 (11%) specified time. CONCLUSION(S): The behaviours detailed in practice standards for Australian pharmacists do not consistently specify behaviours in terms of Action, Actor, Context, Target and Time. Developers in the pharmacy profession, and beyond, should consider the behavioural specificity of their documents to improve interpretability, usability and adherence to the behaviours detailed. This also has implications for the development and evaluation of interventions to change such behaviours and improve quality of care
Low X-Ray Luminosity Galaxy Clusters: Main goals, sample selection, photometric and spectroscopic observations
We present the study of nineteen low X-ray luminosity galaxy clusters (L 0.5--45 erg s), selected from the ROSAT
Position Sensitive Proportional Counters (PSPC) Pointed Observations (Vikhlinin
et al. 1998) and the revised version of Mullis et al. (2003) in the redshift
range of 0.16 to 0.7. This is the introductory paper of a series presenting the
sample selection, photometric and spectroscopic observations and data
reduction. Photometric data in different passbands were taken for eight galaxy
clusters at Las Campanas Observatory; three clusters at Cerro Tololo
Interamerican Observatory; and eight clusters at the Gemini Observatory.
Spectroscopic data were collected for only four galaxy clusters using Gemini
telescopes. With the photometry, the galaxies were defined based on the
star-galaxy separation taking into account photometric parameters. For each
galaxy cluster, the catalogues contain the PSF and aperture magnitudes of
galaxies within the 90\% completeness limit. They are used together with
structural parameters to study the galaxy morphology and to estimate
photometric redshifts. With the spectroscopy, the derived galaxy velocity
dispersion of our clusters ranged from 507 km~s for [VMF98]022 to 775
km~s for [VMF98]097 with signs of substructure. Cluster membership has
been extensively discussed taking into account spectroscopic and photometric
redshift estimates. In this sense, members are the galaxies within a projected
radius of 0.75 Mpc from the X-ray mission peak and with cluster centric
velocities smaller than the cluster velocity dispersion or 6000 km~s,
respectively. These results will be used in forthcoming papers to study, among
the main topics, the red cluster sequence, blue cloud and green populations;
the galaxy luminosity function and cluster dynamics.Comment: 13 pages, 6 tables, 9 figures. Uses emulateapj. Accepted for
publication in The Astronomical Journal. Some formatting errors fixe
The community of advantage
This paper gives an overview of my recently published book, The Community of Advantage: A Behavioural Economistâs Defence of the Market. I explain that my stance as author is that of a behavioural economist and an economic liberal. The book is an attempt to counter the widespread belief that the findings of behavioural economics justify regulatory interventions in the economy that would previously have been thought unacceptably paternalistic. I argue that competitive markets are desirable, not as an efficient means for satisfying the given preferences of assumedly rational individuals, but as an institutional structure that provides opportunities for whatever voluntary transactions people might want to make
Amsterdam properties of C p (X) imply discreteness of X
Abstract. We prove, among other things, that if C p (X) is subcompact in the sense of de Groot then the space X is discrete. This generalizes a series of previous results on completeness properties of function spaces
'Word from the street' : when non-electoral representative claims meet electoral representation in the United Kingdom
Taking the specific case of street protests in the UK â the âword from the streetââ this article examines recent (re)conceptualizations of political representation, most particularly Sawardâs notion of ârepresentative claimâ. The specific example of nonelectoral claims articulated by protestors and demonstrators in the UK is used to illustrate: the processes of making, constituting, evaluating and accepting claims for and by constituencies and audiences; and the continuing distinctiveness of claims based upon electoral representation. Two basic questions structure the analysis: first, why would the political representative claims of elected representatives trump the nonelectoral claims of mass demonstrators and, second, in what ways does the âperceived legitimacyâ of the former differ from the latter
Preventing the Selection of "Deaf Embryos" Under the Human Fertilisation and Embryology Act 2008:Problematizing Disability?
Section 14(4) of the Human Fertilisation and Embryology Act 2008 imposes â within the general licensing conditions listed in the Human Fertilisation and Embryology Act 1990 â a prohibition to prevent the selection and implantation of embryos for the purpose of creating a child who will be born with a âserious disability.â This article offers a perspective that demonstrates the problematic nature of the consultation, review, and legislative reform process surrounding s 14(4). The term âserious disabilityâ is not defined within the legislation, but we highlight the fact that s 14(4) was passed with the case of selecting deaf children in mind. We consider some of the literature on the topic of disability and deafness, which, we think, casts some doubt on the view that deafness is a âserious disability.â The main position we advance is that the lack of serious engagement with alternative viewpoints during the legislative process was unsatisfactory. We argue that the contested nature of deafness necessitates a more robust consultation process and a clearer explanation and defence of the normative position that underpins s 14(4)
The Birmingham Boron Neutron Capture Therapy (BNCT) project : developments towards selective internal particle therapy
This paper will review progress on two aspects of the Birmingham BNCT project. Firstly on evaluation of the effects of high and low LET radiations when delivered simultaneously, and secondly on attempts to optimise delivery of the boron carrier compound BPA through pharmacokinetic studies. Simultaneous or non-simultaneous irradiations of V79 cells with alpha-particle and X-ray irradiations were performed. Alpha doses of 2 and 2.5 Gy were chosen and the impact on survival when delivered separately or simultaneously with variable doses of X-rays was evaluated. The pharmacokinetics of the delivery of a new formulation of BPA (BPA-mannitol) are being investigated in brain tumour patients through a study with 2 Ă 2 design featuring intravenous and intracarotid artery infusion of BPA, with or without a mannitol bolus. On the combined effect of low and high LET radiations, a synergistic effect was observed when alpha and X-ray doses are delivered simultaneously. The effect is only present at the 2.5 Gy alpha dose and is a very substantial effect on both the shape of the survival curve and the level of cell killing. This indicates that the alpha component may have the effect of inhibiting the repair of damage from the low LET radiation dose delivered simultaneously. On the pharmacokinetics of BPA, data on the first three cohorts indicate that bioavailability of BPA in brain ECF is increased substantially through the addition of a mannitol bolus, as well as by the use of intracarotid artery route of infusion. In both cases, for some patients the levels after infusion approach those seen in blood, whereas the ECF levels for intravenous infusion without mannitol are typically less than 10% of the blood values
Like trainer, like bot? Inheritance of bias in algorithmic content moderation
The internet has become a central medium through which `networked publics'
express their opinions and engage in debate. Offensive comments and personal
attacks can inhibit participation in these spaces. Automated content moderation
aims to overcome this problem using machine learning classifiers trained on
large corpora of texts manually annotated for offence. While such systems could
help encourage more civil debate, they must navigate inherently normatively
contestable boundaries, and are subject to the idiosyncratic norms of the human
raters who provide the training data. An important objective for platforms
implementing such measures might be to ensure that they are not unduly biased
towards or against particular norms of offence. This paper provides some
exploratory methods by which the normative biases of algorithmic content
moderation systems can be measured, by way of a case study using an existing
dataset of comments labelled for offence. We train classifiers on comments
labelled by different demographic subsets (men and women) to understand how
differences in conceptions of offence between these groups might affect the
performance of the resulting models on various test sets. We conclude by
discussing some of the ethical choices facing the implementers of algorithmic
moderation systems, given various desired levels of diversity of viewpoints
amongst discussion participants.Comment: 12 pages, 3 figures, 9th International Conference on Social
Informatics (SocInfo 2017), Oxford, UK, 13--15 September 2017 (forthcoming in
Springer Lecture Notes in Computer Science
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