A form of MHD universal equations of unsteady incompressible fluid flow with variable elctroconductivity on heated moving plate

This paper deals with laminar, unsteady flow of viscous, incompressible and electro conductive fluid caused by variable motion of flat plate. Fluid electro conductivity is variable. Velocity of the plate is time function. Plate moves in its own plane and in "still" fluid. Present external magnetic filed is perpendicular to the plate. Plate temperature is a function of longitudinal coordinate and time. Viscous dissipation, Joule heat, Hole and polarization effects are neglected. For obtaining of universal equations system general similarity method is used as well as impulse and energy equation of described problem

Do stone size and impaction influence therapeutic approach to proximal ureteral stones?

Background/Aim. Primary therapeutic approach to lumbar ureteral stones is still contraversial. The aim of the study was to investigate the influence of stone impaction and size on the effectiveness of proximal ureteral stone lithotripsy. Methods. A total of 123 patients with proximal ureteral stones were investigated in this prospective study performed in a 10- month period. The patients were divided into the group I - 86 patients treated with extracorporeal shock wave lithotripsy (ESWL) and the group II - 37 patients treated with 'Swiss' Lithoclast. In the group I, 49 stones (57%) were classified as impacted, while 20 stones (23.3%) were larger than 100 mm2. In the group II, 26 stones (70.3%) were impacted, and 11 stones (29.7%) were larger than 100 mm2. Stones were defined as impacted by the radiographic, echosonographic as well as endoscopic findings in the group II of patients. Stone size was presented in mm2. Chemical composition of stones were almost the same in both groups of the patients. Results. Generally, there was no statistically significant difference in the treatment success between the groups. However, stones larger than 100 mm2 were statistically more successfully treated endoscopically, while there was no statistical difference in the treatment success of impacted stones between these two groups. Conclusion. ESWL can by considered as primary first therapeutic approach in treatment of all proximal ureteral stones except for stones larger than 100 mm2 that should primarily be treated endoscopically

Analgesic efficacy of 0.75% ropivacaine for lower third molar surgery

Introduction: Since there is no data concerning local analgesic efficacy of ropivacaine for lower third molar surgery, the aim of this doubleblind study was to compare local anaesthetic parameters and postoperative analgesic requirements after the use of ropivacaine and bupivacaine for the inferior alveolar nerve block. Materials and Method: 20 healthy patients were equally randomized into the ropivacaine (0.75%, 2 ml) or bupivacaine (0.5%, 2 ml) groups. The onset and duration of anaesthesia (the lower lip numbness and pinprick test) and intensity of anaesthesia (visual analogue and verbal rating scales) were determined. The postoperative pain reports and analgesic requirements were also recorded. Results: There were no significant differences concerning parameters of the achieved anaesthesia. 2 patients in the bupivacaine group felt postoperative pain without the need for pain medication. Conclusion: Ropivacaine is suitable for achieving local anaesthesia in lower third molar surgery, especially when prolonged analgesia is desired

Standardi u oblasti geoinformacija

The paper gives information about the standards that support current standardization initiatives in geoinformation field. Increasing the reliability of the goods and effectiveness of the services which we use depend on standardization level. Aim of standardization process is getting people to agree on an acceptable technical solution. Standards are an important basis for development and implementation of the infrastructure for geodata. They facilitate the development, sharing, and use of geospatial data. In fact, they are ensuring that electronic data content and services are implemented to common standards in order to become easily accessible data. Standardization into geosector has to be coordinated with ongoing work on formulation of the INSPIRE implementing rules and the data sets specifications. The Law on Standardization establishes the legal bases of standardization in the Republic Serbia and defining competence of participants, as well as regulates the principles of preparation and application of standardization normative documents. The Institute for Standardization of Serbia is the only recognized national standardization body with aim to develop and promote standards contributing improvement of products and services of Serbia. Republic Geodetic Authority has started an initiative for establishing standardization Committee. The Institute for Standardization of Serbia formed the Technical Committee for standards in the field of geographic information, marked KS I 211. This Committee deals with standards regarding geographic information through following work of the Technical Committee ISO/TC 211 and CEN/TC 287.U radu su date informacije o standardima koji podržavaju trenutne inicijative za standardizaciju u oblasti geoinformacija. Povećanje pouzdanosti dobara i efektivnosti usluga koje koristimo zavisi od nivoa standardizacije. Cilj procesa standardizacije je da se postigne dogovor između učesnika o prihvatljivom tehničkom rešenju. Standardi su važna osnova za razvoj i implementaciju infrastrukture geopodataka. Oni omogućavaju razvoj, razmenu i korišćenje prostornih podataka. Zapravo, osiguranje da su sadržaj digitalnih podataka i servisa implementirani sa zajedničkim standardima radi lakšeg pristupa podacima. Standardizacija u geosektoru mora biti koordinirana sa tekućim radom na formulisanju INSPIRE implementacionih pravila i tehničkih specifikacija za skupove podataka. Zakon o standardizaciji uspostavlja legalnu osnovu za standardizaciju u Republici Srbiji, definiše nadležnosti učesnika i reguliše načela pripreme i primene standarda. Institut za standardizaciju Srbije, kao nadležno nacionalno telo za standardizaciju, razvija i promoviše standarde doprinoseći unapređenju proizvoda i usluga u Srbiji. Republički geodetski zavod je pokrenuo inicijativu za osnivanje komisije za standardizaciju. Institut za standardizaciju Srbije formirao je Komisiju za standarde iz oblasti geografskih informacija sa oznakom KS I 211. Predmet rada ove komisije su standardi iz oblasti geografskih informacija kroz praćenje rada tehničkih komiteta ISO/TC 211 i CEN/TC 287

DETERMINATION OF AVERAGED AXISYMMETRIC FLOW SURFACES AND MERIDIAN STREAMLINES IN THE CENTRIFUGAL PUMP USING NUMERICAL SIMULATION RESULTS

One of the most important aims in the turbo pump design is to achieve an optimal design of the pump impeller. The basic assumption in the design procedure of the impeller is that of the axisymmetric fluid flow. It can be confirmed or disputed by using the method presented in the paper, which uses the results of numerical simulation of fluid flow in the pump impeller. The method is actually a procedure for determining averaged axisymmetric flow surfaces and meridian streamlines. Furthermore, according to the obtained streamlines, a correction of the impeller blade geometry can be made (if the streamlines deviate significantly from the assumed axisymmetric ones). It is also possible to calculate the specific works of the elementary stages and compare them with the previous assumptions. The pump impeller torque can be calculated as well

Standardi u oblasti geoinformacija

The paper gives information about the standards that support current standardization initiatives in geoinformation field. Increasing the reliability of the goods and effectiveness of the services which we use depend on standardization level. Aim of standardization process is getting people to agree on an acceptable technical solution. Standards are an important basis for development and implementation of the infrastructure for geodata. They facilitate the development, sharing, and use of geospatial data. In fact, they are ensuring that electronic data content and services are implemented to common standards in order to become easily accessible data. Standardization into geosector has to be coordinated with ongoing work on formulation of the INSPIRE implementing rules and the data sets specifications. The Law on Standardization establishes the legal bases of standardization in the Republic Serbia and defining competence of participants, as well as regulates the principles of preparation and application of standardization normative documents. The Institute for Standardization of Serbia is the only recognized national standardization body with aim to develop and promote standards contributing improvement of products and services of Serbia. Republic Geodetic Authority has started an initiative for establishing standardization Committee. The Institute for Standardization of Serbia formed the Technical Committee for standards in the field of geographic information, marked KS I 211. This Committee deals with standards regarding geographic information through following work of the Technical Committee ISO/TC 211 and CEN/TC 287.U radu su date informacije o standardima koji podržavaju trenutne inicijative za standardizaciju u oblasti geoinformacija. Povećanje pouzdanosti dobara i efektivnosti usluga koje koristimo zavisi od nivoa standardizacije. Cilj procesa standardizacije je da se postigne dogovor između učesnika o prihvatljivom tehničkom rešenju. Standardi su važna osnova za razvoj i implementaciju infrastrukture geopodataka. Oni omogućavaju razvoj, razmenu i korišćenje prostornih podataka. Zapravo, osiguranje da su sadržaj digitalnih podataka i servisa implementirani sa zajedničkim standardima radi lakšeg pristupa podacima. Standardizacija u geosektoru mora biti koordinirana sa tekućim radom na formulisanju INSPIRE implementacionih pravila i tehničkih specifikacija za skupove podataka. Zakon o standardizaciji uspostavlja legalnu osnovu za standardizaciju u Republici Srbiji, definiše nadležnosti učesnika i reguliše načela pripreme i primene standarda. Institut za standardizaciju Srbije, kao nadležno nacionalno telo za standardizaciju, razvija i promoviše standarde doprinoseći unapređenju proizvoda i usluga u Srbiji. Republički geodetski zavod je pokrenuo inicijativu za osnivanje komisije za standardizaciju. Institut za standardizaciju Srbije formirao je Komisiju za standarde iz oblasti geografskih informacija sa oznakom KS I 211. Predmet rada ove komisije su standardi iz oblasti geografskih informacija kroz praćenje rada tehničkih komiteta ISO/TC 211 i CEN/TC 287

DETERMINATION OF AVERAGED AXISYMMETRIC FLOW SURFACES AND MERIDIAN STREAMLINES IN THE CENTRIFUGAL PUMP USING NUMERICAL SIMULATION RESULTS

One of the most important aims in the turbo pump design is to achieve an optimal design of the pump impeller. The basic assumption in the design procedure of the impeller is that of the axisymmetric fluid flow. It can be confirmed or disputed by using the method presented in the paper, which uses the results of numerical simulation of fluid flow in the pump impeller. The method is actually a procedure for determining averaged axisymmetric flow surfaces and meridian streamlines. Furthermore, according to the obtained streamlines, a correction of the impeller blade geometry can be made (if the streamlines deviate significantly from the assumed axisymmetric ones). It is also possible to calculate the specific works of the elementary stages and compare them with the previous assumptions. The pump impeller torque can be calculated as well

Theoretical and experimental analysis of dynamic processes of pipe branch for supply water to the Pelton turbine

The paper presents the results of the analysis of pipe branch A6 to feed the Hydropower Plant ”Perućica” with integrated action Pelton turbines. The analysis was conducted experimentally (tensometric) and numerically. The basis of the experimental research is the numerical finite element analysis of pipe branch A6 in pipeline C3. Pipe branch research was conducted in order to set the experiment and to determine extreme stress states. The analysis was used to perform the determination of the stress state of a geometrically complex assembly. This was done in detail as it had never been done before, even in the design phase. The actual states of the body pipe branch were established, along with the possible occurrence of water hammer accompanied by the appearance of hydraulic oscillation. This provides better energetic efficiency of the turbine devices. [Projekat Ministarstva nauke Republike Srbije, br. TR35049 and br. TR 33040

Chemical analysis and antimicrobial activity of essential oils from wild laurel of National park Skadar lake, Montenegro

Laurus nobilis L., Lauraceae, u narodu poznat kao lovor, je cvetni, zimzeleni žbun koji samoniklo raste u većem delu Crne Gore, a često se uzgaja i koristi kao aromatična, začinska i lekovita biljka. Cilj ovog istraživanja je bio da se analizira hemijski sastav etarskog ulja (EU) ploda i lista, a zatim testira antibakterijska i antifungalna aktivnost EU na sledećim sojevima: Staphylococcus aureus ATCC25923, Enterococcus faecalis ATCC29212, Bacillus subtilis ATCC6633 Escherichia coli ATCC25922, Klebsiella pneumoniae ATCC13083, Salmonella Abony NCTC6017, Pseudomonas aeruginosa ATCC27853 i Candida albicans ATCC10231. Ispitivanje kvalitativnog i kvantitativnog sastava etarskih ulja lista i plodova lovora izvršeno je gasnohromatografskom tehnikom spregnutom sa masenom spektrometrijom (GC-MS). Utvrđeno je da je etarsko ulje ploda bogato 1,8-cineolom (33,3%), α-terpenil acetatom (7,0%), α-pinenom (5,8%), β-elemenom (5,7%), sabinenom (5,3%), β- pinenom (4,0%), borneolom (2,1%) i terpinen-4-olom (2,1%). Najvažnije komponente identi�ikovane u EU listova su 1,8-cineol (35,1%), α-terpinil acetat (10,4%) i linalol (7,6%), između ostalih, a u skladu su sa prethodno dobijenim literaturnim podacima (1). Dodatno, ispitivana su antibakterijska i antifungalna svojstva EU lista i ploda lovora bujon mikrodilucionom metodom. EU ploda je pokazao antibakterijsko i antifungalno svojstvo protiv skoro svih testiranih sojeva mikroorganizama, dok je EU lista inhibiralo sledeće sojeve: Staphylococcus aureus ATCC25923, Enterococcus faecalis ATCC29212, Bacillus subtilis ATCC6633 i Candida albicans ATCC10231. Escherichia coli ATCC25922 je bakterijski soj koji je pokazao najveću otpornost na etarska ulja lovora, kako ploda, tako i lista. Dobijeni rezultati za etarska ulja lovora i 1,8 -cineol, koji je njihov glavni sastojak, su u skladu sa prethodnim studijama (2).Laurus nobilis L., Lauraceae, popularly known as laurel, is a flowering, evergreen bush which grows wildly in most parts of Montenegro, and is often cultivated and used as an aromatic, flavoring spice and medicinal plant. The aim of this research was to analyze the chemical composition of the essential oil (EO) of fruit and leaf, and afterwards antibacterial and antifungal activity of EOs on the following strains: Staphylococcus aureus ATCC25923, Enterococcus faecalis ATCC29212, Bacillus subtilis ATCC6633 Escherichia coli ATCC25922, Klebsiella pneumoniae ATCC13083, Salmonella Abony NCTC6017, Pseudomonas aeruginosa ATCC27853 i Candida albicans ATCC10231. The qualitative and quantitative composition of the EOs of fruit and leaves was carried out by using a gas chromatographic analysis coupled with mass spectrometry (GC-MS). The EO of fruit was found to be rich 1,8-cineole (33.3%), α-terpinyl acetate (7.0%), α-pinene (5.8%), β-elemene (5.7%), sabinene (5.3%), β-pinene (4.0%), borneol (2.1%) and terpinene-4-ol (2.1%). The most important components identified in the leaves EO were 1,8-cineol (35.1%), α-terpinyl acetate (10.4%) and linalool (7.6%), among others, are in line with previous literature reports (1). In addition, the antibacterial and antifungal properties of leaf and fruit laurel EOs were examined according to the broth microdilution method. The fruit EO showed antibacterial and antifungal activities against almost all strains of the microorganisms tested, whereas the leaf EO was able to inhibit: Staphylococcus aureus ATCC25923, Enterococcus faecalis ATCC29212, Bacillus subtilis ATCC6633 and Candida albicans ATCC10231. Escherichia coli ATCC25922 was bacterial strain that showed the highest resistance to both tested laurel EOs. The results obtained herein for laurel EO and 1,8-cineole as its main constituent are in accordance with previous studies (2).Treći naučni simpozijum Saveza farmaceutskih udruženja Srbije sa međunarodnim učešćem „Lekovi za specifične populacije pacijenata: inovacijama ka unapređenju zdravstvenih ishoda“, Niš, Srbija, 26. oktobar 2023

Alpha-1-antitrypsin deficiency: Molecular basis, clinical presentation, therapeutic options and an integrative approach in diagnostics

Primarna uloga alfa-1-antitripsina (AAT) jeste da zaštiti plućni parenhim od proteolize dejstvom neutrofilne elastaze. Njegovu biosintezu kontroliše izuzetno polimorfni GEN SERPINA1. Deficijencija AAT (AATD) jeste autozomalno recesivno oboljenje i smatra se najčešćim genetskim uzrokom oboljenja jetre kod dece i emfizema kod odraslih. Prema učestalosti, deficijentni aleli se mogu podeliti na "česte" (Z i S) i "retke" (Mmalton, Mheerlen, Mprocida itd.). Za vrstu, intenzitet i vremenski period u kome se razvijaju kliničke manifestacije smatra se odgovornim interakcija AATD i dodatnih genetskih i stečenih faktora rizika (pušenje, izloženost aerozagađenju i sl.). Kod obolelih se najčešće javljaju preuranjen emfizem, hronični hepatitis, ciroza i hepatocelularni karcinom. Epidemiološke studije naglašavaju potrebu povećanja dijagnostičke efikasnosti kod AATD. Preporučuje se da dijagnostički pristup integriše precizne, međunarodno identifikovane, kliničke kriterijume i standardizovan laboratorijski protokol, zasnovan na biohemijskim i molekularno-biološkim metodama. Terapijski pristup zavisi od vrste kliničkih manifestacija. Kod pulmoloških bolesnika je moguće primeniti terapiju nadoknade, dok kod osoba sa terminalnom fazom oštećenja jetre uzrokovanog AATD transplantacija trenutno predstavlja jedinu specifičnu terapiju. Kod svih obolelih je neophodno preventivno uticati na smanjenje štetnog uticaja životnih navika i faktora sredine. Očekuje se da zdravstveni ishodi kod obolelih budu značajno unapređeni uvođenjem genske terapije. Dosadašnji rezultati istraživanja efikasnosti integrativnog pristupa detekciji AATD u populaciji Srbije su ohrabrujući i upućuju na potrebu njegovog omasovljenja, čime bi se ostvarili uslovi za formiranje nacionalnog registra obolelih.The primary role of Alpha-1-antitrypsin (AAT), encoded by the highly polymorphic SERPINA1 gene, is to protect the lung parenchyma from proteolysis by neutrophil elastase. AAT deficiency (AATD) is an autosomal recessive disease, considered as the most important genetic cause of liver disease in children and emphysema in adults. According to frequency, deficient alleles can be classified as "common" (Z and S) and "rare" (Mmalton, Mheerlen, Mprocida etc). Type, intensity and onset of clinical disease associated with AATD occur as a result of interaction between AATD and additional genetic and acquired factors (tobacco smoking, air pollution exposure etc). The most frequent clinical manifestations include premature emphysema, chronic hepatitis, cirrhosis and hepatocellular carcinoma. Epidemiological studies highlight the need for improvement in diagnostic efficiency for AATD. It is recommended for a diagnostic approach to integrate precise, internationally recognized clinical criteria and a standardized laboratory protocol, based on a combination of biochemical and molecular methods. The predilection site of clinical manifestations guides the therapeutic approach. Augmentation therapy is possible in lung disease, while currently the only specific measure in patients with severe liver failure due to AATD is transplantation. In all patients, preventive measures, ammeliorating the deleterious effects of habits and environmental factors are recommended. Introduction of gene therapy is expected to additionally improve health outcomes in affected persons. Current results with an integrative AATD diagnostic strategy in the Serbian population are highly encouraging, prompting towards its further implementation in common medical practice with the ultimate goal to establish a national register of affected individuals