Elderly health program: a report for experience from the perspective of multiprofissional residents in collective health

Objective: To report on the creation and development of a health education group for the elderly in a Basic Health Unit in the state of Paraná. Methods: The activities took place from May to December 2019, totaling 27 meetings. A report of each meeting was prepared to provide information for the writing of this report. Health education and promotion activities were developed involving physical activities, recreation and leisure, mental health, nutritional education, hygiene, oral and environmental health, among other pertinent subjects. Results: At the end of the meetings, the participants showed improvement in basic knowledge about health issues and quality of life. Conclusion: The creation of health education groups for the elderly reflects positively on health care facilities, contributing to the reduction of service overload due to demands that can be solved collectively

Association of hypertension with coronary artery disease onset in the Lebanese population

The onset of coronary artery disease (CAD) is influenced by cardiovascular risk factors that often occur in clusters and may build on one another. The objective of this study is to examine the relationship between hypertension and CAD age of onset in the Lebanese population. This retrospective analysis was performed on data extracted from Lebanese patients (n = 3,753). Logistic regression examined the association of hypertension with the age at CAD diagnosis after controlling for other traditional risk factors. The effect of antihypertensive drugs and lifestyle changes on the onset of CAD was also investigated. Results showed that hypertension is associated with late onset CAD (OR=0.656, 95% CI=0.504-0.853, p=0.001). Use of antihypertensive drugs showed a similar association with delayed CAD onset. When comparing age of onset in CAD patients with traditional risk factors such as hypertension, diabetes, hyperlipidemia, obesity, smoking and family history of CAD, the age of onset was significantly higher for patients with hypertension compared to those with any of the other risk factors studied (p < 0.001). In conclusion, hypertension and its treatment are associated with late coronary atherosclerotic manifestations in Lebanese population. This observation is currently under investigation to clarify its genetic and/or environmental mechanisms

Impact des pompes d'efflux (abcb1 et abcg2) de la barrière hémato-encéphalique sur le passage cérébral du riluzole et de la minocycline (application à la sclérose latérale amyotrophique)

La sclérose latérale amyotrophique (SLA) est une maladie neurodégénérative fatale. Le seul traitement ayant reçu l'AMM est le riluzole (RLZ). La minocycline (MNC) a montré être neuroprotectrice dans un modèle murin de SLA. L'objectif de ce travail a été d'explorer le passage cérébral du RLZ et de la MNC et plus particulièrement les mécanismes d'efflux médiés par les transporteurs ABC: la P-gp et la BCRP. Nous avons aussi exploré l'intéraction médicamenteuse entre RLZ et MNC. Nos essais ont montré que le RLZ et la MNC sont transportés par la P-gp et que le RLZ est aussi transporté par la BCRP. La MNC est inhibitrice de la P-gp et potentialise ainsi le passage intracérébral du RLZ qui lui a montré pouvoir induire la BCRP. Sur un modèle murin de SLA, l'expression cérébrale de la P-gp est induite et les concentrations cérébrales en RLZ sont plus faibles. Ces études devraient, être intégrées en préclinique, quand une association médicamenteuse est envisagée.Amyotrophic lateral sclerosis (ALS) is a neurodegenerative fatal disease. Riluzole (RLZ) is the only approved drug used in ALS treatment. Minocycline (MNC) showed to be neuroprotective in a murine model of ALS. The objectif of our work was to study the cerebral transport of RLZ and MNC, emphasizing on the role played by P-gp and BCRP in this transport. We also studied the interaction between RLZ and MNC. We showed that both RLZ and MNC are substrates of P-gp and that RLZ is a substrate for BCRP. MNC inhibits P-gp and increases RLZ brain concentrations, while RLZ induces BCRP. In a murine model of ALS, P-gp was induced and RLZ brain concentrations decreased. These studies should be taken into consideration in preclinical studies, especially one two or more drugs are combined.CHATENAY M.-PARIS 11-BU Pharma. (920192101) / SudocSudocFranceF

Association of coronary artery disease and chronic kidney disease in Lebanese population

Background: More evidence is emerging on the strong association between chronic kidney disease (CKD) and cardiovascular disease. We assessed the relationship between coronary artery disease (CAD) and renal dysfunction level (RDL) in a group of Lebanese patients. Methods: A total of 1268 patients undergoing cardiac catheterization were sequentially enrolled in a multicenter cross sectional study. Angiograms were reviewed and CAD severity scores (CADSS) were determined. Estimated glomerular filtration rate (eGFR) was calculated and clinical and laboratory data were obtained. CKD was defined as eGFR < 60 ml/min. Logistic regression model was performed using multivariate analysis including all traditional risk factors associated with both diseases. ANOVA and the Tukeytestswere used to compare subgroups of patients and to assess the impact of each disease on the severity of the other. Results: Among the 82% patients who exhibited variable degrees of CAD, 20.6% had an eGFR < 60 ml/min. Logistic regression analysis revealed a bidirectional independent association between CAD and CKD with an OR = 2.01 (P < 0.01) and an OR = 1.99 (P < 0.01) for CAD and CKD frequencies, respectively. We observed a steady increase in the CADSS mean as eGFR declined and a progressive reduction in renal function with the worsening of CAD (P < 0.05). This correlation remained highly significant despite considerable inter-patient variability and was at its highest at the most advanced stages of both diseases. Conclusions: Our results show a strong, independent and graded bidirectional relationship between CAD severity and RDL. We propose to add CAD to the list of risk factors for the development and progression of CKD