Stellar wind-magnetosphere interaction at exoplanets: computations of auroral radio powers

We present calculations of the auroral radio powers expected from exoplanets with magnetospheres driven by an Earth-like magnetospheric interaction with the solar wind. Specifically, we compute the twin cell-vortical ionospheric flows, currents, and resulting radio powers resulting from a Dungey cycle process driven by dayside and nightside magnetic reconnection, as a function of planetary orbital distance and magnetic field strength. We include saturation of the magnetospheric convection, as observed at the terrestrial magnetosphere, and we present power law approximations for the convection potentials, radio powers and spectral flux densities. We specifically consider a solar-age system and a young (1 Gyr) system. We show that the radio power increases with magnetic field strength for magnetospheres with saturated convection potential, and broadly decreases with increasing orbital distance. We show that the magnetospheric convection at hot Jupiters will be saturated, and thus unable to dissipate the full available incident Poynting flux, such that the magnetic Radiometric Bode's Law (RBL) presents a substantial overestimation of the radio powers for hot Jupiters. Our radio powers for hot Jupiters are $\sim$5-1300 TW for hot Jupiters with field strengths of 0.1-10 $B_J$ orbiting a Sun-like star, while we find that competing effects yield essentially identical powers for hot Jupiters orbiting a young Sun-like star. However, in particular for planets with weaker magnetic fields our powers are higher at larger orbital distances than given by the RBL, and there are many configurations of planet that are expected to be detectable using SKA.Comment: Accepted for publication in Mon. Not. R. Astron. So

Security and confidentiality approach for the Clinical E-Science Framework (CLEF)

Objectives: CLEF is an MRC sponsored project in the E-Science programme that aims to establish methodologies and a technical infrastructure for the next generation of integrated clinical and bioscience research. Methods: The heart of the CLEF approach to this challenge is to design and develop a pseudonymised repository of histories of cancer patients that can be accessed by researchers. Robust mechanisms and policies have been developed to ensure that patient privacy and confidentiality are preserved while delivering a repository of such medically rich information for the purposes of scientific research. Results: This paper summarises the overall approach adopted by CLEF to meet data protection requirements, including the data flows, pseudonymisation measures and additional monitoring policies that are currently being developed. Conclusion: Once evaluated, it is hoped that the CLEF approach can serve as a model for other distributed electronic health record repositories to be accessed for research

Security and confidentiality approach for the Clinical E-Science Framework (CLEF)

CLEF is an MRC sponsored project in the E-Science programme that aims to establish policies and infrastructure for the next generation of integrated clinical and bioscience research. One of the major goals of the project is to provide a pseudonymised repository of histories of cancer patients that can be accessed by researchers. Robust mechanisms and policies are needed to ensure that patient privacy and confidentiality are preserved while delivering a repository of such medically rich information for the purposes of scientific research. This paper summarises the overall approach adopted by CLEF to meet data protection requirements, including the data flows and pseudonymisation mechanisms that are currently being developed. Intended constraints and monitoring policies that will apply to research interrogation of the repository are also outlined. Once evaluated, it is hoped that the CLEF approach can serve as a model for other distributed electronic health record repositories to be accessed for research

An Upper Bound to Zero-Delay Rate Distortion via Kalman Filtering for Vector Gaussian Sources

We deal with zero-delay source coding of a vector Gaussian autoregressive (AR) source subject to an average mean squared error (MSE) fidelity criterion. Toward this end, we consider the nonanticipative rate distortion function (NRDF) which is a lower bound to the causal and zero-delay rate distortion function (RDF). We use the realization scheme with feedback proposed in [1] to model the corresponding optimal "test-channel" of the NRDF, when considering vector Gaussian AR(1) sources subject to an average MSE distortion. We give conditions on the vector Gaussian AR(1) source to ensure asymptotic stationarity of the realization scheme (bounded performance). Then, we encode the vector innovations due to Kalman filtering via lattice quantization with subtractive dither and memoryless entropy coding. This coding scheme provides a tight upper bound to the zero-delay Gaussian RDF. We extend this result to vector Gaussian AR sources of any finite order. Further, we show that for infinite dimensional vector Gaussian AR sources of any finite order, the NRDF coincides with the zero-delay RDF. Our theoretical framework is corroborated with a simulation example.Comment: 7 pages, 6 figures, accepted for publication in IEEE Information Theory Workshop (ITW

Constrained Dynamics of Tachyon Field in FRWL Spacetime

In this paper we continue study of tachyon scalar field described by a Dirac-Born-Infeld (DBI) type action with constraints in the cosmological context. The proposed extension of the system introducing an auxiliary field in the minisuperspace framework is discussed. A new equivalent set of constraints is constructed, satisfying the usual regularity conditions.Comment: 10 pages, to be published in the Special Issue of the Facta Universitatis Series: Physics, Chemistry and Technology devoted to the SEENET-MTP Balkan Workshop BSW2019 (3-14 June 2018, Nis, Serbia

Diagnostic and therapeutic considerations in idiopathic hypereosinophilia with warm autoimmune hemolytic anemia.

Hypereosinophilic syndrome (HES) encompasses numerous diverse conditions resulting in peripheral hypereosinophilia that cannot be explained by hypersensitivity, infection, or atopy and that is not associated with known systemic diseases with specific organ involvement. HES is often attributed to neoplastic or reactive causes, such as chronic eosinophilic leukemia, although a majority of cases remains unexplained and are considered idiopathic. Here, we review the current diagnosis and management of HES and present a unique case of profound hypereosinophilia associated with warm autoimmune hemolytic anemia requiring intensive management. This case clearly illustrates the limitations of current knowledge with respect to hypereosinophilia syndrome as well as the challenges associated with its classification and management