ОСОБЕННОСТИ ВОСПРОИЗВОДСТВА ЧЕЛОВЕЧЕСКОГО КАПИТАЛА В СОЦИАЛЬНОМ ИНСТИТУТЕ СЕМЬИ

Article retractedSubject / topic. The article deals with the problem of increasing the qualitytion of human capital on the basis of enhancing the role of the social institution of the family. The issues of socialization of young people and involving them in a motivated work.Purpose. The main purpose of the presentation material in this article we conclude, is to find methods to increase efficiency chelovechesky potential on the basis of family relationships.Methodology. In this paper, the methods used: abstractstion, analysis and synthesis, analogy, dialectic method of induction and deduction, observation, generalization, objectivism, compare.Conclusions / relevance. In the context of the trends of aging and reduction of the country's population, the reform of the pension system creates a number of conditions on the one hand, contribute to the solution of the demographic problem, but on the other – has a multifactorial effect on the quality of human capital as a result of parental work. The article presents the possible approaches to solving this problem. Practical application of the results of this work will allow to rethink the approach to the concept of human resources, improving the socio-economic development of theRussian Federation. Статья отозванаПредмет / тема. В статье рассматриваются проблемы повышения качества человеческого капитала на основе повышение роли такого социального института как семья. Рассматриваются вопросы социализации молодежи и их привлечения к мотивированной трудовой деятельности. Цель. Основная цель изложения материалов в данной статье заключается в поиске методов повышения эффективности использования человеческого потенциала на основе семейных отношений.Методология. В настоящей работе использованы методы: абстрагирования, анализа и синтеза, аналогии, диалектики, метод индукции и дедукции, наблюдения, обобщения, объективизма, сравнения.Выводы / значимость. В условиях тенденции старения и сокращения населения страны, реформа пенсионной системы создает ряд условий, с одной стороны, способствующих решению демографической проблемы, а с другой – оказывающих многофакторное влияние на качество человеческого капитала как результата родительского труда. В статье приводятся возможные подходы к решению данной проблемы.Практическое применение результатов данной работы позволит переосмыслить подход к концепции человеческих ресурсов, повышение эффективности социально-экономического развития Российской Федерации.

Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation

FEATURES OF REPRODUCTION OF THE HUMAN CAPITAL IN THE SOCIAL INSTITUTION OF THE FAMILY

Article retractedSubject / topic. The article deals with the problem of increasing the qualitytion of human capital on the basis of enhancing the role of the social institution of the family. The issues of socialization of young people and involving them in a motivated work.Purpose. The main purpose of the presentation material in this article we conclude, is to find methods to increase efficiency chelovechesky potential on the basis of family relationships.Methodology. In this paper, the methods used: abstractstion, analysis and synthesis, analogy, dialectic method of induction and deduction, observation, generalization, objectivism, compare.Conclusions / relevance. In the context of the trends of aging and reduction of the country's population, the reform of the pension system creates a number of conditions on the one hand, contribute to the solution of the demographic problem, but on the other – has a multifactorial effect on the quality of human capital as a result of parental work. The article presents the possible approaches to solving this problem. Practical application of the results of this work will allow to rethink the approach to the concept of human resources, improving the socio-economic development of theRussian Federation

Dryocoetiops krivetsae sp. n. (Coleoptera: Curculionidae: Scolytinae: Dryocoetini), the northernmost species of the genus: conflicts between molecular and morphological data in the tribe Dryocoetini

Kerchev, Ivan A., Ilinsky, Yury Yu., Bykov, Roman A., Mandelshtam, Mikhail Yu. (2023): Dryocoetiops krivetsae sp. n. (Coleoptera: Curculionidae: Scolytinae: Dryocoetini), the northernmost species of the genus: conflicts between molecular and morphological data in the tribe Dryocoetini. Zootaxa 5369 (2): 269-276, DOI: 10.11646/zootaxa.5369.2.6, URL: https://www.mapress.com/zt/article/download/zootaxa.5369.2.6/5224

FIGURE 1 in Dryocoetiops krivetsae sp. n. (Coleoptera: Curculionidae: Scolytinae: Dryocoetini), the northernmost species of the genus: conflicts between molecular and morphological data in the tribe Dryocoetini

FIGURE 1. Dryocoetiops krivetsae (female), paratype, habitus and details. A–F: habitus; C: frons; G: antennae; D, H: declivity.Published as part of <i>Kerchev, Ivan A., Ilinsky, Yury Yu., Bykov, Roman A. & Mandelshtam, Mikhail Yu., 2023, Dryocoetiops krivetsae sp. n. (Coleoptera: Curculionidae: Scolytinae: Dryocoetini), the northernmost species of the genus: conflicts between molecular and morphological data in the tribe Dryocoetini, pp. 269-276 in Zootaxa 5369 (2)</i> on page 271, DOI: 10.11646/zootaxa.5369.2.6, <a href="http://zenodo.org/record/10150742">http://zenodo.org/record/10150742</a&gt

FIGURE 2 in Dryocoetiops krivetsae sp. n. (Coleoptera: Curculionidae: Scolytinae: Dryocoetini), the northernmost species of the genus: conflicts between molecular and morphological data in the tribe Dryocoetini

FIGURE 2. The maximum likelihood phylogenetic tree of the tribe Dryocoetini based on the 417 bp COI region. The GenBank or BOLD accession numbers are indicated. The new species Dryocoetiops krivetsae is highlighted in bold. Bootstrap (1000 replicates) values higher than 60 are provided. N.B.: synonyms of D. moestus (=D. coffeae and D. cf. eugeniae) are given according to invalid specific epithets listed in GenBank.Published as part of <i>Kerchev, Ivan A., Ilinsky, Yury Yu., Bykov, Roman A. & Mandelshtam, Mikhail Yu., 2023, Dryocoetiops krivetsae sp. n. (Coleoptera: Curculionidae: Scolytinae: Dryocoetini), the northernmost species of the genus: conflicts between molecular and morphological data in the tribe Dryocoetini, pp. 269-276 in Zootaxa 5369 (2)</i> on page 273, DOI: 10.11646/zootaxa.5369.2.6, <a href="http://zenodo.org/record/10150742">http://zenodo.org/record/10150742</a&gt

FIGURE 3 in Dryocoetiops krivetsae sp. n. (Coleoptera: Curculionidae: Scolytinae: Dryocoetini), the northernmost species of the genus: conflicts between molecular and morphological data in the tribe Dryocoetini

FIGURE 3. The maximum likelihood phylogenetic tree of the tribe Dryocoetini based on the 406 bp 28S rRNA region. The GenBank or BOLD accession numbers are indicated. The new species Dryocoetiops krivetsae is highlighted in bold. Bootstrap (1000 replicates) values higher than 60 are provided. N.B.: Synonyms of D. moestus (=D. coffeae and D. cf. eugeniae) are given according to invalid specific epithets listed in GenBank.Published as part of <i>Kerchev, Ivan A., Ilinsky, Yury Yu., Bykov, Roman A. & Mandelshtam, Mikhail Yu., 2023, Dryocoetiops krivetsae sp. n. (Coleoptera: Curculionidae: Scolytinae: Dryocoetini), the northernmost species of the genus: conflicts between molecular and morphological data in the tribe Dryocoetini, pp. 269-276 in Zootaxa 5369 (2)</i> on page 274, DOI: 10.11646/zootaxa.5369.2.6, <a href="http://zenodo.org/record/10150742">http://zenodo.org/record/10150742</a&gt

ZnO Particles Stabilized in Polymeric Matrix for Liquid-Phase Methanol Synthesis

ZnO supported on hypercrosslinked polystyrene was developed for liquid-phase methanol synthesis. The synthesized catalyst was characterized using the low-temperature nitrogen physisorption, TEM, XPS, XAS, and CO DRIFT methods. The analysis showed that the catalyst has a high specific surface area (720 m2/g) and is characterized by the micro-mesoporous structure typical of the polymer used. The active phase is represented by ZnO species with a hexagonal wurtzite structure. ZnO-HPS showed high activity, selectivity, and stability in liquid-phase methanol synthesis in comparison with the industrial catalyst. The activity of the proposed catalyst was found to be 1.64 times higher than that of the conventional Cu/ZnO/Al2O3

Preliminary insights into enamel formation in a human tooth from Dong Son Metal Period Northern Vietnam

Human dental enamel forms in a regular fashion, producing incremental and periodic layers that can be studied microstructurally. Long-period lines, known as striae of Retzius, are used by histologists to reconstruct dental growth and development in modern and ancient human populations. Here we report first and preliminary insights into enamel formation rates in an ancient human upper third molar representing a Dong Son Metal Age (c. 2000 BP) sample from northern Vietnam. Nine Retzius lines (RL) from the lateral enamel on the mesiobuccal paracone cusp were measured in a thin section to estimate the average Retzius periodicity (RP) between two adjacent RL’s. The average RL thickness was then analysed using daily secretion rates that range from 3.5 to 4.5 µm. The average RL thickness measured approximately 34.95 µm. The RP for this tooth lay between 7.77 and 9.99 days which suggests a single RP value that lies between 8 to 10 days. Our estimate of RP for this ancient Vietnamese individual’s tooth is higher when compared to data available for modern Chinese and Chinese-Singaporean populations. However, the RP for this individual from northern Vietnam lies within the range of RP’s between 6 to 12 days for modern human permanent teeth. Ongoing research will aim to source more dental samples to expand the RP dataset

Primary Amine Nucleophilic Addition to Nitrilium <i>Closo</i>-Dodecaborate [B₁₂H₁₁NCCH₃]⁻: A Simple and Effective Route to the New BNCT Drug Design

In the present work, a convenient and straightforward approach to the preparation of borylated amidines based on the closo-dodecaborate anion [B12H11NCCH3NHR]−, R=H, Alk, Ar was developed. This method has two stages. A nitrile derivative of the general form [B12H11NCCH3]− was obtained, using a modified technique, in the first stage. On the second stage the resulting molecular system interacted with primary amines to form the target amidine products. This approach is characterised by a simple chemical apparatus, mild conditions and high yields of the final products. The mechanism of the addition of amine to the nitrile derivative of the closo-dodecaborate anion was studied, using quantum-chemical methods. The interaction between NH3 and [B12H11NCCH3]− ammonia was chosen as an example. It was found that the structure of the transition state determines the stereo-selectivity of the process. A study of the biological properties of borylated amidine sodium salts indicated that the substances had low toxicity and could accumulate in cancer cells in significant amounts