Magnetic-Responsive Doxorubicin-Containing Materials Based on Fe3O4 Nanoparticles with a SiO2/PEG Shell and Study of Their Effects on Cancer Cell Lines

Novel nanocomposite materials based on Fe3O4 magnetic nanoparticles (MNPs) coated with silica and covalently modified by [(3-triethoxysilyl)propyl]succinic acid–polyethylene glycol (PEG 3000) conjugate, which provides a high level of doxorubicin (Dox) loading, were obtained. The efficiency of Dox desorption from the surface of nanomaterials under the action of an alternating magnetic field (AMF) in acidic and neutral media was evaluated. Their high cytotoxicity against tumor cells, as well as the drug release upon application of AMF, which leads to an increase in the cytotoxic effect, was demonstrated

Sustainable Pulping and Papermaking Technology Using Blends of Woodchips with Agricultural Residue

Presented on April 18, 2013 from 11:00 am - 12:30 pm in the Georgia Tech Library Wilby RoomRuntime: 70:30 minutesThe Moving Toward a Sustainable Future panel presented research on such sustainability topics from climate change to saving trees by making paper from grains.Levit: A new approach to pulping agricultural residue is presented where wood chips are pulped together with wheat straw and corn stover in one digester. The availability and cost of virgin fiber are often limiting the mill’s productivity hence utilization of compatible agricultural residue may at least partially solve the problem as well as establish new products with modified and improved properties. This study employs annual crop residues as biorenewable resources that can be substituted for 10, 15 and 20 % of woodchips without special changes in pulping conditions. The benefit of using agricultural residues is their low cost and wide availability. Slightly higher yields and increase in Kappa number are observed for brownstock while mechanical properties of handsheets are improved significantly. Bleaching of pulps made from blends containing agricultural residue and hardwood chips was also investigated by applying a relatively mild sequence to achieve target brightness ISO 89. Overall a maximum increase in tensile index was 29% and 12% in tear index for unrefined samples containing wheat straw in comparison to hardwood-only control sample. Viscosities of pulps and carbohydrate profiles were traced throughout the pulping and bleaching process and black liquor analysis was performed. Physical properties development is attributed to higher levels of xylan that is introduced with agricultural fiber and an attempt is made to correlate xylan content to the strength of handsheets

Improving Physical Properties of Kraft Hardwood Pulps by Copulping with Agricultural Residues

Wheat straw and corn stover are promising biorenewable resources that can be utilized in the pulp and paper industry. This study examines changes in the physical strength of pulps made from blends of agricultural residue and hardwoods. Wheat straw and corn stover were substituted for hardwood chips in the amounts of 10, 15, and 20 wt % in kraft pulping experiments while keeping the H-factor constant. This substitution allows a maximum 29% increase in tensile index and 12%increase in tear index for unrefined samples containing wheat straw. Pulp yields and kappa numbers changed slightly with increasing woodchip replacement levels. Three substituted pulps were bleached using a relatively mild OD­(E + P + O)­D sequence, and the viscosities and sugar profiles were traced throughout the process. The strength improvement can be attributed to the increased xylan contents of pulps made with agricultural residue. Fully bleached pulps preserved the improved mechanical properties, and an attempt was made to correlate the xylan content with the degree of strength development

Synthesis of Charge-Compensated <i>nido</i>-Carboranyl Derivatives of Sulfur-Containing Amino Acids and Biotin

A new group of charge-compensated nido-carboranyl derivatives of sulfur-containing amino acids and biotin has been synthesized in which the boron atom in position 9 or 10 of carborane is attached to a positively charged sulfur atom. The possibilities of obtaining symmetrical B(10)-substituted and asymmetric B(9)-substituted nido-carboranes were studied. Using the example of (S)-methionine and D-biotin derivatives, water-soluble S-substituted charge-compensated nido-carboranes with free functional groups were prepared. The results obtained open up prospects for the development of potential boron delivery agents for BNCT as well as new bioactive compounds containing a negatively charged nido-carboranyl fragment bearing a positive charge on the sulfur atom associated with the boron cluster

Cultural Anthropology of Education. Vol. 2. Language Portraits of an Educated Man in the Cultural History

Данной книгой продолжен проект, посвященный анализу исторических аспектов культурной антропологии образования. Вторая книга проекта представляет филологическое исследование языковых портретов "человека образованного" в различных культурах - в культуре античного Рима, западного (латиноязычного) Средневековья и Японии эпохи Мэйдзи

Pan-TGFβ inhibition by SAR439459 relieves immunosuppression and improves antitumor efficacy of PD-1 blockade

TGFβ is a pleiotropic cytokine that may have both tumor inhibiting and tumor promoting properties, depending on tissue and cellular context. Emerging data support a role for TGFβ in suppression of antitumor immunity. Here we show that SAR439459, a pan-TGFβ neutralizing antibody, inhibits all active isoforms of human and murine TGFβ, blocks TGFβ-mediated pSMAD signaling, and TGFβ-mediated suppression of T cells and NK cells. In vitro, SAR439459 synergized with anti-PD1 to enhance T cell responsiveness. In syngeneic tumor models, SAR439459 treatment impaired tumor growth, while the combination of SAR439459 with anti–PD-1 resulted in complete tumor regression and a prolonged antitumor immunity. Mechanistically, we found that TGFβ inhibition with PD-1 blockade augmented intratumoral CD8+ T cell proliferation, reduced exhaustion, evoked proinflammatory cytokines, and promoted tumor-specific CD8+ T cell responses. Together, these data support the hypothesis that TGFβ neutralization using SAR439459 synergizes with PD-1 blockade to promote antitumor immunity and formed the basis for the ongoing clinical investigation of SAR439459 in patients with cancer (NCT03192345)