Comparing the Seed Cotton and Wheat Marketing Chains in Sindh

This paper contrasts the operation of seed cotton and wheat marketing systems in Sindh. Analysis of marketing margins indicates that the private sector cotton marketing chain appears to be working efficiently, given the many adverse aspects of its socioeconomic environment. There is evidence that higher domestic prices resulting from alignment with world markets have been transmitted through the marketing chain to producers, and that production has increased. In contrast to cotton, the government continues to be heavily involved in wheat procurement and storage, with private traders usually acting as intermediaries between the Food Department and the grower. Despite expensive involvement of the same private traders as in cotton, the wheat market is characterised by bureaucratic failure and rent-seeking behaviour, leading to stagnation of incentives and production. For cotton, the primary recommendations are to sustain liberalisation of the market and to support the developing beneficial model of private competition through improvements in communications and transport infrastructure. The practical means to improve the grading of cotton lint and seed cotton should also be developed and promoted to provide incentives for higher quality output. For wheat, the main recommendations are to liberalise farmgate prices, reduce the state’s role in procurement, and privatise government godowns. Research is needed on how this might best be achieved, with attention to the conditions necessary for private financing of storage activities, and to ways of minimising price and supply fluctuations. The impact of higher flour prices on poor consumers also needs to be addressed.

Levelling the playing field between rural schools and urban schools in a HE context : a Scottish case study

Funding: Scottish Funding Council, Scottish Government.At a time when interventions in widening access to, and participation in, higher education aim to maximise impact by engaging with schools located in the most deprived communities, school pupils in rural communities, and who experience deprivation, are, in practice, less likely to benefit. Using statistics available from the Scottish government, we show that state secondary schools located in Scottish remote or rural areas are not well served by the indicators capturing socio‐economic, educational, or geographical deprivation widely used in the selection of schools for these outreach interventions. We construct a marker that identifies schools facing higher levels of deprivation than the Scottish average. We argue that (1) this marker is a step in the direction towards levelling the playing field between remote or rural schools and urban schools; and (2) it selects a wider range of schools for outreach interventions.Publisher PDFPeer reviewe

Evolutionary and Physiological Importance of Hub Proteins

It has been claimed that proteins with more interaction partners (hubs) are both physiologically more important (i.e., less dispensable) and, owing to an assumed high density of binding sites, slow evolving. Not all analyses, however, support these results, probably because of biased and less-than reliable global protein interaction data. Here we provide the first examination of these issues using a comprehensive literature-curated dataset of well-substantiated protein interactions in Saccharomyces cerevisiae. Whereas use of less reliable yeast two-hybrid data alone can reject the possibility that local connectivity correlates with measures of dispensability, in higher quality datasets a relatively robust correlation is observed. In contrast, local connectivity does not correlate with the rate of protein evolution even in reliable datasets. This perhaps surprising lack of correlation with evolutionary rate appears in part to arise from the fact that hub proteins do not have a higher density of residues associated with binding. However, hub proteins do have at least one other set of unusual features, namely rapid turnover and regulation, as manifest in high mRNA decay rates and a large number of phosphorylation sites. This, we suggest, is an adaptation to minimize unwanted activation of pathways that might be mediated by adventitious binding to hubs, were they to actively persist longer than required at any given time point. We conclude that hub proteins are more important for cellular growth rate and under tight regulation but are not slow evolving

Community-based Suicide Prevention Research in Remote On-Reserve First Nations Communities

Suicide is a complex problem linked to genetic, environmental, psychological and community factors. For the Aboriginal population more specifically, loss of culture, history of traumatic events, individual, family and community factors may also play a role in suicidal behaviour. Of particular concern is the high rate of suicide among Canadian Aboriginal youth. While the need to develop interventions to reduce suicidal behaviour for First Nations on-reserve populations is evident, there may be an element of distrust of researchers by Aboriginal communities. Furthermore, research in mental health and specifically suicide is much more sensitive than studying medical illnesses like diabetes. Clearly, this issue requires a unique and insightful approach. While numerous suicide prevention/intervention plans and guidelines have been published specifically for work involving Aboriginal people, the literature lacks a comprehensive discussion of the methodological and logistical issues faced by research teams and Aboriginal communities attempting to develop culturally-grounded and community-specific suicide prevention and intervention strategies. This paper outlines the research process, key challenges and lessons learned in a collaborative University-First Nations suicide prevention project conducted with eight north-western Manitoba First Nations communities (Canada)

PSMA-targeting positron emission agents for imaging solid tumors other than non-prostate carcinoma : a systematic review

Despite its name, prostate-specific membrane antigen (PSMA) has been shown using immunohistochemistry (IHC) to also be over-expressed in the tumor neovasculature of a wide variety of solid tumors other than prostate carcinoma. Accordingly, positron-emitting radiolabeled small molecules targeting PSMA, initially developed for positron emission tomography in prostate carcinomas, are currently being explored for their staging and restaging potential as an alternative imaging modality in other solid tumor types where 18-F-fluorodeoxyglucose (FDG)-PET imaging has low diagnostic accuracy. In this paper, the currently available literature in this field is reviewed. Preliminary, mainly retrospective studies are encouraging, with evidence of improved diagnostic sensitivity and specificity in clear cell renal carcinoma, glioma, and hepatocellular carcinoma, leading to a change in patient management in several patients. However, the results published thus far warrant confirmation by larger prospective studies additionally assessing the longitudinal impact on patient outcomes

Activist experiences of solidarity work

In the runup to Mayday 2014 the special issue editors invited activists to comment on a range of questions about their experience of solidarity work and its practical challenges. We’ve edited the responses together into a single piece which we hope will provoke reflection