Digitalization or flexibilization? The changing role of technology in the political economy of Japan

We are increasingly surrounded by talk of digitalization. Yet, we remain unsure about what impact this digitalization will have upon socio-economic institutions, how the introduction of this digitalization will be contested, the likely role of the state in managing the adoption of digital technology, and the likely consequences for the broader political economy if and when it is introduced. This article examines the process of digitalization as it has unfolded in the service sector in Japan. Based on qualitative interviews with managers in the hospitality industry and union officials, the paper depicts a process that contrasts starkly with the more optimistic view adopted by some commentators, according to which digitalization has the potential to improve working conditions and contribute to a more stable form of growth. Instead, the paper draws on Regulation Theory to argue that the introduction of digitalization is part of a wider process of neoliberalization. As such, digitalization has contributed to deskilling, the fragmentation of work tasks, a digital divide, the intensification of work, and higher levels of workplace surveillance. This represents a further dismantling of the social compromise that underpinned Japan’s earlier period of economic growth

The Upregulation of Molecules Related to Tumor Immune Escape in Human Pituitary Adenomas

Human pituitary adenomas are one of the most common intracranial neoplasms. Although most of these tumors are benign and can be treated medically or by transsphenoidal surgery, a subset of these tumors are fast-growing, aggressive, recur, and remain a therapeutic dilemma. Because antibodies against immune checkpoint receptors PD-1 and CLTA-4 are now routinely used for cancer treatment, we quantified the expression of mRNA coding for PD-1, CLTA-4, and their ligands, PD-L1, PD-L2, CD80, and CD86 in human pituitary adenomas and normal pituitary glands, with the ultimate goal of exploiting immune checkpoint therapy in aggressive pituitary adenomas. Aggressive pituitary adenomas demonstrated an increased expression of PD-L2, CD80, and CD86 in compared to that of normal human pituitary glands. Furthermore, aggressive pituitary tumors demonstrated significantly higher levels of CD80 and CD86 compared to non-aggressive tumors. Our results establish a rationale for studying a potential role for immune checkpoint inhibition therapy in the treatment of pituitary adenomas