A review of symptomatic leg length inequality following total hip arthroplasty

Leg length inequality (LLI) following total hip replacement is a complication which features increasingly in the recent literature. The definition of LLI is complicated by lack of consensus regarding radiological measurement, clinical measurement and the incomplete relationship between LLI and associated symptoms. This paper reviews 79 reports relating to LLI post hip replacement, detailing definitions and classification and highlighting patient populations prone to symptomatic LLI. While there is no universal definition of LLI, there is a broad consensus that less than 10 mm of difference on AP view plain radiographs is clinically acceptable. There are few techniques described that consistently produce a postoperative LLI of less than this magnitude. Where postoperative LLI exists, lengthening appears to cause more problems than shortening. In cases of mild LLI, non-surgical management produces adequate outcomes in the majority of cases, with functional LLI cases doing better than those with true LLI. Operative correction is effective in half of cases, even where nerve palsy is present, and remains an important option of last resort. Poor outcomes in patients with LLI may be minimised if individuals at risk are identified and counselled appropriately

Is monocyte chemotactic protein 1 elevated in aseptic loosening of TKA? A pilot study

Item does not contain fulltextBACKGROUND: Failure of TKA from aseptic loosening is a growing concern, as TKA is performed with increasing frequency. Loosening is multifactorial and may be associated with elevated inflammatory cytokines in addition to biomechanical failure. QUESTIONS/PURPOSES: We asked whether proinflammatory cytokines and chemokines are elevated in synovial fluid from patients undergoing revision surgery as compared to those with osteoarthritis (OA) or rheumatoid arthritis (RA). METHODS: We obtained synovial fluid samples from 20 patients: six with aseptic loosening of TKA (all with bone loss), 10 with primary OA, and four with RA. A panel of cytokines/chemokines was screened using a SearchLight((R)) Array (Pierce Biotechnology, Rockford, IL, USA) in one revision sample. Using these data, we assayed the synovial fluids for monocyte chemotactic protein 1 (MCP-1) by ELISA. RESULTS: We observed an increase in synovial MCP-1 levels in samples from patients planned for TKA revision compared to those with OA or RA. In patients undergoing revision arthroplasty, the mean (+/- SD) MCP-1 concentration was 21,233 +/- 18,966 pg/mL (range, 1550-50,657 pg/mL; n = 6). In patients with OA, the mean MCP-1 level was 3012 +/- 3321 pg/mL. In patients with RA, the mean MCP-1 concentration was 690 +/- 561 pg/mL. CONCLUSIONS: All patients undergoing revision TKA showed elevated concentrations of MCP-1 compared to patients with OA and RA, suggesting MCP-1 may serve as a potential marker or predictor of bone loss in patients undergoing revision surgery. CLINICAL RELEVANCE: MCP-1 may be a novel biomarker in patients showing early symptoms of aseptic loosening of TKA

Femoral neck cut level affects positioning of modular short-stem implant

A trend in total hip arthroplasty surgery has been to design more bone-preserving procedures, especially for younger patients. This study investigated the final implant positioning of a short metaphyseal femoral neck type of implant to determine whether leg length, caput collum diaphysis (CCD) angle, and offset could be re-created with different levels of femoral neck resection. Ten cadaveric hips in 6 whole-body specimens were used, with 3 fiducial markers to allow registration of computer navigation points to computed tomography scan data. Three femoral neck resection levels were investigated: 0 mm, +5 mm (the recommended level of resection), and +10 mm from the base of the femoral neck. Results showed that the CCD angle was significantly higher with 0-mm neck cut and the offset was lower, whereas the highest neck cut had longer leg-length results. Surgeons who use a short metaphyseal stem need to realize the importance of a proper femoral neck cut to restore anatomic parameters as well as the possible benefit of computer-assisted surgery to restore these anatomic parameters during surgery