13 research outputs found
Saúde Mental em meio prisional : avaliação de necessidades de cuidados em reclusos com perturbação mental
RESUMO: A população prisional é constituída por indivíduos geralmente sujeitos a alguma forma
de exclusão social e que apresentam problemas de saúde física e mental mais frequentes do
que na população em geral.
A prevalência mais elevada de perturbações mentais e de suicídio nos reclusos, em
relação à população civil, é consensual e está demonstrada em numerosos estudos
internacionais. O abuso/dependência de substâncias, a depressão, as psicoses e a
perturbação anti-social de personalidade são as perturbações mais comuns na população
prisional. As perturbações mentais são importantes factores de risco de suicídio, de
vitimização, de reincidência e de reentrada no sistema prisional. Assim sendo, o grupo de
reclusos com perturbação mental constitui um grupo de risco relevante.
A avaliação de necessidades de cuidados foi iniciada no Reino Unido como um método
para o planeamento, medição dos resultados e financiamento dos cuidados de saúde. Para
esta avaliação foram desenvolvidos instrumentos que avaliam as necessidades em diversos
domínios (clínicos e sociais) para aplicação aos utentes, cuidadores e profissionais.
Até aos anos noventa, a avaliação de necessidades no contexto prisional incidia
especialmente nas necessidades de segurança dos serviços, segundo a perspectiva dos
profissionais. Contudo, a partir do relatório Reed (1992), sobre a situação dos reclusos com
perturbação mental, verificou-se uma abordagem mais abrangente, que incluía a avaliação das
necessidades de cuidados dos reclusos.
Embora as necessidades dos reclusos com perturbação mental pareçam ser similares
às dos doentes psiquiátricos em geral, existem diferenças em determinados domínios como a
comorbilidade do eixo II, o abuso de substâncias e o risco de violência. Por este motivo, as
necessidades de cuidados de saúde mental dos reclusos são elevadas e frequentemente não
se encontram satisfeitas. De forma a incluir estas especificidades foi desenvolvida a versão
forense do Camberwell Assessment of Need (CAN), designada por CAN - Forensic Version
(CANFOR).
Actualmente existe um consenso generalizado entre as instituições internacionais do
dever de proporcionar aos reclusos cuidados de saúde, de prevenção e de tratamento,
equivalentes aos cuidados disponíveis para a população civil - o princípio da equivalência de
cuidados.
A presente investigação pretendeu caracterizar e avaliar as necessidades de cuidados
dos reclusos acompanhados nos serviços de psiquiatria prisionais na área da Grande Lisboa
(internamento no Serviço de Psiquiatria do Hospital Prisional de S. João de Deus (HPSJD) e
consultas nos Estabelecimentos Prisionais (EP) de Caxias e de Tires). De modo a estabelecer uma comparação com sujeitos civis foi seleccionada uma amostra de conveniência de
pacientes acompanhados num departamento de psiquiatria da mesma região, segundo um
emparelhamento por sexo, escalão etário, e por diagnóstico, num período de 3 meses.
Realizou-se um estudo de tipo observacional, transversal e comparativo. Aplicaram-se
os seguintes instrumentos de avaliação: questionário específico, Brief Psychiatric Rating Scale
4.0, Mini International Neuropsychiatric Interview 5.0.0, Global Assessment Functioning, CAN-R
e CANFOR-R.
No período do estudo (12 meses) foram assistidos 149 reclusos, dos quais, 35 (23,5%)
não cumpriram os critérios de inclusão. A amostra final de reclusos (PRs) (n=114) foi
constituída por 79 homens (69,3%) e 35 mulheres (30,7%), dos quais 77 eram condenados
(67,5%) e 37 (32,5%) encontravam-se detidos preventivamente.
A amostra final de participantes civis (PCs) foi constituída por 121 indivíduos, dos quais
76 eram homens (62,8%) e 45 eram mulheres (37,2%).A amostra final de participantes civis (PCs) foi constituída por 121 indivíduos, dos quais
76 eram homens (62,8%) e 45 eram mulheres (37,2%).
Relativamente aos PRs, o diagnóstico mais frequente foi a Perturbação Anti-social da
Personalidade (57,9%), seguida pela Depressão Major (56,1%). A maioria (53,5%) apresentava
três ou mais categorias diagnósticas. Aproximadamente um terço dos PRs (30%) pontuou o
nível elevado de risco de suicídio. A probabilidade deste risco aumentava, significativamente,
nos portadores de Depressão Major, de um maior nível de psicopatologia e de uma
condenação actual.
Perto de metade dos PRs (47,4%) possuía duas ou mais condenações prévias e mais
de metade estavam envolvidos em crimes contra pessoas (53,5%). A probabilidade de
condenações múltiplas foi significativamente superior nos portadores de Perturbação Antisocial
da Personalidade e nos reclusos com maior número de necessidades totais.
Entre os PRs dos dois sexos, as principais diferenças significativas residiram na maior
frequência de consumo de substâncias e no maior número de necessidades de cuidados nãosatisfeitas
nos homens versus mulheres.
A comparação entre os PRs, antes da detenção, e os PCs mostrou que os primeiros
possuíam menor escolaridade, menos medicação psiquiátrica, mas mais emprego e mais
consumos de substâncias ilícitas. A Perturbação Anti-social da Personalidade (OR=26,4;
IC95%: 10,7-64,9), a Perturbação Pós-stress Traumático (OR=15,0; IC95%: 3,5-65,4), a
Dependência/Abuso de Substâncias (OR=8,5; IC95%: 4,2-17,6) a Depressão Major (OR=2,6;
IC95%: 1,5-4,4) e o Risco de Suicídio Elevado (OR=2,6; IC95%: 1,4-5,0) foram
significativamente mais frequentes nos PRs versus PCs.
Relativamente à avaliação de necessidades de cuidados, os PRs mostraram maior
número de necessidades não-satisfeitas e maior necessidade de ajuda profissional, em relação
aos PCs. Embora diversas necessidades não-satisfeitas possam resultar da condição de
recluso, outras, em domínios da saúde física, da segurança do próprio e dos consumos tóxicos,
poderão indicar que os PRs recebem um nível de cuidados inferior ao necessário, em
comparação com os PCs.
Os PRs apresentaram patologia mental, predominantemente não-psicótica e elevado
risco de suicídio/auto-agressão, associado a depressão, necessidades de cuidados e uma pena de prisão. Possuíam, numa frequência elevada, características, consistentemente,
associadas à reincidência criminal (personalidade anti-social, consumos tóxicos, condenações
anteriores), pelo que se justifica um especial acompanhamento deste grupo, no período pré e
pós-libertação.
A comparação de necessidades de cuidados no contexto civil e prisional indica um
maior nível de necessidades e um menor nível de cuidados recebidos pelos PRs, em relação
aos PCs. O princípio da equivalência de cuidados poderá estar comprometido nos indivíduos
reclusos com perturbação mental.
A utilização do CANFOR foi fácil e poderá contribuir para um melhor planeamento,
oferta e avaliação de resultados ao nível individual.
Os PRs e PCs revelaram características clínicas e de necessidades muito diferentes
entre si, pelo que, os reclusos com perturbação mental deverão ser assistidos em serviços de
saúde mental preparados para abordar as suas especificidades.---------------ABSTRACT: The prison population is generally made up of individuals who are usually subject to
some sort of social exclusion and who show physical and mental problems more frequently than
the general population.
Various international studies have found higher rates of mental disturbances and
suicide within the prison population. The most common mental disturbances found are
substance abuse or dependency, depression, psychosis, and anti-social personality
disturbance. Such mental disturbances are important factors in suicide, victimization,
delinquency recurrence, and the risk of reentry into prison. As a result, prison inmates with
mental disturbances are a relevant at risk group. Assessment of needs of care first started in the United Kingdom as a method of care
planning, results measuring and finance health care. The method involved the development of
certain measuring instruments to be used by patients, caregivers and professionals in order to
evaluate needs in various domains (clinical and social).
Until the nineties, the assessment of needs of care in a prison context focused mainly
on the service’s security needs. However, after the Reed (1992) report on mentally disturbed
inmates, a much wider approach was considered, which included evaluation of the inmate’s
needs of care.
However similar mentally disturbed prison inmates’ needs may appear to those of other psychiatric patients, there are some differences in particular domains, namely, co-morbidity of
Axis II, substance abuse and the risk of violence. For this reason, inmates’ mental health care
needs are high and very often not met. In order to include these specificities, a forensic version
of the Camberwell assessment of need (CAN,) designated CAN – Forensic version (CANFOR)
was developed. There is now generalized consensus among international institutions of the duty
under the equivalent health care principle to provide inmates with preventative health care and
treatment, that are equivalent to the care available to the civil population.
This investigation aims to characterize and assess the health care provision of prison
inmates admitted to Lisbon’s Psychiatric Prison ward - the Psychiatric Ward of São João de
Deus Hospital (HPSJD) - and inmates in the Caxias and Tires Prison Establishments (EP)
undertaking outpatient treatment. In order to establish a comparison between prison and
civilian patients, a convenience sample was selected from civilian patients being treated in a
psychiatric ward in the same geographical area. This sample was paired by gender, age group
and diagnosis during a three month period.
The study was observational, transversal and comparative. The following measuring
instruments were used: a purpose-built questionnaire, Brief Psychiatric Rating Scale 4.0, Mini
International Neuropsychiatric Interview 5.0.0, Global Assessment Functioning Scale, CAN-R
and CANFOR-R. During the research period (12 months), 149 inmates received care, of whom 35
(23.5%) did not comply with the prerequisite criteria of this study. The final sample of inmates
(PRs) (n=114) comprised 79 men (69.3%) and 35 (30.7%) women, of whom 77 (67.5%) were
convicted prisoners and 37 (32.5%) were in preventive custody.
The final sample for Civilian Participants (PCs) was made up of 121 individuals, of
whom 76 (62.8%) were men and 45 (37.2%) were women.
The most common diagnosis among the PRs was Anti-Social Personality Disorder
(57.9%), followed by Major Depression (56.1%). More than half of the subjects in the sample
(53.5%) showed three or more diagnostic categories. Approximately one third (30%) of the PRs
showed a high level of suicide risk. The probability of this risk was significantly higher among
Major Depression patients, those showing a higher level of psychopathology and those with a
current conviction.
Almost half of the PRs (47.4%) had been given two or more prior convictions and more
than half (53.5%) were involved in crimes against people. The probability of multiple convictions
was significantly higher among inmates with Anti-Social Personality Disorder and in those with
more total needs.
With regard to gender, the main significant difference among the PRs was that men
were found to have a higher frequency of substance use and a greater number of unsatisfied
caring needs than women.
Comparison between the PRs prior to detention and PCs revealed that the former held
lower educational qualifications and received less psychiatric medication, but had higher levels
of employment and showed greater consumption of illicit substances. In addition Anti-Social
Personality Disorder (OR=26.4; IC 95%: 10.7-64.9), Post-Stress Traumatic Disturbance
(OR=15.0; IC 95%: 3.5-65.4), Substance Dependency/Abuse (OR=8.5; IC 95%: 4.2-17.6),
Major Depression (OR=2.6; IC 95%: 1.5-4.4), and High Suicide Risk (OR=2.6; IC 95%: 1.4-5.0)
were significantly more frequent amongst PRs than PCs.
The results for needs assessment revealed that the PRs showed higher levels of unmet
needs and a greater need for professional help in comparison with the PCs. Although various
unmet needs may result from the inmate’s condition, other needs - in particular those regarding
physical health, personal security and toxic substance use - suggest that the care given to PRs
may be inadequate in comparison with that given to PCs. This implies that the principle of
equivalent health care for PRs with mental illnesses may not be upheld.
Furthermore, the mental morbidity results of the PRs indicated that they suffer
predominantly from non-psychotic and high suicide/self inflicted aggression risk associated with
depression, caring needs and a prison sentence. They also often showed characteristics that
are consistently associated with criminal recidivism (Anti-social Personality, use of toxic
substances, prior convictions). This result justifies that there should be special follow-up for this
group in the pre- and after release period.
The use of CANFOR proved to be simple and the application delay was acceptable. No
difficulties were encountered in the understanding of its categories by its users. As a result, itcould contribute towards better planning, supply and assessment of results at an individual
level.
Given that the PRs and PCs revealed different clinical and needs characteristics, it is
recommended that inmates with mental disturbances should be assisted in mental health
services that are adequately prepared to address their specificities
First-episode psychosis in a 15 year-old female with clinical presentation of anti-NMDA receptor encephalitis: a case report and review of the literature
© 2016 The Author(s). Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.Background: Anti-NMDA receptor encephalitis is an autoimmune disease that was identified in 2007, and manifests in a stepwise manner with psychiatric, neurological and autonomic symptoms. The disease is caused by autoantibodies against NMDA receptors. It can have a paraneoplastic origin, mainly secondary to ovarian teratomas, but it can also be unrelated to the tumor. This disease can affect both sexes and all ages.
Case presentation: Here, we present a case of a 15 year-old female adolescent with first-episode psychosis with anti-NMDA receptor encephalitis not related to tumor, which manifested with delusion, hallucinations, panic attacks, agitation, and neurological symptoms, and later with autonomic instability. She was treated with immunotherapy and psychiatric medication resulting in improvement of her main psychiatric and neurological symptoms.
Conclusion: Our main objective in presenting this case is to alert clinicians to this challenging and recent disease that has a clinical presentation that might resemble a functional psychiatric condition and can be underdiagnosed in the context of child and adolescent psychiatry.info:eu-repo/semantics/publishedVersio
CANFOR Portuguese version: validation study
This study is embedded in the larger project "Needs Assessment of the Mentally Disordered Prisoners" funded by Fundacao para a Ciencia e Tecnologia (PIC/IC/83257/2007). We acknowledge the General-Director for Prison Services for his authorization, the Prisons' Directors for their support, the medical and non-medical staff who collaborated in this study and detainees for their participation. Special thanks to Dr Ana Cabral for her support inside the prisons and Dr Jorge Pereira for his assistance in manuscript preparation. In memory of our late friend Dr Jose Morais, who collaborated on and supported this study from the beginning.BACKGROUND The increase in prisoner population is a troublesome reality in several regions of the world. Along with this growth there is increasing evidence that prisoners have a higher proportion of mental illnesses and suicide than the general population. In order to implement strategies that address criminal recidivism and the health and social status of prisoners, particularly in mental disordered offenders, it is necessary to assess their care needs in a comprehensive, but individual perspective. This assessment must include potential harmful areas like comorbid personality disorder, substance misuse and offending behaviours. The Camberwell Assessment of Need - Forensic Version (CANFOR) has proved to be a reliable tool designed to accomplish such aims. The present study aimed to validate the CANFOR Portuguese version. METHODS The translation, adaptation to the Portuguese context, back-translation and revision followed the usual procedures. The sample comprised all detainees receiving psychiatric care in four forensic facilities, over a one year period. A total of 143 subjects, and respective case manager, were selected. The forensic facilities were chosen by convenience: one prison hospital psychiatric ward (n=68; 47.6%), one male (n=24; 16.8%) and one female (n=22; 15.4%) psychiatric clinic and one civil security ward (n=29; 20.3%), all located nearby Lisbon. Basic descriptive statistics and Kappa weighted coefficients were calculated for the inter-rater and the test-retest reliability studies. The convergent validity was evaluated using the Global Assessment of Functioning and the Brief Psychiatric Rating Scale scores. RESULTS The majority of the participants were male and single, with short school attendance, and accused of a crime involving violence against persons. The most frequent diagnosis was major depression (56.1%) and almost half presented positive suicide risk. The reliability study showed average Kappa weighted coefficients of 0.884 and 0.445 for inter-rater and test-retest agreement, respectively. The convergent validity study presented highly significant correlations between unmet needs scores, GAF and BPRS scores. CONCLUSIONS The CANFOR Portuguese version revealed similar psychometric properties to the original English version. Moreover, the results of the reliability and validity studies indicate that the tool is appropriate for individual care needs assessment and as a guide for the mental health and social interventions in forensic psychiatric services.publishersversionpublishe
The need to improve care transition interventions in psychiatry and mental health
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Arachnoid cyst in a patient with psychosis: Case report
<p>Abstract</p> <p>Background</p> <p>The aetiology of a psychotic disturbance can be due to a functional or organic condition. Organic aetiologies are diverse and encompass organ failures, infections, nutritional deficiencies and space-occupying lesions. Arachnoid cysts are rare, benign space-occupying lesions formed by an arachnoid membrane containing cerebrospinal fluid (CSF). In most cases they are diagnosed by accident. Until recently, the coexistence of arachnoid cysts with psychiatric disturbances had not been closely covered in the literature. However, the appearance of some references that focus on a possible link between arachnoid cysts and psychotic symptoms has increased the interest in this subject and raised questions about the etiopathogeny and the therapeutic approach involved.</p> <p>Clinical presentation</p> <p>We present the clinical report of a 21-year-old man, characterised by the insidious development of psychotic symptoms of varying intensity, delusional ideas with hypochondriac content, complex auditory/verbal hallucinations in the second and third persons, and aggressive behaviour. The neuroimaging studies revealed a voluminous arachnoid cyst at the level of the left sylvian fissure, with a marked mass effect on the left temporal and frontal lobes and the left lateral ventricle, as well as evidence of hypoplasia of the left temporal lobe. Despite the symptoms and the size of the cyst, the neurosurgical department opted against surgical intervention. The patient began antipsychotic therapy and was discharged having shown improvement (behavioural component), but without a complete remission of the psychotic symptoms.</p> <p>Conclusion</p> <p>It is difficult to be absolutely certain whether the lesion had influence on the patient's psychiatric symptoms or not.</p> <p>However, given the anatomical and neuropsychological changes, one cannot exclude the possibility that the lesion played a significant role in this psychiatric presentation. This raises substantial problems when it comes to choosing a therapeutic strategy.</p
Internamento compulsivo em psiquiatria. estudo comparativo de doentes com internamento compulsivo versus voluntário na Grande Lisboa
RESUMO
O internamento compulsivo em psiquiatria é uma intervenção de última linha
nos indivíduos que manifestam perturbações mentais graves e recusam tratamento,
fundamentada nos princípios de necessidade terapêutica e de protecção social.
Em Portugal, a última lei que regulamenta o internamento compulsivo vigora
desde 1999 (Lei 36/98 de 24 de Julho) e configura esta medida como um internamento
por decisão judicial, à semelhança de outros países europeus.
A presente investigação, de características exploratórias, pretendeu avaliar os
doentes internados involuntariamente do ponto de vista socio-demográfico e clínico e
estudar as diferenças entre estes doentes e os doentes internados voluntariamente na
região da Grande Lisboa. Para atingir estes objectivos foi delineado um estudo
observacional, transversal e comparativo. A partir de uma amostra de conveniência de
doentes internados compulsivamente procedeu-se ao emparelhamento dos doentes com
psicoses “funcionais”, segundo as variáveis sexo, idade, diagnóstico e duração da
doença, com igual número de doentes internados voluntariamente. Como instrumentos
de avaliação foram aplicados uma entrevista semi-estruturada para as variáveis sociodemográficas
e clínicas, o Brief Psychiatric Rating Scale 4.0 para a psicopatologia e
duas sub-escalas do Historical, Clinical, Risk Management-20 para o risco de violência.
No período do estudo (1 de Março a 30 de Junho de 2002) foram internados
compulsivamente 74 indivíduos, metade dos quais foram conduzidos aos serviços de
urgência com mandado da Autoridade de Saúde. O internamento de urgência foi o
procedimento inicial em cerca de noventa por cento dos casos. A maioria dos doentes
pertenciam ao sexo masculino (60%) e apresentavam quadros psicóticos “funcionais”
(82%). Na amostra emparelhada de 102 doentes não se observaram variáveis
sociodemográficas ou clínicas significativamente diferentes em relação aos doentes
internados voluntariamente, com excepção dos antecedentes e risco de violência.
Os resultados sugerem que a proposta de internamento compulsivo neste grupo
de doentes seguiu um modelo de decisão baseado na prevenção de perigo
Acute Psychosis as Major Clinical Presentation of Legionnaires’ Disease
We report a case of a 61-year-old woman who presented with acute psychosis as a major manifestation of Legionnaires’ disease in the absence of other neuropsychiatric symptoms. Clinical history revealed dry cough and nausea. Observation showed fever and auscultation crackles in the lower lobe of the right lung. Laboratory testing demonstrated elevated C-reactive protein and lung chest radiograph showed patchy peribronchial and right lower lobe consolidation. Soon after admission, she started producing purulent sputum. Epidemiological data suggested Legionella pneumophila as possible cause of the clinical picture that was confirmed by urinary antigen detection and polymerase chain reaction of the sputum. She was treated with levofloxacin 750 mg/day for 10 days with complete remission of pulmonary and psychiatric symptoms. She has not had further psychotic symptoms
Retrospective study on structural neuroimaging in first-episode psychosis
Background. No consensus between guidelines exists regarding neuroimaging in first-episode psychosis. The purpose of this study is to assess anomalies found in structural neuroimaging exams (brain computed tomography (CT) and magnetic resonance imaging (MRI)) in the initial medical work-up of patients presenting first-episode psychosis. Methods. The study subjects were 32 patients aged 18–48 years (mean age: 29.6 years), consecutively admitted with first-episode psychosis diagnosis. Socio-demographic and clinical data and neuroimaging exams (CT and MRI) were retrospectively studied. Diagnostic assessments were made using the Operational Criteria Checklist +. Neuroimaging images (CT and MRI) and respective reports were analysed by an experienced consultant psychiatrist. Results. None of the patients had abnormalities in neuroimaging exams responsible for psychotic symptoms. Thirty-seven percent of patients had incidental brain findings not causally related to the psychosis (brain atrophy, arachnoid cyst, asymmetric lateral ventricles, dilated lateral ventricles, plagiocephaly and falx cerebri calcification). No further medical referral was needed for any of these patients. No significant differences regarding gender, age, diagnosis, duration of untreated psychosis, in-stay and cannabis use were found between patients who had neuroimaging abnormalities versus those without. Discussion. This study suggests that structural neuroimaging exams reveal scarce abnormalities in young patients with first-episode psychosis. Structural neuroimaging is especially useful in first-episode psychosis patients with neurological symptoms, atypical clinical picture and old age
Depressive symptoms and suicidal behavior after first-episode psychosis : a comprehensive systematic review
© 2017 Elsevier B.V. All rights reserved.Depressive symptoms and suicidal behavior are common among patients that suffered a first-episode psychosis. We searched Web of KnowledgeSM and Pubmed® for English and Portuguese original articles investigating prevalence of depressive symptoms and/or suicidal behavior and associated factors after first-episode psychosis. We included 19 studies from 12 countries, 7 studied depressive symptoms and 12 suicidal behavior. The findings confirm that depressive symptoms and suicidal behavior have high rates in the years after first-episode psychosis. Factors identified as being associated with depressive symptoms after first-episode psychosis were anomalies of psychosocial development, poor premorbid childhood adjustment, greater insight, loss, shame, low level of continuing positive symptoms and longer duration of untreated psychosis. Suicidal behavior was associated with previous suicide attempt, sexual abuse, comorbid polysubstance use, lower baseline functioning, longer time in treatment, recent negative events, older patients, longer duration of untreated psychosis, higher positive and negative psychotic symptoms, family history of severe mental disorder, substance use, depressive symptoms and cannabis use. Data also indicate that treatment and early intervention programs reduce depressive symptoms and suicidal behavior after first-episode psychosis. Future research should overcome some methodological discrepancies that exist between studies and limit generalization of current findings.info:eu-repo/semantics/publishedVersio
Depressão Psicótica no Idoso: Desafio Diagnóstico e Papel da Eletroconvulsivoterapia
Os autores descrevem o caso clínico de um doente com 69 anos com depressão psicótica e sintomas físicos exuberantes. Dados os sintomas físicos significativos e o escalão etário foi efetuada avaliação médica que permitiu excluir doença orgânica. Apesar da terapêutica psicofarmacológica realizada, o doente não apresentou melhoria clínica significativa. Foi efetuada terapêutica eletroconvulsiva ainda na fase aguda, e por recidiva sob terapêutica antidepressiva, também de continuação e de manutenção. Atingiu-se assim uma remissão total do quadro clínico e de funcionamento, tendo o doente retomado a sua atividade profissional. O relato deste caso justifica-se pela sua apresentação peculiar e pelo benefício alcançado com a realização da eletroconvulsivoterapia (aguda e de continuação/manutenção), associado a terapêutica psicofarmacológica que garantiu uma remissão clínica significativa