Changes in sedimentary provenance and climate off the coast of Northeast Brazil since the Last Interglacial

Neodymium (Nd) and strontium (Sr) isotopic signatures in marine sediments reflect the geology of the associated drainage basin from which those sediments are supplied. These signatures are significantly affected by relief, weathering, transport, and deposition of sedimentary contributions from the respective sources. This work makes available new data of Sr–Nd isotope ratios and Rare Earth Element (REE) concentrations, which provides a record of the sedimentary provenance of marine sediment supplied to the continental slope off the coast of northeastern Brazil since the last 130 thousand years. Our results indicate the main source of sediments to this site was the Parnaíba sedimentary basin. Furthermore, the fluctuations in Fe/K, Al/Si ratios, and Sr values are explained by geochemical processes operating within the region, which likely reflects changes in the hydrological regime and relative sea-level, and intensity of weathering in continental rocks in glacial-interglacial timescales. We suggest that low values of 87Sr/86Sr ratios during glacial are a result of dry conditions. Also, minor fluctuations within the last glacial period may be a consequence of displacements of the Intertropical Convergence Zone (ITCZ). Such displacements cause changes in rainfall and consequently variations in chemical weathering which affect Sr isotopic fractionation. During past humid intervals, the low Nd (non-radiogenic) signal observed could be explained as a process of penetration of rainwater into the deepest non-radiogenic sediment and subsequent replacement of the isotopic signal in the environment in glacial-interglacial timescales

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population