First record of Xenopsylla gratiosa Jordan & Rothschild, 1923 from the Maltese Islands (Siphonaptera: Pulicidae)

Xenopsylla gratiosa is reported for the first time from the Maltese Islands. The species was found in an abandoned nest of a Cory’s Shearwater, Calonectris diomedea on the island of Filfla. Brief notes are included on previous records of fleas from the Maltese Islands and taxonomic, distributional and ecological notes are provided for Xenopsylla gratiosapeer-reviewe

Safety implications of low-dose amitriptyline in neuropathic pain

Background: Treatment guidelines in neuropathic pain list amitriptyline as a first-line option. Modest evidence on efficacy and safety concerns possibly shape the rationale behind dosing recommendations. An observational study was carried out to understand the usefulness of safety monitoring for this established medicine. Methods: Twenty-six (26) subjects were categorized into 2 groups: 13 patients under pain management receiving 10 mg amitriptyline daily for less than 12 months, and 13 patients under psychiatric care receiving a daily dose of 25–75 mg for over 12 months. Dose-related reference ranges were calculated and blood levels were assessed for the case examples presented. Adverse events and ECGs were collated. QT intervals were corrected using Bazett’s and Fridericia’s formulae. Side-effect frequencies were evaluated both within the research groups, and in the broader perspective of spontaneous ADR reporting through EudraVigilance. Results: The applicability of dose-related reference ranges, considering confounding factors such as drug interactions and metabolizer status, is discussed. Patients in both groups reported on average three side-effects, with drowsiness being reported more significantly in the 10 mg group and possibly attenuating with time; an observation not replicated for dry mouth. ADR reports with non-granulated information limit the usefulness of the data retrieved. Comparison of QT corrected with Bazett’s and Fridericia’s formulae suggests that Bazett’s may overestimate the number of patients on amitriptyline with QTc prolongation. Conclusions: This research supports the adoption of evolving research observations to understand the implications of dosing recommendations and safety assessments in attempt of delivering individualized treatment with minimal risk.peer-reviewe

Flipping between Polycomb repressed and active transcriptional states introduces noise in gene expression.

Polycomb repressive complexes (PRCs) are important histone modifiers, which silence gene expression; yet, there exists a subset of PRC-bound genes actively transcribed by RNA polymerase II (RNAPII). It is likely that the role of Polycomb repressive complex is to dampen expression of these PRC-active genes. However, it is unclear how this flipping between chromatin states alters the kinetics of transcription. Here, we integrate histone modifications and RNAPII states derived from bulk ChIP-seq data with single-cell RNA-sequencing data. We find that Polycomb repressive complex-active genes have greater cell-to-cell variation in expression than active genes, and these results are validated by knockout experiments. We also show that PRC-active genes are clustered on chromosomes in both two and three dimensions, and interactions with active enhancers promote a stabilization of gene expression noise. These findings provide new insights into how chromatin regulation modulates stochastic gene expression and transcriptional bursting, with implications for regulation of pluripotency and development.Polycomb repressive complexes modify histones but it is unclear how changes in chromatin states alter kinetics of transcription. Here, the authors use single-cell RNAseq and ChIPseq to find that actively transcribed genes with Polycomb marks have greater cell-to-cell variation in expression

Distinct regulation of hippocampal neuroplasticity and ciliary genes by corticosteroid receptors

Glucocorticoid hormones (GCs) are of critical importance for maintaining brain health, but their involvement in mental disorders is poorly understood. Here the authors show how GCs act through hippocampal mineralocorticoid and glucocorticoid receptors to impact the gene regulatory programs underpinning neuronal plasticity, ciliogenesis and behavioral adaptation

“To trust a LIAR”: does machine learning really classify fine-grained, fake news statements?

Fake news refers to deceptive online content and is a problem which causes social harm. Early detection of fake news is therefore a critical but challenging problem. In this paper we attempt to determine if state-of-the-art models, trained on the LIAR dataset can be leveraged to reliably classify short claims according to 6 levels of veracity that range from “True” to “Pants on Fire” (absolute lies). We investigate the application of transformer models BERT, RoBERTa and ALBERT that have previously performed significantly well on several natural language processing tasks including text classification. A simple neural network (FcNN) was also used to enhance each model’s result by utilising the sources’ reputation scores. We achieved higher accuracy than previous studies that used more data or more complex models. Yet, after evaluating the models’ behaviour, numerous flaws appeared. These include bias and the fact that they do not really model veracity which makes them prone to adversarial attacks. We also consider the possibility that language-based, fake news classification, on such short statements is an ill-posed problem.peer-reviewe

Mediterran

Ġabra ta’ poeżiji u proża li tinkludi: Għal Ġorġ Pisani ta’ Joe Zammit Tabona – Din gżira niexfa ta’ Clare Azzopardi – Ersaqt lejn il-baħar ta’ Charles Bezzina – Passaġġi ta’ Ġorġ Borg – Firenze ta’ Louis Briffa – Riħet ix-xemgħa ta’ John Caruana – Jum ir-riflessjoni ta’ Antoine Cassar – Fjura fqajra ta’ Carmel Ġ. Cauchi – Qatra ta’ Maria Grech Ganado – Lill-bufula ta’ fuq iz-zuntier ta’ Maurice Mifsud Bonnici – Tinsinix! ta’ Joe Zammit Tabona – In-nanna lbieraħ u jien illum! – tifkiriet ta’ Lina Brockdorff – L-għaddas ta’ Alex Vella Gera – Għassa ta’ Adrian Grima – It-tfajla tal-ħolm ta’ Anne Marie Scerri – Meta tagħmel l-ewwel xita ta’ Trevor Żahra – Ħajta deni ta’ Jordi Punti, traduzzjoni ta’ Immanuel Mifsud – Arnarstapi, l-Iżlanda ta’ Susan Richardson, traduzzjoni ta’ Simone Inguanez – Ħuta ta’ Aki Salmela, traduzzjoni ta’ Simone Inguanez – Ma kellniex triq oħra ta’ Roman Simic, traduzzjoni ta’ Immanuel Mifsud – Mediterran ta’ Cruciani Valerio, traduzzjoni ta’ Antoine Cassar.peer-reviewe

Recurrent intragenic rearrangements of EGFR and BRAF in soft tissue tumors of infants.

Soft tissue tumors of infancy encompass an overlapping spectrum of diseases that pose unique diagnostic and clinical challenges. We studied genomes and transcriptomes of cryptogenic congenital mesoblastic nephroma (CMN), and extended our findings to five anatomically or histologically related soft tissue tumors: infantile fibrosarcoma (IFS), nephroblastomatosis, Wilms tumor, malignant rhabdoid tumor, and clear cell sarcoma of the kidney. A key finding is recurrent mutation of EGFR in CMN by internal tandem duplication of the kinase domain, thus delineating CMN from other childhood renal tumors. Furthermore, we identify BRAF intragenic rearrangements in CMN and IFS. Collectively these findings reveal novel diagnostic markers and therapeutic strategies and highlight a prominent role of isolated intragenic rearrangements as drivers of infant tumors

Figuring Rhetoric: From Antistrophe to Apostrophe through Catastrophe

This essay explores rhetoric tropologically through various strophes: antistrophe, catastrophe, and apostrophe. Our purpose is to delineate problems and possibilities that these tropes pose for rhetoric in an effort to create new rhetorics. We seek to display the antistrophic and catastrophic figurations of rhetoric and then use visual lenses of photography and cinema to disrupt the figurations. Following the disruption, we seek to heighten sensibilities to other figurations, in particular an apostrophic figuration. We cast apostrophe as a figure for change because it marks a deeply felt turn toward difference and otherness. Turned as such, rhetoric becomes erotic

Silta mill-"Antigone" ta’ Sofokle

Ġabra ta’ poeżiji u proża li tinkludi: Ħajki ta’ Josette Attard – Din l-għanja tiegħi ta’ Rena Balzan – Fl-irdum fejn jidwi ta’ Charles Bezzina – Naqa’ biss ta’ Ġorġ Borg – Gambrinu, 7.45 a.m. ta’ Norbert Bugeja – Għadam ta’ Joseph Buttigieg – Tħarisx biss fil-wiċċ ta’ John Caruana – Petra ta’ Priscilla Cassar – Mhux iżjed dan il-pajjiż tiegħi ta’ Victor Fenech – Twieqi magħluqa ta’ Maria Grech Ganado – Joseph quddiem ir-ritratt ta’ sieħbu jitfarrak ta’ Adrian Grima – Ta’ l-ilma l-fruntieri tiegħek ta’ Simone Inguanez – Għall-kaċċa tal-grejtwajt ta’ Daniel Massa – Ftit weraq mis-Slovenja ta’ Immanuel Mifsud – Dak li kien ta’ Achille Mizzi – Wassalni ta’ Anna Pullicino – Tamiet fiergħa ta’ Patrick Sammut – Fost l-isbaħ jiem ta’ Lillian Sciberras – Kelma ta’ Marcel Zammit Marmarà – Lill-Imdina żagħżugħa ta’ Joe Zammit Tabona – Sodda ta’ l-ilma ta’ Clare Azzopardi – Kurċifiss ta’ Paul P. Borg – Mera mkissra ta’ Lina Brockdorff – No(ra)vella ta’ Joe Friggieri – L-abbati ta’ Henry Holland – L-eħrex ġurnata tal-gwerra ta’ Maurice Mifsud Bonnici – Marija ta’ Lino Spiteri – Ikla ta’ Trevor Żahra – Il-mara midinba ta’ Albert Camus, traduzzjoni ta’ Toni Aquilina – Silta mill-"Antigone" ta’ Sofokle, traduzzjoni ta’ Victor Xuereb.peer-reviewe