16 research outputs found
Magnetic and superconducting instabilities of the Hubbard model at the van Hove filling
We use a novel temperature-flow renormalization group technique to analyze
magnetic and superconducting instabilities in the two-dimensional t-t' Hubbard
model for particle densities close to the van Hove filling as a function of the
next-nearest neighbor hopping t'. In the one-loop flow at the van Hove filling,
the characteristic temperature for the flow to strong coupling is suppressed
drastically around t'_c approx. -0.33t, suggesting a quantum critical point
between d-wave pairing at moderate t'>t'_c and ferromagnetism for t'<t'_c. Upon
increasing the particle density in the latter regime the leading instability
occurs in the triplet pairing channel.Comment: 4 pages, to appear in Physical Review Letter
The German National Registry of Primary Immunodeficiencies (2012-2017)
Introduction: The German PID-NET registry was founded in 2009, serving as the first national registry of patients with primary immunodeficiencies (PID) in Germany. It is part of the European Society for Immunodeficiencies (ESID) registry. The primary purpose of the registry is to gather data on the epidemiology, diagnostic delay, diagnosis, and treatment of PIDs.
Methods: Clinical and laboratory data was collected from 2,453 patients from 36 German PID centres in an online registry. Data was analysed with the software Stata® and Excel.
Results: The minimum prevalence of PID in Germany is 2.72 per 100,000 inhabitants. Among patients aged 1–25, there was a clear predominance of males. The median age of living patients ranged between 7 and 40 years, depending on the respective PID. Predominantly antibody disorders were the most prevalent group with 57% of all 2,453 PID patients (including 728 CVID patients). A gene defect was identified in 36% of patients. Familial cases were observed in 21% of patients. The age of onset for presenting symptoms ranged from birth to late adulthood (range 0–88 years). Presenting symptoms comprised infections (74%) and immune dysregulation (22%). Ninety-three patients were diagnosed without prior clinical symptoms. Regarding the general and clinical diagnostic delay, no PID had undergone a slight decrease within the last decade. However, both, SCID and hyper IgE- syndrome showed a substantial improvement in shortening the time between onset of symptoms and genetic diagnosis. Regarding treatment, 49% of all patients received immunoglobulin G (IgG) substitution (70%—subcutaneous; 29%—intravenous; 1%—unknown). Three-hundred patients underwent at least one hematopoietic stem cell transplantation (HSCT). Five patients had gene therapy.
Conclusion: The German PID-NET registry is a precious tool for physicians, researchers, the pharmaceutical industry, politicians, and ultimately the patients, for whom the outcomes will eventually lead to a more timely diagnosis and better treatment
How to prune trees
Cover title.Includes bibliographical references (p. 26).Mode of access: Internet