447 research outputs found
Incorporating Student Interns & Grant-Funded Collection Development to improve DEI in Library Collections
Growth and characterization of multiferroic BiMnO thin films
We have grown epitaxial thin films of multiferroic BiMnO using pulsed
laser deposition. The films were grown on SrTiO (001) substrates by
ablating a Bi-rich target. Using x-ray diffraction we confirmed that the films
were epitaxial and the stoichiometry of the films was confirmed using Auger
electron spectroscopy. The films have a ferromagnetic Curie temperature ()
of 855 K and a saturation magnetization of 1 /Mn. The electric
polarization as a function of electric field () was measured using an
interdigital capacitance geometry. The plot shows a clear hysteresis that
confirms the multiferroic nature of the thin films.Comment: 4 pages, 4 figures, submitted to J. Appl. Phy
The Effect of Language Type and Perceived Controllability on Stigma and Compassion
Previous research suggests that mental health stigma creates significant barriers to treatment seeking and adherence, diminishes treatment outcomes, and motivates social rejection towards people experiencing mental illness; by contrast, compassion seems to offer protective effects, improving treatment outcomes and helping behavior. The current work extends the established literature by experimentally examining the independent and interactive effects of two factors theorized to influence stigma and compassion: controllability and language. Participants read vignettes about hypothetical mental illnesses explained with a genetic attribution (indicating low controllability) or a behavioral attribution (indicating high controllability) and completed measures of perceived controllability, stigma, and compassion. We found that genetic etiology, compared to behavioral etiology, decreased stigma and increased compassion. Although not statistically significant, preliminary evidence suggests that language might interact with etiology to affect stigma. In the behavioral etiology condition, identity-first language (compared to person-first) exacerbated stigma, whereas, in the genetic etiology condition, this effect was descriptively reversed, though statistically nonsignificant. Our findings provide evidence that emphasizing the contribution of uncontrollable factors (e.g., genetics) to psychopathology could help reduce stigma and increase compassion for people experiencing mental illness. Language may also interact with controllability to inform stigma. This work could aid in advising empathetic and supportive language practices dependent on condition characteristics (e.g., perceived controllability), however, replication is needed to demonstrate the reliability of these effects
Ethnography, Engagement, Evaluations, and Endings: The Achievements and Limitations of Community Outreach at Çatalhöyük
Middle Eastern Studie
General Principles for the Design of Visible-Light-Responsive Photoswitches:Tetra-ortho-Chloro-Azobenzenes
Molecular photoswitches enable reversible external control of biological systems, nanomachines, and smart materials. Their development is driven by the need for low energy (green-red-NIR) light switching, to allow non-invasive operation with deep tissue penetration. The lack of clear design principles for the adaptation and optimization of such systems limits further applications. Here we provide a design rulebook for tetra-ortho-chloroazobenzenes, an emerging class of visible-light-responsive photochromes, by elucidating the role that substituents play in defining their key characteristics: absorption spectra, band overlap, photoswitching efficiencies, and half-lives of the unstable cis isomers. This is achieved through joint photochemical and theoretical analyses of a representative library of molecules featuring substituents of varying electronic nature. A set of guidelines is presented that enables tuning of properties to the desired application through informed photochrome engineering
Local Anisotropy of Fluids using Minkowski Tensors
Statistics of the free volume available to individual particles have
previously been studied for simple and complex fluids, granular matter,
amorphous solids, and structural glasses. Minkowski tensors provide a set of
shape measures that are based on strong mathematical theorems and easily
computed for polygonal and polyhedral bodies such as free volume cells (Voronoi
cells). They characterize the local structure beyond the two-point correlation
function and are suitable to define indices of
local anisotropy. Here, we analyze the statistics of Minkowski tensors for
configurations of simple liquid models, including the ideal gas (Poisson point
process), the hard disks and hard spheres ensemble, and the Lennard-Jones
fluid. We show that Minkowski tensors provide a robust characterization of
local anisotropy, which ranges from for vapor
phases to for ordered solids. We find that for fluids,
local anisotropy decreases monotonously with increasing free volume and
randomness of particle positions. Furthermore, the local anisotropy indices
are sensitive to structural transitions in these simple
fluids, as has been previously shown in granular systems for the transition
from loose to jammed bead packs
The ELSA trial: single versus combinatory effects of non-prohibited beta-2 agonists on skeletal muscle metabolism, cardio-pulmonary function and endurance performance—study protocol for a randomized 4-way balanced cross-over trial
Background
Asthma and/or airway hyper-responsiveness (AHR) are common in elite endurance athletes with a high prevalence rate of beta-2 adrenoreceptor (beta-2) agonists use. Nevertheless, there are data on dose-dependent ergogenic effects of beta-2 agonists suggesting increased muscle strength, endurance and neuromuscular performance. Therefore, most beta-2 agonists belong to the World Anti Doping Agency (WADA) list of prohibited substances and it is tempting to speculate that illegitimate use of beta-2 agonists might be a common practice to boost performance in competitive sports. It is currently unknown whether or not inhaled beta-2 agonists enhance performance by stimulatory effects in skeletal and cardiac muscle.
Methods
The ELSA trial is a double-blinded, placebo-controlled, randomized, balanced, four-way cross-over study. Study participants (n=24, 12 ♀, 12 ♂) complete four study arms (i.e. periods with treatment A, placebo; B, salbutamol; C, formoterol; D, formoterol + salbutamol) in random order after an initial preliminary testing session. Participants inhale the study medication 20 min before the 10-min time trial (TT; exercise performance test), where participants cycle 10 min at the highest possible workload. Cardiac output is measured continuously. A skeletal muscle biopsy is collected 3 h after the TT. Study endpoints include measures of skeletal muscle expression of nuclear receptors, hormones and cytokine levels, urinary and plasma concentrations of salbutamol and formoterol, circulating cardiac markers, cardiopulmonary function and exercise performance (average power and peak power during the TT). Blood and urine are collected and respiratory testing is performed 24 h post TT.
Summary/conclusions
This clinical trial evaluates the potential performance-enhancing effects of non-prohibited, not medically indicated inhaled short- and long-acting beta-2 agonists on skeletal muscle gene expression, endocrine regulation, cardiac biomarkers, cardiopulmonary function and acute endurance exercise performance. These data will be used by WADA to adapt the annually published list of prohibited substances (WADA 2021) and will be published in scientific journals
Minkowski Tensors of Anisotropic Spatial Structure
This article describes the theoretical foundation of and explicit algorithms
for a novel approach to morphology and anisotropy analysis of complex spatial
structure using tensor-valued Minkowski functionals, the so-called Minkowski
tensors. Minkowski tensors are generalisations of the well-known scalar
Minkowski functionals and are explicitly sensitive to anisotropic aspects of
morphology, relevant for example for elastic moduli or permeability of
microstructured materials. Here we derive explicit linear-time algorithms to
compute these tensorial measures for three-dimensional shapes. These apply to
representations of any object that can be represented by a triangulation of its
bounding surface; their application is illustrated for the polyhedral Voronoi
cellular complexes of jammed sphere configurations, and for triangulations of a
biopolymer fibre network obtained by confocal microscopy. The article further
bridges the substantial notational and conceptual gap between the different but
equivalent approaches to scalar or tensorial Minkowski functionals in
mathematics and in physics, hence making the mathematical measure theoretic
method more readily accessible for future application in the physical sciences
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