322 research outputs found
Current-voltage characteristics of quasi-one-dimensional superconductors: An S-curve in the constant voltage regime
Applying a constant voltage to superconducting nanowires we find that its
IV-characteristic exhibits an unusual S-behavior. This behavior is the direct
consequence of the dynamics of the superconducting condensate and of the
existence of two different critical currents: j_{c2} at which the pure
superconducting state becomes unstable and j_{c1}<j_{c2} at which the phase
slip state is realized in the system.Comment: 4 pages, 5 figures, replaced with minor change
La dinamica del crecimiento urbano dentro del valle de Jequetepeque : ciudad de Chepen : documento de trabajo
Mild hypothermia attenuates the excitatory amino acids overflow and diminishes the nitric oxide synthase activity during reperfusion after asphyxial cardiac arrest in rats
Theory of terahertz electric oscillations by supercooled superconductors
We predict that below T_c a regime of negative differential conductivity
(NDC) can be reached. The superconductor should be supercooled to T<T_c in the
normal phase under DC voltage. In such a nonequilibrium situation the NDC of
the superconductor is created by the excess conductivity of the fluctuation
Cooper pairs. We propose NDC of supercooled superconductors to be used as an
active medium for generation of electric oscillations. Such generators can be
used in the superconducting electronics as a new type THz source of radiation.
Oscillations can be modulated by the change of the bias voltage, electrostatic
doping by a gate electrode when the superconductor is the channel of a field
effect transistor, or by light. When small amplitude oscillations are
stabilized near the critical temperature T_c the generator can be used as a
bolometer. The essential for the applications NDC is predicted by the solution
of the Boltzmann kinetic equation for the metastable in the normal phase Cooper
pairs. Boltzmann equation for fluctuation Cooper pairs is a result of
state-of-the-art application of the microscopic theory of superconductivity.
Our theoretical conclusions are based on some approximations like time
dependent Ginzburg-Landau theory, but nevertheless can reliably predict
appearance of NDC. The maximal frequency at which superconductors can operate
as generators is determined by the critical temperature \hbar omega_max ~ k_B
T_c. For high-T_c superconductors this maximal frequency falls well inside the
terahertz range. Technical conditions to avoid nucleation of the
superconducting phase are briefly discussed. We suggest that nanostructured
high-T_c superconductors patterned in a single chip can give the best technical
performance of the proposed oscillator.Comment: 7 page
Impressions of force in visual perception of collision events: A test of the causal asymmetry hypothesis
Outline of a sensory-motor perspective on intrinsically moral agents
This is the accepted version of the following article: Christian Balkenius, Lola Cañamero, Philip Pärnamets, Birger Johansson, Martin V Butz, and Andreas Olson, ‘Outline of a sensory-motor perspective on intrinsically moral agents’, Adaptive Behaviour, Vol 24(5): 306-319, October 2016, which has been published in final form at DOI: https://doi.org/10.1177/1059712316667203 Published by SAGE ©The Author(s) 2016We propose that moral behaviour of artificial agents could (and should) be intrinsically grounded in their own sensory-motor experiences. Such an ability depends critically on seven types of competencies. First, intrinsic morality should be grounded in the internal values of the robot arising from its physiology and embodiment. Second, the moral principles of robots should develop through their interactions with the environment and with other agents. Third, we claim that the dynamics of moral (or social) emotions closely follows that of other non-social emotions used in valuation and decision making. Fourth, we explain how moral emotions can be learned from the observation of others. Fifth, we argue that to assess social interaction, a robot should be able to learn about and understand responsibility and causation. Sixth, we explain how mechanisms that can learn the consequences of actions are necessary for a robot to make moral decisions. Seventh, we describe how the moral evaluation mechanisms outlined can be extended to situations where a robot should understand the goals of others. Finally, we argue that these competencies lay the foundation for robots that can feel guilt, shame and pride, that have compassion and that know how to assign responsibility and blame.Peer reviewedFinal Accepted Versio
Mind the Gap: Investigating Toddlers’ Sensitivity to Contact Relations in Predictive Events
Toddlers readily learn predictive relations between events (e.g., that event A predicts event B). However, they intervene on A to try to cause B only in a few contexts: When a dispositional agent initiates the event or when the event is described with causal language. The current studies look at whether toddlers’ failures are due merely to the difficulty of initiating interventions or to more general constraints on the kinds of events they represent as causal. Toddlers saw a block slide towards a base, but an occluder prevented them from seeing whether the block contacted the base; after the block disappeared behind the occluder, a toy connected to the base did or did not activate. We hypothesized that if toddlers construed the events as causal, they would be sensitive to the contact relations between the participants in the predictive event. In Experiment 1, the block either moved spontaneously (no dispositional agent) or emerged already in motion (a dispositional agent was potentially present). Toddlers were sensitive to the contact relations only when a dispositional agent was potentially present. Experiment 2 confirmed that toddlers inferred a hidden agent was present when the block emerged in motion. In Experiment 3, the block moved spontaneously, but the events were described either with non-causal (“here’s my block”) or causal (“the block can make it go”) language. Toddlers were sensitive to the contact relations only when given causal language. These findings suggest that dispositional agency and causal language facilitate toddlers’ ability to represent causal relationships.John Templeton Foundation (#12667)James S. McDonnell Foundation (Causal Learning Collaborative Initiative)National Science Foundation (U.S.) (Career Award (# 0744213
Separate cortical stages in amodal completion revealed by functional magnetic resonance adaptation
<p>Abstract</p> <p>Background</p> <p>Objects in our environment are often partly occluded, yet we effortlessly perceive them as whole and complete. This phenomenon is called visual amodal completion. Psychophysical investigations suggest that the process of completion starts from a representation of the (visible) physical features of the stimulus and ends with a completed representation of the stimulus. The goal of our study was to investigate both stages of the completion process by localizing both brain regions involved in processing the physical features of the stimulus as well as brain regions representing the completed stimulus.</p> <p>Results</p> <p>Using fMRI adaptation we reveal clearly distinct regions in the visual cortex of humans involved in processing of amodal completion: early visual cortex – presumably V1 -processes the local contour information of the stimulus whereas regions in the inferior temporal cortex represent the completed shape. Furthermore, our data suggest that at the level of inferior temporal cortex information regarding the original local contour information is not preserved but replaced by the representation of the amodally completed percept.</p> <p>Conclusion</p> <p>These findings provide neuroimaging evidence for a multiple step theory of amodal completion and further insights into the neuronal correlates of visual perception.</p
Differential expression of 12 histone deacetylase (HDAC) genes in astrocytomas and normal brain tissue: class II and IV are hypoexpressed in glioblastomas
<p>Abstract</p> <p>Background</p> <p>Glioblastoma is the most lethal primary malignant brain tumor. Although considerable progress has been made in the treatment of this aggressive tumor, the clinical outcome for patients remains poor. Histone deacetylases (HDACs) are recognized as promising targets for cancer treatment. In the past several years, HDAC inhibitors (HDACis) have been used as radiosensitizers in glioblastoma treatment. However, no study has demonstrated the status of global <it>HDAC </it>expression in gliomas and its possible correlation to the use of HDACis. The purpose of this study was to evaluate and compare mRNA and protein levels of class I, II and IV of HDACs in low grade and high grade astrocytomas and normal brain tissue and to correlate the findings with the malignancy in astrocytomas.</p> <p>Methods</p> <p>Forty-three microdissected patient tumor samples were evaluated. The histopathologic diagnoses were 20 low-grade gliomas (13 grade I and 7 grade II) and 23 high-grade gliomas (5 grade III and 18 glioblastomas). Eleven normal cerebral tissue samples were also analyzed (54 total samples analyzed). mRNA expression of class I, II, and IV <it>HDACs </it>was studied by quantitative real-time polymerase chain reaction and normalized to the housekeeping gene <it>β-glucuronidase</it>. Protein levels were evaluated by western blotting.</p> <p>Results</p> <p>We found that mRNA levels of class II and IV <it>HDACs </it>were downregulated in glioblastomas compared to low-grade astrocytomas and normal brain tissue (7 in 8 genes, <it>p </it>< 0.05). The protein levels of class II HDAC9 were also lower in high-grade astrocytomas than in low-grade astrocytomas and normal brain tissue. Additionally, we found that histone H3 (but not histone H4) was more acetylated in glioblastomas than normal brain tissue.</p> <p>Conclusion</p> <p>Our study establishes a negative correlation between <it>HDAC </it>gene expression and the glioma grade suggesting that class II and IV <it>HDACs </it>might play an important role in glioma malignancy. Evaluation of histone acetylation levels showed that histone H3 is more acetylated in glioblastomas than normal brain tissue confirming the downregulation of <it>HDAC </it>mRNA in glioblastomas.</p
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