21 research outputs found

    Chondrotoxicity of Quinolone Antimicrobial Agents

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    The Arrival Direction of EAS Observed by Kinki Array with Energy Around 10^<15> eV

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    [Abstract] A search for the arrival direction of EAS has been studied for the data of Kinki array and the galactic coordinates with energy range between 10^ and 10^eV at sea level. No strong statistical significance of deviation from isotropy was found for the galactic plane enhancement. Concerning on the galactic enhancement tactor fe a comparison with some other higher energy experiment is also presented. It seems that the distribution of arrival direction of EAS suggests very weak energy dependence of fe for EAS at low energy region. In this report, I will present some basic calculation results about the distribution of arrival distribution of EAS in the galactic coordinates

    The Arrival Direction of EAS Observed by Kinki Array with Energy Around 10^<15> eV (II)

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    [Abstract] We have reported a seriese of asearch for the directional analysis of EAS for the Kinki data concerning on the galactic coordinates with energy range between 10^ and 10^eV at sea level. In this report, I will present some basic results about the distribution of arrival distribution of EAS in the galactic coordinates. No strong statistical significance of deviation from isotropy was found for the galactic plane enhancement. Concerning on the galactic enhancement tactor f_e a comparison with some other higher energy experiment is also presented

    Multiplexed Chemical Control of Signaling Pathways by Orthogonal, Plasma Membrane-Specific SLIPT Systems

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    Most cell behaviors are the outcome of processing information from multiple signals generated upon cell stimulation. A systematic understanding of cellular systems requires methods that activate multiple signaling molecules or pathways in single cells. However, the construction of tools for such multiplexed signal control is challenging. Here we present orthogonal chemogenetic systems that allow control of multiple signaling pathways in living mammalian cells based on self-localizing ligand-induced protein translocation (SLIPT). Two orthogonal SLIPT systems were constructed to enable chemically inducible, individual translocation of two proteins from the cytoplasm to the inner-leaflet of the plasma membrane in the same cell. The SLIPT systems combined with fluorescent reporters achieved simultaneous multiplexed activation and monitoring of endogenous Ras/ERK and PI3K/Akt pathways in single cells. Thus, orthogonal SLIPT systems provide a powerful platform for multiplexed chemical signal control in single cells, offering new opportunities for dissecting cell signaling networks and synthetic cell manipulation.<br /

    A study of a phenomena deviated from random feature in EAS energy around 100TeV with new Kinki Array

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    [Abstract]An EAS observation system was rebuilt in July 1998 at Kinki University which consists of seven 0.25m2 plastic scintillators with fast PMTs. The system works well to detect EASs energy around 100TeV at sea level. In the observation of more than 103 hours, the detector records some phenomenae deviated from average feature in triggering rate, which means each series of the events has extremely small expected frequency in short term data acquisition period. For number of total events this set of consequtive events with upper limit of significant level of 3.6 × 10-2 was found. Although this is not strong evidence deviating from random Poisson distribution, but it has a value of 5σ from average rate. The new Kinki Array is reported briefly and this phenomena is also reported in detail
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