21 research outputs found
[DRG and urinary tract infections in Paediatrics]
The aim of this study was the evaluation of admissions in 1995 in the two public hospitals of Verona (Azienda Ospedaliera di Verona) ascribed to the DRG 322 (urinary tract infections from birth to 17 years). Seventy-six patients with actual diagnosis of urinary tract infection were evaluated. The coefficient of variation of hospitalization for the DRG 322 was 52%, attesting a good grade of internal homogeneity. A more detailed subdivision of the DRG 322 on the basis of age is required in pediatric patients
Comparison of the effects of cefuroxime axetil and cefaclor on the fecal flora in pediatric patients
Multicentric retrospective study of children affected by Wilson disease with hepatic presentation
J Pediatr Gastroenterol Nut
Serum transaminases in children with Wilson's disease
Objectives: The response of serum transaminase levels to penicillamine and zinc treatment in Wilson's disease is poorly understood. The aim of this multicenter retrospective study was to evaluate transaminase levels after penicillamine and zinc treatment in children with Wilson's disease.Patients and Methods: One hundred and nine patients with Wilson's disease (median age at diagnosis, 7.2 years; range, 1 to 18 years), treated for at least 12 months and observed in the last 20 years at 11 Paediatric Departments were studied. Clinical, laboratory and histologic features at diagnosis and initial treatment were recorded. Efficacy parameters were normalization of serum transaminase level and improved clinical and/or laboratory signs. One hundred and two patients had clinical or laboratory signs of liver disease.Results: Fifty-six of 87 patients (64%) given penicillamine normalized serum alanine aminotransferase (ALT) levels within a median of 17 months (range, 2 to 96 months). Of the 29 patients with persistent hyper-ALT, 17 (59%) switched to zinc; only four of these normalized ALT on zinc within a (50%) of the 22 patients given zinc alone normalized ALT within a median period of 6 months (range, 1 to 36 months). Of the 11 patients with persistent hyper-ALT, five switched to penicillamine. Three of the five normalized ALT within a median period of 6 months (range, 6 to 9 months). Overall, in penicillamine-treated and zinc-treated patients with persistent hypertransaminasemia, ALT decreased from a basal median of 236 IU/L (range, 54 to 640 IU/L) to a median of 78 (range, 46 to 960 IU/L) at the end of follow-up (P = 0.0245). Poor compliance was suspected in only 10% of cases. No predictive factor of persistent hypertransaminasemia was identified. Liver disease did not worsen in any patient during the study.Conclusions: Although the efficacy of penicillamine and zinc is well documented, it is notable that a subset of children with Wilson's disease-related liver disease (36%) had hypertransaminasemia despite appropriate treatment with penicillamine or zinc. (C) 2004 Lippincott Williams Wilkins
Persistence of elevated aminotransferases in Wilson's disease despite adequate therapy
Elevated aminotransferase activity can persist in patients with Wilson's disease despite adequate therap
Persistence of elevated aminotransferases in Wilson's disease despite adequate therapy
Elevated aminotransferase activity can persist in patients with Wilson's disease despite adequate therap