Dentoskeletal effects of the bitejumping appliance and the twin-block appliance in the treatment of skeletal class ii malocclusion: A retrospective controlled clinical trial

The current retrospective controlled trial aimed to compare the dentoskeletal effects of the Bite-Jumping (BJ) and the Twin- Block Appliance (TB) in the treatment of skeletal Class II malocclusion. The sample was screened for eligibility criteria including skeletal and dental Class II malocclusion; Cervical Vertebral Maturation at Stage 3 at treatment start, and Func- tional orthopedic treatment with either a TB or BJ appliances. Twenty-three patients treated with TB, and twenty-three treated with BJ were included. Cephalometric data were compared with a control group of 15 untreated subjects retrieved from the American Association of Orthodontists Foundation Craniofacial Growth Legacy Collection. Baseline character- istics were similar between groups. A significant increase for the AO-BO dimension, and a significant decrease in the over- jet, were registered for both study groups respect to controls. TB was more effective than BJ in increasing the mandibu- lar length (Co-Gn), in reducing the ANB angle and changing the SNB angle. The resulting differences between the two groups could be attributed to the different appliances. In conclusion, both appliances demonstrated a clinical efficacy in treating Class II. TB seems therefore better indicated, respect to BJ, in Class II cases with a predominant component of mandibular hypoplasia

The neutrophil to lymphocyte ratio (NLR) and the presence of large nodal mass are independent predictors of early response: A subanalysis of the prospective phase II PET-2-adapted HD0607 trial

The neutrophil to lymphocyte ratio (NLR) and the lymphocyte to monocyte ratio (LMR) can reflect both the myeloid dysfunction and T-cell immune suppression and have prognostic significance

Predictors of atrial fibrillation detection in embolic stroke of undetermined source patients with implantable loop recorder

BackgroundCovert atrial fibrillation (AF) is a predominant aetiology of embolic stroke of undetermined source (ESUS). Evidence suggested that AF is more frequently detected by implantable loop recorder (ILR) than by conventional monitoring. However, the predictive factors associated with occult AF detected using ILRs are not well established yet. In this study we aim to investigate the predictors of AF detection in patients with ESUS undergoing an ILR.MethodsThis observational multi-centre study included consecutive ESUS patients who underwent ILR implantation. The infarcts were divided in deep, cortical infarcts or both. The infarction sites were categorized as anterior and middle cerebral artery, posterior cerebral artery with and without brainstem/cerebellum involvement. Multivariable logistic regression analysis was performed to investigate variables associated with AF detection.ResultsOverall, 3,000 patients were initially identified. However, in total, 127 patients who consecutively underwent ILR implantation were included in our analysis. AF was detected in 33 (26%) out of 127 patients. The median follow-up was 411 days. There were no significant differences in clinical characteristics and comorbidities between patients with and without AF detected. AF was detected more often after posterior cerebral artery infarct with brainstem/cerebellum involvement (p < 0.001) whereas less often after infarction in the anterior and middle cerebral artery (p = 0.021). Multivariable regression analysis demonstrated that posterior cerebral artery infarct with brainstem/cerebellum involvement was an independent predictor of AF detection.ConclusionOur study showed that posterior circulation infarcts with brainstem/cerebellum involvement are associated with AF detection in ESUS patients undergoing ILR. Larger prospective studies are needed to validate our findings

Severe pneumococcal meningitis heralding a deep hypogammaglobulinaemia related to common variable immunodeficiency, at the age of 27 years.

none6noneR. Manfredi; N. Dentale; L. Fortunato; M. Pavoni; L. Calza; F. ChiodoR. Manfredi; N. Dentale; L. Fortunato; M. Pavoni; L. Calza; F. Chiod

Durable viral suppression in an HIV-infected patient in the absence of antiretroviral therapy

We describe the case of a young woman with an acute HIV infection characterized at onset by neurological features. The patient spontaneously controlled her HIV infection and recovered in a short period of time. The patient's clinical and virological history showed a peculiar evolution of HIV infection, with an MDR HIV-1 in CSF and a wild HIV strain in PBMCs. The patient's PBMC showed a rapid shift from a wild type to an MDR strain in few days