BC-SIM-IAPSUPA-TR-001 HRIC NECP report

The present document has been issued with the aim of describing the NECP (Near Earth Commissioning Phase) Tests results of HRIC channel part of the SIMBIO-SYS instrument suite on board the BepiColombo ESA mission

Wearable proximity sensors for monitoring a mass casualty incident exercise: a feasibility study

Over the past several decades, naturally occurring and man-made mass casualty incidents (MCI) have increased in frequency and number, worldwide. To test the impact of such event on medical resources, simulations can provide a safe, controlled setting while replicating the chaotic environment typical of an actual disaster. A standardised method to collect and analyse data from mass casualty exercises is needed, in order to assess preparedness and performance of the healthcare staff involved. We report on the use of wearable proximity sensors to measure proximity events during a MCI simulation. We investigated the interactions between medical staff and patients, to evaluate the time dedicated by the medical staff with respect to the severity of the injury of the victims depending on the roles. We estimated the presence of the patients in the different spaces of the field hospital, in order to study the patients' flow. Data were obtained and collected through the deployment of wearable proximity sensors during a mass casualty incident functional exercise. The scenario included two areas: the accident site and the Advanced Medical Post (AMP), and the exercise lasted 3 hours. A total of 238 participants simulating medical staff and victims were involved. Each participant wore a proximity sensor and 30 fixed devices were placed in the field hospital. The contact networks show a heterogeneous distribution of the cumulative time spent in proximity by participants. We obtained contact matrices based on cumulative time spent in proximity between victims and the rescuers. Our results showed that the time spent in proximity by the healthcare teams with the victims is related to the severity of the patient's injury. The analysis of patients' flow showed that the presence of patients in the rooms of the hospital is consistent with triage code and diagnosis, and no obvious bottlenecks were found

BC-SIM-TR-032 HRIC ICO4 REPORT

The present document has been issued to describe the Instrument Check Out Phase (ICO#4) Tests of HRIC, channel of the Spectrometers and Imagers for MPO BepiColombo Integrated Observatory SYStem (SIMBIO-SYS)

Effects of the Calix[4]arene Derivative Compound OTX008 on High Glucose-Stimulated ARPE-19 Cells: Focus on Galectin-1/TGF-β/EMT Pathway

Diabetic retinopathy (DR) is a neurovascular disease characterized by the reduction of retina integrity and functionality, as a consequence of retinal pigment epithelial cell fibrosis. Although galectin-1 (a glycan-binding protein) has been associated with dysregulated retinal angiogenesis, no evidence has been reported about galectin-1 roles in DR-induced fibrosis. ARPE-19 cells were cultured in normal (5 mM) or high glucose (35 mM) for 3 days, then exposed to the selective galectin-1 inhibitor OTX008 (2.5-5-10 μM) for 6 days. The determination of cell viability and ROS content along with the analysis of specific proteins (by immunocytochemistry, Western blotting, and ELISA) or mRNAs (by real time-PCR) were performed. OTX008 5 μM and 10 μM improved cell viability and markedly reduced galectin-1 protein expression in cells exposed to high glucose. This was paralleled by a down-regulation of the TGF-β/, NF-kB p65 levels, and ROS content. Moreover, epithelial-mesenchymal transition markers were reduced by OTX008 5 μM and 10 μM. The inhibition of galectin-1 by OTX008 in DR may preserve retinal pigment epithelial cell integrity and functionality by reducing their pro-fibrotic phenotype and epithelial-mesenchymal transition phenomenon induced by diabetes

The Test Planning for the SIMBIO-SYS Near Earth Commissioning Phase

In this document we describe all the tests to be performed during the Near Earth Commissioning Phase (NECP) for the Spectrometers and Imagers for MPO BepiColombo Integrated Observatory SYStem (SIMBIO-SYS)

The Role of Optical Coherence Tomography in an Atypical Case of Oculocutaneous Albinism: A Case Report

Background: Oculocutaneous albinism is a group of autosomal recessive disorders featuring hypopigmentation of the hair, skin and eyes. Ocular signs associated with the disease are nystagmus, decreased visual acuity, hypopigmentation of the retina, foveal hypoplasia, translucency of the iris, macular transparency, photophobia and abnormal decussation of nerve fibers at the chiasm. Case Report: An 8-year-old Caucasian girl presented to our clinic ‘Referral Center for Hereditary Retinopathies’ of the Second University of Naples with a diagnosis of Stargardt disease and a progressive reduction in visual acuity in both eyes. She underwent a complete ophthalmic examination including standard electroretinography and optical coherence tomography (OCT). A molecular analysis was also performed. Best-corrected visual acuity was 20/30 in the right eye and 20/40 in the left eye. Biomicroscopy of the anterior segment revealed a transparent cornea, in situ and transparent lens and normally pigmented iris. A mild diffuse depigmentation and macular dystrophy were observed at fundus examination. Standard electroretinography showed normal scotopic and photopic responses. OCT revealed high reflectivity across the fovea without depression. The typical OCT pattern led us to direct the molecular analysis towards the genes involved in oculocutaneous albinism. The molecular analysis identified mutations in the TYR gene. Conclusion: In this case, the role of OCT was crucial in guiding the molecular analysis for the diagnosis of albinism. OCT is therefore instrumental in similar cases that do not present typical characteristics of a disease. The case also proves the relevance of molecular analysis to confirm clinical diagnoses in hereditary retinal diseases

Calibration activities on the BepiColombo High-Resolution Channel (HRIC) of SIMBIO-SYS instrument

HRIC (High Resolution Imaging Channel) is the high resolution channel of the SIMBIO-SYS instrument on- board the ESA BepiColombo Mission. Calibration activities were performed at SelexES premises in spring- summer 2014 in order to check for Channel performances (radiometric performances, quality image and geometrical performances) and to obtain data necessary to setup a calibration pipeline necessary to process the raw images acquired by the channel when in operative scenario

Planning the HRIC (High Resolution Imaging Channel) observations of Mercury surface

The High Resolution Imaging Channel (HRIC) of SIMBIOSYS [1]onboard the BepiColombo mission to Mercury, is the visible imaging camera devoted to the detailed characterization of the Hermean surface. The potential huge amount of data that HRIC can produce must cope with the allocated (and shared) mission resources in terms of power, data volume,and pointing maneuvers. For this reason , well before the mission launch, it is extremely important the definition of an operative plan compatible with both the available resources and the scientific objectives accomplishment

Archivio storico della provincia di Salerno. A.4, n.1/4(1924)

Esemplare posseduto dalla Biblioteca Provinciale di SalernoA.4,n.1/2(1924): De Angelis M., Le origini dell'architettura nell'Italia meridionale ed i musaici della Cattedrale di Salerno, P. 152; Della Corte M., Notizie archeologiche, P. 53-56; Sinno A., Vicende dei Benedettini e di S. Massimo in Salerno, P. 57-74; De Crescenzo A., Salerno nel 1860, P. 75-89; Bilotti P. E., Avvenimenti e ricordi, P. 90-95. -A.4,n.3/4(1924): De Angelis M., La porta Elina di Salerno, P. 99-135; De’ Santi M., Notizie di due chiese di Fioccano, S. Pietro ad Floccanum e S. Maria del Presepe in Nocera Inferiore, raccolte da M. De' Santi (pubbl. a cura di G. D'Alessio), P. 136-143; Sorrentino A., Di una cronaca inedita del Salernitano (parte I), P. 144-160; Bilotti P. E., Il tempio di S. Maria Maggiore in Nocera (Dagli atti della Commissione Provinciale per la conservazione dei monumenti e delle opere d'arte) (parte I), P. 161-162; Guariglia A., Per l'inaugurazione in Raito della lapide ai patriotti 1820-27 e 1848, P. 163-169; Millosevich F., recensione a Monti Gennaro Maria, Storia dell'Università di Napoli, Napoli, Ricciardi, 1924, P. 170-173; Sinno A., recensione a Rotunno A., Lo storico della Certosa di Padula (Mons. Antonio Sacco), P. 174-176

BC-SIM-TR-025 HRIC ICO3 REPORT

The present document has been issued to describe the Instrument Check Out Phase (ICO#3) Tests of HRIC, channel of the Spectrometers and Imagers for MPO BepiColombo Integrated Observatory SYStem (SIMBIO-SYS)