Parathyroid Retrospective Analysis of Neoplasms Incidence (pTRANI Study): An Italian Multicenter Study on Parathyroid Carcinoma and Atypical Parathyroid Tumour

Background: Parathyroid cancer (PC) is a rare sporadic or hereditary malignancy whose histologic features were redefined with the 2022 WHO classification. A total of 24 Italian institutions designed this multicenter study to specify PC incidence, describe its clinical, functional, and imaging characteristics and improve its differentiation from the atypical parathyroid tumour (APT). Methods: All relevant information was collected about PC and APT patients treated between 2009 and 2021. Results: Among 8361 parathyroidectomies, 351 patients (mean age 59.0 ± 14.5; F = 210, 59.8%) were divided into the APT (n = 226, 2.8%) and PC group (n = 125, 1.5%). PC showed significantly higher rates (p < 0.05) of bone involvement, abdominal, and neurological symptoms than APT (48.8% vs. 35.0%, 17.6% vs. 7.1%, 13.6% vs. 5.3%, respectively). Ultrasound (US) diameter >3 cm (30.9% vs. 19.3%, p = 0.049) was significantly more common in the PC. A significantly higher frequency of local recurrences was observed in the PC (8.0% vs. 2.7%, p = 0.022). Mortality due to consequences of cancer or uncontrolled hyperparathyroidism was 3.3%. Conclusions: Symptomatic hyperparathyroidism, high PTH and albumin-corrected serum calcium values, and a US diameter >3 cm may be considered features differentiating PC from APT. 2022 WHO criteria did not impact the diagnosis

Dante nella letteratura inglese

Dante nella letteratura inglese / Michele Renzulli. - Firenze : La via, stampa 1925 Dedica manoscritta dell'autore: All'illustre Scrittore / Sig. Emilio Bodrero, Professore / nella R. Universita' di Padova / omaggio dell'autore / Phila. ottobre 1925 / 6500 Haverfordave https://galileodiscovery.unipd.it/discovery/fulldisplay?context=L&vid=39UPD_INST:VU1&search_scope=MyInst_and_CI&tab=Everything&docid=alma99000235961020604

Petrography, major-trace elements and isotopic compositions of the lavas from El Tigre volcano (Fonseca Gulf, Honduras): increasing data on the Central America Volcanic Front

El Tigre volcano is located within the Fonseca Gulf, Honduras, where there is a break in the strike of the Central America Volcanic Front (Walker et al., 2000; Carr et al., 2003; Bolge et al., 2009). The origin of this gulf arise from the intersection of three first-order tectonic structures, and such a complex tectonic setting is the result of the oblique subduction on the Central American trench (Carr et al., 2003; Burkart & Self, 1985). For these reasons, the knowledge of El Tigre is of paramount importance for unravelling the magmatological and volcanological evolution of this area. Lavas from El Tigre consist of basalts and basaltic andesites with calc-alkaline affinity. The fundamental mineralogical assemblage is typical of relatively primitive subalkaline rocks, and is made of plagioclase, olivine, clinopyroxene, orthopyroxene and opaques. Lavas show a significant LILE enrichment and Nb depletion, a strong slab signature and incompatible element contents similar to those in the main front of the adjacent volcanoes from El Salvador and Nicaragua (e.g. Ba/La up to 80). However, a small group of basalts from El Tigre, with higher MgO content (> 5 wt%) and lower Ba/La, Ba/Nb and Zr/Nb ratios (34-39, 35-49 and 5-7, respectively), emphasizes that mantle-derived magmas were not produced by the same source or process throughout the span-time activity of the volcano. El Tigre lavas are characterized by higher 87Sr/86Sr (0.7038) and lower 143Nd/144Nd (0.51301) with respect to arc volcanoes of El Salvador and Nicaragua, whereas 208Pb/204Pb and 206Pb/204Pb isotope ratios are very similar (38.2 and 18.5, respectively)

Defining the Shallow Geothermal Heat-Exchange Potential for a Lower Fluvial Plain of the Central Apennines: The Metauro Valley (Marche Region, Italy)

In this work we assessed the shallow geothermal heat-exchange potential of a fluvial plain of the Central Apennines, the lower Metauro Valley, where about 90,000 people live. Publicly available geognostic drilling data from the Italian Seismic Microzonation studies have been exploited together with hydrogeological and thermophysical properties of the main geological formations of the area. These data have been averaged over the firsts 100 m of subsoil to define the thermal conductivity, the specific heat extraction rates of the ground and to establish the geothermal potential of the area (expressed in MWh y−1). The investigation revealed that the heat-exchange potential is mainly controlled by the bedrock lithotypes and the saturated conditions of the sedimentary infill. A general increase in thermal conductivity, specific heat extraction and geothermal potential have been mapped moving from the coast, where higher sedimentary infill thicknesses have been found, towards the inland where the carbonate bedrock approaches the surface. The geothermal potential of the investigated lower Metauro Valley is mostly between ~9.0 and ~10 MWh y−1 and the average depth to be drilled to supply a standard domestic power demand of 4.0 kW is ~96 m (ranging from 82 to 125 m all over the valley). This investigation emphasizes that the Seismic Microzonation studies represent a huge database to be exploited for the best assessment of the shallow geothermal potential throughout the Italian regions, which can be addressed by the implementation of heating and cooling through vertical closed-loop borehole heat exchanger systems coupled with geothermal heat pumps

Magmas with slab fluid and decompression melting signatures coexisting in the Gulf of Fonseca: evidence from Isla El Tigre volcano (Honduras, Central America)

none4noIsla El Tigre volcano is located in the Gulf of Fonseca (Honduras) along the Central America volcanic front, where a significant change in the strike of the volcanic chain is observed. The studied samples of this poorly investigated volcano are mainly subalkaline basic to intermediate lavas (basalts and basaltic andesites) and subordinate subalkaline/alkaline transitional basalts, both having the typical mineralogical and geochemical characteristics of arc volcanic rocks. On the basis of petrographic and geochemical features, two groups of rocks have been distinguished. Lavas from the main volcanic edifice are highly porphyritic and hy-qz normative, and have lower MgO contents (5 wt%), are ol-hy normative and show lower HFSE depletions relative to LILE and LREE, with lower Ba/La, Ba/Nb and Zr/Nb ratios. This suggests that mantle-derived magmas were not produced by the same process throughout the activity of the volcano. The bulk rock geochemistry and 87Sr/86Sr (0.70373-0.70382), 143Nd/144Nd (0.51298-0.51301), 206Pb/204Pb (18.55-18.58), 207Pb/204Pb (15.54-15.56) and 208Pb/204Pb (38.23-38.26) isotopic data of Isla El Tigre compared with the other volcanoes of the Gulf of Fonseca and all available literature data for Central America suggests that this stratovolcano was mainly built by mantle-derived melts driven by slab-derived fluid-flux melting, while magmas erupted through its parasitic cones have a clear signature of decompression melting with minor slab contribution. The coexistence of these two different mantle melting generation processes is likely related to the complex geodynamic setting of the Gulf of Fonseca, where the volcanic front changes direction by ca. 30° and two fundamental tectonic structures of the Chortis continental block, mainly the N-S Honduras Depression and the NE-SW Guayape Fault Zone, cross each other.restrictedMattioli Michele; Renzulli Alberto; Agostini Samuele; Lucidi RobertoMattioli, Michele; Renzulli, Alberto; Agostini, Samuele; Lucidi, Robert

Silicate melt inclusions in the cumulate minerals of gabbroic nodules from Stromboli Volcano (Aeolian Islands, Italy): main component of the fluid phase and crystallisation temperatures

The studied gabbroic nodules occurring in the Petrazza pyroclastic rocks consist mainly of plagioclasc (An95-87), olivine (Fo83-73) and clinopyroxene (Mg# 90-77), with subordinate opaques (Ti-magnetite) and amphibole (Mg-hastingsite), which constitute the cumulate minerals. Interstitial material has a relatively high, but variable, degree of vesicularity and consists of variable amounts of glass and quenched crystals of plagioclase (An71-55), amphibole, clinopyroxene and rare biotite, olivine and opaques. Silicate melt inclusions are abundant in the cumulate minerals, but complete homogenization to melt has been observed only in the inclusions occurring in clinopyroxene, where the temperatures of homogenization vary from 1134 to 1190°C. Microthermometric investigations of fluid inclusions and of the shrinkage bubble of the melt inclusions suggest that the magma contained CO2. The apparent scarcity of H2O indicates that this component was strongly partitioned into the magma at the time of crystallization of the investigated minerals; this is further supported by the occurence of (1) daughter biotite- and amphibole-bearing inclusions which show that the H2O activity in the magma was sufficiently high to allow their crystallization, and (2) calcic plagioclase (An95-87) which can be crystallized from a high-alumina basaltic magma at pressure ≤2 kbar, temperatures in the range 1050-1100°C and in the presence of 3-4 wt.% of water (MELTS software simulations). The composition of the melt inclusions suggests that the hosting plagioclase, olivine and clinopyroxene crystallized from slightly different batches of magma. The S content in the melt inclusions of clinopyroxene and olivine is high (up to 0.41 wt.%). The presence of Fe-Cu(-Ni)-rich blebs of sulphide in plagioclase, olivine, amphibole, and locally in the melt inclusions too, further supports the important role of sulphur in the primitive magmas of the investigated gabbros. Small differences in redox conditions or in the Fe content of the melts favoured S mobilization as sulphide