Comment on "Prospect of optical frequency standard based on a 43Ca+ ion"

A recent evaluation of the frequency uncertainty expected for an optical frequency standard based on a single trapped $^{43}$Ca$^+$ ion was published in Phys. Rev. A {\bf 72} (2005) 043404. The paper contains some interesting information like systematic frequency shifts but fails to depict their uncertainty, leading to confuse accuracy and precision. The conclusions about the major contribution to the frequency shift are not consistent with the presented calculations and omit comparisons with data published previously

Long-term stabilization of the length of an optical reference cavity

To obtain a high degree of long-term length stabilisation of an optical reference cavity, its free-spectral range is locked by means of an accurate and stable frequency synthesizer. The locking scheme is twofold: a laser is locked on the N$^{th}$ mode of a reference Fabry-Perot cavity and part of the laser light is shifted in frequency to be in resonance with the (N+1)$^{th}$ mode of the cavity. This shift is generated by an acousto-optical modulator (AOM) mounted in a double-pass scheme, matching half of the free spectral range of the reference cavity. The resulting absolute stabilization of the length of the cavity reaches the 10$^{-11}$ level per second, limited by the lock transfer properties and the frequency stability of the AOM control synthesizer

Metastable level lifetimes from electron-shelving measurements with ion clouds and single ions

The lifetime of the 3d^2D_5/2-level in singly-ionized calcium has been measured by the electron-shelving technique on different samples of rf trapped ions. The metastable state has been directly populated by exciting the dipole-forbidden 4S_1/2 - 3D_5/2 transition. In ion clouds, the natural lifetime of this metastable level has been measured to be (1095+-27) ms. For the single-ion case, we determined a lifetime of (1152+-20) ms. The 1sigma-error bars at the 2%-level have different origins for the two kinds of experiments: data fitting methods for lifetime measurements in an ion cloud and control of experimental parameters for a single ion. De-shelving effects are extensively discussed. The influence of differing approaches for the processing of the single-ion quantum jump data on the lifetime values is shown. Comparison with recent measurements shows excellent agreement when evaluated from a given method

Safety, tolerability and effects on cardiometabolic risk factors of empagliflozin monotherapy in drug-naïve patients with type 2 diabetes: a double-blind extension of a Phase III randomized controlled trial

BACKGROUND: To investigate the long-term efficacy and safety of empagliflozin monotherapy compared with placebo and sitagliptin in drug-naïve patients with type 2 diabetes mellitus. METHODS: Of 899 patients randomized to receive empagliflozin 10 mg, empagliflozin 25 mg, placebo, or sitagliptin 100 mg once daily for 24 weeks, 615 continued in a double-blind extension trial for ≥52 weeks. Exploratory endpoints included changes from baseline in HbA1c, weight and blood pressure at week 76. RESULTS: Compared with placebo, adjusted mean changes from baseline in HbA1c at week 76 were −0.78 % (95 % CI −0.94, −0.63; p < 0.001) and −0.89 % (95 % CI −1.04, −0.73; p < 0.001) for empagliflozin 10 mg and 25 mg, respectively. Compared with placebo, adjusted mean changes from baseline in weight at week 76 were −1.8 kg (95 % CI −2.4, −1.3; p < 0.001) and −2.0 kg (95 % CI −2.6, −1.5; p < 0.001) for empagliflozin 10 mg and 25 mg, respectively. Empagliflozin led to reductions in systolic blood pressure (SBP) compared with placebo in the primary analysis but not in sensitivity analyses. Compared with sitagliptin, empagliflozin 25 mg reduced HbA1c and both empagliflozin doses reduced weight and SBP. Adverse events (AEs) were reported in 76.8, 78.0, 76.4 and 72.2 % of patients on empagliflozin 10 mg, empagliflozin 25 mg, placebo and sitagliptin, respectively. Confirmed hypoglycaemic AEs (glucose ≤3.9 mmol/l and/or requiring assistance) were reported in two patients (0.9 %) per treatment group. CONCLUSIONS: Empagliflozin monotherapy for ≥76 weeks was well tolerated and led to sustained reductions in HbA1c and weight compared with placebo

A História da Alimentação: balizas historiográficas

Os M. pretenderam traçar um quadro da História da Alimentação, não como um novo ramo epistemológico da disciplina, mas como um campo em desenvolvimento de práticas e atividades especializadas, incluindo pesquisa, formação, publicações, associações, encontros acadêmicos, etc. Um breve relato das condições em que tal campo se assentou faz-se preceder de um panorama dos estudos de alimentação e temas correia tos, em geral, segundo cinco abardagens Ia biológica, a econômica, a social, a cultural e a filosófica!, assim como da identificação das contribuições mais relevantes da Antropologia, Arqueologia, Sociologia e Geografia. A fim de comentar a multiforme e volumosa bibliografia histórica, foi ela organizada segundo critérios morfológicos. A seguir, alguns tópicos importantes mereceram tratamento à parte: a fome, o alimento e o domínio religioso, as descobertas européias e a difusão mundial de alimentos, gosto e gastronomia. O artigo se encerra com um rápido balanço crítico da historiografia brasileira sobre o tema

Collisional quenching and j-mixing rate constants for the 3 D levels of Ca+

International audienceno abstrac

Investigation of a Ca+ rf stored ion cloud and observation of the forbidden S-D transitions,

International audienceno abstrac

Collisional quenching and j-mixing rate constants for the 3 D levels of Ca+

International audienceno abstrac

Investigation of a Ca+ rf stored ion cloud and observation of the forbidden S-D transitions,

International audienceno abstrac