First Triassic palaeomagnetic constraints from Junggar (NW China) and their implications for the Mesozoic tectonics in Central Asia

International audienceNorthwestern China belts result from the Palaeozoic collage of Central Asia and the subsequent reactivations due to far-field effects of the Mesozoic Tibetan and the Cenozoic Himalayan collisions. Triassic is a crucial period to understand and decipher the tectonics related to these two episodes. About 250 oriented palaeomagnetic cores from 43 sites were collected from six sections of Upper Permian to Late Triassic sandstone, in South and West Junggar, Northwestern China. Thermomagnetic, IRM and hysteresis measurements reveal magnetite as the main carrier of the magnetic remanence with minor hematite and maghemite. Stepwise thermal demagnetisation has generally isolated two components. The low temperature component, up to 300-350 °C, displays a direction consistent with the present-day geomagnetic field. The locality-mean directions related to the high temperature component (above 350 °C) were also calculated. Two out of six sections display intense viscous magnetisation and the occurrence of maghemite reveals a possible Cenozoic chemical remagnetisation for these two localities. For the other four localities, we assume that the magnetisation is primary because: (1) AMS measurements reveal a primary fabric, (2) there are local occurrences of antipodal polarities, and (3) palaeolatitudes of tilt-corrected poles are compatible with previous studies. The consistency between the Early Triassic poles of West and South Junggar indicates that Junggar evolved as a rigid block only since Early Mesozoic. The comparison of the Late Palaeozoic and the Early Mesozoic poles of Junggar and those of Siberia and Tarim shows major rotations between the Late Permian and the Late Jurassic-Early Cretaceous. These periods of discrete rotations are characterized by strike-slip faulting in Tianshan and Altai and they may correlate with the major episodes of coarse-grained detrital sedimentation and uplift of the range. Especially, the counter-clockwise rotations of Junggar relative to Tarim and Siberia, which occurred between the Early and the Late Triassic and between the Late Triassic and the Late Jurassic, are accommodated by transpressive tectonics in the Tianshan and the Altai belts. This reactivation is a far-field effect of Tibetan blocks diachronous collisions. Therefore, these first Triassic palaeomagnetic results from Junggar infer that post-Carboniferous rotations were due to the combined effect of the post-orogenic transcurrent movement and the Mesozoic oblique reactivation

Publisher Correction: An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence.

An amendment to this paper has been published and can be accessed via a link at the top of the paper

The 5′HS4 insulator element is an efficient tool to analyse the transient expression of an Eμ-GFP vector in a transgenic mouse model

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An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence.

The pharmacokinetic properties of antibodies are largely dictated by the pH-dependent binding of the IgG fragment crystallizable (Fc) domain to the human neonatal Fc receptor (hFcRn). Engineered Fc domains that confer a longer circulation half-life by virtue of more favorable pH-dependent binding to hFcRn are of great therapeutic interest. Here we developed a pH Toggle switch Fc variant containing the L309D/Q311H/N434S (DHS) substitutions, which exhibits markedly improved pharmacokinetics relative to both native IgG1 and widely used half-life extension variants, both in conventional hFcRn transgenic mice and in new knock-in mouse strains. engineered specifically to recapitulate all the key processes relevant to human antibody persistence in circulation, namely: (i) physiological expression of hFcRn, (ii) the impact of hFcγRs on antibody clearance and (iii) the role of competing endogenous IgG. DHS-IgG retains intact effector functions, which are important for the clearance of target pathogenic cells and also has favorable developability

Activation-induced deaminase in B lymphocyte maturation and beyond.

International audienceActivation-induced deaminase (AID), a member of the AID/apolipoprotein B mRNA-editing enzyme-catalytic (APOBEC) family, deaminates DNA cytidines into uridines and is the major trans-acting player of immunoglobulin (Ig) genes' diversification in mature B lymphocytes. It allows multiple antigen-driven Ig modifications through gene conversion and/or somatic hypermutation of variable region genes and also permits to switch from IgM expression to other antibody classes after class switch recombination, or to stop Ig expression after locus suicide recombination. AID is expressed at high levels into germinal center activated B cells with a very stringent temporal and spatial regulation. Despite multiple levels of regulation, off-target effects of AID are quite frequent in the B cell lineage and can affect a number of non-Ig genes, albeit at lower level than Ig genes. Beyond the immune system, AID also contributes to cytosine demethylation in undifferentiated cells by deaminating methylcytosines into thymines which are further processed by thymidine glycosylase. This contributes to the maintenance of pluripotency and to the limitation of genetic imprinting. Since AID attacks on DNA can induce replication errors, base excision repair, or mismatch repair, they are strongly mutagenic and are also driving forces of tumorigenesis, not only in B cell malignancies but also in some non-lymphoid tumors involving ectopic AID expression

BCR expression and B Cell Fate

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Regulation of immunoglobulin expression in mature B cells

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Symposium "Allelic gene regulation in health and disease"

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