Effets des programmes de prévention à focus neuromusculaire chez l’athlète adolescente: revue de la littérature et méta-analyse

Dans la pratique du sport, les athlètes adolescentes sont particulièrement à risque de blessures en raison du niveau élevé d'exposition à un stade de grands changements physiologiques. La pratique des échauffements à focus neuromusculaire lors des entraînements ainsi qu’en compétition semble représenter une approche optimale afin de diminuer le taux de blessures. L’objectif de notre revue est d’évaluer l’effet des programmes de prévention à focus neuromusculaire sur le risque de blessures du membre inférieur chez l’adolescente sportive.Während des Sporttreibens sind jugendliche Athleten aufgrund der grossen physiognomischen Veränderungen, denen sie ausgesetzt sind, besonders verletzungsgefährdet. Ein Aufwärmen mit Fokus auf die Neuromuskulär während des Trainings sowie des Wettkampfes scheint daher ein optimaler Ansatz zu sein um die Anzahl Verletzungen zu verringern. Ziel dieser Arbeit ist es, den Effekt von präventiven Programmen mit Fokus auf die Neuromuskulär auf das Risiko von Verletzungen der Unteren Extremität der Jugendlichen zu evaluieren

Effect of cationic chemical disorder on defect formation energies in uranium-plutonium mixed oxides

At the atomic scale, uranium-plutonium mixed oxides (U,Pu)O_2 are characterized by cationic chemical disorder, which entails that U and Pu cations are randomly distributed on the cation sublattice. In the present work, we study the impact of disorder on point-defect formation energies in (U,Pu)O_2 using interatomic-potential and Density Functional Theory (DFT+U) calculations. We focus on bound Schottky defects (BSD) that are among the most stable defects in these oxides. As a first step, we estimate the distance R_D around the BSD up to which the local chemical environment significantly affects their formation energy. To this end, we propose an original procedure in which the formation energy is computed for several supercells at varying levels of disorder. We conclude that the first three cation shells around the BSD have a non-negligible influence on their formation energy (R_{D} = 7.0 \{AA}). We apply then a systematic approach to compute the BSD formation energies for all the possible cation configurations on the first and second nearest neighbor shells around the BSD. We show that the formation energy can range in an interval of 0.97 eV, depending on the relative amount of U and Pu neighboring cations. Based on these results, we propose an interaction model that describes the effect of nominal and local composition on the BSD formation energy. Finally, the DFT+U benchmark calculations show a satisfactory agreement for configurations characterized by a U-rich local environment, and a larger mismatch in the case of a Pu-rich one. In summary, this work provides valuable insights on the properties of BSD defects in (U,Pu)O_2, and can represent a valid strategy to study point defect properties in disordered compounds.Comment: 33 pages, 20 figure

Introduction

International audienc

DC-SIGN–mediated Infectious Synapse Formation Enhances X4 HIV-1 Transmission from Dendritic Cells to T Cells

Dendritic cells (DCs) are essential for the early events of human immunodeficiency virus (HIV) infection. Model systems of HIV sexual transmission have shown that DCs expressing the DC-specific C-type lectin DC-SIGN capture and internalize HIV at mucosal surfaces and efficiently transfer HIV to CD4+ T cells in lymph nodes, where viral replication occurs. Upon DC–T cell clustering, internalized HIV accumulates on the DC side at the contact zone (infectious synapse), between DCs and T cells, whereas HIV receptors and coreceptors are enriched on the T cell side. Viral concentration at the infectious synapse may explain, at least in part, why DC transmission of HIV to T cells is so efficient

The decomposition and emission factors of a wide range of PFAS in diverse, contaminated organic waste fractions undergoing dry pyrolysis

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Characterization of human mesenchymal stem cell secretome at early steps of adipocyte and osteoblast differentiation

<p>Abstract</p> <p>Background</p> <p>It is well established that adipose tissue plays a key role in energy storage and release but is also a secretory organ and a source of stem cells. Among different lineages, stem cells are able to differentiate into adipocytes and osteoblasts. As secreted proteins could regulate the balance between both lineages, we aimed at characterizing the secretome of human multipotent adipose-derived stem cell (hMADS) at an early step of commitment to adipocytes and osteoblasts.</p> <p>Results</p> <p>A proteomic approach, using mono-dimensional electrophoresis and tandem mass spectrometry, allowed us to identify a total of 73 proteins at day 0 and day 3 of adipocyte and osteoblast differentiation. Analysis of identified proteins showed that 52 % corresponded to classical secreted proteins characterized by a signal peptide, that 37 % previously described in the extracellular compartment were devoid of signal peptide and that 11 % neither exhibited a signal peptide nor had been previously described extracellularly. These proteins were classified into 8 clusters according to their function. Quantitative analysis has been performed for 8 candidates: PAI-1, PEDF, BIGH3, PTX3, SPARC, ENO1, GRP78 and MMP2. Among them, PAI-1 was detected at day 0 and day 3 of osteoblast differentiation but never in adipocyte secretome. Furthermore we showed that PAI-1 mRNA was down-regulated in the bone of ovariectomized mice.</p> <p>Conclusion</p> <p>Given its regulation during the early events of hMADS cell differentiation and its status in ovariectomized mice, PAI-1 could play a role in the adipocyte/osteoblast balance and thus in bone diseases such as osteoporosis.</p

Managing the symptom burden associated with maintenance dialysis: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

Individuals with kidney failure undergoing maintenance dialysis frequently report a high symptom burden that can interfere with functioning and diminish life satisfaction. Until recently, the focus of nephrology care for dialysis patients has been related primarily to numerical targets for laboratory measures, and outcomes such as cardiovascular disease and mortality. Routine symptom assessment is not universal or standardized in dialysis care. Even when symptoms are identified, treatment options are limited and are initiated infrequently, in part because of a paucity of evidence in the dialysis population and the complexities of medication interactions in kidney failure. In May of 2022, Kidney Disease: Improving Global Outcomes (KDIGO) held a Controversies Conference-Symptom-Based Complications in Dialysis-to identify the optimal means for diagnosing and managing symptom-based complications in patients undergoing maintenance dialysis. Participants included patients, physicians, behavioral therapists, nurses, pharmacists, and clinical researchers. They outlined foundational principles and consensus points related to identifying and addressing symptoms experienced by patients undergoing dialysis and described gaps in the knowledge base and priorities for research. Healthcare delivery and education systems have a responsibility to provide individualized symptom assessment and management. Nephrology teams should take the lead in symptom management, although this does not necessarily mean taking ownership of all aspects of care. Even when options for clinical response are limited, clinicians should focus on acknowledging, prioritizing, and managing symptoms that are most important to individual patients. A recognized factor in the initiation and implementation of improvements in symptom assessment and management is that they will be based on locally existing needs and resources