1,690 research outputs found
NIMBUS SPACECRAFT DEVELOPMENT
Nimbus meteorological satellite system for data on worldwide atmospheric processes - real-time weather forecasting and researc
Synthetic Mudscapes: Human Interventions in Deltaic Land Building
In order to defend infrastructure, economy, and settlement in Southeast Louisiana, we must construct new land to
mitigate increasing risk. Links between urban environments and economic drivers have constrained the dynamic delta
landscape for generations, now threatening to undermine the ecological fitness of the entire region. Static methods of
measuring, controlling, and valuing land fail in an environment that is constantly in flux; change and indeterminacy are
denied by traditional inhabitation.
Multiple land building practices reintroduce deltaic fluctuation and strategic deposition of fertile material to form the
foundations of a multi-layered defence strategy. Manufactured marshlands reduce exposure to storm surge further
inland. Virtual monitoring and communication networks inform design decisions and land use becomes determined
by its ecological health. Mudscapes at the threshold of land and water place new value on former wastelands. The
social, economic, and ecological evolution of the region are defended by an expanded web of growing land
Harnessing Nature’s Diversity: Discovering organophosphate bioscavenger characteristics among low molecular weight proteins
Organophosphate poisoning can occur from exposure to agricultural pesticides or chemical weapons. This exposure inhibits acetylcholinesterase resulting in increased acetylcholine levels within the synaptic cleft causing loss of muscle control, seizures, and death. Mitigating the effects of organophosphates in our bodies is critical and yet an unsolved challenge. Here, we present a computational strategy that integrates structure mining and modeling approaches, using which we identify novel candidates capable of interacting with a serine hydrolase probe (with equilibrium binding constants ranging from 4 to 120 μM). One candidate Smu. 1393c catalyzes the hydrolysis of the organophosphate omethoate (kcat/Km of (2.0 ± 1.3) × 10−1 M−1s−1) and paraoxon (kcat/Km of (4.6 ± 0.8) × 103 M−1s−1), V- and G-agent analogs respectively. In addition, Smu. 1393c protects acetylcholinesterase activity from being inhibited by two organophosphate simulants. We demonstrate that the utilized approach is an efficient and highly-extendable framework for the development of prophylactic therapeutics against organophosphate poisoning and other important targets. Our findings further suggest currently unknown molecular evolutionary rules governing natural diversity of the protein universe, which make it capable of recognizing previously unseen ligands
A Search for Sigma^0_5, N^0_5 and Theta^++ Pentaquark States
A high-resolution (sigma_instr. = 1.5 MeV) search for narrow states (Gamma <
10 MeV) with masses of M_x approx 1500-1850 MeV in ep -> e'K^+ X, e'K^- X and
e' pi^+ X electroproduction at small angles and low Q^2 was performed. These
states would be candidate partner states of the reported Theta^+(1540)
pentaquark. No statistically significant signal was observed in any of the
channels at 90% C.L. Upper limits on forward production were determined to be
between 0.7% and 4.2% of the Lambda(1520) production cross section, depending
on the channel and the assumed mass and width of the state.Comment: 5 pages, 5 figures, to appear in Phys. Rev. C, update with responses
to referee suggestion
Baboon-to-human liver transplantation
Our ability to control both the cellular and humoral components of xenograft rejection in laboratory experiments, together with an organ shortage that has placed limits on clinical transplantation services, prompted us to undertake a liver transplantation from a baboon to a 35-year-old man with B virus-associated chronic active hepatitis and human immunodeficiency virus infection. Liver replacement was performed according to conventional surgical techniques. Immunosuppression was with the FK 506-prednisone-prostaglandin regimen used routinely for hepatic allotransplantation, to which a daily non-myelotoxic dose of cyclophosphamide was added. During 70 days of survival, there was little evidence of hepatic rejection by biochemical monitoring or histopathological examination. Products of hepatic synthesis, including clotting factors, became those of the baboon liver with no obvious adverse effects. Death followed a cerebral and subarachnoid haemorrhage that was caused by an angioinvasive aspergillus infection. However, the underlying cause of death was widespread biliary sludge that formed in the biliary tree despite a seemingly satisfactory choledochojejunostomy. During life and in necropsy samples, there was evidence of the chimerism that we believe is integral to the acceptance of both xenografts and allografts. Our experience has shown the feasibility of controlling the rejection of the baboon liver xenograft in a human recipient. The biliary stasis that was the beginning of lethal infectious complications may be correctable by modifications of surgical technique. In further trials, the error of over-immunosuppression should be avoidable. © 1993
Search for a new gauge boson in the Experiment (APEX)
We present a search at Jefferson Laboratory for new forces mediated by
sub-GeV vector bosons with weak coupling to electrons. Such a
particle can be produced in electron-nucleus fixed-target scattering and
then decay to an pair, producing a narrow resonance in the QED trident
spectrum. Using APEX test run data, we searched in the mass range 175--250 MeV,
found no evidence for an reaction, and set an upper limit of
. Our findings demonstrate that fixed-target
searches can explore a new, wide, and important range of masses and couplings
for sub-GeV forces.Comment: 5 pages, 5 figures, references adde
Glial TNFα in the spinal cord regulates neuropathic pain induced by HIV gp120 application in rats
<p>Abstract</p> <p>Background</p> <p>HIV-associated sensory neuropathy (HIV-SN) is one of the most common forms of peripheral neuropathy, affecting about 30% of people with acquired immune deficiency syndrome (AIDS). The symptoms of HIV-SN are dominated by neuropathic pain. Glia activation in the spinal cord has become an attractive target for attenuating chronic pain. This study will investigate the role of spinal TNFα released from glia in HIV-related neuropathic pain.</p> <p>Results</p> <p>Peripheral gp120 application into the rat sciatic nerve induced mechanical allodynia for more than 7 weeks, and upregulated the expression of spinal TNFα in the mRNA and the protein levels at 2 weeks after gp120 application. Spinal TNFα was colocalized with GFAP (a marker of astrocytes) and Iba1 (a marker of microglia) in immunostaining, suggesting that glia produce TNFα in the spinal cord in this model. Peripheral gp120 application also increased TNFα in the L4/5 DRG. Furthermore, intrathecal administration of TNFα siRNA or soluble TNF receptor reduced gp120 application-induced mechanical allodynia.</p> <p>Conclusions</p> <p>Our results indicate that TNFα in the spinal cord and the DRG are involved in neuropathic pain, following the peripheral HIV gp120 application, and that blockade of the glial product TNFα reverses neuropathic pain induced by HIV gp120 application.</p
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