106 research outputs found
The Adoption of RFID Technology in the Retail Supply Chain
This article examines current developments regarding the adoption of RFID technology in the retail supply chain. An explanation is provided of what Radio Frequency Technology (RFID) is and how it works. The benefits of this technology to retailers are outlined in contrast to Bar Coding. Though the technology offers promise for retailers, it does present a number of concerns, which are outlined. Lastly, the article identifies research needs with regard to the new technology
Maternal fucosyltransferase 2 status affects the gut bifidobacterial communities of breastfed infants.
BackgroundIndividuals with inactive alleles of the fucosyltransferase 2 gene (FUT2; termed the 'secretor' gene) are common in many populations. Some members of the genus Bifidobacterium, common infant gut commensals, are known to consume 2'-fucosylated glycans found in the breast milk of secretor mothers. We investigated the effects of maternal secretor status on the developing infant microbiota with a special emphasis on bifidobacterial species abundance.ResultsOn average, bifidobacteria were established earlier and more often in infants fed by secretor mothers than in infants fed by non-secretor mothers. In secretor-fed infants, the relative abundance of the Bifidobacterium longum group was most strongly correlated with high percentages of the order Bifidobacteriales. Conversely, in non-secretor-fed infants, Bifidobacterium breve was positively correlated with Bifidobacteriales, while the B. longum group was negatively correlated. A higher percentage of bifidobacteria isolated from secretor-fed infants consumed 2'-fucosyllactose. Infant feces with high levels of bifidobacteria had lower milk oligosaccharide levels in the feces and higher amounts of lactate. Furthermore, feces containing different bifidobacterial species possessed differing amounts of oligosaccharides, suggesting differential consumption in situ.ConclusionsInfants fed by non-secretor mothers are delayed in the establishment of a bifidobacteria-laden microbiota. This delay may be due to difficulties in the infant acquiring a species of bifidobacteria able to consume the specific milk oligosaccharides delivered by the mother. This work provides mechanistic insight into how milk glycans enrich specific beneficial bacterial populations in infants and reveals clues for enhancing enrichment of bifidobacterial populations in at risk populations - such as premature infants
NICMOS and VLA Observations of the Gravitatonally Lensed Ultraluminous BAL Quasar APM~08279+5255: Detection of a Third Image
We present a suite of observations of the recently identified ultraluminous
BAL quasar APM 08279+5255, taken both in the infra-red with the NICMOS high
resolution camera on board the Hubble Space Telescope, and at 3.5cm with the
Very Large Array. With an inferred luminosity of ~5x10^15 Solar luminosities,
APM 08279+5255 is apparently the most luminous system known. Extant
ground-based images show that APM 08279+5255 is not point-like, but is instead
separated into two components, indicative of gravitational lensing. The much
higher resolution images presented here also reveal two point sources, A and B,
of almost equal brightness (f_B/f_A=0.782 +/- 0.010), separated by 0."378 +/-
0."001, as well as a third, previously unknown, fainter image, C, seen between
the brighter images. While the nature of C is not fully determined, several
lines of evidence point to it being a third gravitationally lensed image of the
quasar, rather than being the lensing galaxy. Simple models which recover the
relative image configuration and brightnesses are presented. While proving to
be substantially amplified, APM 08279+5255 possesses an intrinsic bolometric
luminosity of ~10^14 to 10^15 Solar luminosities and remains amongst the most
luminous objects known.Comment: 21 pages, 5 figures (2 as GIF files); accepted for publication in the
Astronomical Journa
Submillimeter Observations of the Ultraluminous BAL Quasar APM 08279+5255
With an inferred bolometric luminosity of 5\times10^{15}{\rm \lsun}, the
recently identified z=3.87, broad absorption line quasar APM 08279+5255 is
apparently the most luminous object currently known. As half of its prodigious
emission occurs in the infrared, APM 08279+5255 also represents the most
extreme example of an Ultraluminous Infrared Galaxy. Here, we present new
submillimeter observations of this phenomenal object; while indicating that a
vast quantity of dust is present, these data prove to be incompatible with
current models of emission mechanisms and reprocessing in ultraluminous
systems. The influence of gravitational lensing upon these models is considered
and we find that while the emission from the central continuum emitting region
may be significantly enhanced, lensing induced magnification cannot easily
reconcile the models with observations. We conclude that further modeling,
including the effects of any differential magnification is required to explain
the observed emission from APM 08279+5255.Comment: 12 Pages with Two figures. Accepted for publication in the
Astrophysical Journal Letter
APM 08279+5255: an ultraluminous BAL quasar at a redshift z=3.87
We report on the discovery of a highly luminous, broad absorption line quasar
at a redshift of which is positionally coincident, within one
arcsecond, with the IRAS FSC source F08279+5255. A chance alignment of the
quasar and the IRAS source is extremely unlikely and we argue that the optical
and FIR flux are different manifestations of the same object. With an R-band
magnitude of 15.2, and an IRAS 60\mum flux of 0.51\jy, APM 08279+5255 is
(apparently) easily the most intrinsically luminous object known, with
L_{Bol}\sim5\times10^{15}L_{\odot}}. Imaging suggests that gravitational
lensing may play a role in amplifying the intrinsic properties of the system.
The optical spectrum of the quasar clearly reveals the presence of three
potential lensing galaxies, \mg absorption systems at and ,
and a \ly absorption system at . We estimate the total amplification of
the optical component to be , but, due to the larger scale of the
emitting region, would expect the infrared amplification to be significantly
less. Even making the conservative assumption that all wavelengths are
amplified by a factor 40, APM 08279+5255 still possesses a phenomenal
luminosity of \simgt 10^{14L_{\odot}}, indicating that it belongs to a small,
but significant population of high--redshift, hyperluminous objects with
copious infrared emission.Comment: 15 Pages with Four figures. Accepted for publication in the
Astrophysical Journa
Great Circle tidal streams: evidence for a nearly spherical massive dark halo around the Milky Way
An all high-latitude sky survey for cool carbon giant stars in the Galactic
halo has revealed 75 such stars, of which the majority are new detections. Of
these, more than half are clustered on a Great Circle on the sky which
intersects the center of Sagittarius dwarf galaxy (Sgr) and is parallel to its
proper motion vector, while many of the remainder are outlying Magellanic Cloud
C-stars. A pole-count analysis of the carbon star distribution clearly
indicates that the Great Circle stream we have isolated is statistically
significant, being a 5-6 sigma over-density. These two arguments strongly
support our conclusion that a large fraction of the Halo carbon stars
originated in Sgr. The stream orbits the Galaxy between the present location of
Sgr, 16 kpc from the Galactic center, and the most distant stream carbon star,
at ~60 kpc. It follows neither a polar nor a Galactic plane orbit, so that a
large range in both Galactic R and z distances are probed. That the stream is
observed as a Great Circle indicates that the Galaxy does not exert a
significant torque upon the stream, so the Galactic potential must be nearly
spherical in the regions probed by the stream. We present N-body experiments
simulating this disruption process as a function of the distribution of mass in
the Galactic halo. A likelihood analysis shows that, in the Galactocentric
distance range 16 kpc < R < 60 kpc, the dark halo is most likely almost
spherical. We rule out, at high confidence levels, the possibility that the
Halo is significantly oblate, with isodensity contours of aspect q_m < 0.7.
This result is quite unexpected and contests currently popular galaxy formation
models. (Abridged)Comment: 26 pages, 13 figures (6 in color, 8 chunky due to PS compression),
minor revisions, accepted by Ap
Injury Due to Mechanical Falls: Future Directions in Gender-specific Surveillance, Screening, and Interventions in Emergency Department Patients.
The Centers for Disease Control and Prevention report that among older adults (≥65 years), falls are the leading cause of injury-related death. Fall-related fractures among older women are more than twice as frequent as those for men. Gender-specific evidence-based fall prevention strategy and intervention studies show that improved patient-centered outcomes are elusive. There is a paucity of emergency medicine literature on the topic. As part of the 2014 Academic Emergency Medicine (AEM) consensus conference on Gender-Specific Research in Emergency Care: Investigate, Understand, and Translate How Gender Affects Patient Outcomes, a breakout group convened to generate a research agenda on priority questions to be answered on this topic. The consensus-based priority research agenda is presented in this article
LEM-3 – A LEM Domain Containing Nuclease Involved in the DNA Damage Response in C. elegans
The small nematode Caenorhabditis elegans displays a spectrum of DNA damage responses similar to humans. In order to identify new DNA damage response genes, we isolated in a forward genetic screen 14 new mutations conferring hypersensitivity to ionizing radiation. We present here our characterization of lem-3, one of the genes identified in this screen. LEM-3 contains a LEM domain and a GIY nuclease domain. We confirm that LEM-3 has DNase activity in vitro. lem-3(lf) mutants are hypersensitive to various types of DNA damage, including ionizing radiation, UV-C light and crosslinking agents. Embryos from irradiated lem-3 hermaphrodites displayed severe defects during cell division, including chromosome mis-segregation and anaphase bridges. The mitotic defects observed in irradiated lem-3 mutant embryos are similar to those found in baf-1 (barrier-to-autointegration factor) mutants. The baf-1 gene codes for an essential and highly conserved protein known to interact with the other two C. elegans LEM domain proteins, LEM-2 and EMR-1. We show that baf-1, lem-2, and emr-1 mutants are also hypersensitive to DNA damage and that loss of lem-3 sensitizes baf-1 mutants even in the absence of DNA damage. Our data suggest that BAF-1, together with the LEM domain proteins, plays an important role following DNA damage – possibly by promoting the reorganization of damaged chromatin
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