13 research outputs found
Validation of a method for the determination of the anticancer agent Combretastatin A1 phosphate (CA1P, OXi4503) in human plasma by HPLC with post-column photolysis and fluorescence detection
No full textQuantitative determination of the anticancer prodrug combretastatin A1 phosphate (OXi4503, CA1P), the active CA1 and its glucuronide metabolites in human urine and of CA1 in plasma by HPLC with mass spectrometric detection
No full textFree hydroxyl radicals are formed on reaction between the neutrophil-derived species Superoxide anion and hypochlorous acid
Get PDFAbstractSuperoxide anion reacts with hypochlorous acid to yield free hydroxyl radicals, as shown by the hydroxylation of benzoate. This reaction is analogous to the Haber-Weiss reaction but in the absence of metal ions is at least six orders of magnitude faster
Radicals from one-electron reduction of nitro compounds, aromatic N-oxides and quinones: the kinetic basis for hypoxia-selective, bioreductive drugs
No full textAdministration of nicotinamide during a five- to seven-week course of radiotherapy: pharmacokinetics, tolerance, and compliance
No full textIminoxyl radicals and stable products from the one-electron oxidation of 1-methylindole-3-carbaldehyde oximes
No full textFree hydroxyl radicals are formed on reaction between the neutrophil-derived species Superoxide anion and hypochlorous acid
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Phase I Clinical and Pharmacokinetic Evaluation of the Vascular-Disrupting Agent OXi4503 in Patients with Advanced Solid Tumors
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