54 research outputs found
Effect of acid pretreatment and the germination period on the composition and antioxidant activity of rice bean (Vigna umbellata)
- Author
- Aguilera
- Annegowda
- AOAC
- Benzie
- Bewley
- Brand-Williams
- Burachat Sritongtae
- Cevallos-Casals
- Duangmal
- Elias
- Fouad
- Fournier
- Ghavidel
- Gujral
- Hao
- Katoch
- Kaur
- Kiattisak Duangmal
- Kim
- Kudre
- Kumar
- Laemmli
- Lou
- Lowry
- López-Barrios
- Masood
- McCue
- Michael R.A. Morgan
- Oomah
- Pająk
- Peterson
- Randhir
- Raut
- Rayle
- Shen
- Singleton
- Thasanporn Sangsukiam
- Wheeler
- Wongsiri
- Xu
- Yao
- Świeca
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/07/2017
- Field of study
This research evaluated effect of germination period and acid pretreatment on chemical composition and antioxidant activity of rice bean sprouts. Moisture, total phenolics, reducing sugar and B vitamins (thiamine, riboflavin, and niacin) content of steamed sprouts increased with increasing germination time (p ⩽ 0.05). Pretreatment with 1% (w/v) citric acid for 6 h significantly increased the total phenolic content. The 18-h-germinated rice beans showed the highest crude protein content, as determined using the Kjeldahl method. During germination, acid pretreatment led to a significant decrease in the intensity of the 76-kDa band. Germination caused a significant increase in radical scavenging activity and ferric reducing antioxidant power, especially in sprouts from citric acid-treated seeds. The antioxidant activities of the ethanolic extracts from both pretreated beans and the control were 1.3–1.6 times higher than those obtained from the water extracts. Major phenolics found in both 0-h and 18-h-germinated rice beans were catechin and rutin
The Public Repository of Xenografts enables discovery and randomized phase II-like trials in mice
- Author
- Andreeff M. (Michael)
- Armand P. (Philippe)
- Aster J.C. (Jon)
- Ballen K.K. (Karen)
- Barzaghi-Rinaudo P. (Patrizia)
- Bertagnolli M.M. (Monica)
- Brown M. (Myles)
- Cahill S. (Sarah)
- Christie A.L. (Amanda)
- Christodoulou A. (Alexandra)
- Clark R.A. (Rachael)
- Cooke V.G. (Vesselina)
- Davids M.S. (Matthew)
- DeAngelo D.J. (Daniel)
- DeSouza T.A. (Tiffany)
- Dorfman D.M.
- Eaton H. (Hilary)
- Ebert B.L. (Benjamin)
- Etchin J. (Julia)
- Firestone B. (Brant)
- Fisher D.C. (David)
- Freedman A.S. (Arnold)
- Galinsky (), I.A. (Ilene)
- Gamache-Ottou F. (Francine)
- Gao H. (Hui)
- Garcia (), J.S. (Jacqueline)
- Graubert T.A. (Timothy)
- Griffin J.D. (James)
- Gutierrez A. (Alejandro)
- Halilovic E. (Ensar)
- Harris M.H. (Marian)
- Herbert Z.T. (Zachary)
- Horwitz S.M. (Steven)
- Hummelen P. (Paul) van
- Inghirami G. (Giorgio)
- Intlekofer A.M. (Andrew)
- Ito M. (Moriko)
- Izraeli S. (Shai)
- Jacobsen E.D. (Eric)
- Jacobson C.A. (Caron)
- Jeay S. (Sébastien)
- Jeremias I. (Irmela)
- Kallgren S.P. (Scott)
- Kelliher M.A. (Michelle)
- Koch R. (Raphael)
- Konopleva M. (Marina)
- Kopp N. (Nadja)
- Kornblau S.M. (Steven)
- Kung A.L. (Andrew)
- Kupper T.S. (Thomas)
- Köster J. (Johannes)
- LaCasce A.S. (Ann)
- Lane A.A. (Andrew)
- LeBoeuf N.R. (Nicole)
- Lees E. (Emma)
- Letai A. (Anthony)
- Li L.S. (Loretta)
- Liu H. (Huiyun)
- Long H. (Henry)
- Look A.T. (Thomas)
- Montero J. (Joan)
- Morgan E.A. (Elizabeth)
- Murakami M. (Masato)
- Murakami M.A. (Mark)
- Muschen M. (Markus)
- Neuberg D. (Donna)
- Ng S.Y. (Samuel)
- Odejde O.O. (Oreofe)
- Orkin S.H. (Stuart)
- Paquette R.R. (Rachel)
- Place A.A. (Andrew)
- Plana O. (Olivia)
- Rao P. (Prakash)
- Ritz J. (Jerome)
- Roderick J.E. (Justine)
- Ryan J.A. (Jeremy)
- Sallan S.E. (Stephen)
- Shipp M.A. (Margaret)
- Shoji B. (Brent)
- Silverman L.B. (Lewis)
- Soiffer R.J. (Robert)
- Steensma D.P. (David)
- Stegmaier K. (Kimberley)
- Stevenson K.E. (Kristen)
- Stone R.M. (Richard)
- Tamburini J. (Jerome)
- Thorner A.R. (Aaron)
- Townsend E.C. (Elizabeth)
- Vadhi R. (Raga)
- Wadleigh M. (Martha)
- Weinstock D.M. (David)
- Weng A.P. (Andrew)
- Wiesmann M. (Marion)
- Williams D.A. (David)
- Wollison B.M. (Bruce)
- Wu S.-C. (Shuo-Chieh)
- Wuerthner J.U. (Jens)
- Publication venue
- 'Elsevier BV'
- Publication date
- 11/04/2016
- Field of study
More than 90% of drugs with preclinical activity fail in human trials, largely due to insufficient efficacy. We hypothesized that adequately powered trials of patient-derived xenografts (PDX) in mice could efficiently define therapeutic activity across heterogeneous tumors. To address this hypothesis, we established a large, publicly available repository of well-characterized leukemia and lymphoma PDXs that undergo orthotopic engraftment, called the Public Repository of Xenografts (PRoXe). PRoXe includes all de-identified information relevant to the primary specimens and the PDXs derived from them. Using this repository, we demonstrate that large studies of acute leukemia PDXs that mimic human randomized clinical trials can characterize drug efficacy and generate transcriptional, functional, and proteomic biomarkers in both treatment-naive and relapsed/refractory disease
Erratum: Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017
- Author
- Abate Degu
- Abate Kalkidan Hassen
- Abbafati Cristiana
- Abbasi Nooshin
- Abbastabar Hedayat
- Abd-Allah Foad
- Abdela Jemal
- Abdelalim Ahmed
- Abdollahpour Ibrahim
- Abdulkader Rizwan Suliankatchi
- Abebe Molla
- Abebe Zegeye
- Abera Semaw Ferede
- Abil Olifan Zewdie
- Abraha Haftom Niguse
- Abu Raddad Laith J
- Abun Rmeileh Niveen M.E
- Accrombessi Manfred Mario Kokou
- Acharya Dilaram
- Acharya Pawan
- Adamu Abdu Abdullahi
- Adane Akilew Awoke
- Adebayo Oladimeji
- Adedoyin Rufus Adesoji
- Adekanmbi Victor T
- Ademi Zanfina
- Adetokunboh Olatunji O
- Adib Mina G
- Admasie Amha
- Adsuar Jose C
- Afanvi Kossivi Agbélénko
- Afarideh Mohsen
- Afshin Ashkan
- Agarwal Gina
- Aggarwal Anju
- Aghayan Sargis A
- Agrawal Anurag
- Agrawal Sutapa
- Ahmadi Moghadam M
- Ahmadi Alireza
- Ahmadieh Hamid
- Ahmed Muktar Beshir
- Aichour Amani Nidhal
- Aichour Ibtihel
- Aichour Miloud Taki Eddine
- Akbari Mohammad Esmaeil
- Akinyemiju Tomi F.
- Akseer Nadia
- Al Aly Ziyad
- Al Eyadhy Ayman A
- Al Mekhlafi H. M
- Alahdab Fares
- Alam Khurshid
- Alam Samiah
- Alam Tahiya
- Alashi Alaa
- Alavian Seyed Moayed
- Alene Kefyalew Addis
- Ali Komal
- Ali Syed Mustafa
- Alijanzadeh Mehran
- Alizadeh Navaei Reza
- Aljunid Syed Mohamed
- Alkerwi Ala'a
- Alla F
- Alsharif Ubai
- Altirkawi Khalid A
- Alvis Guzman Nelson
- Amare Azmeraw T
- Ammar Walid S
- Anber Nahla
- Anderson Jason A
- Andrei Cǎtǎlina Liliana
- Androudi S
- Animut Megbaru Debalkie
- Anjomshoa Mina
- Ansha Mustafa Geleto
- Antonio Carl Abelardo T
- Antó Josep María
- Anwari Palwasha
- Appiah Lambert Tetteh
- Appiah Seth Christopher Yaw
- Arabloo Jalal
- Aremu Olatunde
- Artaman Al
- Aryal Krishna Kumar
- Asayesh Hamid
- Ataro Zerihun
- Ausloos Marcel
- Avokpaho Euripide Frinel G.Arthur
- Awasthi Ashish
- Ayala Quintanilla Beatriz Paulina
- Ayer Rakesh
- Ayuk Tambe Betrand
- Azzopardi Peter S
- Babazadeh Arefeh
- Badali Hamid
- Badawi Alaa
- Balakrishnan Kalpana
- Bali Ayele Geleto
- Ball Kylie
- Ballew Shoshana H
- Banach Maciej
- Banoub Joseph Adel Mattar
- Barac Aleksandra
- Barker Collo Suzanne Lyn
- Barrero Lope Hugo
- Basu Sanjay
- Baune Bernhard T
- Bazargan Hejazi Shahrzad
- Bedi Neeraj
- Beghi Ettore
- Behzadifar Masoud
- Behzadifar Meysam
- Bekele Bayu Begashaw
- Bekru Eyasu Tamiru
- Belay Ezra
- Belay Yihalem Abebe
- Bell Michelle L.
- Bello Aminu K
- Bennett Derrick A
- Benseñor Isabela M
- Bergeron Gilles
- Berhane Adugnaw
- Bernabe Eduardo
- Bernstein Robert Steven
- Beuran Mircea
- Beyranvand Tina
- Bhala Neeraj B
- Bhalla Ashish K
- Bhattarai Suraj
- Bhutta Zulfiqar A
- Biadgo Belete
- Bijani Ali
- Bijot Yannick
- Bikbov Boris
- Bilano Ver
- Bililign Nigus
- Bin Sayeed Muhammad Shahdaat
- Bisanzio Donal
- Biswas Tuhin
- Björge Tone
- Blacker Brigette F
- Bleyer Archie
- Borschmann Rohan D
- Bou Orm Ibrahim R
- Boufous Soufiane
- Bourne Rupert R.A
- Brady Oliver J
- Brauer Michael
- Bražinová Alexandra
- Breitborde Nicholas J.K
- Brenner Hermann
- Briko A. N
- Britton Gabrielle
- Brugha Traolach Sean
- Buchbinder Rachelle
- Burnett Richard T
- Busse Reinhard
- Butt Zahid A
- Bärnighausen Till Winfried
- Cahill Leah E
- Cahuana Hurtado Lucero
- Campos Nonato Ismael Ricardo
- Carreras G
- Carrero Juan Jesuś A
- Carvalho Malta Deborah
- Castañeda Orjuela C. A
- Castillo Rivas Jacqueline
- Castro Franz
- Catalá López Ferrán
- Causey Kate
- Cercy Kelly M
- Cerin Ester
- Chaiah Yazan
- Chang Hsingyi
- Chang Jungchen
- Chang Kailan
- Charlson Fiona J
- Chattopadhyay Aparajita
- Chattu Vijay Kumar
- Chee Miaoli
- Cheng Ching Yu
- Chew Adrienne
- Chiang Peggy Pei Chia
- Chimed Ochir Odgerel
- Chin Ken Lee
- Chitheer Abdulaal
- Choi Jee Young Jasmine J
- Chowdhury Rajiv
- Christensen Hanne Krarup
- Chung Sheng Chia
- Cicuttini Flavia M
- Cirillo Massimo
- Cohen Aaron J
- Collado Mateo Daniel
- Cooper Cyrus
- Cooper Owen R
- Coresh Josef
- Cornaby Leslie
- Cortesi Paolo Angelo
- Cortinovis Monica
- Costa Megan E
- Cousin Ewerton
- Criqui Michael H
- Cromwell Elizabeth A.M
- Cundiff David Keith
- Cárdenas Rosario
- Daba Alemneh Kabeta
- Dachew Berihun Assefa
- Dadi Abel Fekadu
- Damasceno Albertino Antonio Moura
- Dandona Lalit
- Dandona Rakhi A
- Darby Sarah C
- Dargan Paul I
- Daryani Ahmad
- das Neves José
- Dasa Tamirat Tesfaye
- Dash Aditya Prasad
- Davitoiu Dragos Virgil
- Davletov K
- De La Cruz Góngora Vanessa
- De la Hoz Fernando Pío
- De Leo Diego
- De Neve Jan Walter
- Degenhardt Louisa
- Deiparine Selina
- Dellavalle Robert P
- Demoz Gebre Teklemariam
- Denova Gutiérrez Edgar
- Deribe Kebede
- Dervenis Nikolaos Alemayehu
- Deshpande Aniruddha
- Dessie Getenet Ayalew
- Devasahayam Jesudas Christopher
- DeVeber Gabrielle Aline
- Dey Subhojit
- Dharmaratne Samath Dhamminda
- Dhimal Megnath
- Dias Carvalho Félix
- Dinberu Mesfin Tadese
- Ding Eric L
- Diro Helen Derara
- Djalalinia Shirin S
- Do Huyen Phuc
- Dokova Klara G
- Doku David Teye
- Doyle Kerrie E
- Driscoll Tim Robert
- Dubey Manisha
- Dubljanin Eleonora S
- Duken Eyasu Ejeta
- Duncan Bruce Bartholow
- Durães André Rodrigues Odrigues
- Ebert Natalie
- Ebrahimi Hedyeh
- Ebrahimpour Soheil
- Edvardsson Jan David
- Effiong Andem I
- Eggen Anne Elise
- El Bcheraoui Charbel E
- El Khatib Ziad
- Elyazar Iqbal R.F
- Enayati Ahmad Ali
- Endries Aman Yesuf
- Er Benjamin
- Erskine Holly E
- Eskandarieh Sharareh
- Esteghamati Alireza
- Estep Kara
- Fakhim Hamed
- Faramarzi M
- Fareed Mohammad F
- Farid Talha A
- Farioli Andrea
- Faro André
- Farvid Maryam S
- Farzaei Mohammad Hosein
- Fatima Batool
- Fay Kairsten A
- Fazaeli Ali Akbar
- Feigin Valery L
- Feigl Andrea B
- Fereshtehnejad Seyed Mohammad
- Fernandes Eduarda
- Fernandes João C
- Ferrara Giannina
- Ferrari Alize J
- Ferreira M. L
- Filip Irina
- Finger Jonas David
- Fischer Florian S
- Foigt Nataliya A
- Foreman Kyle J
- Fukumoto Takeshi
- Fullman Nancy
- Furtado João M
- Futran Neal David
- Fürst Thomas
- Gakidou Emmanuela
- Gall Seana L
- Gallus Silvano
- Gamkrelidze Amiran
- Ganji Morsaleh
- García Basteiro Alberto L
- Gardner William M
- Gebre Abadi Kahsu
- Gebremedhin Amanuel Tesfay
- Gebremichael Teklu Gebrehiwo
- Gelano Tilayie Feto
- Geleijnse Johanna M
- Geramo Yilma Chisha Dea
- Gething Peter William
- Gezae Kebede Embaye
- Ghadimi Reza
- Ghadiri Keyghobad
- Ghasemi Falavarjani Khalil
- Ghasemi Kasman Maryam
- Ghimire Mamata
- Ghosh Rakesh
- Ghoshal Aloke Gopal
- Giampaoli Simona
- Gill Paramjit Singh
- Gill Tiffany K
- Gillum Richard Frank
- Ginawi Ibrahim Abdelmageem Mohamed
- Giussani Giorgia
- Gnedovskaya E. V
- Godwin William W
- Goli Srinivas
- Gona Philimon Nyakauru
- Gopalani Sameer Vali
- Goulart Alessandra Carvalho
- Grada Ayman
- Grams Morgan E
- Grosso Giuseppe
- Gugnani Harish Chander C
- Guo Yuming
- Gupta Rahul
- Gupta Rajat Das
- Gupta Rajeev K
- Gupta Tanush
- Gutiérrez Torres D. S
- Gutiérrez Reyna Alma
- Gómez Dantés Héctor
- Haagsma Juanita A
- Habtewold Tesfa Dejenie
- Hachinski Vladimir
- Hafezi Nejad Nima
- Hagos Tekleberhan Beyene
- Hailegiyorgis Tewodros Tesfa
- Hailu Gessessew Bugssa
- Haj Mirzaian Arvin
- Haj Mirzaian Arya
- Hamadeh Randah R
- Hamidi Samer
- Handal Alexis J
- Hankey Graeme J
- Hao Yuantao
- Harb Hilda L
- Harikrishnan Sivadasanpillai
- Haro Josep María
- Hasankhani Hadi
- Hassen Hamid Yimam
- Havmoeller Rasmus J
- Hawley Caitlin N
- Hay Simon I
- Hedayatizadeh Omran Akbar
- Heibati Behzad
- Heidari Behnam
- Heidari Mohsen
- Hendrie Delia V
- Henok Andualem
- Heredia Pi Ileana B
- Herteliu Claudiu
- Heydarpour Fatemeh
- Heydarpour S
- Hibstu Desalegn Tsegaw
- Higazi Tarig B
- Hilawe Esayas Haregot
- Hoek Hans Wijbrand
- Hoffman Howard J
- Hole Michael K
- Homaie Rad Enayatollah
- Hoogar Praveen
- Hosgood H. Dean
- Hosseini Sayed Mostafa
- Hosseinzadeh Mehdi
- Hostiuc Mihaela
- Hostiuc Sorin
- Hoy Damian G
- Hsaïri Mohamed
- Hsiao Thomas
- Hu Guoqing
- Hu Howard
- Huang John J.Emmanuel
- Hussen Mamusha Aman A
- Huynh Chantal K
- Iburg Kim Moesgaard
- Ikeda Nayu
- Ilesanmi Olayinka Stephen
- Iqbal Usman
- irnliv Johan
- Irvine Caleb Mackay Salpeter
- Islam Sheikh Mohammad Shariful
- Islami Farhad
- Jackson Maria D
- Jacobsen Kathryn H
- Jahangiry Leila
- Jahanmehr Nader
- Jain Sudhir Kumar
- Jakovljevic Mihajlo
- James Spencer Lewis
- Jassal Simerjot Kaur
- Jayatilleke Achala Upendra
- Jeemon Panniyammakal
- Jha Ravi Prakash
- Jha Vivekanand
- Ji John S
- Jonas Jost Bruno
- Jonnagaddala Jitendra
- Jorjoran Shushtari Zahra J
- Joshi Ankur
- Jóźwiak Jacek Jerzy
- JÜRISSON Mikk
- Kabir Zubair
- Kahsay Amaha
- Kalani Rizwan E
- Kanchan Tanuj
- Kant Surya
- Kar Chittaranjan
- Karami Manoochehr
- Karamimatin Behzad
- Karch André
- Karema Corine Kakizi
- Karimi Narges
- Karimi Seyed Mohammad
- Kasaeian Amir
- Kassa Dessalegn Haile
- Kassa Tesfaye Dessale
- Kassebaum Nicholas J
- Katikireddi Srinivasa V
- Kaul Anil K
- Kawakami Norito
- Kazemi Karyani Ali
- Kazemi Zhila
- Kefale Adane Teshome
- Keiyoro Peter Njenga
- Kemp Grant Rodgers
- Kengne Andre Pascal
- Keren André
- Kesavachandran Chandrasekharan Nair
- Khader Yousef Saleh
- Khafaei Behzad
- Khafaie Morteza Abdullatif
- Khajavi Alireza
- Khalid Nauman
- Khalil Ibrahim A
- Khan Gulfaraz
- Khan Muhammad Ali
- Khan Muhammad Shahzeb
- Khang Young-ho
- Khater Mona M
- Khazaei Mohammad
- Khazaie Habibolah
- Khoja Abdullah Tawfih
- Khosravi Ardeshir
- Khosravi Mohammad Hossein
- Kiadalir Ali
- Kiirithio Daniel Ngari
- Kim Choil
- Kim Daniel
- Kim Young-eun
- Kim Yun Jin
- Kim Yun-jin
- Kimokoti Ruth W
- Kinfu Yohannes
- Kisa Adnan
- Kissimova Skarbek Katarzyna
- Kivimäki Mika
- Knibbs L. D
- Knudsen Ann Kristin Skrindo
- Kochhar Sonali
- Kokubo Yoshihiro
- Kolola Tufa
- Kopeć Jacek A
- Kosen Soewarta
- Koul P. A
- Koyanagi Ai
- Kravchenko Michael A
- Krishan K
- Krohn Kristopher J
- Kromhout Hans
- Kuate Defo B
- Kumar Gopal Anil
- Kumar Manasi
- Kuzin Igor
- Kyu Hmwe Hmwe
- Küçük Biçer Burcu
- Lachat Carl K
- Lad Deepesh P
- Lad Sheetal D
- Lafranconi Alessandra
- Lalloo Ratilal
- Lallukka Tea
- Lami Faris Hasan
- Lang Justin J
- Lansingh Van C
- Larson Samantha Leigh
- Latifi Arman
- Lazarus J. V
- Lee Paul H
- Leigh James
- Leili Mostafa
- Leshargie Cheru Tesema
- Leung Janni
- Levi Miriam
- Lewycka Sonia
- Li Shanshan
- Li Yichong
- Liang Juan
- Liang Xiaofeng
- Liao Yu
- Liben Misgan Legesse
- Lim Lee Ling
- Lim Stephen S
- Linn Shai
- Liu Shiwei
- Lodha Rakesh
- Logroscino Giancarlo C
- Lorkowski Stefan
- Lotufo Paulo Andrade
- Lozano Rafael
- Lucas Tim C.D
- Lunevicius Raimundas
- López Alan D
- Ma Stefan
- MacArayan Erlyn Rachelle King
- Machado Ísis Eloah
- Madotto Fabiana
- Mahesh Padukudru Anand
- Mai Hue Thi
- Majdan Marek
- Majdzadeh Seyyed Reza
- Majeed Azeem
- Malekzadeh Reza
- Mamun Abdullah Al
- Manda Ana Laura
- Manguerra Helena
- Mansournia Mohammed Ali
- Mantovani Lorenzo G
- Maravilla Joemer Calderon
- Marcenes Wagner Segura
- Marks Ashley
- Martin Randall V
- Martins Sheila Cristina Ouriques
- Martins-Melo Francisco Rogerlândio
- Marzan Melvin Barrientos
- Massenburg Benjamin B
- Mathur Manu Raj
- Mathur Prashant
- Matsushita Kunihiro
- Maulik Pallab K
- Mazidi Mohsen
- McAlinden Colm Gebremichael
- McGrath John J
- McKee Martin
- Mehrotra Ravi
- Mehta Kala Mehendra
- Mehta Varshil
- Meier Toni
- Mekonnen Fantahun Ayenew
- Melaku Yohannes Adama
- Melese Addisu
- Melku Mulugeta
- Memiah Peter T.N
- Memish Ziad A
- Mendoza Walter
- Mengistu Desalegn Tadese
- Mensah George A
- Mensink Gert B.M
- Mereta Seid Tiku
- Meretoja Atte
- Meretoja Tuomo J
- Meštrović Tomislav
- Miazgowski Bartosz
- Miazgowski Tomasz
- Millear Anoushka I
- Miller Ted R
- Miller-Petrie Molly Katherine
- Mirici Andreea
- Mirrakhimov Erkin
- Mirrakhimov Erkin
- Mirrakhimov Erkin
- Mirrakhimov Erkin
- Misganaw Awoke Temesgen
- Mitiku Habtamu
- Moazen Babak
- Mohajer Bahram
- Mohammad Karzan Abdulmuhsin
- Mohammadi Moslem
- Mohammadi Moslem
- Mohammadi Moslem
- Mohammadifard Noushin
- Mohammadifard Noushin
- Mohammadnia-Afrouzi Mousa
- Mohammadnia-Afrouzi Mousa
- Mohammed Shafiu
- Mohammed Shafiu
- Mohebi Farnam
- Mokdad Ali H
- Molokhia Mariam
- Momeniha Fatemeh
- Monasta Lorenzo
- Moodley Yoshan
- Moradi Ghobad
- Moradi-Lakeh Maziar
- Moradinazar Mehdi
- Moraga Paula
- Morawska Lidia
- Morgado-Da-Costa Joana
- Morrison Shane Douglas
- Moschos Marilita M
- Mouodi Simin
- Mousavi Seyyed Meysam
- Mozaffarian Dariush
- Mruts Kalayu Brhane
- Muche Achenef Asmamaw
- Muchie Kindie Fentahun
- Mueller Ulrich Otto
- Muhammed Oumer Sada S
- Mukhopadhyay Satinath
- Muller Kate
- Mullu Kassa Getachew
- Murray Christopher J.L
- Mustafa Ghulam
- Márz Winfried
- Nabhan Ashraf Fawzy
- Naghavi Mohsen
- Naghibi Irvani Seyed Sina
- Naheed Aliya
- Nahvijou Azin
- Naik Gurudatta
- Naik Nitish
- Najafi Farid
- Nangia Vinay B
- Nansseu Jobert Richie Njingang
- Nascimento Bruno Ramos
- Neal Bruce
- Neamati Nahid
- Negoi Ionuț
- Negoi Ruxandra Irina
- Neupane Subas
- Newton Charles Richard James
- Ngunjiri Josephine Wanjiku
- Nguyen Anh Quynh
- Nguyen Grant
- Nguyen Ha Thu
- Nguyen Huong Lan Thi
- Nguyen Huong Thanh M
- Nguyen Minh Thao
- Nguyen Nam Ba
- Nichols Emma
- Nie Jing
- Ningrum Dina Nur Anggraini
- Nirayo Yirga Legesse
- Nishi Nobuo
- Nixon Molly R
- Nojomi Marzieh
- Nomura Shuhei
- Norheim Ole Frithjof
- Noroozi Mehdi
- Norrving Bo
- Noubiap Jean Jacques
- Nouri Hamid Reza
- Nourollahpour Shiadeh Malihe
- Nowroozi Mohammad Reza
- Nsoesie Elaine O
- Nyasulu Peter Suwirakwenda
- Obermeyer Carla Makhlouf
- Odell Christopher M
- Ofori-Asenso Richard
- Ogbo Felix Akpojene
- Oh In-hwan
- Oladimeji Olanrewaju
- Olagunju Andrew Toyin
- Olagunju Tinuke Oluwasefunmi
- Olivares Pedro R
- Olsen Helen Elizabeth
- Olusanya Bolajoko Olubukunola
- Olusanya Jacob Olusegun
- Ong Kanyin Liane
- Ong Sok King
- Oren Eyal
- Orpana Heather M
- Ortiz Alberto
- Ota Erika
- Otstavnov Stanislav S
- Owolabi Mayowa Ojo
- Pacella Rosana
- Pakhare Abhijit P
- Pakpour Amir Haji Agha
- Panda-Jonas Songhomitra
- Panǎ Adrian
- Park Eun-kee
- Parry Charles D.H
- Parsian Hadi
- Patel Shanti K
- Pati Sanghamitra S
- Patil Snehal T
- Patle Ajay
- Patton George C
- Paudel Deepak
- Paulson Katherine R
- Paz-Ballesteros Wayra Citlali
- Pearce Neil
- Pereira Alexandre
- Pereira David M
- Perico Norberto
- Pesudovs Konrad
- Petzold Max Gustav
- Pham Hai Quang
- Phillips Michael Robert
- Pillay Julian David
- Piradov Michael A
- Pirsaheb Meghdad
- Pischon Tobias
- Pishgar Farhad
- Plana-Ripoll Oleguer
- Plaß Dietrich
- Polinder Suzanne
- Polkinghorne Kevan Roy
- Postma Maarten Jacobus
- Poulton Richie G
- Pourshams Akram
- Poustchi Hossein
- Prabhakaran Dorairaj
- Prakash Swayam
- Prasad Narayan M
- Purcell Caroline A
- Purwar Manorama B
- Qorbani Mostafa
- Radfar Amir
- Rafay Anwar
- Rafiei Alireza
- Rahim Fakher
- Rahimi Zohreh
- Rahimi-Movaghar Afarin
- Rahimi-Movaghar Vafa
- Rahman Mahfuzar Moklesur
- Rahman Mohammad Hifz Ur
- Rahman Muhammad Aziz
- Rai Rajesh Kumar
- Rajati Fatemeh
- Rajsic Sasa
- Raju Sree Bhushan
- Ram Usha
- Ranabhat Chhabi Lal
- Ranjan Prabhat
- Rath Gourva Kishor
- Rawaf David Laith
- Rawaf Salman
- Reddy Srinath K
- Rehm Colin D
- Rehm Jürgen
- Reiner Robert Charles
- Reitsma Marissa Bettay
- Remuzzi Giuseppe
- Renzaho Andre M.N
- Resnikoff Serge
- Reynales-Shigematsu Luz Miriam
- Rezaei Satar
- Ribeiro Antônio Luiz Pinho
- Rivera Juan Ángel
- Roba Aklilu Abrham
- Roba Kedir Teji
- Rodríguez Ramírez Sonia
- Roever Leonardo
- Román Yesenia
- Ronfani Luca
- Roshandel Gholamreza H
- Rostami Ali
- Roth Gregory A
- Rothenbacher Dietrich
- Roy Ambuj K
- Rubagotti Enrico
- Rushton Lesley
- Sabanayagam Charumathi
- Sachdev Perminder S
- Saddik Basema
- Sadeghi Ehsan
- Saeedi Moghaddam Sahar
- Safari Faramani Roya
- Safari Hosein
- Safari Yahya
- Safdarian Mahdi
- Safi Sare
- Safiri Saeid
- Sagar Rajesh
- Sahebkar Amirhossein
- Sahraian Mohammad Ali
- Sajadi Haniye Sadat
- Salam Nasir
- Salamati Payman
- Saleem Zikria
- Salimi Yahya
- Salimzadeh Hamideh
- Salomon Joshua A
- Salvi Devashri Digvijay
- Salz Inbal Weiss
- Samy Abdallah M
- Sanabria Juan Ramon
- Sanders Taren
- Sang Yingying
- Santomauro Damian
- Santos Itamar Souza
- Santos João Vasco
- Sao Jose Bruno Piassi
- Sardana Mayank
- Sarker Abdur Razzaque
- Sarmiento Suárez Rodrigo
- Sarrafzadegan Nizal
- Sartorius Benn
- Sarvi Shahabeddin
- Sathian Brijesh
- Satpathy Maheswar
- Sawant Arundhati R
- Sawhney Monika
- Saylan Mete
- Sayyah Mehdi
- Schaeffner Elke S
- Schmidt Maria Inês
- Schneider Ione Jayce Ceola
- Schutte Aletta Elisabeth
- Schwebel David C
- Schwendicke Falk
- Schöttker Ben
- Scott James G
- Seedat Soraya
- Sepanlou Sadaf Ghajarieh
- Serre Marc L
- Serván Mori Edson E
- Seyedmousavi Seyedmojtaba
- Shabaninejad Hossien
- Shaddick Gavin
- Shafieesabet Azadeh
- Shahbazi Mehdi
- Shaheen Amira A
- Shaikh Masood Ali A
- Shamah Levy Teresa
- Shams Beyranvand Mehran
- Shamsi Mohammad Bagher
- Sharafi Heidar
- Sharafi Kiomars
- Sharif Alhoseini Mahdi
- Sharif Mehdi
- Sharifi Hamid
- Sharma Jayendra
- Sharma Meenakshi P
- Sharma Rajesh S
- She June
- Sheikh Aziz
- Shi Peilin
- Shibuya Kenji
- Shiferaw Mekonnen Sisay
- Shigematsu Mika
- Shin Min Jeong
- Shiri Rahman
- Shirkoohi Reza
- Shiue Ivy J
- Shokraneh Farhad
- Shoman Haitham
- Shrime Mark G
- Shupler Matthew S
- Si Si
- Siabani Soraya
- Sibai Abla Mehio
- Siddiqi Tariq Jamal
- Sigfúsdóttir Inga Dóra
- Sigurvinsdóttir Rannveig
- Silva Diego Augusto Santos
- Silva Joaõ Pedro
- Silveira Dayane Gabriele Alves
- Singh Jasvinder A
- Singh Narinder Pal
- Singh Virendra P
- Sinha Dhirendra Narain
- Skiadaresi Eirini Yurievich
- Skirbekk Vegard F
- Smith David L
- Smith Mari
- Sobaih Badr Hasan A
- Sobhani Soheila
- Somayaji Ranjani
- Soofi Moslem
- Sorensen Reed J.D
- Soriano Joan B
- Soyiri Ireneous N
- Spinelli Angela
- Sposato Luciano A
- Sreeramareddy Chandrashekhar T
- Srinivasan Vinay
- Stanaway Jeffrey D
- Starodubov V. I
- Steckling Nadine
- Stein Dan J
- Stein Murray B
- Stevanović Goran D
- Stockfelt Leo
- Stokes Mark
- Sturua Lela Z
- Subart Michelle L
- Sudaryanto Agus
- Sufiyan Mu'awiyyah Babale
- Sulo Gerhard
- Sunguya Bruno Fokas
- Sur Patrick John
- Sykes Bryan Ltza
- Szoeke Cassandra
- Sá Farinha Carla Sofia E
- Sánchez Niño María Dolores
- Sánchez Pimienta Tania G
- Tabarés Seisdedos Rafael
- Tabuchi Takahiro
- Tadakamadla Santosh Kumar
- Takahashi Ken
- Tandon Nikhil
- Tassew Segen Gebremeskel
- Tavakkoli Mohammad
- Taveira Nuno
- Tehrani Banihashemi Arash
- Tekalign Tigist Gashaw
- Tekelemedhin Shishay Wahdey
- Tekle Merhawi Gebremedhin
- Temesgen Habtamu Denekew
- Temsah Mohamad Hani
- Temsah Omar
- Terkawi Abdullah Sulieman
- Tessema Belay
- Teweldemedhin Mebrahtu
- Thankappan Kavumpurathu Raman
- Theis Andrew M
- Thirunavukkarasu Sathish
- Thomas Hannah J
- Thomas Matthew Lloyd
- Thomas Nihal J
- Thurston George D
- Tilahun Binyam Chakilu
- Tillmann Taavi
- To Quyen G
- Tobollik Myriam
- Tonelli Marcello
- Topór Ma̧dry Roman
- Torre Anna E
- Tortajada Girbés Miguel
- Touvier Mathilde
- Tovani Palone Marcos Roberto
- Towbin Jeffrey A
- Tran Bach Xuan
- Tran Khanh Bao
- Truelsen Thomas Clement
- Truong Nu Thi
- Tsadik Afewerki Gebremeskel
- Tudor Car Lorainne
- Tuzcu E. Murat
- Tymeson Hayley D
- Tyrovolas Stefanos
- Ukwaja Kingsley N
- Ullah Irfan
- Updike Rachel L
- Usman Muhammad Shariq
- Uthman Olalekan A
- Vaduganathan Muthiah
- Vaezi Afsane
- Valdez Pascual Rubén
- van Donkelaar Aaron
- Varavikova Elena A
- Varughese Santosh
- Vasankari Tommi Juhani
- Venkateswaran Vidhya
- Venketasubramanian Narayanaswamy
- Villafaina Santos
- Violante Francesco Saverio
- Vladimirov Sergey K
- Vlassov Vasiliy Victorovich
- Vollset Stein Emil
- Vos Theo
- Vosoughi Kia
- Vu Giang Thu
- Vujčić Isidora S
- Wagnew Fasil Shiferaw
- Waheed Yasir
- Waller Stephen G
- Walson Judd L
- Wang Yafeng
- Wang Yanping
- Wang Yuan Pang
- Weiderpass Elisabete
- Weintraub Robert G
- Weldegebreal Fitsum
- Werdecker Andrea
- Werkneh Adhena Ayaliew
- West James Jason
- Westerman Ronny
- Whiteford Harvey A
- Widecka Justyna
- Wijeratne Tissa
- Winkler Andrea Sylvia
- Wiyeh Alison Beriliy
- Wiysonge Charles Shey
- Wong Tienyin
- Wu Shouling
- Wu Shouling
- Xavier Denis
- Xu Gelin
- Yadgir Simon
- Yadollahpour Ali
- Yahyazadeh Jabbari Seyed Hossein
- Yamada Tomohide
- Yan Lijing L
- Yano Yuichirou
- Yaseri Mehdi
- Yasin Yasin Jemal
- Yeshaneh Alex
- Yimer Ebrahim M
- Yip Paul S.F
- Yisma Engida
- Yonemoto Naohiro
- Yoon Seokjun
- Yotebieng Marcel
- Younis Mustafa Z.“Mike”
- Yousefifard Mahmoud
- Yu Chuanhua
- Zaidi Zoubida
- Zaman Sojib Bin
- Zamani Mohammad
- Zavala-Arciniega Luis
- Zhang Anthonylin
- Zhang Hao
- Zhang Kai
- Zhou Maigeng
- Zimsen Stephanie R.M
- Zodpey Sanjay P
- Øverland Simon
- Šantrić Milićević Milena M.M
- Šekerija Mario
- Publication venue
- 'Elsevier BV'
- Publication date
- 28/06/2019
- Field of study
Interpretation: By quantifying levels and trends in exposures to risk factors and the resulting disease burden, this assessment offers insight into where past policy and programme efforts might have been successful and highlights current priorities for public health action. Decreases in behavioural, environmental, and occupational risks have largely offset the effects of population growth and ageing, in relation to trends in absolute burden. Conversely, the combination of increasing metabolic risks and population ageing will probably continue to drive the increasing trends in non-communicable diseases at the global level, which presents both a public health challenge and opportunity. We see considerable spatiotemporal heterogeneity in levels of risk exposure and risk-attributable burden. Although levels of development underlie some of this heterogeneity, O/E ratios show risks for which countries are overperforming or underperforming relative to their level of development. As such, these ratios provide a benchmarking tool to help to focus local decision making. Our findings reinforce the importance of both risk exposure monitoring and epidemiological research to assess causal connections between risks and health outcomes, and they highlight the usefulness of the GBD study in synthesising data to draw comprehensive and robust conclusions that help to inform good policy and strategic health planning
Partitioning the Heritability of Tourette Syndrome and Obsessive Compulsive Disorder Reveals Differences in Genetic Architecture
- Author
- Arnold P.D. (Paul)
- Barr C.L. (Cathy)
- Bellodi L. (Laura)
- Benarroch F. (Fortu)
- Berrio G.B. (Gabriel Bedoya)
- Bienvenu O.J. (Oscar)
- Bloch J. (Jocelyne)
- Blom R.M. (Rianne)
- Bruun R.D. (Ruth)
- Budman C.L. (Cathy)
- Camarena B. (Beatriz)
- Campbell D. (Desmond)
- Cappi C. (Carolina)
- Cardona Silgado J.C. (Julio)
- Cath D. (Daniëlle)
- Cavallini M.C. (Maria)
- Chavira D.A. (Denise)
- Chouinard S.
- Conti G. (Giario)
- Cook E.H. (Edwin)
- Coric V. (Vladimir)
- Cox N.J. (Nancy)
- Cullen C.
- Davis L.K. (Lea)
- Deforce D. (Dieter)
- Delorme R. (Richard)
- Denys D.A.J.P. (Damiaan)
- Derks E.M. (Eske)
- Dion Y. (Yves)
- Edlund C.K. (Christopher)
- Egberts K. (Karin)
- Evans P.
- Falkai P. (Peter)
- Fernandez T.V. (Thomas)
- Freimer N.B. (Nelson)
- Gallagher P. (Patience)
- Gamazon E. (Eric)
- Garrido H. (Helena)
- Geller D. (Daniel)
- Girard S.L. (Simon)
- Grabe H.J. (Hans Jörgen)
- Grados M. (Marco)
- Greenberg B.D. (Benjamin)
- Gross-Tsur V. (Varda)
- Haddad S. (Stephen)
- Hanna G.L. (Gregory)
- Heiman M.L. (Mark)
- Hemmings S.M.J. (Sian)
- Heutink P. (Peter)
- Hounie A.G. (Ana)
- Illmann C. (Cornelia)
- Jankovic J. (Joseph)
- Jenike M.A. (Michael)
- Keenan C.L. (Clare)
- Kennedy J.L.
- King R.A.
- Knowles J.A. (James)
- Konkashbaev A.I. (Anuar)
- Kremeyer B. (Barbara)
- Kurlan R. (Roger)
- Lanzagorta N. (Nuria)
- Leboyer M. (Marion)
- Leckman J.F.
- Lee S.H. (Sang Hong)
- Lennertz L. (Leonhard)
- Liu C. (Chunyu)
- Lochner C. (Christine)
- Lowe T.L. (Thomas)
- MacCiardi F. (Fabio)
- Mathews C.A.
- McCracken J.T. (James)
- McGrath L.M.
- McMahon W.M. (William)
- Mesa Restrepo S.C. (Sandra)
- Miguel E.C. (Euripedes)
- Moessner R. (Rainald)
- Morgan J. (John)
- Muller H.
- Murphy D.L. (Dennis)
- Naarden A.L. (Allan)
- Neale B.M. (Benjamin)
- Nestadt G. (Gerald)
- Nicolini H. (Humberto)
- Nieuwerburgh F. (Filip) van
- Ochoa W.C. (William Cornejo)
- Oostra B.A. (Ben)
- Ophoff R.A. (Roel)
- Osiecki L. (Lisa)
- Pakstis A.J.
- Pato C. (Carlos)
- Pato C. (Carlos)
- Pauls D.L. (David)
- Piacentini J. (John)
- Pittenger C. (Christopher)
- Pollak M.N. (Michael)
- Posthuma D. (Danielle)
- Rauch S.L. (Scott)
- Renner T.J. (Tobias)
- Reus V.I. (Victor)
- Richter M.A. (Margaret)
- Riddle M.A. (Mark)
- Robertson M.M.
- Romero R. (Roxana)
- Rosenberg D. (David)
- Rosário M.C. (Maria)
- Rouleau G. (Guy)
- Ruhrmann S. (Stephan)
- Ruiz-Linares A. (Andres)
- Sampaio A.S. (Aline)
- Samuels J. (Jonathan)
- Sandor P.
- Scharf J.M.
- Sheppard B. (Brooke)
- Shugart Y.Y.
- Singer H.S.
- Smit J.H. (Jan)
- Stein D.J. (Dan)
- Stewart S.E.
- Strengman E. (Eric)
- Tischfield J.A. (Jay)
- Valencia Duarte A.V. (Ana)
- Vallada H. (Homero)
- Veenstra-Vanderweele J. (Jeremy)
- Wagner M. (Michael)
- Walitza S. (Susanne)
- Wang Y. (Ying)
- Wendland A. (Annika)
- Westenberg H.G.M. (Herman G.)
- Wray N.R. (Naomi)
- Yang J. (Joanna)
- Yu D. (D.)
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/10/2013
- Field of study
The direct estimation of heritability from genome-wide common variant data as implemented in the program Genome-wide Complex Trait Analysis (GCTA) has provided a means to quantify heritability attributable to all interrogated variants. We have quantified the variance in liability to disease explained
Mouse Chromosome 11
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- A. Ashworth
- A. Bartke
- A. Graham
- A. Gropp
- A. Gropp
- A. Gropp
- A. Gropp
- A. Gropp
- A. Peterson
- A. Smith
- A. Swaroop
- A. Weydert
- A.A. Davies
- A.G. Searle
- A.G. Searle
- A.G. Searle
- A.L. Joyner
- A.L.J. George
- A.M. Buchberg
- A.M. Buchberg
- A.M. Buchberg
- A.M. Killary
- B. Debuire
- B. Robert
- B.A. Taylor
- B.A. Taylor
- B.A. Taylor
- B.A.J. Ponder
- B.M. Cattanach
- B.M. Cattanach
- B.R.e.a. Seizinger
- B.T.I. Archer
- B.U. Zabel
- C. Abbot
- C. Barletta
- C. Blatt
- C. Kozak
- C.A. Kozak
- C.A. Kozak
- C.E. Keeler
- C.L. Hsieh
- C.M. Disteche
- C.M. Hearne
- C.P. Hart
- C.V. Beechey
- C.V. Beechey
- D. Barker
- D. Beeson
- D. Berube
- D. Goldman
- D. Malo
- D. Meruelo
- D. Pravtcheva
- D.E. Shupp Byrne
- D.E. Wilson
- D.J. Tweardy
- D.M. Swallow
- D.P. Barlow
- D.R. Joseph
- D.S. Falconer
- D.S. Falconer
- D.W. Bailey
- E. Brownell
- E. Capanna
- E. Capanna
- E. Hull
- E.L. Green
- E.M. Eicher
- E.P. Evans
- E.P. Evans
- E.S. Russell
- F. Arwert
- F. Biddle
- F. Martiniuk
- F. Martinjuk
- F. Mitelman
- G.C. Webb
- G.R. Sutherland
- G.R. Sutherland
- G.R. Sutherland
- H. Czosnek
- H. Meier
- H. Winking
- H. Winking
- H.G. Uiterdijk
- H.H. Czosnek
- H.O. Sweet
- I. Jackson
- I. Kola
- I. Santisteban
- I.D. Adler
- I.J. Karolyi
- I.J. Mason
- J. Hilgers
- J. Hozier
- J. Peters
- J. Seharaseyon
- J. Silver
- J. Stahl
- J.A. Todd
- J.B. Whitney III
- J.D. Mishkin
- J.H. Nadeau
- J.H. Nadeau
- J.H. Nadeau
- J.H. Nadeau
- J.M. Ferguson
- J.M. Love
- J.N. Ihle
- J.P. Sanford
- J.P. Sanford
- J.S. Lee
- J.S. Mackensen
- K. Huebner
- K. Huebner
- K. Said
- K.M. Kirk
- L. Bernier
- L. Pajunen
- L. Zech
- L.A. Cannizzaro
- L.A. Leinwand
- L.C. Showe
- L.L. Jackson-Grusby
- M. Cho
- M. Danciger
- M. Frater-Schroder
- M. Frater-Schroder
- M. Levine
- M. Mehrabian
- M. Munke
- M. Munke
- M. Munke
- M. Prochazka
- M. Takahashi
- M.-G Mattei
- M.-G. Mattei
- M.C. Green
- M.D. Hoggan
- M.D. Miller
- M.F. Lyon
- M.F. Lyon
- M.F. Lyon
- M.G. Mattei
- M.G. Mattei
- M.J. Pettenati
- M.L. Summar
- M.M. Dickie
- M.M. Dickie
- M.M. Dickie
- M.P. Colombo
- M.S. Bartolomei
- M.S. Buckwalter
- M.S. Do
- M.T. Davisson
- M.T. Davisson
- M.T. Davisson
- M.T. Davisson
- N. Dobrovolskaia-Zavadskaia
- N. Tuteja
- N.A. Jenkins
- N.A. Jenkins
- N.C. Popescu
- N.K. Spurr
- N.M. Gough
- O. Heidmann
- O.W. McBride
- P. D'Eustachio
- P. Lonai
- P. Neumann
- P. Tsipouras
- P. Tuinen van
- P.A. Baldacci
- P.B. Mather
- P.C. Brooker
- P.C. Brooker
- P.W. Lane
- P.W. Lane
- R. Jaenisch
- R. Nusse
- R. Nusse
- R. Zakut-Houri
- R.A. Popp
- R.A. Popp
- R.D. Cox
- R.J. Cornall
- R.J. Oakey
- R.S. Holmes
- R.S. Holmes
- R.W. Elliott
- S. Adolf
- S. Itoh
- S. Maza
- S. Mazan
- S. Miyatake
- S. Pagliusi
- S.D. Wilson
- S.G. Irving
- S.H. Rider
- S.K. Michael
- S.K. Moore
- S.P. Flanagan
- S.V. Cheng
- T. Watanabe
- T.H. Roderick
- T.J. Aitman
- T.J. Robinson
- T.L. Yang-Feng
- U.K. Rout
- V.J. Buckle
- V.J. Buckle
- W. Xu
- W.C. Morgan
- W.E. Heston
- W.J. Keir
- W.N. Frankel
- W.N. Frankel
- W.N. Frankel
- W.N. Frankel
- W.R. Weimar
- Y.H. Edwards
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1992
- Field of study
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46996/1/335_2004_Article_BF00648429.pd
Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses
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- Adeniji K.
- Aggleton J.P.
- Agranoff D.
- Agwuh K.
- Ahmed K.A.
- Ail D.
- Al-Chalabi A.
- Aldera E.L.
- Alegria A.
- Alex B.
- Allen C.M.
- Allen S.
- Amin J.
- Andrikopoulos P.
- Angus B.
- Armour C.
- Armstrong J.A.
- Ashish A.
- Ashworth M.
- Asiimwe I.G.
- Atkinson D.
- Bach B.
- Baillie J.K.
- Baillie J.K.
- Baker M.R.
- Bakshi S.
- Barclay W.S.
- Bari S.
- Barlow G.
- Barlow S.L.
- Barnass S.
- Barrett N.
- Barrett S.
- Bassford C.
- Basu N.
- Basude S.
- Batra R.
- Baxter D.
- Beadsworth M.
- Benjamin L.
- Bernatoniene J.
- Berridge J.
- Berry C.
- Best N.
- Bethlehem R.
- Blackledge B.
- Boardman S.A.
- Bogaert D.
- Booth L.
- Bothma P.
- Bradley J.R.
- Bradley J.R.
- Breen D.P.
- Breen G.
- Breen G.
- Brennan B.
- Breuer J.
- Brittain-Long R.
- Broome M.R.
- Bullmore E.
- Bullock K.
- Bulteel N.
- Burden T.
- Burtenshaw A.
- Butler M.
- Carlucci N.
- Carracedo A.D.
- Carson A.
- Carson G.
- Caruth V.
- Cass E.
- Catterall B.W.
- Cavanagh J.
- Cavanagh J.
- Chadwick D.
- Chambler D.
- Chand M.
- Chechi K.
- Chee N.
- Child J.
- Chinnery P.F.
- Chiollaz A.-C.
- Christmas D.
- Christmas D.M.
- Chukkambotla S.
- Clark J.J.
- Clark J.J.
- Clark R.
- Clark T.
- Clarke E.A.
- Clohisey S.
- Cole S.
- Coleman J.R.
- Coles A.
- Coles A.J.
- Collie C.
- Collie C.
- Collini P.
- Connor M.
- Cooke G.S.
- Cooper L.
- Cosgrove C.
- Cossette N.
- Cousins D.
- Coutts A.
- Cox H.
- Cupitt J.
- Cutino-Moguel M.-T.
- da Silva A.
- Dalton J.
- Darby A.
- Dark P.
- David A.S.
- Davies N.
- Davis C.
- Dawson C.
- de Silva T.
- Defres S.
- Dervisevic S.
- Digby R.
- Dincarslan O.
- Docherty A.B.
- Dodd K.C.
- Donegan C.
- Donnelly L.
- Donnison P.
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- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 22/12/2023
- Field of study
To understand neurological complications of COVID-19 better both acutely and for recovery, we measured markers of brain injury, inflammatory mediators, and autoantibodies in 203 hospitalised participants; 111 with acute sera (1–11 days post-admission) and 92 convalescent sera (56 with COVID-19-associated neurological diagnoses). Here we show that compared to 60 uninfected controls, tTau, GFAP, NfL, and UCH-L1 are increased with COVID-19 infection at acute timepoints and NfL and GFAP are significantly higher in participants with neurological complications. Inflammatory mediators (IL-6, IL-12p40, HGF, M-CSF, CCL2, and IL-1RA) are associated with both altered consciousness and markers of brain injury. Autoantibodies are more common in COVID-19 than controls and some (including against MYL7, UCH-L1, and GRIN3B) are more frequent with altered consciousness. Additionally, convalescent participants with neurological complications show elevated GFAP and NfL, unrelated to attenuated systemic inflammatory mediators and to autoantibody responses. Overall, neurological complications of COVID-19 are associated with evidence of neuroglial injury in both acute and late disease and these correlate with dysregulated innate and adaptive immune responses acutely
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease
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- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 01/04/2024
- Field of study
One in ten severe acute respiratory syndrome coronavirus 2 infections result in prolonged symptoms termed long coronavirus disease (COVID), yet disease phenotypes and mechanisms are poorly understood1. Here we profiled 368 plasma proteins in 657 participants ≥3 months following hospitalization. Of these, 426 had at least one long COVID symptom and 233 had fully recovered. Elevated markers of myeloid inflammation and complement activation were associated with long COVID. IL-1R2, MATN2 and COLEC12 were associated with cardiorespiratory symptoms, fatigue and anxiety/depression; MATN2, CSF3 and C1QA were elevated in gastrointestinal symptoms and C1QA was elevated in cognitive impairment. Additional markers of alterations in nerve tissue repair (SPON-1 and NFASC) were elevated in those with cognitive impairment and SCG3, suggestive of brain–gut axis disturbance, was elevated in gastrointestinal symptoms. Severe acute respiratory syndrome coronavirus 2-specific immunoglobulin G (IgG) was persistently elevated in some individuals with long COVID, but virus was not detected in sputum. Analysis of inflammatory markers in nasal fluids showed no association with symptoms. Our study aimed to understand inflammatory processes that underlie long COVID and was not designed for biomarker discovery. Our findings suggest that specific inflammatory pathways related to tissue damage are implicated in subtypes of long COVID, which might be targeted in future therapeutic trials
SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination
- Author
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- van Tonder L.
- Vancheeswaran R.
- Ventura M.
- Vere J.
- Vickers C.
- Vincent R.
- Vincent-Smith L.
- Vinson B.
- Visuvanathan S.
- Vuylsteke A.
- Waddy S.
- Wade E.
- Wade P.
- Wain L.V.
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- Wainwright T.
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- Whitworth V.
- Wight A.
- Wijesinghe M.
- Wilcock E.
- Wild J.
- Wilkins M.
- Wilkinson D.
- Willett B.J.
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- Williams-Howard S.A.
- Willicombe M.
- Willis G.
- Willoughby J.
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- Wilson I.
- Wilson L.
- Winchester S.
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- Wiselka M.
- Witham M.
- Wolf-Roberts R.
- Wolverson A.
- Wood C.
- Woodhead F.
- Woods J.
- Wootton D.G.
- Wootton D.G.
- Wootton D.G.
- Workman A.
- Wormleighton J.
- Worsley J.
- Wraith D.
- Wrey Brown C.
- Wright C.
- Wright L.
- Wright S.
- Wrobel N.
- Wyles J.
- Wynter I.
- Xu M.
- Yasmin N.
- Yasmin S.
- Yates B.
- Yates T.
- Yip K.P.
- Young A.
- Young B.
- Young P.
- Young S.
- Yousuf A.J.
- Zambon M.
- Zawia A.
- Zeidan L.
- Zhang J.E.
- Zhao B.
- Zheng B.
- Zongo O.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2023
- Field of study
BACKGROUND: Most studies of immunity to SARS-CoV-2 focus on circulating antibody, giving limited insights into mucosal defences that prevent viral replication and onward transmission. We studied nasal and plasma antibody responses one year after hospitalisation for COVID-19, including a period when SARS-CoV-2 vaccination was introduced. METHODS: In this follow up study, plasma and nasosorption samples were prospectively collected from 446 adults hospitalised for COVID-19 between February 2020 and March 2021 via the ISARIC4C and PHOSP-COVID consortia. IgA and IgG responses to NP and S of ancestral SARS-CoV-2, Delta and Omicron (BA.1) variants were measured by electrochemiluminescence and compared with plasma neutralisation data. FINDINGS: Strong and consistent nasal anti-NP and anti-S IgA responses were demonstrated, which remained elevated for nine months (p < 0.0001). Nasal and plasma anti-S IgG remained elevated for at least 12 months (p < 0.0001) with plasma neutralising titres that were raised against all variants compared to controls (p < 0.0001). Of 323 with complete data, 307 were vaccinated between 6 and 12 months; coinciding with rises in nasal and plasma IgA and IgG anti-S titres for all SARS-CoV-2 variants, although the change in nasal IgA was minimal (1.46-fold change after 10 months, p = 0.011) and the median remained below the positive threshold determined by pre-pandemic controls. Samples 12 months after admission showed no association between nasal IgA and plasma IgG anti-S responses (R = 0.05, p = 0.18), indicating that nasal IgA responses are distinct from those in plasma and minimally boosted by vaccination. INTERPRETATION: The decline in nasal IgA responses 9 months after infection and minimal impact of subsequent vaccination may explain the lack of long-lasting nasal defence against reinfection and the limited effects of vaccination on transmission. These findings highlight the need to develop vaccines that enhance nasal immunity. FUNDING: This study has been supported by ISARIC4C and PHOSP-COVID consortia. ISARIC4C is supported by grants from the National Institute for Health and Care Research and the Medical Research Council. Liverpool Experimental Cancer Medicine Centre provided infrastructure support for this research. The PHOSP-COVD study is jointly funded by UK Research and Innovation and National Institute of Health and Care Research. The funders were not involved in the study design, interpretation of data or the writing of this manuscript
Mudança organizacional: uma abordagem preliminar
- Author
- 0'TOOLE James
- 0LSON Philip D
- 0UCHI William
- 1SABELLA L.A
- ABRAHAMSON E
- ACAR W
- ACHROL R.S
- ADIZES lchak
- ANDERSON D.L.
- ARAUJO Luis Cesar G. de
- ARAUJO Luis Cesar Gon lves de
- ARCHIER Georges
- ARGYRIS Chris
- ARONOFF C.E
- BAKOS S.C
- BARDWICK J.M
- BARTUNEK J.N
- BASIL Douglas Constantine
- BENNIS Warren G.
- BERMAN Marshall
- BERTRAND Kate
- BETZ T.G.
- BICE M
- BICE M
- BRAMSON R.A
- BRATKOVICH J.R
- BROWN J.S.
- BROWN R
- BRYAN J.E.
- BURNS Tom
- BUSH JR. J. B
- BYRD Richard E
- CALISH lrwing G
- CALORI R
- CARAVANTES Geraldo Ronchetti
- CARLTON M.R
- CARR C.D
- CHADWICK S.
- CHAISTIANS lan
- CHORN N.H.
- COHN Steven F
- COLE R.L.
- CONNOR P.E
- CORBITT G. F.
- COYLE J
- CULLEN John B
- CUMMINGS T.G
- CZARNECKI Gerald W
- DAILEY R.C
- DALZIEL Murray M
- DAMANPOUR F
- DAMANPOUR F
- DANIELSON Christer
- DAVIDSON K.M
- DAVIS S.M
- DE CHAMBEAU F.A
- DEAL Terence
- DEEPROSE D
- DeLISI P.S
- DENOVA C.C
- DERVEN M.G
- DONNELLON Anne
- DRAZIN R
- DREILINGER C
- DRUCKER Peter F
- DRUCKER Peter F
- DUMAINE Brian
- DUPUY J
- DYER William G
- ELLIOTI Ronald D
- ENGELBART D
- FARQUHAR C.R
- FARRELL L
- FELDENKIRCHEN Wilfried
- FITZGERALD J
- FITZGERALD T.H
- FLAMHOLTZ E
- FLETT F
- FONVIELLE William
- FOSTER Lawrence W
- FREITAS Maria Ester de
- FRIEDMAN S.D.
- FRITZ Norma R
- FROHMAN M
- FROHMAN M
- FROST Peter J
- GARCIA R.M
- GARCIA R.M
- GARCIA Ramon Moreira
- GIBSON J.l.
- GINSBERG A
- GIOIA D.A.
- GMELCH W.H.
- GOLEMBIEWSKI R.T
- GORDON G.G
- GOURVISH T.R
- GRANDORI A
- GREEINER L.E
- GREEN A
- GRIMM C.M.
- GRINYER P
- GROSSMAN Lee
- HAGGERTY A.G
- HALL J
- HALL L
- HANDY Charles
- HARARI 0
- HARARI 0
- HARRISON J. Richard
- HARRISON M.l
- HARRISON M.l
- HAUGH J.W
- HELFGOTI Roy B
- HENRICI S.B
- HERRINGTON G.M
- HERSEY Paul
- HERZBERG F
- HERZOG J.P
- HOLT J
- HORNSTEIN Harvey A
- HORTON T.R
- HORTON T.R
- HORTON Thomas R
- HOUNSHELL David A
- HOUSTON P
- HUEY J
- JACOBS D
- JAQUES Elliott
- JOHNSON J.D.
- JOHNSON Michael
- JONES Christopher G
- KANTER Rosabeth Moss
- KANTER Rosabeth Moss
- KANTER Rosabeth Moss
- KAZEMEK E.A.
- KAZEMEK Edward A
- KELLY D
- KETS DE VRIES Manfred F.R
- KIEL L. Douglas
- KILMANN R.H
- KILMANN R.H.
- KILMANN Ralph H
- KILMANN Ralph H
- KIMBERLY J.R
- KING Bob
- KING R.P.
- KIRKLAND R.I.
- KNIGHT K
- KOCH Donald L.
- KOTIER John P
- KOTLER Philip
- KRAM K.E.
- KUHN Robert Lawrence
- KUHN Thomas S
- LAND George
- LAURIE J
- LEHRER Robert N
- LINDER JaneC
- LIPPITI Gordon L
- LIPPITT Gordon
- LORD V
- MACCOBY M
- MACLAGAN Patrick W
- MACLEOD J.S.
- MAISEL L.S
- MALEKZADEH A.R
- MANN R.W
- MARCH JamesG
- MARGERISON C
- MARTIN D
- MASTENBROEK W.F.G
- MASTENBROEK W.F.G.
- McDONNELL E.D.
- McKAY Noble
- McKENDRICK J.E
- McQUADE H.A.
- MEARES Larry B
- MILLER J.T.
- MILLER S.G.
- MILLS D. Quinn
- MIRONOFF A
- MIRVIS Philip H
- MISAWA Mitsuru
- MOODY M.H
- MORAN Robert T
- MORGAN Gareth
- MORGAN John S
- MOURA Paulo Cavalcanti da Costa
- NADLER D.A.
- NAISBITI John
- NAISBITT John
- NAISBITT John
- NEIMAN A.A.
- NELSON Reed E
- NEWMAN G
- NICHOLAS John M
- NODELL R.S
- OVELLETTE L.P
- PARKER D
- PASCALE R.T
- PAYNE T
- PEREIRA Maria Jose L. Bretas
- PETERS T
- PETERS Tom
- PETERS Tom
- POLLERT Anna
- POLLOCK T
- PONDY L.R
- POWER B.L
- PRENTICE G
- PRIGOGINE llya
- RAMOS Alberto Guerreiro
- RANDOLPH W.A.
- RAUDSEPP E
- RICE A.K.
- ROSS G.H.B.
- ROTHWELL William J
- RUBIN I
- SAKAI Kun asu
- SANDY W
- SANDY W
- SANDY W
- SCHAEFFER D
- SCHEIN Edgar H
- SCHONBERGER Richard J
- SCHRAGE M
- SCHULER R.S.
- SCHUSTER M
- SCHWASS G.L
- SCOTT S
- SEMLER Ricardo
- SHERIDAN J.H
- SHERMAN C.F.
- SINK D Scott
- SPARKS R
- STEELE B
- STEVENS C.A.
- SULLIVAN J.J
- TAFT Susan Hoefflir
- THOMAS John M
- Thomaz Wood Jr
- THORNE P
- THORNE P
- TOFFLER Alvin
- TOWSEND Robert
- UTTERBACK J.M
- VAN DER ERVE M
- VASCONCELLOS Joao Gualberto Moreira
- VICKERY H.B
- VOZIKIS George S
- WALKER J.P.
- WANT J.H
- WARD K
- WATERMAN JR Robert H
- WATERMAN JR Robert H
- WEBER K.F.
- WELCH Jonathan B
- WERNER M
- WILLIAMS M.M
- WILSON Ira G
- WILSON l
- WRIGHT P.C
- YORKS Lyle
- ZMUD Robert W
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
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- Šantak G.
- Šimko K.
- Žatecký J.
- Publication venue
- Oxford University Press (OUP)
- Publication date
- 01/07/2023
- Field of study
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries
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