Advocacy coalitions involved in California's menu labeling policy debate: Exploring coalition structure, policy beliefs, resources, and strategies.

Advocacy coalitions often play an important role in the state health policymaking process, yet little is known about their structure, composition, and behavior. In 2008, California became the first state to enact a menu labeling law. Using the advocacy coalition framework, we examine different facets of the coalitions involved in California's menu labeling policy debate. We use a qualitative research approach to identify coalition members and explore their expressed beliefs and policy arguments, resources, and strategies by analyzing legislative documents (n = 87) and newspaper articles (n = 78) produced between 1999 and 2009. Between 2003 and 2008, six menu labeling bills were introduced in the state's legislature. We found the issue received increasing media attention during this period. We identified two advocacy coalitions involved in the debate-a public health (PH) coalition and an industry coalition. State organizations acted as coalition leaders and participated for a longer duration than elected officials. The structure and composition of each coalition varied. PH coalition leadership and membership notably increased compared to the industry coalition. The PH coalition, led by nonprofit PH and health organizations, promoted a clear and consistent message around informed decision making. The industry coalition, led by a state restaurant association, responded with cost and implementation arguments. Each coalition used various resources and strategies to advance desired outcomes. PH coalition leaders were particularly effective at using resources and employing advocacy strategies, which included engaging state legislators as coalition members, using public opinion polls and information, and leveraging media resources to garner support. Policy precedence and a local policy push emerged as important policymaking strategies. Areas for future research on the state health policymaking process are discussed

Structural properties of silicon dioxide thin films densified by medium-energy particles

Classical molecular-dynamics simulations have been carried out to investigate densification mechanisms in silicon dioxide thin films deposited on an amorphous silica surface, according to a simplified ion-beam assisted deposition (IBAD) scenario. We compare the structures resulting from the deposition of near-thermal (1 eV) SiO$_{2}$ particles to those obtained with increasing fraction of 30 eV SiO$_{2}$ particles. Our results show that there is an energy interval - between 12 and 15 eV per condensing SiO$_2$ unit on average - for which the growth leads to a dense, low-stress amorphous structure, in satisfactory agreement with the results of low-energy ion-beam experiments. We also find that the crossover between low- and high-density films is associated with a tensile to compressive stress transition, and a simultaneous healing of structural defects of the {\em a-}SiO$_2$ network, namely three- and four-fold rings. It is observed, finally, that densification proceeds through significant changes at intermediate length scales (4--10 \AA), leaving essentially unchanged the ``building blocks'' of the network, viz. the Si(O$_{1/2}$)$_{4}$ tetrahedra. This latter result is in qualitative agreement with the mechanism proposed to explain the irreversible densification of amorphous silica recovered from high pressures ($\sim$ 15--20 GPa).Comment: 12 pages including 10 postscript figures; submitted to Phys. Rev. B; related publications can be found on web site http://www.centrcn.umontreal.ca/~lewi

Agent-Based Team Aiding in a Time Critical Task

In this paper we evaluate the effectiveness of agent-based aiding in support of a time-critical team-planning task for teams of both humans and heterogeneous software agents. The team task consists of human subjects playing the role of military commanders and cooperatively planning to move their respective units to a common rendezvous point, given time and resource constraints. The objective of the experiment was to compare the effectiveness of agent-based aiding for individual and team tasks as opposed to the baseline condition of manual route planning. There were two experimental conditions: the Aided condition, where a Route Planning Agent (RPA) finds a least cost plan between the start and rendezvous points for a given composition of force units; and the Baseline condition, where the commanders determine initial routes manually, and receive basic feedback about the route. We demonstrate that the Aided condition provides significantly better assistance for individual route planning and team-based re-planning

ARAS: an automated radioactivity aliquoting system for dispensing solutions containing positron-emitting radioisotopes.

BackgroundAutomated protocols for measuring and dispensing solutions containing radioisotopes are essential not only for providing a safe environment for radiation workers but also to ensure accuracy of dispensed radioactivity and an efficient workflow. For this purpose, we have designed ARAS, an automated radioactivity aliquoting system for dispensing solutions containing positron-emitting radioisotopes with particular focus on fluorine-18 ((18)F).MethodsThe key to the system is the combination of a radiation detector measuring radioactivity concentration, in line with a peristaltic pump dispensing known volumes.ResultsThe combined system demonstrates volume variation to be within 5 % for dispensing volumes of 20 μL or greater. When considering volumes of 20 μL or greater, the delivered radioactivity is in agreement with the requested amount as measured independently with a dose calibrator to within 2 % on average.ConclusionsThe integration of the detector and pump in an in-line system leads to a flexible and compact approach that can accurately dispense solutions containing radioactivity concentrations ranging from the high values typical of [(18)F]fluoride directly produced from a cyclotron (~0.1-1 mCi μL(-1)) to the low values typical of batches of [(18)F]fluoride-labeled radiotracers intended for preclinical mouse scans (~1-10 μCi μL(-1))

In vitro evaluation of In-111-DOTA-anti-bcl-2-PNA-Tyr-3-octreotate in Chronic Lymphocytic Leukemia cells

Abstract only availableThe B-cell lymphoma/leukemia-2 (bcl-2) gene is overexpressed in many cancers. This gene increases cell survival by blocking apoptosis, or programmed cell death. The objective of this study was to evaluate radiolabeled peptide nucleic acid (PNA)-peptide conjugates targeting bcl-2 gene expression. DOTA-anti-bcl-2-PNA-Tyr-3-octreotate conjugate was labeled with In-111. Uptake, internalization, and efflux studies were performed in the human chronic lymphocytic leukemia (CLL) cell line Mec-1, which expresses both somatostatin receptors and bcl-2 mRNA. In the conjugate, octreotate is the somatostatin receptor ligand. Receptor and mRNA binding were also evaluated. Internalization of In-111-DOTA-anti-bcl-2-PNA-octreotate increased from 58.29% at 1min to 67.9% at 15min and reached 81% at 4h, whereas the internalized In-111-DOTA-Tyr-3-octreotate in Mec-1 cells started from 31.1% at 1min and gradually increased to 49.28% and 66.1% at 15min and 4h, respectively. Efflux analysis of Mec-1-In-111-DOTA-anti-bcl-2-PNA-Tyr-3-octreotate showed that 84.9% of radioactivity remained in the cells after 1min incubation and 60.0% of cell associated radioactivity was retained 4h later. Analysis of In-111-DOTA-Tyr-3-octreotate showed the cell associated radioactivity dropped from 85.1% at 1min to 69.1% at 4h.The western blot assay study showed a 51.0% bcl-2 protein synthesis inhibition by treatment with DOTA-anti-bcl-2-PNA-Tyr-3-octreotate. As a result, a peptide conjugate, which contains two molecular functions, was developed. These functions are receptor mediated tumor cell delivery and oncogene mRNA targeting. This agent has the potential to be used for detection of tumor bcl-2 expression by non-invasive molecular imaging.Louis Stokes Missouri Alliance for Minority Participatio

Data assimilation for the Martian atmosphere using MGS Thermal Emission Spectrometer observations

From the introduction: Given the quantity of data expected from current and forthcoming spacecraft missions to Mars, it is now possible to use data assimilation as a means of atmospheric analysis for the first time for a planet other than the Earth. Several groups have described plans to develop assimilation schemes for Mars [Banfield et al., 1995; Houben, 1999; Lewis and Read, 1995; Lewis et al., 1996, 1997; Zhang et al., 2001]. Data assimilation is a technique for the analysis of atmospheric observations which combines currently valid information with prior knowledge from previous observations and dynamical and physical constraints, via the use of a numerical model. Despite the number of new missions, observations of the atmosphere of Mars in the near future are still likely to be sparse when compared to those of the Earth, perhaps comprising one orbiter and a few surface stations at best at any one time. Data assimilation is useful as a means to extract the maximum information from such observations, both by a form of interpolation in space and time using model constraints and by the combination of information from different observations, e.g. temperature profiles and surface pressure measurements which may be irregularly distributed. The procedure can produce a dynamically consistent set of meteorological fields and can be used directly to test and to refine an atmospheric model against observations

Assimilation of TES data from the Mars Global Surveyor scientifc mapping phase

The Thermal Emission Spectrometer (TES)aboard Mars Global Surveyor has produced data which cover almost two Martian years so far (during its scientific mapping phase). Thermal profiles for the atmosphere below 40 km and total dust opacities can be retrieved from TES nadir spectra and assimilated into a Mars general circulation model (MGCM), by using the assimilation techniques described in detail by Lewis et al. (2002). This paper describes some preliminary results from assimilations of temperature data from the period Ls=141°- 270° corresponding to late northern summer until winter solstice on Mars. Work in progress is devoted to assimilate both temperature and total dust opacity data for the full period for which they are already available

Computer graphics interactive workshop for two-dimensional fractals

We present in this study an interactive computer graphics workshop for two-dimensional fractals. The workshop enables the user to learn about fractals through experimentation with the generation of Koch-like fractal curves. A variety of Koch-like fractal curves, Julia sets and the Mandelbrot set are presented as examples. Algorithms are presented for creating the Mandelbrot set and for creating Kock-like fractal curves. Keywords and Phrases: fractals, Kock-like Fractal curves, Julia sets, interactive computer graphicsU.S. Army Combat Development Experimentation Center (USACDEC) under MIPR ATEC 46-86 and in part by funds provided through the Commodore Grace Murray Hopper Research Chair in Computer Science at the Naval Postgraduate School.http://archive.org/details/computergraphicsin00masoN0003986WRDQ200N

Regional Stratigraphic Framework of Surficial Sediments and Bedrock Beneath Lake Ontario

Approximately 2550 km of single-channel high-resolution seismic reflection profiles have been interpreted and calibrated with lithological and geochronological information from four representative piston cores and one grab sample to provide a regional stratigraphie framework for the subbottom deposits of Lake Ontario. Five units overlying Paleozoic bedrock were identified and mapped. These are classified as informal units and represent, from oldest to youngest: (A) subglacial till (?) deposited by the Port Huron ice at the end of the Wisconsin glaciation; (B) an ice-marginal (?) unit confined to the western part of the lake that was probably deposited during retreat of the Port Huron ice shortly after 13 ka; (C) a regionally extensive unit of laminated glacio-lacustrine clay that accumulated until about 11 ka; (D) a weakly laminated to more massive lake clay deposited during a period of reduced water supply and rising water levels after the drawdown of the high-level glacial lakes (Iroquois and successors); and (E) modern lake clay less than 10 m thick that began accumulating around 6-8 ka with the subsequent return of upper Great Lakes drainage through the Ontario basin. Seismic reflections also define the configuration of the bedrock surface and pre-glacial stream valleys incised in the bedrock surface. Several anomalous bottom and subbottom features in the surficial sediments are mapped, such as discontinuous and offset reflections, furrows, gas pockets, and areas of large subbottom relief. None of these features appear to be spatially correlative with the diffuse seismicity that characterizes the lake area or with deeper structures such as Paleozoic bedrock faults or crustal-penetrating faults in the Precambrian basement.On a interprété et étalonné environ 2550 km de profils de sismique réflexion monocanal à haute résolution selon les données lithologiques et géochronologique de quatre sondages représentatifs faits par carottier à piston et un échantillon prélevé avec une benne afin d'établir le cadre stratigraphique des dépôts accumulés sous le fond du lac Ontario. Cinq unités recouvrant le substratum paiéozoïque ont été identifées et cartographiées. Ces unités informelles, de la plus ancienne à la plus jeune, sont : (A) un till sous-glaciaire (?) déposé par les glaces de Port Huron à la fin de la glaciation wisconsienne; (B) une unité de limite glaciaire (?) confinée à la partie ouest du lac et qui a probablement été déposée pendant le retrait des glaces de Port Huron, peu après 13 ka; (C) une unité d'étendue régionale d'argile glaciolacustre feuilletée qui s'est accumulée jusqu'à environ 11 ka; (D) une argile lacustre, de faiblement feuilletée à massive, mise en place au cours d'une période où il y eut approvisionnement en eau réduit et hausse du niveau de l'eau après l'abaissement des lacs glaciaires (Iroquois et ultérieurs); et (E) une argile lacustre moderne de moins de 10 m d'épaisseur qui a commencé à s'accumuler à partir de 6-8 ka après la reprise du drainage des Grands Lacs par le bassin Ontario. La sismique réflexion a aussi permis de délimiter la configuration de la surface du socle et des vallées pré-glaciaires qui y sont entaillées. Plusieurs éléments des sédiments de surface du fond du lac et sous le fond ont été cartographies, comme des réflexions de discontinuités et de décalages, des rainures, des poches de gaz et des zones de grandes formes enfouies. Aucun de ces éléments ne semble correspondre spatialement à la sis-micité diffuse qui caractérise la région du lac ou aux structures profondes comme les failles de substratum paiéozoïque ou celle du socle précambrien.Ungefàhr 2550 km seismischer Reflexionsprofile wurden interpretiert und kalibiriert mit lithologischen und geochronologischen Informationen von vier repràsentativen Kolbenbohrkernen und einer ausges-chùrften Probe, um den regionalen stratigraphischen Rahmen fur die unter dem Bett des Ontariosees gelegenen Ablagerungen zu erhalten. Man hat fùnf Einheiten, die das anstehende Gestein aus dem Palàozoikum ùberlagern, identifiziert und kartographiert: (A) eine subglaziale Grundmoràne (?), die durch das Eis von Port Huron am Ende der Wisconsin-Vereisung abgelagert wurde; (B) eine auf den westlichen Teil des Sees begrenzte Eisrand (?)-Einheit, die wahrs-cheinlich wàhrend des Rùckzugs des Port Huron-Eises kurz nach 13ka abgelagert wurde; (C) eine regional ausgedehnte Einheit von blâttrigem glaziallimnischem Lehm, die sien bis etwa 11 ka ansammelte, (D) ein schwachbis massivblàttriger Seelehm, der wàhrend einer Période verminderter Wasserzufuhr und steigenden Wasserspiegeln sich ansammelte; und (E) moderner Seelehm von weniger als 10 m Dicke, der sich um etwa 6-8 ka anzusammeln begann, mit der Rùckkehr der Drainage der oberen GroRen Seen durch das Ontariobecken. Seismische Reflexionen las-sen auch die Konfiguration der Sockeloberflàche und der pràglazialen in die Sockeloberflàche eingeschnittenen FluBtàler erkennen. Mehrere unregelmàfîige Grundund Untergrunderscheinungen der Oberflàchensedimente wurden kartographiert, wie Diskontinuitàt und Hôhenunschiede der Reflexionen, Mulden, Gastaschen und Gebiete mit breitem Untergrundrelief. Keine dieser Erscheinungen scheint ràumlich mit der fur das Seen-Gebiet charakteristischen Seismik zu korrelieren oder mit tieferen Strukturen, wie die Verwerfungen des anstehenden Gestems aus dem Palàozoikum order durch die Kruste dringende Verwergungen im pràkambrischen Untergrund