2,014 research outputs found
Development of a Thermal Management System for Electrified Aircraft
This paper describes the development and optimization of a conceptual thermal management system for electrified aircraft. Here, a vertical takeoff and landing (VTOL) vehicle is analyzed with the following electrically sourced heat loads considered: motors, generators, rectifiers, and inverters. The vehicle will employ liquid-cooling techniques in order to acquire, transport, and reject waste heat from the vehicle. The purpose of this paper is to threefold: 1) Present a potential modeling framework for system level thermal management system simulation, 2) Analyze typical system characteristics, and 3) Perform optimization on a system developed for a specific vehicle to minimize weight gain, power utilization, and drag. Additionally, the paper will study the design process, specifically investigating the differences between steady state and transient sizing, comparing simulation techniques with a lower fidelity option and quantifying expected error
Host-driven diversification of gall-inducing Acacia thrips and the aridification of Australia
BACKGROUND: Insects that feed on plants contribute greatly to the generation of biodiversity. Hypotheses explaining rate increases in phytophagous insect diversification and mechanisms driving speciation in such specialists remain vexing despite considerable attention. The proliferation of plant-feeding insects and their hosts are expected to broadly parallel one another where climate change over geological timescales imposes consequences for the diversification of flora and fauna via habitat modification. This work uses a phylogenetic approach to investigate the premise that the aridification of Australia, and subsequent expansion and modification of arid-adapted host flora, has implications for the diversification of insects that specialise on them. RESULTS: Likelihood ratio tests indicated the possibility of hard molecular polytomies within two co-radiating gall-inducing species complexes specialising on the same set of host species. Significant tree asymmetry is indicated at a branch adjacent to an inferred transition to a Plurinerves ancestral host species. Lineage by time diversification plots indicate gall-thrips that specialise on Plurinerves hosts differentially experienced an explosive period of speciation contemporaneous with climatic cycling during the Quaternary period. Chronological analyses indicated that the approximate age of origin of gall-inducing thrips on Acacia might be as recent as 10 million years ago during the Miocene, as truly arid landscapes first developed in Australia. CONCLUSION: Host-plant diversification and spatial heterogeneity of hosts have increased the potential for specialisation, resource partitioning, and unoccupied ecological niche availability for gall-thrips on Australian Acacia
On Optimizing the Conditional Value-at-Risk of a Maximum Cost for Risk-Averse Safety Analysis
The popularity of Conditional Value-at-Risk (CVaR), a risk functional from
finance, has been growing in the control systems community due to its intuitive
interpretation and axiomatic foundation. We consider a non-standard optimal
control problem in which the goal is to minimize the CVaR of a maximum random
cost subject to a Borel-space Markov decision process. The objective takes the
form , where is a
risk-aversion parameter representing a fraction of worst cases, is a
stage or terminal cost, and is the length of a finite
discrete-time horizon. The objective represents the maximum departure from a
desired operating region averaged over a given fraction of worst
cases. This problem provides a safety criterion for a stochastic system that is
informed by both the probability and severity of the potential consequences of
the system's trajectory. In contrast, existing safety analysis frameworks apply
stage-wise risk constraints (i.e., must be small for all , where
is a risk functional) or assess the probability of constraint violation
without quantifying its possible severity. To the best of our knowledge, the
problem of interest has not been solved. To solve the problem, we propose and
study a family of stochastic dynamic programs on an augmented state space. We
prove that the optimal CVaR of a maximum cost enjoys an equivalent
representation in terms of the solutions to this family of dynamic programs
under appropriate assumptions. We show the existence of an optimal policy that
depends on the dynamics of an augmented state under a measurable selection
condition. Moreover, we demonstrate how our safety analysis framework is useful
for assessing the severity of combined sewer overflows under precipitation
uncertainty.Comment: A shorter version is under review for IEEE Transactions on Automatic
Control, submitted December 202
Prospecting Period Measurements with LSST - Low Mass X-ray Binaries as a Test Case
The Large Synoptic Survey Telescope (LSST) will provide for unbiased sampling
of variability properties of objects with mag 24. This should allow for
those objects whose variations reveal their orbital periods (), such
as low mass X-ray binaries (LMXBs) and related objects, to be examined in much
greater detail and with uniform systematic sampling. However, the baseline LSST
observing strategy has temporal sampling that is not optimised for such work in
the Galaxy. Here we assess four candidate observing strategies for measurement
of in the range 10 minutes to 50 days. We simulate multi-filter
quiescent LMXB lightcurves including ellipsoidal modulation and stochastic
flaring, and then sample these using LSST's operations simulator (OpSim) over
the (mag, ) parameter space, and over five sightlines sampling a range
of possible reddening values. The percentage of simulated parameter space with
correctly returned periods ranges from 23 %, for the current baseline
strategy, to 70 % for the two simulated specialist strategies. Convolving
these results with a distribution, a modelled Galactic spatial
distribution and reddening maps, we conservatively estimate that the most
recent version of the LSST baseline strategy will allow determination
for 18 % of the Milky Way's LMXB population, whereas strategies that do
not reduce observations of the Galactic Plane can improve this dramatically to
32 %. This increase would allow characterisation of the full binary
population by breaking degeneracies between suggested distributions
in the literature. Our results can be used in the ongoing assessment of the
effectiveness of various potential cadencing strategies.Comment: Replacement after addressing minor corrections from the referee -
mainly improvements in clarificatio
A target repurposing approach identifies N-myristoyltransferase as a new candidate drug target in filarial nematodes
Myristoylation is a lipid modification involving the addition of a 14-carbon unsaturated fatty acid, myristic acid, to the N-terminal glycine of a subset of proteins, a modification that promotes their binding to cell membranes for varied biological functions. The process is catalyzed by myristoyl-CoA:protein N-myristoyltransferase (NMT), an enzyme which has been validated as a drug target in human cancers, and for infectious diseases caused by fungi, viruses and protozoan parasites. We purified Caenorhabditis elegans and Brugia malayi NMTs as active recombinant proteins and carried out kinetic analyses with their essential fatty acid donor, myristoyl-CoA and peptide substrates. Biochemical and structural analyses both revealed that the nematode enzymes are canonical NMTs, sharing a high degree of conservation with protozoan NMT enzymes. Inhibitory compounds that target NMT in protozoan species inhibited the nematode NMTs with IC50 values of 2.5-10 nM, and were active against B. malayi microfilariae and adult worms at 12.5 µM and 50 µM respectively, and C. elegans (25 µM) in culture. RNA interference and gene deletion in C. elegans further showed that NMT is essential for nematode viability. The effects observed are likely due to disruption of the function of several downstream target proteins. Potential substrates of NMT in B. malayi are predicted using bioinformatic analysis. Our genetic and chemical studies highlight the importance of myristoylation in the synthesis of functional proteins in nematodes and have shown for the first time that NMT is required for viability in parasitic nematodes. These results suggest that targeting NMT could be a valid approach for the development of chemotherapeutic agents against nematode diseases including filariasis
Does the Spine Surgeon’s Experience Affect Fracture Classification, Assessment of Stability, and Treatment Plan in Thoracolumbar Injuries?
Study Design: Prospective survey-based study. Objectives: The AO Spine thoracolumbar injury classification has been shown to have good reproducibility among clinicians. However, the influence of spine surgeons’ clinical experience on fracture classification, stability assessment, and decision on management based on this classification has not been studied. Furthermore, the usefulness of varying imaging modalities including radiographs, computed tomography (CT) and magnetic resonance imaging (MRI) in the decision process was also studied. Methods: Forty-one spine surgeons from different regions, acquainted with the AOSpine classification system, were provided with 30 thoracolumbar fractures in a 3-step assessment: first radiographs, followed by CT and MRI. Surgeons classified the fracture, evaluated stability, chose management, and identified reasons for any changes. The surgeons were divided into 2 groups based on years of clinical experience as \u3c10 years (n = 12) and \u3e10 years (n = 29). Results: There were no significant differences between the 2 groups in correctly classifying A1, B2, and C type fractures. Surgeons with less experience hadmore correct diagnosis in classifyingA3 (47.2% vs 38.5%in step 1, 73.6% vs 60.3% in step 2 and 77.8% vs 65.5% in step 3), A4 (16.7% vs 24.1% in step 1, 72.9% vs 57.8% in step 2 and 70.8% vs 56.0%in step3) and B1 injuries (31.9% vs 20.7% in step 1, 41.7% vs 36.8% in step 2 and 38.9% vs 33.9% in step 3). In the assessment of fracture stability and decision on treatment, the less and more experienced surgeons performed equally. The selection of a particular treatment plan varied in all subtypes except in A1 and C type injuries. Conclusion: Surgeons’ experience did not significantly affect overall fracture classification, evaluating stability and planning the treatment. Surgeons with less experience had a higher percentage of correct classification in A3 and A4 injuries. Despite variations between them in classification, the assessment of overall stability and management decisions were similar between the 2 groups. © The Author(s) 2017
Isospectral domains with mixed boundary conditions
We construct a series of examples of planar isospectral domains with mixed
Dirichlet-Neumann boundary conditions. This is a modification of a classical
problem proposed by M. Kac.Comment: 9 figures. Statement of Theorem 5.1 correcte
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