The role of the human papillomavirus (HPV) in cervical cancer : a review about HPV-induced carcinogenesis and its epidemiology, diagnosis, management and prevention

The human papillomavirus (HPV) was the first virus known to induce carcinogenesis and is associated with cancers of the uterine cervix, anogenital tumors and malignancies of the head and neck. This paper reviews the structure and basic genomic characteristics of the virus and outlines the clinical involvement of the main HPV serotypes, focusing on the carcinogenic role of HPV-16 and 18. The mecha¬nisms that occur in the development of cervical neoplasia due to the oncogenic proteins E6 and E7 which interfere with the regulation of the cell cycle through their interaction with p53 and retinoblastoma protein are described. Epidemiological factors, diagnostic tools and the management of the disease are also reviewed, along with the available vaccines to prevent the viral infection. Insights on current research on involvement of oxidative stress and micro-RNAs in cervical carcinogenesis are also explored as they may unlock new means of diagnosis and treatment in the future.peer-reviewe

Moore & Martin 2016 JEB longevity data

Longevity values for all dragonflies included in this stud

Moore & Martin 2016 JEB territorial disputes

Outcomes of all territorial dispute

Moore & Martin 2016 JEB territorial tenures

Territorial tenures and phenotypic values for all individuals in study

Moore & Martin 2016 JEB decoy experiment

Responses of all territorial males to decoys pre- vs post-experimental augmentatio

Moore & Martin 2016 JEB immune assays

Immune assay scores and phenotypic values of dragonflies included in stud

Moore_Riesch_Martin_2016_Divergence_Trade_offs

see ReadMe file for meta-dat

Moore_Riesch_Martin_2016_All_Species_Divergences

see ReadMe file for meta-dat

S1-tortuga parenquima carbacol 10 μM 1 from Pulmonary ventilation–perfusion mismatch: a novel hypothesis for how diving vertebrates may avoid the bends

Video showing contraction of loggerhead sea turtle lung parenchyma when exposed to carbachol (parasympathetic) at a concentration of 10μ

Additional file 1: Table S1. of Antidepressant use and risk of epilepsy and seizures in people aged 20 to 64Â years: cohort study using a primary care database

List of Read codes included in the definition of the epilepsy/seizures outcome. Table S2. Read codes used for identification of patients with depression and their assigned severity. Table S3. Baseline characteristics of patients according to the class of antidepressant first prescribed. Table S4. 5-year hazard ratios for epilepsy/seizures by antidepressant class, dose and individual drug, with SSRIs, mid-dose SSRI and citalopram as the reference categories respectively. Table S5. 5-year hazard ratios for epilepsy/seizures by antidepressant class, dose and individual drug, with untreated patients excluded from the cohort. Table S6. 5-year hazard ratios for epilepsy/seizures by antidepressant class, dose and individual drug, with patients on anticonvulsants at baseline excluded from the cohort. Table S7. 1-year hazard ratios for epilepsy/seizures by antidepressant class, dose and individual drug. Table S8. 1-year hazard ratios for epilepsy/seizures by antidepressant class, dose and individual drug, with SSRIs, mid-dose SSRI and citalopram as the reference categories respectively. (PDF 731 kb