Summary of an experimental investigation on the ground vortex

The results of an experimental investigation into the position and characteristics of the ground vortex are summarized. A 48-inch wind tunnel was modified to create a testing environment suitable for the ground vortex study. Flow visualization was used to document the jet-crossflow interaction and a two-component Laser Doppler Velocimeter (LDV) was used to survey the flowfield in detail. Measurements of the ground vortex characteristics and location as a function of freestream-to-jet velocity ratio, jet height, pressure gradient and upstream boundary layer thickness were obtained

Reduction in size and unsteadiness of a VTOL ground vortex by ground fences

A ground vortex, produced when a jet impinges on the ground in the presence of cross flow, is encountered by V/STOL aircraft hovering near the ground and is known to be hazardous to the aircraft. The objective of this research was to identify a ground-based technique by which both the mean size and fluctuation in size of the ground vortex could be reduced. A simple passive method was identified and examined in the laboratory. Specifically, one or two fine wire mesh screens (ground fences) bent in a horseshoe shape and located on the ground in front of the jet impingement point proved to be very effective. The ground fences work by decreasing the momentum of the upstream-traveling wall jet, effectively causing a higher freestream-to-jet velocity ratio (V(sub infinity)/V(sub j)) and thus, a ground vortex smaller in size and unsteadiness. At(V(sub infinity)/V(sub j)) = 0.15, the addition of a single ground fence resulted in a 70 percent reduction in mean size of the ground vortex. With two ground fences, the mean size decreased by about 85 percent. Fluctuations in size decreased nearly in proportion to the mean size, for both the single and double fence configurations. These results were consistent over a wide range of jet Reynolds number (10(exp 4) less than Re(sub jet) less than 10(exp 5)); further development and full-scale Reynolds number testing are required, however, to determine if this technique can be made practical for the case of actual VTOL aircraft

Summary of STOL ground vortex investigation

An experimental facility was developed in the 1.23 (48 inch) wind tunnel of the Applied Research Lab. at the Pennsylvania State Univ. to model the ground vortex. The purpose of the facility was to study the effect of various parameters on the location and characteristics of a ground vortex. An experimental investigation was conducted in the tunnel into the formation, stability and strength of the ground vortex for several flow parameters. The design of the facility, special instrumentation and results are summarized

A many-analysts approach to the relation between religiosity and well-being

The relation between religiosity and well-being is one of the most researched topics in the psychology of religion, yet the directionality and robustness of the effect remains debated. Here, we adopted a many-analysts approach to assess the robustness of this relation based on a new cross-cultural dataset (N=10,535 participants from 24 countries). We recruited 120 analysis teams to investigate (1) whether religious people self-report higher well-being, and (2) whether the relation between religiosity and self-reported well-being depends on perceived cultural norms of religion (i.e., whether it is considered normal and desirable to be religious in a given country). In a two-stage procedure, the teams first created an analysis plan and then executed their planned analysis on the data. For the first research question, all but 3 teams reported positive effect sizes with credible/confidence intervals excluding zero (median reported β=0.120). For the second research question, this was the case for 65% of the teams (median reported β=0.039). While most teams applied (multilevel) linear regression models, there was considerable variability in the choice of items used to construct the independent variables, the dependent variable, and the included covariates

A Many-analysts Approach to the Relation Between Religiosity and Well-being

The relation between religiosity and well-being is one of the most researched topics in the psychology of religion, yet the directionality and robustness of the effect remains debated. Here, we adopted a many-analysts approach to assess the robustness of this relation based on a new cross-cultural dataset (N = 10, 535 participants from 24 countries). We recruited 120 analysis teams to investigate (1) whether religious people self-report higher well-being, and (2) whether the relation between religiosity and self-reported well-being depends on perceived cultural norms of religion (i.e., whether it is considered normal and desirable to be religious in a given country). In a two-stage procedure, the teams first created an analysis plan and then executed their planned analysis on the data. For the first research question, all but 3 teams reported positive effect sizes with credible/confidence intervals excluding zero (median reported β = 0.120). For the second research question, this was the case for 65% of the teams (median reported β = 0.039). While most teams applied (multilevel) linear regression models, there was considerable variability in the choice of items used to construct the independent variables, the dependent variable, and the included covariates

NOD‐like receptor C4 Inflammasome Regulates the Growth of Colon Cancer Liver Metastasis in NAFLD

Nonalcoholic fatty liver disease (NAFLD) enhances the growth and recurrence of colorectal cancer (CRC) liver metastasis. With the rising prevalence of NAFLD, a better understanding of the molecular mechanism underlying NAFLD-associated liver metastasis is crucial. Tumor-associated macrophages (TAMs) constitute a large portion of the tumor microenvironment that promotes tumor growth. NOD-like receptor C4 (NLRC4), a component of an inflammasome complex, plays a role in macrophage activation and interleukin (IL)-1β processing. We aimed to investigate whether NLRC4-mediated TAM polarization contributes to metastatic liver tumor growth in NAFLD. Wild-type and NLRC4-/- mice were fed low-fat or high-fat diet for 6 weeks followed by splenic injection of mouse CRC MC38 cells. The tumors were analyzed 2 weeks after CRC cell injection. High-fat diet-induced NAFLD significantly increased the number and size of CRC liver metastasis. TAMs and CD206-expressing M2 macrophages accumulated markedly in tumors in the presence of NAFLD. NAFLD up-regulated the expression of IL-1β, NLRC4, and M2 markers in tumors. In NAFLD, but not normal livers, deletion of NLRC4 decreased liver tumor growth accompanied by decreased M2 TAMs and IL-1β expression in tumors. Wild-type mice showed increased vascularity and vascular endothelial growth factor (VEGF) expression in tumors with NAFLD, but these were reduced in NLRC4-/- mice. When IL-1 signaling was blocked by recombinant IL-1 receptor antagonist, liver tumor formation and M2-type macrophages were reduced, suggesting that IL-1 signaling contributes to M2 polarization and tumor growth in NAFLD. Finally, we found that TAMs, but not liver macrophages, produced more IL-1β and VEGF following palmitate challenge. Conclusion: In NAFLD, NLRC4 contributes to M2 polarization, IL-1β, and VEGF production in TAMs, which promote metastatic liver tumor growth