Gribov Copies in the Maximally Abelian Gauge and Confinement

We fix $SU(2)$ lattice gauge fields to the Maximally Abelian gauge in both three and four dimensions. We extract the corresponding $U(1)$ fields and monopole current densities and calculate separately the confining string tensions arising from these $U(1)$ fields and monopole `condensates'. We generate multiple Gribov copies and study how the $U(1)$ fields and monopole distributions vary between these different copies. As expected, we find substantial variations in the number of monopoles, their locations and in the values of the $U(1)$ field strengths. The string tensions extracted from `extreme' Gribov copies also differ but this difference appears to be no more than about 20\%. We also directly compare the fields of different Gribov copies. We find that on the distance scales relevant to confinement the $U(1)$ and monopole fluxes that disorder Wilson loops are highly correlated between these different Gribov copies. All this suggests that while there is indeed a Gribov copy problem the resulting ambiguity is, in this gauge and for the study of confinement, of limited importance.Comment: 31 pages LaTeX plus 5 PostScript figures. Uses epsf.sty. Self-unpacking, uuencoded tar-compressed fil

String Tension from Monopoles in SU(2) Lattice Gauge Theory

The axis for Figure 2 was wrong. It has been fixed and the postscript file replaced (The file was called comp.ps).Comment: (22 pages latex (revtex); 2 figures appended as postscript files - search for mono.ps and comp.ps. Figures mailed on request--send a note to [email protected]) Preprint ILL-(TH)-94-#1

Experimental H-type and L-type bovine spongiform encephalopathy in cattle: observation of two clinical syndromes and diagnostic challenges

<p>Abstract</p> <p>Background</p> <p>The majority of atypical bovine spongiform encephalopathy (BSE) cases so far identified worldwide have been detected by active surveillance. Consequently the volume and quality of material available for detailed characterisation is very limiting. Here we report on a small transmission study of both atypical forms, H- and L-type BSE, in cattle to provide tissue for test evaluation and research, and to generate clinical, molecular and pathological data in a standardised way to enable more robust comparison of the two variants with particular reference to those aspects most relevant to case ascertainment and confirmatory diagnosis within existing regulated surveillance programmes.</p> <p>Results</p> <p>Two groups of four cattle, intracerebrally inoculated with L-type or H-type BSE, all presented with a nervous disease form with some similarities to classical BSE, which progressed to a more dull form in one animal from each group. Difficulty rising was a consistent feature of both disease forms and not seen in two BSE-free, non-inoculated cattle that served as controls. The pathology and molecular characteristics were distinct from classical BSE, and broadly consistent with published data, but with some variation in the pathological characteristics. Both atypical BSE types were readily detectable as BSE by current confirmatory methods using the medulla brain region at the obex, but making a clear diagnostic distinction between the forms was not consistently straightforward in this brain region. Cerebellum proved a more reliable sample for discrimination when using immunohistochemistry.</p> <p>Conclusions</p> <p>The prominent feature of difficulty rising in atypical BSE cases may explain the detection of naturally occurring cases in emergency slaughter cattle and fallen stock. Current confirmatory diagnostic methods are effective for the detection of such atypical cases, but consistently and correctly identifying the variant forms may require modifications to the sampling regimes and methods that are currently in use.</p

Dual Superconductor Scenario of Confinement: A Systematic Study of Gribov Copy Effects

We perform a study of the effects from maximal abelian gauge Gribov copies in the context of the dual superconductor scenario of confinement, on the basis of a novel approach for estimation of systematic uncertainties from incomplete gauge fixing. We present numerical results, in SU(2) lattice gauge theory, using the overrelaxed simulated annealing gauge fixing algorithm. We find abelian and non-abelian string tensions to differ significantly, their ratio being 0.92(4) at BETA = 2.5115. An approximate factorization of the abelian potential into monopole and photon contributions has been confirmed, the former giving rise to the abelian string tension.Comment: 35 pages uucompressed LaTeX with 10 encapsuled postscript figure

Monopole clusters in Abelian projected gauge theories

We show that the monopole currents which one obtains in the maximally Abelian gauge of SU(2) fall into two quite distinct classes (when the volume is large enough). In each field configuration there is precisely one cluster that permeates the whole lattice volume. It has a current density and a magnetic screening mass that scale and it produces the whole of the string tension. The remaining clusters have a number density that follows an approximate power law proportional to the inverse cube of l where l is the length of the monopole world line in lattice units. These clusters are localised in space-time with radii which vary as the square root of l. In terms of the radius r these `lumps' have a scale-invariant distribution proportional to (dr/r . 1/{r^4}). Moreover they appear not to contribute at all to the string tension. The fact that they are scale-invariant at small distances would seem to rule out an instanton origin.Comment: LaTeX, 31 pages, 11 PostScript figures. Typo in Table 2 correcte

Immunohistochemical and biochemical characteristics of BSE and CWD in experimentally infected European red deer (Cervus elaphus elaphus)

<p>Abstract</p> <p>Background</p> <p>The cause of the bovine spongiform encephalopathy (BSE) epidemic in the United Kingdom (UK) was the inclusion of contaminated meat and bone meal in the protein rations fed to cattle. Those rations were not restricted to cattle but were also fed to other livestock including farmed and free living deer. Although there are no reported cases to date of natural BSE in European deer, BSE has been shown to be naturally or experimentally transmissible to a wide range of different ungulate species. Moreover, several species of North America's cervids are highly susceptible to chronic wasting disease (CWD), a transmissible spongiform encephalopathy (TSE) that has become endemic. Should BSE infection have been introduced into the UK deer population, the CWD precedent could suggest that there is a danger for spread and maintenance of the disease in both free living and captive UK deer populations. This study compares the immunohistochemical and biochemical characteristics of BSE and CWD in experimentally-infected European red deer (<it>Cervus elpahus elaphus</it>).</p> <p>Results</p> <p>After intracerebral or alimentary challenge, BSE in red deer more closely resembled natural infection in cattle rather than experimental BSE in small ruminants, due to the lack of accumulation of abnormal PrP in lymphoid tissues. In this respect it was different from CWD, and although the neuropathological features of both diseases were similar, BSE could be clearly differentiated from CWD by immunohistochemical and Western blotting methods currently in routine use.</p> <p>Conclusion</p> <p>Red deer are susceptible to both BSE and CWD infection, but the resulting disease phenotypes are distinct and clearly distinguishable.</p

Free energy of an SU(2) monopole-antimonopole pair

We present a high-statistic numerical study of the free energy of a monopole-antimonopole pair in pure SU(2) theory. We find that the monopole-antimonopole interaction potential exhibits a screened behavior, as one would expect in presence of a monopole condensate. Screening occurs both in the low-temperature, confining phase of the theory, and in the high-temperature deconfined phase, with no evidence of a discontinuity of the screening mass across the transition. The mass of the object responsible for the screening at low temperature is approximately twice the established value for the lightest glueball, indicating a prevalent coupling to glueball excitations. At high temperature, the screening mass increases. We contrast the behavior of the quantum system with that of the corresponding classical system, where the monopole-antimonopole potential is of the Coulomb type.Comment: Latex, 22 pages, 8 figures. A mistake in the computer program implementing the multihistogram method has been corrected and all the affected numerical data have been revised. The main conclusions of the paper are unchanged, but the screening masses turn out somehow larger. (We thank Philippe de Forcrand for correspondence which helped us find the error.

Detection and Localisation of PrPSc in the Liver of Sheep Infected with Scrapie and Bovine Spongiform Encephalopathy

Prions are largely contained within the nervous and lymphoid tissue of transmissible spongiform encephalopathy (TSE) infected animals. However, following advances in diagnostic sensitivity, PrPSc, a marker for prion disease, can now be located in a wide range of viscera and body fluids including muscle, saliva, blood, urine and milk, raising concerns that exposure to these materials could contribute to the spread of disease in humans and animals. Previously we demonstrated low levels of infectivity in the liver of sheep experimentally challenged with bovine spongiform encephalopathy. In this study we show that PrPSc accumulated in the liver of 89% of sheep naturally infected with scrapie and 100% of sheep challenged with BSE, at both clinical and preclinical stages of the disease. PrPSc was demonstrated in the absence of obvious inflammatory foci and was restricted to isolated resident cells, most likely Kupffer cells

Experimental transmission of chronic wasting disease agent from mule deer to cattle by the intracerebral route

This communication reports final observations on experimental transmission of chronic wasting disease (CWD) from mule deer to cattle by the intracerebral route. Thirteen calves were inoculated intracerebrally with brain suspension from mule deer naturally affected with CWD. Three other calves were kept as uninoculated controls. The experiment was terminated 6 years after inoculation. During that time, abnormal prion protein (PrPres) was demonstrated in the central nervous system (CNS) of 5 cattle by both immunohistochemistry and Western blot. However, microscopic lesions suggestive of spongiform encephalopathy (SE) in the brains of these PrPres-positive animals were subtle in 3 cases and absent in 2 cases. Analysis of the gene encoding bovine PRNP revealed homozygosity for alleles encoding 6 octapeptide repeats, serine (S) at codon 46, and S at codon 146 in all samples. Findings of this study show that although PrPres amplification occurred after direct inoculation into the brain, none of the affected animals had classic histopathologic lesions of SE. Furthermore, only 38% of the inoculated cattle demonstrated amplification of PrPres. Although intracerebral inoculation is an unnatural route of exposure, this experiment shows that CWD transmission in cattle could have long incubation periods (up to 5 years). This finding suggests that oral exposure of cattle to CWD agent, a more natural potential route of exposure, would require not only a much larger dose of inoculum but also may not result in amplification of PrPres within CNS tissues during the normal lifespan of cattle