Workshop on Mars Sample Return Science

Martian magnetic history; quarantine issues; surface modifying processes; climate and atmosphere; sampling sites and strategies; and life sciences were among the topics discussed

Complement inhibitors for age-related macular degeneration

Given the relatively high prevalence of age-related macular degeneration (AMD) and the increased incidence of AMD as populations age, the results of trials of novel treatments are awaited with much anticipation. The complement cascade describes a series of proteolytic reactions occurring throughout the body that generate proteins with a variety of roles including the initiation and promotion of immune reactions against foreign materials or micro-organisms. The complement cascade is normally tightly regulated, but much evidence implicates complement overactivity in AMD and so it is a logical therapeutic target in the treatment of AMD

On the Reproducibility of Power Analyses in Motor Behavior Research

Recent metascience suggests that motor behavior research may be underpowered, on average. Researchers can perform a priori power analyses to ensure adequately powered studies. However, there are common pitfalls that can result in underestimating the required sample size for a given design and effect size of interest. Critical evaluation of power analyses requires successful analysis reproduction, which is conditional on the reporting of sufficient information. Here, we attempted to reproduce every power analysis reported in articles (k = 84/635) in three motor behavior journals between January 2019 and June 2021. We reproduced 7% of analyses using the reported information, which increased to 43% when we assumed plausible values for missing parameters. Among studies that reported sufficient information to evaluate, 63% reported using the same statistical test in the power analysis as in the study itself, and in 77%, the test addressed at least one of the identified hypotheses. Overall, power analyses were not commonly reported with sufficient information to ensure reproducibility. A nontrivial number of power analyses were also affected by common pitfalls. There is substantial opportunity to address the issue of underpowered research in motor behavior by increasing adoption of power analyses and ensuring reproducible reporting practices

Symmetric Instantons and Skyrme Fields

By explicit construction of the ADHM data, we prove the existence of a charge seven instanton with icosahedral symmetry. By computing the holonomy of this instanton we obtain a Skyrme field which approximates the minimal energy charge seven Skyrmion. We also present a one parameter family of tetrahedrally symmetric instantons whose holonomy gives a family of Skyrme fields which models a Skyrmion scattering process, where seven well-separated Skyrmions collide to form the icosahedrally symmetric Skyrmion.Comment: 22 pages plus 1 figure in GIF forma

NE Iowa Watershed and Karst Map

https://ir.uiowa.edu/igs_ofm/1076/thumbnail.jp

What Do Healthy Rural Economies Look Like in the U.S., and How Might Conservation Organizations Help Support Them?

Report of the 2012 Berkley Workshop Held at the Wingspread Conference Center, Racine,WI - July 201

Alternative Transcript Initiation and Splicing as a Response to DNA Damage

Humans are exposed to the DNA damaging agent, ionizing radiation (IR), from background radiation, medical treatments, occupational and accidental exposures. IR causes changes in transcription, but little is known about alternative transcription in response to IR on a genome-wide basis. These investigations examine the response to IR at the exon level in human cells, using exon arrays to comprehensively characterize radiation-induced transcriptional expression products. Previously uncharacterized alternative transcripts that preferentially occur following IR exposure have been discovered. A large number of genes showed alternative transcription initiation as a response to IR. Dose-response and time course kinetics have also been characterized. Interestingly, most genes showing alternative transcript induction maintained these isoforms over the dose range and times tested. Finally, clusters of co-ordinately up- and down-regulated radiation response genes were identified at specific chromosomal loci. These data provide the first genome-wide view of the transcriptional response to ionizing radiation at the exon level. This study provides novel insights into alternative transcripts as a mechanism for response to DNA damage and cell stress responses in general

Within-species trade-offs in plant-stimulated soil enzyme activity and growth, flowering, and seed size

Soil microbial communities affect species demographic rates of plants. In turn, plants influence the composition and function of the soil microbiome, potentially resulting in beneficial feedbacks that alter their fitness and establishment. For example, differences in the ability to stimulate soil enzyme activity among plant lineages may affect plant growth and reproduction. We used a common garden study to test differences in plant-stimulated soil enzyme activity between lineages of the same species across developmental stages. Lineages employed different strategies whereby growth, days to flowering and seed size traded-off with plant-stimulated soil enzyme activity. Specifically, the smaller seeded lineage stimulated more enzyme activity at the early stage of development and flowered earlier while the larger seeded lineage sustained lower but consistent enzyme activity through development. We suggest that these lineages, which are both successful invaders, employ distinct strategies (a colonizer and a competitor) and differ in their influence on soil microbial activity. Synthesis. The ability to influence the soil microbial community by plants may be an important trait that trades off with growth, flowering, and seed size for promoting plant establishment, reproduction, and invasion

Integrating Science and Mathematics Education Research into Teaching: A Conference for Students, Teachers and University Faculty in Science, Mathematics, and Related Fields

This proposal from the University of Maine Center for Science and Mathematics Education is a request for a TPC Conference/Symposium to fund a six-day national conference and summer academy entitled Integrating Science and Mathematics Education Research into Teaching. The purposes of the conference are: (1) to bring together all participants in the science and mathematics education research enterprise (teachers, administrators, scientists and mathematicians, education faculty, future teachers) to exchange ideas about research and curriculum innovation ongoing in their fields; and (2) help teachers integrate research-based instructional strategies, particularly those that depend on innovative uses of technology, into their teaching practices