Chemical Repellents

Agricultural depredations caused by blackbirds can be managed with various lethal and nonlethal methods, including chemical repellents. For many people, nonlethal chemical repellents represent an appealing approach to managing crop depredation because the depredating birds are targeted but not killed; they are just inconvenienced. An effective repellent application can cause the crop-depredating birds to leave their present feeding site and seek food elsewhere. Where the birds go to feed is immaterial to the producer as long as the birds leave the producer\u27s field. Thus, an effective repellent application will not likely affect the overall size of the blackbird population, but it may reduce the population associated with depredation and thereby reduce losses within the treated field. As a consequence, nearby crop fields might incur greater damage unless appropriate crop protection measures are employed. Blackbirds flock to fields of rice, sunflower, corn, and other crops because these sites represent accessible sources of abundant and energy-rich food that is obtainable with relatively little effort. Agricultural crops are especially important to young birds and, in the late summer and fall, newly fledged birds constitute a large portion of many depredating blackbird flocks. Crop fields can provide ideal feeding situations for blackbirds learning to fend for themselves. Ever-increasing alteration of the natural landscape to accommodate expansion of human activities makes it increasingly difficult for blackbirds to find natural sources of food. Field crops are powerful attractions to blackbirds, and depredating birds are not easily dissuaded. The potential benefits of feeding on the crop are great, so there must be a commensurately high potential cost to the birds to discourage them

PRELIMINARY EVALUATION OF A GRANULAR TRIMETHACARB FORMULATION FOR DETERRING GRAZING BY AMERICAN COOTS

In a 0.2 ha flight pen, groups of 4 American coots were tested to determine if their grazing activity could be affected by application of a registered granular-trimethacarb insecticide. In the 3 days following treatment (3 kg/ha, a.i.), grazing activity in the treated portions of the 200 m2 experimental plots was reduced an average of 47X. Overall use of the treated areas followed a similar pattern but was less consistent among groups. The addition of methylpyrazine, a strong odorant, produced a strong initial suppression of grazing activity in the treated halves of the plots. However, subsequent rain and a change in the coots\u27 grazing behavior prevented a definitive evaluation of the methylpyrazine treatment. Two birds that died during the trimethacarb-only portion of the study did not have abnormally low levels of brain cholinesterase. However, this finding does not preclude the possibility that they were unable to distinguish treated from untreated grass and consumed lethal amounts of trimethacarb. Additional investigation of methylpyrazine appears warranted; such materials may act to decrease the likelihood that birds will ingest lethal quantities of repellent

Movement as Medicine for Cardiovascular Disease Prevention : Pilot Feasibility Study of a Physical Activity Promotion Intervention for At-Risk Patients in Primary Care

Publisher Copyright: © Keegan Knittle, Sarah J Charman, Sophie O'Connell, Leah Avery, Michael Catt, Falko F Sniehotta, Michael I TrenellBackground: Physical activity (PA) can reduce cardiovascular disease (CVD) risk factors, and although primary care settings offer a large reach to promote PA and reduce CVD risk, primary health care professionals may lack self-efficacy and tools to effectively promote PA in practice. Movement as Medicine for CVD Prevention is a suite of 2 theory-based, web-based behavioral interventions-one for health care professionals and one for patients-which may offer a pathway for promoting PA and reducing CVD risk in primary care. Objective: This study aims to examine the feasibility and possible effects of Movement as Medicine for CVD Prevention. Methods: This nonrandomized pilot study recruited participants from primary care organizations in the Northeast of England. Enrolled health care professionals followed a theory-based, web-based course on PA counseling and motivational interviewing techniques. After the course, health care professionals delivered behavior change consultations based on motivational interviewing to inactive individuals with >20% risk of developing CVD within 10 years. Patients were then given access to a website based on self-determination and self-regulation theories, which targeted increased levels of PA. Outcomes were assessed at baseline and after 3 months, and patient data were analyzed on an intention-to-treat basis in a multiple imputation data set. Results: Recruitment rates of primary care organizations fell below expectations. A total of 11 health care professionals from 3 enrolled primary care organizations completed the web-based course and reported increases in important theoretical determinants of PA promotion in practice (eg, self-efficacy, Cohen d=1.24, 95% CI 0.67-1.80; and planning, Cohen d=0.85, 95% CI −0.01 to 1.69). A total of 83 patients were enrolled in the study, and 58 (70%) completed both the baseline and 3-month assessments. Compared with baseline, patients had higher levels of objective (Cohen d=0.77, 95% CI 0.13-1.41) but not subjective (Cohen d=0.40, 95% CI −0.03 to 0.83) moderate to vigorous PA at 3 months. Patients also reported higher levels of the PA determinants of intention, self-efficacy, intrinsic motivation, and action planning and action control at 3 months (effect sizes ranged from Cohen d=0.39 to 0.60). Conclusions: The Movement as Medicine for CVD Prevention intervention seems to have the potential to improve patient PA behaviors and important determinants of health care professionals' PA promotion practices. However, the recruitment rates of primary care organizations in this study were low and would need to be increased to examine the efficacy of the program. This study offers several insights into improving the feasibility of this primary care PA promotion pathway.Peer reviewe

Daptomycin-Nonsusceptible Vancomycin-Intermediate Staphylococcus aureus Vertebral Osteomyelitis Cases Complicated by Bacteremia Treated with High-Dose Daptomycin and Trimethoprim-Sulfamethoxazole

We report two cases of daptomycin (DAP)-nonsusceptible (DNS) vancomycin-intermediate Staphylococcus aureus (VISA) vertebral osteomyelitis cases complicated by bacteremia treated with high-dose daptomycin and trimethoprim-sulfamethoxazole. Both patients responded rapidly and favorably to this combination. The clinical isolates from the two patients were tested post hoc in an in vitro pharmacokinetic/pharmacodynamic (PK/PD) model to confirm the bactericidal activity and enhancement of daptomycin and trimethoprim-sulfamethoxazole. The combination of high-dose daptomycin and trimethoprim-sulfamethoxazole should be explored further for the treatment of DNS VISA strains.M.J.R. has received grant support, consulted for, or provided lectures for Astellas, Cubist, Forest, Clinical Therapeutics, Theravance, and Rib- X. L.M.A has served as an advisory board member (Forest) and provided lectures (Astellas) and owns stock (Merck). M.E.S., A.E.W., and M.H. have no potential conflicts of interest

DEVELOPMENT OF A SYNTHETIC MATERIALS MIMIC FOR VULTURE OLFACTION RESEARCH

Since the early 1990\u27s, an increase in damage associated with the activities of black (Coragyps atratus) and turkey (Cathartes aura) vultures has been observed. These activities include extensive damage to real and personal property. Vultures display an affinity for objects made of synthetic materials such as vinyl or plastic, and frequently damage items such as seat cushions, roof shingles, and caulking sealant. To explore whether this behavior in vultures is olfactorily driven, volatile compounds emitted by 21 vulture-damaged objects were collected and analyzed using purge-and-trap gas chromatography/mass spectrometry. Results from these analyses were tabulated and the 27 most commonly occurring compounds were identified. Six of the vulture-damaged samples contained at least 23 of the 27 identified compounds, and hexanal, octanal, undecane, and nonanal were found in all 21 vulture-damaged samples. Using these data, a water-based emulsion containing the 27 most frequently observed compounds in the vulture-damaged samples was formulated to serve as a synthetic materials mimic (SMM). A sustained volatile release delivery system utilizing cellulose sponges was also developed, and used to deliver the SMM for bioassay trials examining the response of captive vultures to the SMM

The effect of social context and social scale on the perception of relationships in monk parakeets

Social relationships formed within a network of interacting group members can have a profound impact on an individual’s behavior and fitness. However, we have little understanding of how individuals perceive their relationships and how this perception relates to our external measures of interactions. We investigated the perception of affiliative and agonistic relationships at both the dyadic and emergent social levels in two captive groups of monk parakeets (Myiopsitta monachus, n = 21 and 19) using social network analysis and playback experiments. At the dyadic social scale, individuals directed less aggression towards their strong affiliative partners and more aggression towards non-partner neighbors.At the emergent social scale, there was no association between relationships in different social contexts and an individual’s dominance rank did not correlate with its popularity rank. Playback response patterns were mainly driven by relationships in affiliative social contexts at the dyadic scale. In both groups, individual responses to playback experiments were significantly affected by strong affiliative relationships at the dyadic social scale, albeit in different directions in the two groups. Response patterns were also affected by affiliative relationships at the emergent social scale, but only in one of the two groups. Within affiliative relationships, those at the dyadic social scale were perceived by individuals in both groups, but those at the emergent social scale only affected responses in one group. These results provide preliminary evidence that relationships in affiliative social contexts may be perceived as more important than agonistic relationships in captive monk parakeet groups. Our approach could be used in a wide range of social species and comparative analyses could provide important insight into how individuals perceive relationships across social contexts and social scales [Current Zoology 61 (1): 55–69, 2015]

The Galaxy Luminosity Function and Luminosity Density at Redshift z=0.1

Using a catalog of 147,986 galaxy redshifts and fluxes from the Sloan Digital Sky Survey (SDSS), we measure the galaxy luminosity density at z = 0.1 in five optical bandpasses corresponding to the SDSS bandpasses shifted to match their rest-frame shape at z = 0.1. We denote the bands (0.1)u, (0.1)g, (0.1)r, (0.1)i, (0.1)z with lambda(eff) = (3216; 4240; 5595; 6792; 8111 Angstrom), respectively. To estimate the luminosity function, we use a maximum likelihood method that allows for a general form for the shape of the luminosity function,fits for simple luminosity and number evolution, incorporates the flux uncertainties, and accounts for the flux limits of the survey. We find luminosity densities at z = 0.1 expressed in absolute AB magnitudes in a Mpc(3) to be (-14.10 +/- 0.15, -15.18 +/- 0.03, - 15.90 +/- 0.03, -16.24 +/- 0.03, -16.56 +/- 0.02) in ((0.1)u, (0.1)g, (0.1)r, (0.1)i, (0.1)z), respectively, for a cosmological model with Omega(0) = 0.3, Omega(Lambda) = 0.7, and h = 1 and using SDSS Petrosian magnitudes. Similar results are obtained using Sersic model magnitudes, suggesting that flux from outside the Petrosian apertures is not a major correction. In the (0.1)r band, the best-fit Schechter function to our results has phi* = (1.49 +/- 0.04) x 10(-2) h(3) Mpc(-3), M-* - 5 log(10) h = - 20.44 +/- 0.01, and alpha = - 1.05 +/- 0.01. In solar luminosities, the luminosity density in (0.1)r is (1.84 +/- 0.04) x 10(8) h L-0.1r,L-. Mpc(-3). Our results in the (0.1)g band are consistent with other estimates of the luminosity density, from the Two-Degree Field Galaxy Redshift Survey and the Millennium Galaxy Catalog. They represent a substantial change ( similar to 0.5 mag) from earlier SDSS luminosity density results based on commissioning data, almost entirely because of the inclusion of evolution in the luminosity function model

STK39 polymorphisms and blood pressure: an association study in British Caucasians and assessment of cis-acting influences on gene expression

<p>Abstract</p> <p>Background</p> <p>Blood pressure (BP) has significant heritability, but the genes responsible remain largely unknown. Single nucleotide polymorphisms (SNPs) at the <it>STK39 </it>locus were recently associated with hypertension by genome-wide association in an Amish population; <it>in vitro </it>data from transient transfection experiments using reporter constructs suggested that altered <it>STK39 </it>expression might mediate the effect. However, other large studies have not implicated <it>STK39 </it>in hypertension. We determined whether reported SNPs influenced <it>STK39 </it>expression <it>in vivo</it>, or were associated with BP in a large British Caucasian cohort.</p> <p>Methods</p> <p>1372 members of 247 Caucasian families ascertained through a hypertensive proband were genotyped for reported risk variants in <it>STK39 </it>(rs6749447, rs3754777, rs35929607) using Sequenom technology. MERLIN software was used for family-based association testing. <it>Cis</it>-acting influences on expression were assessed <it>in vivo </it>using allelic expression ratios in cDNA from peripheral blood cells in 35 South African individuals heterozygous for a transcribed SNP in <it>STK39 </it>(rs1061471) and quantified by mass spectrometry (Sequenom).</p> <p>Results</p> <p>No significant association was seen between the SNPs tested and systolic or diastolic BP in clinic or ambulatory measurements (all p > 0.05). The tested SNPs were all associated with allelic expression differences in peripheral blood cells (p < 0.05), with the most significant association for the intronic SNP rs6749447 (P = 9.9 × 10^-4). In individuals who were heterozygous for this SNP, on average the G allele showed 13% overexpression compared to the T allele.</p> <p>Conclusions</p> <p><it>STK39 </it>expression is modified by polymorphisms acting in <it>cis </it>and the typed SNPs are associated with allelic expression of this gene, but there is no evidence for an association with BP in a British Caucasian cohort.</p