Another Corn Rootworm Management Tool Fails: Assessing the Status of Western Corn Rootworms Laying Eggs in Soybeans

A variant of western com rootworm that lays eggs in crops other than com was recognized in east-central Illinois as early as 1987 (Steffey et al. 1992), although at the time we believed we were witnessing the phenomenon of extended diapause. Thereafter, the problem with com rootworm larvae damaging com planted after soybean in east-central Illinois and northwestern Indiana increased in frequency and severity during the early 1990s and emerged as a full-blown crisis in 1995. Since then, entomologists throughout the Com Belt have watched warily as the problem spread throughout northern Indiana and into southern Michigan and western Ohio. The spread of the problem westward and northward in Illinois has occurred relatively slowly. However, we annually add counties to the list of counties threatened by the new variant of western corn rootworm

Substrate Activity Screening with Kinases: Discovery of Small‐Molecule Substrate‐Competitive c‐Src Inhibitors

Substrate‐competitive kinase inhibitors represent a promising class of kinase inhibitors, however, there is no methodology to selectively identify this type of inhibitor. Substrate activity screening was applied to tyrosine kinases. By using this methodology, the first small‐molecule substrates for any protein kinase were discovered, as well as the first substrate‐competitive inhibitors of c‐Src with activity in both biochemical and cellular assays. Characterization of the lead inhibitor demonstrates that substrate‐competitive kinase inhibitors possess unique properties, including cellular efficacy that matches biochemical potency and synergy with ATP‐competitive inhibitors. SASsy inhibitors : Small‐molecule substrate‐competitive inhibitors of the tyrosine kinase c‐Src were discovered through the application of substrate activity screening (SAS). Characterization of the lead inhibitor demonstrates that substrate‐competitive kinase inhibitors possess unique properties, including cellular efficacy that matches biochemical potency and synergy with ATP‐competitive inhibitors.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/107499/1/7010_ftp.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/107499/2/anie_201311096_sm_miscellaneous_information.pd

Initial clinical experience with frameless optically guided stereotactic radiosurgery/radiotherapy in pediatric patients

The objective of this study is to report our initial experience treating pediatric patients with central nervous system tumors using a frameless, optically guided linear accelerator. Pediatric patients were selected for treatment after evaluation by a multidisciplinary neuro-oncology team including neurosurgery, neurology, pathology, oncology, and radiation oncology. Prior to treatment, all patients underwent treatment planning using magnetic resonance imaging (MRI) and treatment simulation on a standard computed tomography scanner (CT). For CT simulation, patients were fitted with a customized plastic face mask with a bite block attached to an optical array with four reflective markers. After ensuring adequate reproducibility, these markers were tracked during treatment by an infra-red camera. All treatments were delivered on a Varian Trilogy linear accelerator. The follow-up period ranges from 1–18 months, with a median follow-up of 6 months. Nine patients, ages ranging from 12 to 19 years old (median age 15 years old), with a variety of tumors have been treated. Patients were treated for juvenile pilocytic astrocytoma (JPA; n = 2), pontine low-grade astrocytoma (n = 1), pituitary adenoma (n = 3), metastatic medulloblastoma (n = 1), acoustic neuroma (n = 1), and pineocytoma (n = 1). We followed patients for a median of 12 months (range 3–18 months) with no in-field failures and were able to obtain encouraging toxicity profiles. Frameless stereotactic optically guided radiosurgery and radiotherapy provides a feasible and accurate tool to treat a number of benign and malignant tumors in children with minimal treatment-related morbidity

On Target: 2006 Annual Summary of Field Crop Insect Management Trials

Since its inception in 1984, the University of Illinois Insect Management and Insecticide Evaluation Program has provided the producers of Illinois complete and informative evaluations of registered insecticides and new chemical and transgenic tools for the management of insect pests in Illinois. It is our intention to provide scientifically sound efficacy data to aid the producers of Illinois in their insect pest management decision making.University of Illinois Extension and Department of Crop Science

On Target: 2005 Annual Summary of Field Crop Insect Management Trials

Since its inception in 1984, the University of Illinois Insect Management and Insecticide Evaluation Program has provided the producers of Illinois complete and informative evaluations of registered insecticides and new chemical and transgenic tools for the management of insect pests in Illinois. It is our intention to provide scientifically sound efficacy data to aid the producers of Illinois in their insect pest management decision making.University of Illinois Extension and Department of Crop Science

On Target: 2007 Annual Summary of Field Crop Insect Management Trials

Since its inception in 1984, the University of Illinois Insect Management and Insecticide Evaluation Program has provided the producers of Illinois complete and informative evaluations of registered insecticides and new chemical and transgenic tools for the management of insect pests in Illinois. It is our intention to provide scientifically sound efficacy data to aid the producers of Illinois in their insect pest management decision making.University of Illinois Extension and Department of Crop Science

Comparison of experimental and commercially available granular insecticides to control corn rootworm larvae (Diabrotica spp.) in Illinois, 2008

Annual summary of field crop insect management trials, Department of Crop Services, University of Illinois. Providing accurate and unbiased evaluations of insect control products and management strategies to assist growers in Illinois.University of Illinois Extension and Department of Crop Science

Evaluation of transgenic hybrids and insecticidal seed treatments for control of black cutworm larvae (Agrotis ipsilon) in Illinois, 2008

Annual summary of field crop insect management trials, Department of Crop Services, University of Illinois. Providing accurate and unbiased evaluations of insect control products and management strategies to assist growers in Illinois.University of Illinois Extension and Department of Crop Science