Simulating 0+1 Dimensional Quantum Gravity on Quantum Computers: Mini-Superspace Quantum Cosmology and the World Line Approach in Quantum Field Theory

Quantum computers are a promising candidate to radically expand computational science through increased computing power and more effective algorithms. In particular quantum computing could have a tremendous impact in the field of quantum cosmology. The goal of quantum cosmology is to describe the evolution of the Universe through the Wheeler-DeWitt equation or path integral methods without having to first formulate a full theory of quantum gravity. The quantum computer provides an advantage in this endeavor because it can perform path integrals in Lorentzian space and does not require constructing contour integrations in Euclidean gravity. Also quantum computers can provide advantages in systems with fermions which are difficult to analyze on classical computers. In this study, we first employed classical computational methods to analyze a Friedmann-Robertson-Walker mini-superspace with a scalar field and visualize the calculated wave function of the Universe for a variety of different values of the spatial curvature and cosmological constant. We them used IBM's Quantum Information Science Kit Python library and the variational quantum eigensolver to study the same systems on a quantum computer. The framework can also be extended to the world line approach to quantum field theory.Comment: 5 pages, 4 figure

Evidence for a non-genomic action of testosterone in skeletal muscle which may improve athletic performance: Implications for the female athlete

This review will focus on the proposed second mode of testosterone action (now termed non-genomic) that appears to occur independently of the traditional transcriptional mechanism in mammalian skeletal muscle cells which may enhance skeletal muscle contractile properties. This mechanism of testosterone action differs from the traditional pathway, originating at the cell membrane, having a rapid onset of action, requiring second messengers to execute its effects and is insensitive to inhibitors of traditional androgen receptor action, transcription and protein synthesis. Importantly, unlike the traditional action of testosterone in skeletal muscle, this non-genomic pathway is shown to have a direct acute effect on calcium-dependent components important for the contractile process. The changes within the contractile apparatus may enhance the ability of the muscle to produce explosive power during athletic performance. Rapid increases in Inositol triphosphate mass and calcium release from the sarcoplasmic reticulum have been reported in rodent skeletal muscle cells, and a rapid androgen (dihydrotestosterone)- induced increase in peak force production has been recorded in intact rodent skeletal muscle fibre bundles while showing increases in the activity of the Ras/MAP/ERK mediated pathway. Because the non-genomic action of testosterone is enhanced during increases in exposure to testosterone and is acute in its action, implications for athletic performance are likely greater in females than males due to natural fluctuations in circulating testosterone levels during the female menstrual cycle, reproductive pathology, and changes induced by hormonal contraceptive methods. Research should be undertaken in humans to confirm a pathway for non-genomic testosterone action in human skeletal muscle. Specifically, relationships between testosterone fluctuations and physiological changes within skeletal muscle cells and whole muscle exercise performance need to be examined

A review of cricket fielding requirements

Cricket is played in three formats at elite level: Test, One Day and Twenty20. Fielding is an important component of cricket, as all players are obliged to field. However, there is a paucity of literature on fielding compared with that on batting and bowling. We review the available literature in terms of technical, mental, physiological and physical factors important to fielding, to identify knowledge gaps and better understand the performance requirements of fielding in cricket

The influence of different length between match microcycles on neuromuscular, hormonal and perceptual responses in professional rugby league players

Optimal recovery between matches is critically important in team sports. Indeed, altered neuromuscular performance, hormone levels and increased fatigue can manifest in under recovered team sport athletes. However, the recovery patterns in these variables in the days following professional rugby league matches is unknown. The purpose of this study was to examine the influence of different between-match training periods on neuromuscular, hormonal and perceptual measures in professional rugby league players. Following familiarization, 12 professional rugby league players from the same team were assessed for changes in countermovement jump (CMJ) (force, power, flight time), perceptual responses (fatigue, well being and muscle soreness) and salivary hormone (testosterone (T) and cortisol (C)) levels during 5, 7 and 9 day periods between matches. Measures were taken 4h prior to the initial match, and then 1, 2, 4, 6*, 7*, 8* and 9* days following (*depending on group). All training was prescribed by the coaches and monitored using the session-RPE method. Lower daily training load was completed on the 5-day compared with the 7 and 9-day conditions (p\u3c0.05). Some CMJ variables (flight time and flight time:contraction time), perception of fatigue, well-being and muscle soreness were reduced in the 2 days following the match in each condition (p\u3c0.05). All CMJ variables returned to near baseline values following 4 days in each condition. Both CMJ maximum and relative power were lower in the 7 day condition when compared with the 9 day condition (p\u3c0.05). Fatigue levels were reduced at 48 h in the 7 and 9-day groups (p\u3c0.05) but had returned to baseline in the 5-day group. All perceptual measures returned to baseline levels prior to the following match in each condition and followed changes in training load. Salivary T and C did not change in response to the match. These results show that neuromuscular performance and perception of fatigue are reduced for at least 48 h following a rugby league match but these can be fully recovered within 4 days. CMJ variables involving flight time appear to be best for assessing acute fatigue caused by a match, and variables involving power may be useful in assessing accumulated fatigue. The perceptual measures were sensitive to both acute fatigue and accumulated fatigue. The salivary hormone analyses were of limited value for assessing recovery. These findings show that with correct training, it is possible to recover neuromuscular, perceptual and endocrine measures within 4 days after a rugby league match

Effects of two contrast training programs on jump performance in rugby union players during a competition phase

Purpose: There is little literature comparing contrast training programs typically performed by team-sport athletes within a competitive phase. We compared the effects of two contrast training programs on a range of measures in high-level rugby union players during the competition season. Methods: The programs consisted of a higher volume-load (strength-power) or lower volume-load (speed-power) resistance training; each included a tapering of loading (higher force early in the week, higher velocity later in the week) and was performed twice a week for 4 wk. Eighteen players were assessed for peak power during a bodyweight countermovement jump (BWCMJ), bodyweight squat jump (BWSJ), 50 kg countermovement jump (50CMJ), 50 kg squat jump (50SJ), broad jump (BJ), and reactive strength index (RSI; jump height divided by contact time during a depth jump). Players were then randomized to either training group and were reassessed following the intervention. Inferences were based on uncertainty in outcomes relative to thresholds for standardized changes. Results: There were small between-group differences in favor of strength-power training for mean changes in the 50CMJ (8%; 90% confidence limits, ±8%), 50SJ (8%; ±10%), and BJ (2%; ±3%). Differences between groups for BWCMJ, BWSJ, and reactive strength index were unclear. For most measures there were smaller individual differences in changes with strength-power training. Conclusion: Our findings suggest that high-level rugby union athletes should be exposed to higher volume-load contrast training which includes one heavy lifting session each week for larger and more uniform adaptation to occur in explosive power throughout a competitive phase of the season

Charged Black Holes in Two-Dimensional String Theory

We discuss two dimensional string theories containing gauge fields introduced either via coupling to open strings, in which case we get a Born-Infeld type action, or via heterotic compactification. The solutions to the modified background field equations are charged black holes which exhibit interesting space-time geometries. We also compute their masses and charges.Comment: 39 page

Novel Approaches to Visualization and Data Mining Reveals Diagnostic Information in the Low Amplitude Region of Serum Mass Spectra from Ovarian Cancer Patients

The ability to identify patterns of diagnostic signatures in proteomic data generated by high throughput mass spectrometry (MS) based serum analysis has recently generated much excitement and interest from the scientific community. These data sets can be very large, with high-resolution MS instrumentation producing 1-2 million data points per sample. Approaches to analyze mass spectral data using unsupervised and supervised data mining operations would greatly benefit from tools that effectively allow for data reduction without losing important diagnostic information. In the past, investigators have proposed approaches where data reduction is performed by a priori peak picking and alignment/warping/smoothing components using rule-based signal-to-noise measurements. Unfortunately, while this type of system has been employed for gene microarray analysis, it is unclear whether it will be effective in the analysis of mass spectral data, which unlike microarray data, is comprised of continuous measurement operations. Moreover, it is unclear where true signal begins and noise ends. Therefore, we have developed an approach to MS data analysis using new types of data visualization and mining operations in which data reduction is accomplished by culling via the intensity of the peaks themselves instead of by location. Applying this new analysis method on a large study set of high resolution mass spectra from healthy and ovarian cancer patients, shows that all of the diagnostic information is contained within the very lowest amplitude regions of the mass spectra. This region can then be selected and studied to identify the exact location and amplitude of the diagnostic biomarkers

Finite Black Hole Entropy and String Theory

An accelerating observer sees a thermal bath of radiation at the Hawking temperature which is proportional to the acceleration. Also, in string theory there is a Hagedorn temperature beyond which one cannot go without an infinite amount of energy. Several authors have shown that in the context of Hawking radiation a limiting temperature for string theory leads to a limiting acceleration, which for a black hole implies a minimum distance from the horizon for an observer to remain stationary. We argue that this effectively introduces a cutoff in Rindler space or the Schwarzschild geometry inside of which accelerations would exceed this maximum value. Furthermore, this natural cutoff in turn allows one to define a finite entropy for Rindler space or a black hole as all divergences were occurring on the horizon. In all cases if a particular relationship exists between Newton's constant and the string tension then the entropy of the string modes agrees with the Bekenstein-Hawking formula.Comment: 17 pages, 1 figure, Florida Preprint UFIFT-HEP-94-0

Factors influencing overweight children's commencement of and continuation in a resistance training program

<p>Abstract</p> <p>Background</p> <p>In light of the child overweight and obesity problem in Australia, resistance training programs have been trialled as an innovative way of assisting children increase lean body mass and reduce body fat. The purpose of this study was to investigate the factors influencing overweight children's participation in a resistance training trial program.</p> <p>Method</p> <p>Parent-child pairs who participated in the trial program were invited to take part in a follow-up individual interview to discuss their program experiences. In total, 22 semi-structured interviews were conducted with 11 parent-child pairs.</p> <p>Results</p> <p>The factors found to be most relevant to program commencement among parents were a desire for their child to lose weight and gain confidence, the proximity of the venue, and no cost for participation. For children, the most relevant factors were the opportunity to build strength and improve fitness and having supportive parents who facilitated program initiation. The factors most relevant to continuation for parents were the quality of the program management, being able to stay for the sessions, the child's improved weight status, coordination, and confidence, and no cost for participation. Weight loss and improved confidence were also motivators for continuation among the children, along with pleasant social interaction with peers and trainers and ongoing parental support.</p> <p>Conclusion</p> <p>Different factors variably influence program commencement and program continuation in both parents and children. This has important implications for future interventions that aim to successfully recruit and retain intervention participants.</p

Effect of natalizumab on disease progression in secondary progressive multiple sclerosis (ASCEND). a phase 3, randomised, double-blind, placebo-controlled trial with an open-label extension

Background: Although several disease-modifying treatments are available for relapsing multiple sclerosis, treatment effects have been more modest in progressive multiple sclerosis and have been observed particularly in actively relapsing subgroups or those with lesion activity on imaging. We sought to assess whether natalizumab slows disease progression in secondary progressive multiple sclerosis, independent of relapses. Methods: ASCEND was a phase 3, randomised, double-blind, placebo-controlled trial (part 1) with an optional 2 year open-label extension (part 2). Enrolled patients aged 18–58 years were natalizumab-naive and had secondary progressive multiple sclerosis for 2 years or more, disability progression unrelated to relapses in the previous year, and Expanded Disability Status Scale (EDSS) scores of 3·0–6·5. In part 1, patients from 163 sites in 17 countries were randomly assigned (1:1) to receive 300 mg intravenous natalizumab or placebo every 4 weeks for 2 years. Patients were stratified by site and by EDSS score (3·0–5·5 vs 6·0–6·5). Patients completing part 1 could enrol in part 2, in which all patients received natalizumab every 4 weeks until the end of the study. Throughout both parts, patients and staff were masked to the treatment received in part 1. The primary outcome in part 1 was the proportion of patients with sustained disability progression, assessed by one or more of three measures: the EDSS, Timed 25-Foot Walk (T25FW), and 9-Hole Peg Test (9HPT). The primary outcome in part 2 was the incidence of adverse events and serious adverse events. Efficacy and safety analyses were done in the intention-to-treat population. This trial is registered with ClinicalTrials.gov, number NCT01416181. Findings: Between Sept 13, 2011, and July 16, 2015, 889 patients were randomly assigned (n=440 to the natalizumab group, n=449 to the placebo group). In part 1, 195 (44%) of 439 natalizumab-treated patients and 214 (48%) of 448 placebo-treated patients had confirmed disability progression (odds ratio [OR] 0·86; 95% CI 0·66–1·13; p=0·287). No treatment effect was observed on the EDSS (OR 1·06, 95% CI 0·74–1·53; nominal p=0·753) or the T25FW (0·98, 0·74–1·30; nominal p=0·914) components of the primary outcome. However, natalizumab treatment reduced 9HPT progression (OR 0·56, 95% CI 0·40–0·80; nominal p=0·001). In part 1, 100 (22%) placebo-treated and 90 (20%) natalizumab-treated patients had serious adverse events. In part 2, 291 natalizumab-continuing patients and 274 natalizumab-naive patients received natalizumab (median follow-up 160 weeks [range 108–221]). Serious adverse events occurred in 39 (13%) patients continuing natalizumab and in 24 (9%) patients initiating natalizumab. Two deaths occurred in part 1, neither of which was considered related to study treatment. No progressive multifocal leukoencephalopathy occurred. Interpretation: Natalizumab treatment for secondary progressive multiple sclerosis did not reduce progression on the primary multicomponent disability endpoint in part 1, but it did reduce progression on its upper-limb component. Longer-term trials are needed to assess whether treatment of secondary progressive multiple sclerosis might produce benefits on additional disability components. Funding: Biogen