Eddington-limited X-ray Bursts as Distance Indicators. I. Systematic Trends and Spherical Symmetry in Bursts from 4U 1728-34

We investigate the limitations of thermonuclear X-ray bursts as a distance indicator for the weakly-magnetized accreting neutron star 4U 1728-34. We measured the unabsorbed peak flux of 81 bursts in public data from the Rossi X-Ray Timing Explorer (RXTE). The distribution of peak fluxes was bimodal: 66 bursts exhibited photospheric radius expansion and were distributed about a mean bolometric flux of 9.2e-8 erg/cm^2/s, while the remaining (non-radius expansion) bursts reached 4.5e-8 erg/cm^2/s, on average. The peak fluxes of the radius-expansion bursts were not constant, exhibiting a standard deviation of 9.4% and a total variation of 46%. These bursts showed significant correlations between their peak flux and the X-ray colors of the persistent emission immediately prior to the burst. We also found evidence for quasi-periodic variation of the peak fluxes of radius-expansion bursts, with a time scale of approximately 40 d. The persistent flux observed with RXTE/ASM over 5.8 yr exhibited quasi-periodic variability on a similar time scale. We suggest that these variations may have a common origin in reflection from a warped accretion disk. Once the systematic variation of the peak burst fluxes is subtracted, the residual scatter is only approximately 3%, roughly consistent with the measurement uncertainties. The narrowness of this distribution strongly suggests that i) the radiation from the neutron star atmosphere during radius-expansion episodes is nearly spherically symmetric, and ii) the radius-expansion bursts reach a common peak flux which may be interpreted as a standard candle intensity.Adopting the minimum peak flux for the radius-expansion bursts as the Eddington flux limit, we derive a distance for the source of 4.4-4.8 kpc.Comment: 9 pages, 7 figures, accepted by ApJ. Minor referee's revisions, also includes 9 newly public X-ray burst

An Approximation for the rp-Process

Hot (explosive) hydrogen burning or the Rapid Proton Capture Process (rp-process) occurs in a number of astrophysical environments. Novae and X-ray bursts are the most prominent ones, but accretion disks around black holes and other sites are candidates as well. The expensive and often multidimensional hydro calculations for such events require an accurate prediction of the thermonuclear energy generation, while avoiding full nucleosynthesis network calculations. In the present investigation we present an approximation scheme applicable in a temperature range which covers the whole range of all presently known astrophysical sites. It is based on the concept of slowly varying hydrogen and helium abundances and assumes a kind of local steady flow by requiring that all reactions entering and leaving a nucleus add up to a zero flux. This scheme can adapt itself automatically and covers situations at low temperatures, characterized by a steady flow of reactions, as well as high temperature regimes where a $(p,\gamma)-(\gamma,p)$-equilibrium is established. In addition to a gain of a factor of 15 in computational speed over a full network calculation, and an energy generation accurate to more than 15 %, this scheme also allows to predict correctly individual isotopic abundances. Thus, it delivers all features of a full network at a highly reduced cost and can easily be implemented in hydro calculations.Comment: 18 pages, LaTeX using astrobib and aas2pp4, includes PostScript figures; Astrophysical Journal, in press. PostScript source also available at http://quasar.physik.unibas.ch/preps.htm

20th Annual UD International Tea Scheduled

News release announces the 20th Annual International Tea at the University of Dayton with the theme Where In The World Are You

SUPPORT Tools for evidence-informed health Policymaking (STP) 4: Using research evidence to clarify a problem

This article is part of a series written for people responsible for making decisions about health policies and programmes and for those who support these decision makers

A Cure for HIV Infection: "Not in My Lifetime" or "Just Around the Corner"?

With the advent and stunning success of combination antiretroviral therapy (ART) to prolong and improve quality of life for persons with HIV infection, HIV research has been afforded the opportunity to pivot towards studies aimed at finding "a cure." The mere idea that cure of HIV might be possible has energized researchers and the community towards achieving this goal. Funding agencies, both governmental and private, have targeted HIV cure as a high priority; many in the field have responded to these initiatives and the cure research agenda is robust. In this "salon" two editors of Pathogens and Immunity, Michael Lederman and Daniel Douek ask whether curing HIV is a realistic, scalable objective. We start with an overview perspective and have asked a number of prominent HIV researchers to add to the discussion

SUPPORT Tools for evidence-informed health Policymaking (STP) 5: Using research evidence to frame options to address a problem

This article is part of a series written for people responsible for making decisions about health policies and programmes and for those who support these decision makers

Asymmetric WIMP dark matter

In existing dark matter models with global symmetries the relic abundance of dark matter is either equal to that of anti-dark matter (thermal WIMP), or vastly larger, with essentially no remaining anti-dark matter (asymmetric dark matter). By exploring the consequences of a primordial asymmetry on the coupled dark matter and anti-dark matter Boltzmann equations we find large regions of parameter space that interpolate between these two extremes. Interestingly, this new asymmetric WIMP framework can accommodate a wide range of dark matter masses and annihilation cross sections. The present-day dark matter population is typically asymmetric, but only weakly so, such that indirect signals of dark matter annihilation are not completely suppressed. We apply our results to existing models, noting that upcoming direct detection experiments will constrain a large region of the relevant parameter space.Comment: 32 pages, 6 figures, updated references, updated XENON100 bounds, typo in figure caption correcte

D-cycloserine augmentation of exposure-based cognitive behavior therapy for anxiety, obsessive-compulsive, and posttraumatic stress disorders: a systematic review and meta-analysis of individual participant data

Importance: Whether and under which conditions D-cycloserine (DCS) augments the effects of exposure-based cognitive behavior therapy for anxiety, obsessive-compulsive, and posttraumatic stress disorders is unclear. Objective: To clarify whether DCS is superior to placebo in augmenting the effects of cognitive behavior therapy for anxiety, obsessive-compulsive, and posttraumatic stress disorders and to evaluate whether antidepressants interact with DCS and the effect of potential moderating variables. Data Sources: PubMed, EMBASE, and PsycINFO were searched from inception to February 10, 2016. Reference lists of previous reviews and meta-analyses and reports of randomized clinical trials were also checked. Study Selection: Studies were eligible for inclusion if they were (1) double-blind randomized clinical trials of DCS as an augmentation strategy for exposure-based cognitive behavior therapy and (2) conducted in humans diagnosed as having specific phobia, social anxiety disorder, panic disorder with or without agoraphobia, obsessive-compulsive disorder, or posttraumatic stress disorder. Data Extraction and Synthesis: Raw data were obtained from the authors and quality controlled. Data were ranked to ensure a consistent metric across studies (score range, 0-100). We used a 3-level multilevel model nesting repeated measures of outcomes within participants, who were nested within studies. Results: Individual participant data were obtained for 21 of 22 eligible trials, representing 1047 of 1073 eligible participants. When controlling for antidepressant use, participants receiving DCS showed greater improvement from pretreatment to posttreatment (mean difference, -3.62; 95% CI, -0.81 to -6.43; P = .01; d = -0.25) but not from pretreatment to midtreatment (mean difference, -1.66; 95% CI, -4.92 to 1.60; P = .32; d = -0.14) or from pretreatment to follow-up (mean difference, -2.98, 95% CI, -5.99 to 0.03; P = .05; d = -0.19). Additional analyses showed that participants assigned to DCS were associated with lower symptom severity than those assigned to placebo at posttreatment and at follow-up. Antidepressants did not moderate the effects of DCS. None of the prespecified patient-level or study-level moderators was associated with outcomes. Conclusions and Relevance: D-cycloserine is associated with a small augmentation effect on exposure-based therapy. This effect is not moderated by the concurrent use of antidepressants. Further research is needed to identify patient and/or therapy characteristics associated with DCS response.2018-05-0

Interpersonal Arrogance and the Incentive Salience of Power <i>Versus</i> Affiliation Cues

The arrogance dimension of the circumplex contrasts people who seemingly value power over affiliation (high arrogance) versus those who do not (low arrogance). Following this line of thinking, and building on an incentive salience model of approach motivation, three studies (total N = 284) examined the differential processing of power versus affiliation stimuli in categorization, perception and approach–avoidance paradigms. All studies found interactions of the same type. In study 2, for example, people high in arrogance perceived power stimuli to be larger than affiliation stimuli, but this differential pattern was not evident at low arrogance levels. People high, but not low, in arrogance also approached power stimuli faster than affiliation stimuli in a motor movement task (study 3). The results contribute to a process–based understanding of how interpersonal arrogance functions while linking such differences to the manner in which power versus affiliation cues are perceived and reacted to. Copyright © 2014 European Association of Personality Psychology </jats:p

Pharmacokinetics of Teriparatide (rhPTH[1–34]) and Calcium Pharmacodynamics in Postmenopausal Women with Osteoporosis

Teriparatide (rhPTH[1–34]) affects calcium metabolism in a pattern consistent with the known actions of endogenous parathyroid hormone (PTH). This report describes the pharmacokinetics and resulting serum calcium response to teriparatide in postmenopausal women with osteoporosis. Pharmacokinetic samples for this analysis were obtained from 360 women who participated in the Fracture Prevention Trial. Postmenopausal women with osteoporosis received daily subcutaneous injections of either teriparatide 20 μg (4.86 μmol) or placebo, median 21 months’ treatment. Serum teriparatide and calcium concentrations were measured throughout the study. An indirect-response model was developed to describe the pharmacokinetic–pharmacodynamic relationship between teriparatide concentrations and serum calcium response. The pharmacokinetics of teriparatide were characterized by rapid absorption (maximum concentration achieved within 30 min) and rapid elimination (half-life of 1 h), resulting in a total duration of exposure to the peptide of approximately 4 h. Teriparatide transiently increased serum calcium, with the maximum effect observed at approximately 4.25 h (median increase 0.4 mg/dl [0.1 mmol/l]). Calcium concentrations returned to predose levels by 16–24 h after each dose. Persistent hypercalcemia was not observed; one teriparatide 20 μg-treated patient had a predose serum calcium value above the normal range but <11.0 mg/dl (2.75 mmol/l). Following once-daily subcutaneous administration, teriparatide produces a modest but transient increase in serum calcium, consistent with the known effects of endogenous PTH on mineral metabolism. The excursion in serum calcium is brief, due to the short length of time that teriparatide concentrations are elevated