Community Advanced Data and Research Analysis: A Mixed Methods Capstone Project

The Community Advanced Data and Research Analysis project, or CADRA, is project that houses an interdisciplinary research team located at the University of Nevada, Las Vegas. The vision of CADRA, as defined by its stakeholders, is to create positive community outcomes by encouraging and engaging nonprofit organizations, as well as student and professional researchers, to develop and evolve their data management practices. CADRA offers three program options including Nonprofit Audits, Program Development and Grant Writing, and Community Data Mining. The purpose of this program evaluation will be to evaluate the Community Advanced Data and Research Analysis (CADRA) Project, with a specific assessment of their access and obtainability to data in the Las Vegas community

Personalising laboratory medicine in the ‘real world’:assessing clinical utility, by clinical indication, of serum total B12 and Active-B12® (holotranscobalamin) in the diagnosis of vitamin B12 deficiency

BACKGROUND: Assessing the pre- and post-test probability of disease in the context of routine health care is challenging. We wished to study how test performance parameters relating to clinical utility vary by clinical indication in a ‘real-world’ setting. METHODS: The diagnostic accuracy of serum total B(12) and Active-B(12)® (holotranscobalamin) was evaluated in a primary care population, using serum methylmalonic acid as the reference standard. We used electronic requesting to establish the clinical indication for each request. Routine requests from primary care for serum total B(12) were included if creatinine was also measured and estimated glomerular filtration rate was at least 60 mL/min/1.73 m(2). RESULTS: Clinical indications included peripheral neuropathy (n = 168), anaemia (n = 168), cognitive decline (n = 125), suspected dietary deficiency (n = 76), other (n = 362). For peripheral neuropathy, the area under the receiver operator curve ± 95% confidence interval (AUC ± CI) was 0.63 (0.54–0.71) (P = 0.002) for total B(12) and 0.68 (0.60–0.77) (P < 0.0001) for Active-B(12)®. For anaemia, AUC ± CI was 0.56 (0.47–0.66) (P = 0.10) for total B(12) and 0.69 (0.59–0.78) (P < 0.0001) for Active-B(12)®. For cognitive decline, AUC ± CI was 0.54 (0.43–0.65) (P = 0.26) for total B(12) and 0.69 (0.58–0.80) (P = 0.0002) for Active-B(12)®. The pre–post-test change in probability of disease varied by clinical indication. CONCLUSION: Combining diagnostic accuracy studies and electronic testing in a ‘real-world’ setting allows clinical utility to be assessed by clinical indication. Wider application of this would permit more personalised laboratory medicine. In this study, diagnostic performance of total B(12) and Active-B(12)® varied across all indications. Active-B(12)® provided better discrimination, but this may have reflected the cut-offs used

The Grizzly, April 29, 2004

As the School Years Ends, The Search for Jobs Begins • Life-Changing Volunteer Work Found At the Clinic • Fad Diets: Do They Work? • Opinions: Chronic Back Pain: Ouch!; Lacking Luster (Again) at La Fontana; Is Donald Trump the Ideal Boss?; Eating Your Veggies Now More Appetizing than Mom Tried to Make it • Staff Spotlight: Jamal Elliot • Ursinus Students Put Learning Into Practice at Model U.N. • Goldwater Scholar Kari Baker • Softball Team Rolls Past Muhlenberg • Leadership: A Key Ingredient in the Success of the Men\u27s Baseball Team • Final Exam Schedulehttps://digitalcommons.ursinus.edu/grizzlynews/1561/thumbnail.jp

The Grizzly, April 8, 2004

Students Find a New Way to Connect • Democrats Club Active in Upcoming Elections • Ursinus and USGA: Who We Are • The 9/11 Investigation: Rice vs. Clarke • Opinions: Unhappy Happy Hour ; UC Chess Tournament; Dine Like the Irish at Kildare\u27s • Student Spotlight: Sarah Kauffman Exposed • Save the Speaker\u27s House • Pew Lecture: Peter Rose Hypnotizes Students with his Work • Young Nucleus Coming Together for UC Men\u27s Lacrosse • Women\u27s Lacrosse Working to Keep Season Alive • Women\u27s Rugby Hanging in Toughhttps://digitalcommons.ursinus.edu/grizzlynews/1558/thumbnail.jp

The Grizzly, February 12, 2004

Spread of Deadly Bird Flu Sparks Fear • Ursinus Club Spotlight: UC Forensics Team is Gaining Recognition Quickly • Buddhist Monks Visit UC • Fellowships Worth up to $24,000 Available for Future Teachers • Opinions: Graduation: Light at the End of the Tunnel or End of the Road?; Janet\u27s Super-boob Incident; Bahama Breeze: Taste of a Caribbean Spring Break; Icy Issues in Letters to the Editor • Stanton Drops 55 Points • Show Me the Money: Should College Athletes be Paid?https://digitalcommons.ursinus.edu/grizzlynews/1553/thumbnail.jp

Antenatal Determinants of Bronchopulmonary Dysplasia and Late Respiratory Disease in Preterm Infants

RATIONALE: Mechanisms contributing to chronic lung disease after preterm birth are incompletely understood. OBJECTIVES: To identify antenatal risk factors associated with increased risk for bronchopulmonary dysplasia (BPD) and respiratory disease during early childhood after preterm birth, we performed a prospective, longitudinal study of 587 preterm infants with gestational age less than 34 weeks and birth weights between 500 and 1,250 g. METHODS: Data collected included perinatal information and assessments during the neonatal intensive care unit admission and longitudinal follow-up by questionnaire until 2 years of age. MEASUREMENTS AND MAIN RESULTS: After adjusting for covariates, we found that maternal smoking prior to preterm birth increased the odds of having an infant with BPD by twofold (P = 0.02). Maternal smoking was associated with prolonged mechanical ventilation and respiratory support during the neonatal intensive care unit admission. Preexisting hypertension was associated with a twofold (P = 0.04) increase in odds for BPD. Lower gestational age and birth weight z-scores were associated with BPD. Preterm infants who were exposed to maternal smoking had higher rates of late respiratory disease during childhood. Twenty-two percent of infants diagnosed with BPD and 34% of preterm infants without BPD had no clinical signs of late respiratory disease during early childhood. CONCLUSIONS: We conclude that maternal smoking and hypertension increase the odds for developing BPD after preterm birth, and that maternal smoking is strongly associated with increased odds for late respiratory morbidities during early childhood. These findings suggest that in addition to the BPD diagnosis at 36 weeks, other factors modulate late respiratory outcomes during childhood. We speculate that measures to reduce maternal smoking not only will lower the risk for preterm birth but also will improve late respiratory morbidities after preterm birth

The Grizzly, February 19, 2004

Campus Safety and S.E.R.V. to Sponsor Lecture at Ursinus College • Ursinus Club Spotlight: Campus Activities Board • Impress Recruiters at the 2004 Ursinus College Job & Internship Fair • Sign the Beam! • Opinions: Ridiculous Reality TV; Sid\u27s: Good Food Close to Campus; Words of Love • UC Grad on Tour with Globetrotters • Men\u27s Basketball Continues to Roll • Gymnastics Team Breaks Four Recordshttps://digitalcommons.ursinus.edu/grizzlynews/1554/thumbnail.jp

The Grizzly, April 22, 2004

A Booming Economy Gives Way to a Promising Job Outlook • Spotlights on 2004 Salutatorians: Jacqueline Carrick and Quinn Dinsmore • Politics in Action: Photo Essay • Opinions: Business Degree = Job?; Cool Defined; Condoleeza Rice: Truth or Cover-up? • Student Spotlight: Nicole Borocci Making Headlines • New Play to Open this Week • Spring Fling 2004 • Skinner Dominating Centennial Conference • Herrmann, Bown Rack up CC Baseball Honorshttps://digitalcommons.ursinus.edu/grizzlynews/1560/thumbnail.jp

Convocation

List of performers and performances