6,640 research outputs found
Farm Level Risk Assessment Using Downside Risk Measures
Recent and presumable future developments tend to increase the risk associated with farming activities. This causes an increasing importance of risk management. Farmers have a wide variety of possibilities to influence the risk exposure of their operations. Among them are the choice of the production program as well as marketing activities including forward pricing and hedging with futures and options. In total all these opportunities comprise a portfolio of activities which must be selected as to match the resources of the farm as well as the farmer's attitudes towards risk. The paper addresses this issue using a whole farm stochastic optimisation approach based on a risk-value framework. The paper starts with a discussion of risk-value models and the relationship between them and the expected utility hypothesis. In the second part the approach is incorporated in a whole farm model that optimizes a portfolio of production activities and risk management instruments. A case study is used to analyse the possibilities and limitations of the approach and to illustrate the effects of yield and production risk on decision making.downside risk, risk management, risk measure, risk-value models, stochastic optimisation, Risk and Uncertainty,
Adaptive evolution of transcription factor binding sites
The regulation of a gene depends on the binding of transcription factors to
specific sites located in the regulatory region of the gene. The generation of
these binding sites and of cooperativity between them are essential building
blocks in the evolution of complex regulatory networks. We study a theoretical
model for the sequence evolution of binding sites by point mutations. The
approach is based on biophysical models for the binding of transcription
factors to DNA. Hence we derive empirically grounded fitness landscapes, which
enter a population genetics model including mutations, genetic drift, and
selection. We show that the selection for factor binding generically leads to
specific correlations between nucleotide frequencies at different positions of
a binding site. We demonstrate the possibility of rapid adaptive evolution
generating a new binding site for a given transcription factor by point
mutations. The evolutionary time required is estimated in terms of the neutral
(background) mutation rate, the selection coefficient, and the effective
population size. The efficiency of binding site formation is seen to depend on
two joint conditions: the binding site motif must be short enough and the
promoter region must be long enough. These constraints on promoter architecture
are indeed seen in eukaryotic systems. Furthermore, we analyse the adaptive
evolution of genetic switches and of signal integration through binding
cooperativity between different sites. Experimental tests of this picture
involving the statistics of polymorphisms and phylogenies of sites are
discussed.Comment: published versio
Jumping Through Loops: On Soft Terms from Large Volume Compactifications
We subject the phenomenologically successful large volume scenario of
hep-th/0502058 to a first consistency check in string theory. In particular, we
consider whether the expansion of the string effective action is consistent in
the presence of D-branes and O-planes. Due to the no-scale structure at
tree-level, the scenario is surprisingly robust. We compute the modification of
soft supersymmetry breaking terms, and find only subleading corrections. We
also comment that for large-volume limits of toroidal orientifolds and fibered
Calabi-Yau manifolds the corrections can be more important, and we discuss
further checks that need to be performed.Comment: 57 page
SEE Test and Data Analysis for Complex FPGA Systems
Critical space applications require knowledge of single event upset (SEU) susceptibility (mission survivability). Generic SEU test and analysis techniques do not provide adequate data for survivability analysis. This presentation provides information on how to: (1) Investigate (test for) SEU susceptibilities of tactical (mission specific) designs that are implemented in a SRAM-based FPGA; and (2) Analyze SEU cross-sections for use in survivability prediction
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