Understanding decreases in land relative humidity with global warming: conceptual model and GCM simulations

Climate models simulate a strong land-ocean contrast in the response of near-surface relative humidity to global warming: relative humidity tends to increase slightly over oceans but decrease substantially over land. Surface energy balance arguments have been used to understand the response over ocean but are difficult to apply over more complex land surfaces. Here, a conceptual box model is introduced, involving moisture transport between the land and ocean boundary layers and evapotranspiration, to investigate the decreases in land relative humidity as the climate warms. The box model is applied to idealized and full-complexity (CMIP5) general circulation model simulations, and it is found to capture many of the features of the simulated changes in land relative humidity. The box model suggests there is a strong link between fractional changes in specific humidity over land and ocean, and the greater warming over land than ocean then implies a decrease in land relative humidity. Evapotranspiration is of secondary importance for the increase in specific humidity over land, but it matters more for the decrease in relative humidity. Further analysis shows there is a strong feedback between changes in surface-air temperature and relative humidity, and this can amplify the influence on relative humidity of factors such as stomatal conductance and soil moisture.Comment: Submitted to Journal of Climate on May 1st, 201

Anderson Localization of Classical Waves in Weakly Scattering Metamaterials

We study the propagation and localization of classical waves in one-dimensional disordered structures composed of alternating layers of left- and right-handed materials (mixed stacks) and compare them to the structures composed of different layers of the same material (homogeneous stacks). For weakly scattering layers, we have developed an effective analytical approach and have calculated the transmission length within a wide region of the input parameters. When both refractive index and layer thickness of a mixed stack are random, the transmission length in the long-wave range of the localized regime exhibits a quadratic power wavelength dependence with the coefficients different for mixed and homogeneous stacks. Moreover, the transmission length of a mixed stack differs from reciprocal of the Lyapunov exponent of the corresponding infinite stack. In both the ballistic regime of a mixed stack and in the near long-wave region of a homogeneous stack, the transmission length of a realization is a strongly fluctuating quantity. In the far long-wave part of the ballistic region, the homogeneous stack becomes effectively uniform and the transmission length fluctuations are weaker. The crossover region from the localization to the ballistic regime is relatively narrow for both mixed and homogeneous stacks. In mixed stacks with only refractive-index disorder, Anderson localization at long wavelengths is substantially suppressed, with the localization length growing with the wavelength much faster than for homogeneous stacks. The crossover region becomes essentially wider and transmission resonances appear only in much longer stacks. All theoretical predictions are in an excellent agreement with the results of numerical simulations.Comment: 19 pages, 16 figures, submitted to PR

Modes of Random Lasers

In conventional lasers, the optical cavity that confines the photons also determines essential characteristics of the lasing modes such as wavelength, emission pattern, ... In random lasers, which do not have mirrors or a well-defined cavity, light is confined within the gain medium by means of multiple scattering. The sharp peaks in the emission spectra of semiconductor powders, first observed in 1999, has therefore lead to an intense debate about the nature of the lasing modes in these so-called lasers with resonant feedback. In this paper, we review numerical and theoretical studies aimed at clarifying the nature of the lasing modes in disordered scattering systems with gain. We will discuss in particular the link between random laser modes near threshold (TLM) and the resonances or quasi-bound (QB) states of the passive system without gain. For random lasers in the localized regime, QB states and threshold lasing modes were found to be nearly identical within the scattering medium. These studies were later extended to the case of more lossy systems such as random systems in the diffusive regime where differences between quasi-bound states and lasing modes were measured. Very recently, a theory able to treat lasers with arbitrarily complex and open cavities such as random lasers established that the TLM are better described in terms of the so-called constant-flux states.Comment: Review paper submitted to Advances in Optics and Photonic

Mucin 1 (MUC1) is a novel partner for MAL2 in breast carcinoma cells

Background: The MAL2 gene, encoding a four-transmembrane protein of the MAL family, is amplified and overexpressed in breast and other cancers, yet the significance of this is unknown. MAL-like proteins have trafficking functions, but their molecular roles are largely obscure, partly due to a lack of known binding partners

Effects of polarization on the transmission and localization of classical waves in weakly scattering metamaterials

We summarize the results of our comprehensive analytical and numerical studies of the effects of polarization on the Anderson localization of classical waves in one-dimensional random stacks. We consider homogeneous stacks composed entirely of normal materials or metamaterials, and also mixed stacks composed of alternating layers of a normal material and metamaterial. We extend the theoretical study developed earlier for the case of normal incidence [A. A. Asatryan et al, Phys. Rev. B 81, 075124 (2010)] to the case of off-axis incidence. For the general case where both the refractive indices and layer thicknesses are random, we obtain the long-wave and short-wave asymptotics of the localization length over a wide range of incidence angles (including the Brewster ``anomaly'' angle). At the Brewster angle, we show that the long-wave localization length is proportional to the square of the wavelength, as for the case of normal incidence, but with a proportionality coefficient substantially larger than that for normal incidence. In mixed stacks with only refractive-index disorder, we demonstrate that p-polarized waves are strongly localized, while for s-polarization the localization is substantially suppressed, as in the case of normal incidence. In the case of only thickness disorder, we study also the transition from localization to delocalization at the Brewster angle.Comment: 15 pages, 11 figures, accepted for publication in PR

Astrochemical Modeling of Propargyl Radical Chemistry in TMC-1

Recent detections of aromatic species in dark molecular clouds suggest formation pathways may be efficient at very low temperatures and pressures, yet current astrochemical models are unable to account for their derived abundances, which can often deviate from model predictions by several orders of magnitude. The propargyl radical, a highly abundant species in the dark molecular cloud TMC- 1, is an important aromatic precursor in combustion flames and possibly interstellar environments. We performed astrochemical modeling of TMC-1 using the three-phase gas-grain code NAUTILUS and an updated chemical network, focused on refining the chemistry of the propargyl radical and related species. The abundance of the propargyl radical has been increased by half an order of magnitude compared to the previous GOTHAM network. This brings it closer in line with observations, but it remains underestimated by two orders of magnitude compared to its observed value. Predicted abundances for the chemically related C4H3N isomers within an order of magnitude of observed values corroborate the high efficiency of CN addition to closed-shell hydrocarbons under dark molecular cloud conditions. The results of our modeling provide insight into the chemical processes of the propargyl radical in dark molecular clouds and highlight the importance of resonance-stabilized radicals in PAH formation.Comment: 31 pages and 17 figures (including the appendix), accepted for publication in The Astrophysical Journa

DRP-1 is required for BH3 mimetic-mediated mitochondrial fragmentation and apoptosis

The concept of using BH3 mimetics as anticancer agents has been substantiated by the efficacy of selective drugs, such as Navitoclax and Venetoclax, in treating BCL-2-dependent haematological malignancies. However, most solid tumours depend on MCL-1 for survival, which is highly amplified in multiple cancers and a major factor determining chemoresistance. Most MCL-1 inhibitors that have been generated so far, while demonstrating early promise in vitro, fail to exhibit specificity and potency in a cellular context. To address the lack of standardised assays for benchmarking the in vitro binding of putative inhibitors before analysis of their cellular effects, we developed a rapid differential scanning fluorimetry (DSF)-based assay, and used it to screen a panel of BH3 mimetics. We next contrasted their binding signatures with their ability to induce apoptosis in a MCL-1 dependent cell line. Of all the MCL-1 inhibitors tested, only A-1210477 induced rapid, concentration-dependent apoptosis, which strongly correlated with a thermal protective effect on MCL-1 in the DSF assay. In cells that depend on both MCL-1 and BCL-XL, A-1210477 exhibited marked synergy with A-1331852, a BCL-XL specific inhibitor, to induce cell death. Despite this selectivity and potency, A-1210477 induced profound structural changes in the mitochondrial network in several cell lines that were not phenocopied following MCL-1 RNA interference or transcriptional repression, suggesting that A-1210477 induces mitochondrial fragmentation in an MCL-1-independent manner. However, A-1210477-induced mitochondrial fragmentation was dependent upon DRP-1, and silencing expression levels of DRP-1 diminished not just mitochondrial fragmentation but also BH3 mimetic-mediated apoptosis. These findings provide new insights into MCL-1 ligands, and the interplay between DRP-1 and the anti-apoptotic BCL-2 family members in the regulation of apoptosis