Fast High Resolution Echelle Spectroscopy Of A Laboratory Plasma

An echelle diffraction grating and a multianode photomultiplier tube are paired to construct a high resolution (R=lambda/delta lambda approximate to 2.5x10(4)) spectrograph with fast time response for use from the UV through the visible. This instrument has analyzed the line shape of C III impurity ion emission at 229.687 nm over the lifetime (approximate to 100 mu s) of the hydrogen plasmas produced at SSX. The ion temperature and line of sight average velocity are inferred from the observed thermal broadening and Doppler shift of the line. The time resolution of these measurements is about 1 mu s, sufficient to observe the fastest magnetohydrodynamic activity

Mechanisms of action of hESC-secreted proteins that enhance human and mouse myogenesis.

Adult stem cells grow poorly in vitro compared to embryonic stem cells, and in vivo stem cell maintenance and proliferation by tissue niches progressively deteriorates with age. We previously reported that factors produced by human embryonic stem cells (hESCs) support a robust regenerative capacity for adult and old mouse muscle stem/progenitor cells. Here we extend these findings to human muscle progenitors and investigate underlying molecular mechanisms. Our results demonstrate that hESC-conditioned medium enhanced the proliferation of mouse and human muscle progenitors. Furthermore, hESC-produced factors activated MAPK and Notch signaling in human myogenic progenitors, and Delta/Notch-1 activation was dependent on MAPK/pERK. The Wnt, TGF-β and BMP/pSmad1,5,8 pathways were unresponsive to hESC-produced factors, but BMP signaling was dependent on intact MAPK/pERK. c-Myc, p57, and p18 were key effectors of the enhanced myogenesis promoted by the hECS factors. To define some of the active ingredients of the hESC-secretome which may have therapeutic potential, a comparative proteomic antibody array analysis was performed and identified several putative proteins, including FGF2, 6 and 19 which as ligands for MAPK signaling, were investigated in more detail. These studies emphasize that a youthful signaling of multiple signaling pathways is responsible for the pro-regenerative activity of the hESC factors

hESC-secreted proteins can be enriched for multiple regenerative therapies by heparin-binding.

This work builds upon our findings that proteins secreted by hESCs exhibit pro-regenerative activity, and determines that hESC-conditioned medium robustly enhances the proliferation of both muscle and neural progenitor cells. Importantly, this work establishes that it is the proteins that bind heparin which are responsible for the pro-myogenic effects of hESC-conditioned medium, and indicates that this strategy is suitable for enriching the potentially therapeutic factors. Additionally, this work shows that hESC-secreted proteins act independently of the mitogen FGF-2, and suggests that FGF-2 is unlikely to be a pro-aging molecule in the physiological decline of old muscle repair. Moreover, hESC-secreted factors improve the viability of human cortical neurons in an Alzheimers disease (AD) model, suggesting that these factors can enhance the maintenance and regeneration of multiple tissues in the aging body

Law School Mission Statements and Librarians' Perceptions: An Analysis of Law School Library Practices

This study examines the mission statements of three different law schools and compares those stated missions to the actual practices of the affiliated law school library. In an attempt to better understand the purpose of law school libraries and what influences their practices, librarians at three law schools with differing missions were interviewed regarding the practices, policies and priorities of the library and the results from those interviews were compared to the content of the libraries' related law school's mission statement. The findings in this study prove that the mission of a law school has a great influence on the practices of the school's library, and the practices of those libraries play a significant role in assisting the school in carrying out its mission. In addition, the findings of this study highlights ways in which law school library practices can both differ and be similar.Master of Science in Information Scienc

Three-Dimensional Magnetohydrodynamics Simulations Of Counter-Helicity Spheromak Merging In The Swarthmore Spheromak Experiment

Recent counter-helicity spheromak merging experiments in the Swarthmore Spheromak Experiment (SSX) have produced a novel compact torus (CT) with unusual features. These include a persistent antisymmetric toroidal magnetic field profile and a slow, nonlinear emergence of the n = 1 tilt mode. Experimental measurements are inconclusive as to whether this unique CT is a fully merged field-reversed configuration (FRC) with strong toroidal field or a partially merged doublet CT configuration with both spheromak- and FRC-like characteristics. In this paper, the SSX merging process is studied in detail using three-dimensional resistive MHD simulations from the Hybrid Magnetohydrodynamics (HYM) code. These simulations show that merging plasmas in the SSX parameter regime only partially reconnect, leaving behind a doublet CT rather than an FRC. Through direct comparisons, we show that the magnetic structure in the simulations is highly consistent with the SSX experimental observations. We also find that the n = 1 tilt mode begins as a fast growing linear mode that evolves into a slower-growing nonlinear mode before being detected experimentally. A simulation parameter scan over resistivity, viscosity, and line-tying shows that these parameters can strongly affect the behavior of both the merging process and the tilt mode. In fact, merging in certain parameter regimes is found to produce a toroidal-field-free FRC rather than a doublet CT. (C) 2011 American Institute of Physics. [doi:10.1063/1.3660533

Additional Comments on Reproductive Strategies and Population Fluctuations in Microtine Rodents

Recently, Schaffer and Tamarin (1973) proposed a model relating changes in reproductive effort (RE) to fluctuating densities in microtine rodents (lemmings and voles). They assumed (and presented data supporting this assumption) that the major effect of increased crowding would be a reduction in survival among prereproductives, thereby lowering the effective fecundity (Schaffer and Rosenzweig 1977) of their parents. As a consequence, Schaffer and Tamarin argued that the optimal reproductive expenditure, E(N), should decline with increasing population size, N. They also deduced the shape of the zero-growth isocline, N*(E), for differing levels of RE and plotted both E(N) and N*(E) on a graph whose axes are reproductive expenditure and population density (Fig1 a)

Adding Why to What? Analyses of an Everyday Explanation

In XAI it is important to consider that, in contrast to explanations for professional audiences, one cannot assume common expertise when explaining for laypeople. But such explanations between humans vary greatly, making it difficult to research commonalities across explanations. We used the dual nature theory, a techno-philosophical approach, to cope with these challenges. According to it, one can explain, for example, an XAI's decision by addressing its dual nature: by focusing on the Architecture (e.g., the logic of its algorithms) or the Relevance (e.g., the severity of a decision, the implications of a recommendation). We investigated 20 game explanations using the theory as an analytical framework. We elaborate how we used the theory to quickly structure and compare explanations of technological artifacts. We supplemented results from analyzing the explanation contents with results from a video recall to explore how explainers justified their explanation. We found that explainers were focusing on the physical aspects of the game first (Architecture) and only later on aspects of the Relevance. Reasoning in the video recalls indicated that EX regarded the focus on the Architecture as important for structuring the explanation initially by explaining the basic components before focusing on more complex, intangible aspects. Shifting between addressing the two sides was justified by explanation goals, emerging misunderstandings, and the knowledge needs of the explainee. We discovered several commonalities that inspire future research questions which, if further generalizable, provide first ideas for the construction of synthetic explanations.Comment: Paper accepted and presented at XAI World Conference 2023, Lisbo

Challenges and Successes Managing Eurasian Watermilfoil in Lake Luzerne: A 25 Year Citizen-Government Partnership

A 25-year, grassroots initiative to manage the spread of Eurasian watermilfoil, an invasive aquatic plant, in a Southern Adirondack lake is described. A dedicated group of long-term volunteers, together with local government and lake association support, employed a variety of management methods to control the Eurasian watermilfoil, keeping the lake attractive for recreational use. The management methods, volunteer effort, funding, and outcome for each epoch are included, along with keys to success, lessons learned, and future challenges