34 research outputs found
Migration of endotacker into the bladder 7 years after laparoscopic retroperitoneal burch application
RETRACTED ARTICLE: Stress urinary incontinence: long-term results of laparoscopic Burch colposuspension
A crowdsourced analysis to identify ab initio molecular signatures predictive of susceptibility to viral infection
The response to respiratory viruses varies substantially between individuals, and there are currently no known molecular predictors from the early stages of infection. Here we conduct a community-based analysis to determine whether pre- or early post-exposure molecular factors could predict physiologic responses to viral exposure. Using peripheral blood gene expression profiles collected from healthy subjects prior to exposure to one of four respiratory viruses (H1N1, H3N2, Rhinovirus, and RSV), as well as up to 24 h following exposure, we find that it is possible to construct models predictive of symptomatic response using profiles even prior to viral exposure. Analysis of predictive gene features reveal little overlap among models; however, in aggregate, these genes are enriched for common pathways. Heme metabolism, the most significantly enriched pathway, is associated with a higher risk of developing symptoms following viral exposure. This study demonstrates that pre-exposure molecular predictors can be identified and improves our understanding of the mechanisms of response to respiratory viruses
Synthesis and photophysical characterisation of new fluorescent triazole adenine analogues
Fluorescent nucleic acid base analogues are powerful probes of DNA structure. Here we describe the synthesis and photo-physical characterisation of a series of 2-(4-amino-5-(1H-1,2,3-triazol-4-yl)-7H-pyrrolo-[2,3-d] pyrimidin-7-yl) and 2-(4-amino-3-(1H-1,2,3-triazol-4-yl)-1H-pyrazolo[3,4-d] pyrimidin-1-yl) analogues via Sonogashira cross-coupling and [3 + 2]-cycloaddition reactions as the key steps in the synthesis. Compounds with a nitrogen atom in position 8 showed an approximately ten-fold increase in quantum yield and decreased Stokes shift compared to analogues with a carbon atom in position 8. Furthermore, the analogues containing nitrogen in the 8-position showed a more red-shifted and structured absorption as opposed to those which have a carbon incorporated in the same position. Compared to the previously characterised C8-triazole modified adenine, the emissive potential was significantly lower (tenfold or more) for this new family of triazoles-adenine compounds. However, three of the compounds have photophysical properties which will make them interesting to monitor inside DNA
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The oxide known as LLZO, with nominal
composition Li<sub>7</sub>La<sub>3</sub>Zr<sub>2</sub>O<sub>12</sub>, is a promising solid
electrolyte for Li-based batteries due to its high Li-ion conductivity
and chemical stability with respect to lithium. Solid electrolytes
may also enable the use of metallic Li anodes by serving as a physical
barrier that suppresses dendrite initiation and propagation during
cycling. Prior linear elasticity models of the Li electrode/solid
electrolyte interface suggest that the stability of this interface
is highly dependent on the elastic properties of the solid separator.
For example, dendritic suppression is predicted to be enhanced as
the electrolyte’s shear modulus increases. In the present study
a combination of first-principles calculations, acoustic impulse excitation
measurements, and nanoindentation experiments are used to determine
the elastic constants and moduli for high-conductivity LLZO compositions
based on Al and Ta doping. The calculated and measured isotropic shear
moduli are in good agreement and fall within the range of 56–61
GPa. These values are an order of magnitude larger than that for Li
metal and far exceed the minimum value (∼8.5 GPa) believed
to be necessary to suppress dendrite initiation. These data suggest
that LLZO exhibits sufficient stiffness to warrant additional development
as a solid electrolyte for Li batteries
Ground-State Recovery Following UV Excitation is Much Slower in G·C−DNA Duplexes and Hairpins Than in Mononucleotides
Discriminate the response of Acute Myeloid Leukemia patients to treatment by using proteomics data and Answer Set Programming
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