Evaluación ecográfica y funcional de la región lumbopélvica en deportistas con hernia discal lumbar

El dolor lumbar es una de las afecciones musculoesqueléticas más frecuentes y con mayores tasas de recidiva, especialmente en las personas que practican deporte. Constituye una gran carga socioeconómica para las personas y la sociedad, impactando de manera significativa en los sistemas de salud con unos costes económicos y sociales muy elevados. La hernia discal lumbar y el estado de la musculatura parecen estar relacionadas con el dolor, puesto que un deterioro del disco podría provocar alteraciones en la propiocepción o la fuerza y, en consecuencia, afectar a la funcionalidad y la percepción dolorosa. Una mejor comprensión de los factores potencialmente modificables podría ayudar a los profesionales sanitarios a optimizar los programas terapéuticos y al desarrollo de estrategias preventivas efectivas centradas en la población deportista con dolor lumbar. La valoración ecográfica y funcional podrían ayudar a una mejor evaluación de estos pacientes y la programación de ejercicios específicos..

Physical Function in Amateur Athletes with Lumbar Disc Herniation and Chronic Low Back Pain: A Case-Control Study

This study aimed to analyze if chronic low back pain (LBP) and lumbar disc herniation induce biomechanics, flexibility, body balance, physical activity, and muscular function alterations compared to a similar asymptomatic cohort. Fifty male volunteers (n = 25 with chronic LBP and lumbar disc herniation and n = 25 pain-free subjects) were enrolled. Range of motion (internal and external hip rotation, ankle dorsiflexion, and active straight leg raise, ASLR), trunk flexibility (finger–floor distance), body balance (Y-balance test) and muscle function (Biering–Sorensen test, prone and lateral bridges) outcomes were assessed. Comparative analyses between sides and group were conducted. Results: Patients showed greater weight and BMI compared with controls (p 0.05) or LBP patients (all, p > 0.05). Regarding the differences between groups, LBP patients showed limited internal hip rotation (p 0.05). The sample of pain-free amateur athletes showed greater range of movement for internal hip rotation, lower finger–floor distance, better body balance, and muscle function. However, the external hip rotation, ankle dorsiflexion, and ASLR tests showed no difference between cases and controls

Effects of peripheral electromagnetic stimulation after an eccentric exercise-induced delayed-onset muscle soreness protocol in professional soccer players: a randomized controlled trial

Examinar los efectos de la estimulación electromagnética periférica en jugadores profesionales de fútbol masculino sobre marcadores de la Molestia Muscular de Inicio Retardado (DOMS, por sus siglas en inglés), inducida por un protocolo de ejercicio (60 minutos de ejercicios excéntricos y pliométricos). Métodos: En un ensayo controlado aleatorio, participaron cuarenta y cinco jugadores profesionales de fútbol con una edad de 22,33 ± 4,82 años. Veintitrés participantes fueron asignados al grupo experimental con estimulación electromagnética periférica (5 estimulaciones de 5 s a 100 HZ con 55 s de descanso, para un total de 5 minutos de tratamiento) y los 22 restantes al grupo de control. Se evaluaron el umbral de dolor a la presión (PPT) del vasto medial, la Escala Visual Análoga-Fatiga (VAS-F), la prueba de media sentadilla (HS) y la máxima contracción voluntaria del cuádriceps. Todas las evaluaciones se realizaron antes y después de 1 hora del ejercicio excéntrico que indujo el DOMS, así como a las 24-48 y 72 horas después. Resultados: Se observó una interacción grupo-por-tiempo en el PPT del vasto medial (p = 0,040) con un efecto de tamaño medio (η2 p = 0,069). Entre las 48 y 72 horas, el grupo experimental mostró un aumento del PPT en comparación con el grupo de control (p = 0,015). No hubo interacción grupo-por-tiempo para HS, fuerza del cuádriceps y VAS-F (p > 0,05). Discusión: La estimulación electromagnética periférica en jugadores profesionales de fútbol masculino no produjo mejoras significativas en la potencia y fuerza de las extremidades inferiores, pero disminuyó la sensibilización periférica del vasto medial después del protocolo de ejercicio excéntrico.Sin financiación4.0 Q2 JCR 20221.028 Q1 SJR 2022No data IDR 2022UE

Mitochondrial bioenergetics boost macrophage activation, promoting liver regeneration in metabolically compromised animals

17 páginas, 6 figurasBackground and aims: Hepatic ischemia-reperfusion injury (IRI) is the leading cause of early posttransplantation organ failure as mitochondrial respiration and ATP production are affected. A shortage of donors has extended liver donor criteria, including aged or steatotic livers, which are more susceptible to IRI. Given the lack of an effective treatment and the extensive transplantation waitlist, we aimed at characterizing the effects of an accelerated mitochondrial activity by silencing methylation-controlled J protein (MCJ) in three preclinical models of IRI and liver regeneration, focusing on metabolically compromised animal models. Approach and results: Wild-type (WT), MCJ knockout (KO), and Mcj silenced WT mice were subjected to 70% partial hepatectomy (Phx), prolonged IRI, and 70% Phx with IRI. Old and young mice with metabolic syndrome were also subjected to these procedures. Expression of MCJ, an endogenous negative regulator of mitochondrial respiration, increases in preclinical models of Phx with or without vascular occlusion and in donor livers. Mice lacking MCJ initiate liver regeneration 12 h faster than WT and show reduced ischemic injury and increased survival. MCJ knockdown enables a mitochondrial adaptation that restores the bioenergetic supply for enhanced regeneration and prevents cell death after IRI. Mechanistically, increased ATP secretion facilitates the early activation of Kupffer cells and production of TNF, IL-6, and heparin-binding EGF, accelerating the priming phase and the progression through G1 /S transition during liver regeneration. Therapeutic silencing of MCJ in 15-month-old mice and in mice fed a high-fat/high-fructose diet for 12 weeks improves mitochondrial respiration, reduces steatosis, and overcomes regenerative limitations. Conclusions: Boosting mitochondrial activity by silencing MCJ could pave the way for a protective approach after major liver resection or IRI, especially in metabolically compromised, IRI-susceptible organs.Peer reviewe

MCJ: A therapeutic target in hepatic ischemia and reperfusion injury

Trabajo presentado en The International Liver Congress, celebrado en Viena (Austria) del 10 al 14 de abril de 2019.[Background and aims]: Ischemia/reperfusion (IR) injury, a frequent pathological process during liver resection, is a leading cause of post transplantation organ dysfunction. The extent of the injury can determine the success of the procedure and the survival of the patient. Therefore, attenuation of pathology caused by the injury and improving liver function after the procedure would be critical for clinicians to diminish IR injury prevalence and improve the outcome. Mitochondria play a key role in liver homeostasis; indeed, more functional mitochondria induce hepatic regeneration. MCJ, also known as DNACJ15, is an endogenous negative regulator of complex I, located in the mitochondrial electron transport chain. While under normal conditions MCJ deficiency does not result in an altered phenotype in mice, its absence improves mitochondrial activity without increasing mitochondrial ROS. We present MCJ as a new target to minimize hepatic damage caused by IR injury and enhance the efficiency of liver regeneration during liver resection.[Method]: Partial hepatectomies (PH) and PH combined with IR injuries were performed in MCJ-KO mice and in WT mice after MCJ silencing.[Results]: We observed that the lack of MCJ reduced liver damage and induced hepatic regeneration after IR injury; MCJ-KO mice showed lower levels of Caspase 3 and a significantly higher Cyclin D1 expression. Moreover, we saw an improved metabolic response to hepatic insufficiency and an accelerated cell cycle progression during liver resection, which led to a faster recovery of the hepatic mass. In the initial phase after the PH, glucagon response was amplified in MCJ-KO mice, characterized by increased cAMP and AKT signaling, along with higher Ca+2 release from the endoplasmic reticulum (ER), glycogen synthase kinase (GSK-3beta) inhibition and nuclear factorKbeta (NFKbeta) translocation to the nucleus. In the proliferative phase, ablation of MCJ accelerated the induction of proliferative markers. Indeed, after MCJ silencing, an improved phenotype was detected in an aging mice model that underwent partial hepatectomy. Hepatic insufficiency was ameliorated, PCNA expression increased and steatosis reverted. Importantly, the combined procedure of PH and IR injury that resemble liver transplant procedure resulted in a 100% survival rate for MCJ-KO mice while just the 33% of MCJ-WT mice survived the operation. Increased levels of MCJ were found in liver biopsies from all liver donors at 60 minutes after normothermic regional perfusion (nRP) was started.[Conclusion]: Overall, MCJ silencing during liver resection emerges as a promising therapy for IR injury and restoration of hepatic mass