12 research outputs found
ChemInform Abstract: The First DMAP-Mediated Palladium-Free Tsuji-Trost-Type Reaction of Cyclic and Acyclic Baylis-Hillman Alcohols with Active Methylene Compounds.
ChemInform Abstract: General and Efficient Transesterification of β-Keto Esters with Various Alcohols Using Et 3
ChemInform Abstract: The First Et3N-Mediated Transesterification of β-Keto Esters Using Baylis-Hillman Alcohols.
ChemInform Abstract: Efficient α-Chlorination of 2-[(1-Oxocyclohex-2-en-2-yl)methyl]-1,3-dicarbonyl Compounds Using Sodium Hypochlorite.
Metal catalyst-free N-allylation/alkylation of imidazole and benzimidazole with Morita–Baylis–Hillman (MBH) alcohols and acetates
A highly α-regioselective N-nucleophilic allylic substitution of cyclic MBH alcohols and acetates with imidazole or benzimidazole, in toluene at reflux with an azeotropic distillation, was successfully carried out with no catalysts or additives, affording the corresponding N-substituted imidazole derivatives in good yields. On the other hand, in refluxing toluene or methanol, the aza-Michael addition of imidazole onto acyclic MBH alcohols was performed using DABCO as an additive, leading to the corresponding 1,4-adducts in 70–84% yields
General and Efficient Transesterification of β-Keto Esters with Various Alcohols Using Et<sub>3</sub>N as a Brønsted Base Additive
<div><p></p><p>Transesterification of β-keto esters with a wide variety of allyl, benzyl, propargyl, and alkyl alcohols using, for the first time, commercially available and inexpensive Et<sub>3</sub>N as a Brønsted base additive, is efficiently performed in toluene at reflux. The corresponding esters are exclusively obtained in 57–98% yields with no trace amounts of γ,δ-ketones, usually expected from the decarboxylative Carroll rearrangement.</p>
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