Untangling the Web of E-Research: Towards a Sociology of Online Knowledge

e-Research is a rapidly growing research area, both in terms of publications and in terms of funding. In this article we argue that it is necessary to reconceptualize the ways in which we seek to measure and understand e-Research by developing a sociology of knowledge based on our understanding of how science has been transformed historically and shifted into online forms. Next, we report data which allows the examination of e-Research through a variety of traces in order to begin to understand how the knowledge in the realm of e-Research has been and is being constructed. These data indicate that e-Research has had a variable impact in different fields of research. We argue that only an overall account of the scale and scope of e-Research within and between different fields makes it possible to identify the organizational coherence and diffuseness of e-Research in terms of its socio-technical networks, and thus to identify the contributions of e-Research to various research fronts in the online production of knowledge

Increased Metabolic Rate in X-linked Hypophosphatemic Mice

Hyp mice are a model for human X-linked hypophosphatemia, the most common form of vitamin D-resistant rickets. It has previously been observed that Hyp mice have a greater food consumption per gram body weight than do normal mice. This led to the search for some alteration in metabolism in Hyp mice. We found that oxygen consumption was significantly higher in Hyp mice than in normal C57BL/6J mice and this was accompanied by an increased percentage of cardiac output being delivered to organs of heat production (liver and skeletal muscle), to the skin, and to bone and a decreased percentage to the gastrointestinal tract of Hyp mice. The increased oxygen consumption in Hyp mice was not associated with increased plasma free T4 levels and was not affected by alterations in plasma phosphate produced by a low phosphate diet. The cause of the increased oxygen consumption is not known, and the role that this change and reported changes in distribution of cardiac output may play in the development of X-linked hypophosphatemia is also unknown. Study of the cardiovascular and thermoregulatory systems in Hyp mice should help increase understanding of the underlying mechanisms of this disease

Web archives: the future

T his report is structured first, to engage in some speculative thought about the possible futures of the web as an exercise in prom pting us to think about what we need to do now in order to make sure that we can reliably and fruitfully use archives of the w eb in the future. Next, we turn to considering the methods and tools being used to research the live web, as a pointer to the types of things that can be developed to help unde rstand the archived web. Then , we turn to a series of topics and questions that researchers want or may want to address using the archived web. In this final section, we i dentify some of the challenges individuals, organizations, and international bodies can target to increase our ability to explore these topi cs and answer these quest ions. We end the report with some conclusions based on what we have learned from this exercise

Assessment of Poly(ADP-ribose) Polymerase1 (PARP1) expression and activity in cells purified from blood and milk of dairy cattle

Poly(ADP-ribosyl)ation (PAR) is a post-translational protein modification catalysed by enzyme member of the poly(ADP-ribose) polymerases (PARPs) family. The activation of several PARPs is triggered by DNA strand breakage and the main PARP enzyme involved in this process is PARP1. Besides its involvement in DNA repair, PARP1 is involved in several cellular processes including transcription, epigenetics, chromatin re-modelling as well as in the maintenance of genomic stability. Moreover, several studies in human and animal models showed PARP1 activation in various inflammatory disorders. The aims of the study were (1) to characterize PARP1 expression in bovine peripheral blood mononuclear cells (PBMC) and (2) to evaluate PAR levels as a potential inflammatory marker in cells isolated from blood and milk samples following different types of infection, including mastitis. Our results show that (i) bovine PBMC express PARP1; (ii) lymphocytes exhibit higher expression of PARP1 than monocytes; (iii) PARP1 and PAR levels were higher in circulating PBMCs of infected cows; (iv) PAR levels were higher in cells isolated from milk with higher Somatic Cell Counts (SCC > 100,000 cells/mL) than in cells from milk with low SCCs. In conclusion, these findings suggest that PARP1 is activated during mastitis, which may prove to be a useful biomarker of mastitis

Mapping the UK Webspace: Fifteen Years of British Universities on the Web

This paper maps the national UK web presence on the basis of an analysis of the .uk domain from 1996 to 2010. It reviews previous attempts to use web archives to understand national web domains and describes the dataset. Next, it presents an analysis of the .uk domain, including the overall number of links in the archive and changes in the link density of different second-level domains over time. We then explore changes over time within a particular second-level domain, the academic subdomain .ac.uk, and compare linking practices with variables, including institutional affiliation, league table ranking, and geographic location. We do not detect institutional affiliation affecting linking practices and find only partial evidence of league table ranking affecting network centrality, but find a clear inverse relationship between the density of links and the geographical distance between universities. This echoes prior findings regarding offline academic activity, which allows us to argue that real-world factors like geography continue to shape academic relationships even in the Internet age. We conclude with directions for future uses of web archive resources in this emerging area of research.Comment: To appear in the proceeding of WebSci 201

Simulations of the IMF in Clusters

We review computational approaches to understanding the origin of the Initial Mass Function (IMF) during the formation of star clusters. We examine the role of turbulence, gravity and accretion, equations of state, and magnetic fields in producing the distribution of core masses - the Core Mass Function (CMF). Observations show that the CMF is similar in form to the IMF. We focus on feedback processes such as stellar dynamics, radiation, and outflows can reduce the accreted mass to give rise to the IMF. Numerical work suggests that filamentary accretion may play a key role in the origin of the IMF.Comment: 8 pages, 1 (4 part) figure, refereed conference proceedings - invited review, to appear in Proceedings of IAU Symposium 270, 2010 "Computational Star Formation", J. Alves, B.G. Elmegreen, J. Miquel, & V. Trimble (eds.

Experimentation with Large-Grained Parallelism using Local Area Networks

HIGHLAND, a distributed-memory parallel processing environment for heterogeneous local area networks, has been developed. Designed as both a teaching and a research tool, its purpose is to provide an effective mechanism by which a number of networked UNIX workstations, dissimilar in both vendor and performance, can be directly manipulated as a single, unified, multiprocessing system. Utilizing the MIT X-windows environment, HIGHLAND supports a highly interactive graphical interface through which a programmer can create, modify, and control complex systems of communicating processe