Predictability of Atrial Fibrillation in Patients having Coronary Artery Bypass Graft Surgery, Based on Selvester Score

Aim:Patients having coronary artery bypass graft (CABG) surgery are influenced mostly by atrial fibrillation (AF), with the peak incidence of 16-44%. Due to post-operative AF (POAF), patients may be hospitalized for longer periods, require intensive care unit care again, necessitate more healthcare resources and even undergo congestive heart failure or stroke. Recent studies have shown that the size of the ventricular scar might be used as an indicator in the pathophysiology of AF. Selvester score was developed for the measurement of myocardial scar volume in patients with abnormal ventricular conduction, reporting its prognostic value in AF. Thus, we aim to investigate a likely relationship of POAF and the Selvester scoring system.Materials and Methods:This retrospective study included 180 patients with CABG from 2017 August to 2018 September. The obtained data had been analyzed in separate cohort of patients with POAF (n=50) and with post-operative sinus rhythm (PSR) (n=130). Intergroup comparisons were made using Selvester scores in particular.Results:The POAF group had higher Selvester scores (p<0.001), score of SYNTAX (p=0.039), serum high-sensitivity C-reactive protein levels (p=0.026), mean age (p<0.001), hypertrophy of left ventricul (LVH) (p=0.019) and hypertension (p=0.007) and decrased ejection fraction (LVEF) (p<0.001) than the PSR group. Logistic multivariable regression analyses showed that there were an independent association of LVH (p=0.041), LVEF (p=0.004), older age (p=0.008) and higher Selvester score (p<0.001) with POAF.Conclusion:Higher scores in Selvester scoring system are closely related to POAF, and Selvester score is a potential indicator for POAF

Relationship between CHA2DS2-VASc and CHADS2 scores with pulmonary hypertension in patients with acute pulmonary embolism

Introduction: Pulmonary hypertension (PH) is the most important prognostic factor after acute pulmonary embolism (PE). Therefore, determination of patients who will develop PH after acute PE is crucial.  The aim of the present study was to evaluate the predictive value of the CHADS2 and CHA2DS2-VASc scores for PH in patients with acute PE.Material and methods: Seventy-nine adults who presented with acute PE, had an admission systolic pulmonary artery pressure (sPAP) measured on echocardiogram and no previous history of PE, were retrospectively identified from the computerized database. 31 patients who had sPAP ≤ 40 mm Hg were categorized as a  “normal pulmonary pressure” group, whereas 48 patients who had sPAP &gt; 40 mm Hg were categorized as a “PH” group.Results: SPAP was &gt; 40 mm Hg in 48 patients (60.8%), with a mean sPAP of 60.9 ± 16.1 mm Hg (median = 60, min–max = 41–100 mm Hg). In multivariate logistic regression models adjusted for CHADS2 and CHA2DS2-VASc score components, only age was found to be related with the development of PH. SPAP was weakly positively correlated with CHADS2 (p = 0.047; r = 0.224) and CHA2DS2-VASc (p = 0.023; r = 0.256) scores. SPAP values were increasing with the severity of the scores.Conclusions: Both CHADS2 and CHA2DS2-VASc scores could be useful in the determination of which patients should be closely followed up in order to prevent the development of PH after acute PE

Relationship between cha2ds2-vasc and chads2 scores with pulmonary hypertension in patients with acute pulmonary embolism

Introduction: Pulmonary hypertension (PH) is the most important prognostic factor after acute pulmonary embolism (PE). Therefore, determination of patients who will develop PH after acute PE is crucial. The aim of the present study was to evaluate the predictive value of the CHADS2 and CHA2DS2-VASc scores for PH in patients with acute PE. Material and methods: Seventy-nine adults who presented with acute PE, had an admission systolic pulmonary artery pressure (sPAP) measured on echocardiogram and no previous history of PE, were retrospectively identified from the computerized database. 31 patients who had sPAP ? 40 mm Hg were categorized as a “normal pulmonary pressure” group, whereas 48 patients who had sPAP > 40 mm Hg were categorized as a “PH” group. Results: SPAP was > 40 mm Hg in 48 patients (60.8%), with a mean sPAP of 60.9 ± 16.1 mm Hg (median = 60, min–max = 41–100 mm Hg). In multivariate logistic regression models adjusted for CHADS2 and CHA2DS2-VASc score components, only age was found to be related with the development of PH. SPAP was weakly positively correlated with CHADS2 (p = 0.047; r = 0.224) and CHA2DS2-VASc (p = 0.023; r = 0.256) scores. SPAP values were increasing with the severity of the scores. Conclusions: Both CHADS2 and CHA2DS2-VASc scores could be useful in the determination of which patients should be closely followed up in order to prevent the development of PH after acute PE. © 2019 PTChP

Stężenie nesfatyny-1 u chorych ze zwolnionym przepływem wieńcowym

Background: Nesfatin-1 is a novel anorectic neuropeptide with potent metabolic regulatory effects. Aim: We aimed to evaluate the relationship between nesfatin-1 levels and slow coronary flow (SCF). Methods: A total of 60 consecutive patients with SCF and 60 consecutive patients with normal coronary flow (NCF) were enrolled into the study. Nesfatin-1 level was measured from blood serum samples using enzyme-linked immunosorbent assay test. Results: Serum nesfatin-1 levels were significantly lower in the SCF group compared to the NCF group (p &lt; 0.001). Low levels of nesfatin-1 were found to be significantly and independently associated with the SCF (odds ratio 0.982, 95% confidence interval 0.969–0.995, p = 0.005). Conclusions: The results of this study showed that serum nesfatin-1 level was lower in the SCF group than in the NCF group. Nesfatin-1 could play a role in the pathogenesis of SCF phenomenon with mechanisms such as inflammation and endothelial dysfunction. Further studies are needed to determine the relation between SCF and nesfatin-1.Wstęp: Nesfatyna-1 jest nowo odkrytym neuropeptydem o działaniu anorektycznym mającym silny wpływ regulacyjny na procesy metaboliczne. Cel: Celem niniejszej pracy była ocena zależności między stężeniem nesfatyny-1 a zwolnionym przepływem wieńcowym (SCF). Metody: Do badania włączono 60 kolejnych pacjentów z SCF oraz kolejnych 60 pacjentów z prawidłowym przepływem wieńcowym (NCF). Pobrano próbki krwi i zmierzono stężenia nesfatyny w surowicy, stosując metodę immunoenzymatyczną. Wyniki: Stężenie nesfatyny-1 w surowicy było istotnie wyższe w grupie SCF niż w grupie NCF (p < 0,001). Niskie stężenie nesfatyny-1 było istotnie i niezależnie związane z SCF (iloraz szans [OR]: 0,982; 95% przedział ufności [CI]: 0,969–0,995; p = 0,005). Wnioski: Podsumowując, wyniki uzyskane w badaniu wskazują, że stężenie nesfatyny-1 w surowicy było niższe w grupie SCF niż w grupie NCF. Nesfatyna-1 może mieć swój udział w patogenezie zjawiska SCF poprzez takie mechanizmy, jak zapalenie i dysfunkcja śródbłonka. Potrzebne są dalsze badania w celu ustalenia zależności między SCF a nesfatyną-1

Unusual ventricular entrainment response: What is the mechanism?

WOS: 000464349700024PubMed ID: 31007802Entrainment is an important tool for the diagnosis and location of reentry. The usefulness of this maneuver requires that, prior to cessation of ventricular pacing, the atrial rate accelerates to the ventricular pacing rate. Moreover, it is important to verify the continuation of the tachycardia following cessation of entrainment. The recognizing the last entrained atrial beat is utmost important to avoid erroneous A-A-V labeling

Monocyte-to-HDL-cholesterol ratio is associated with ascending aorta dilatation in patients with bicuspid aortic valve

*Gül, Murat (Aksaray, Yazar )Background: The importance of monocyte count-to-HDL-cholesterol ratio (MHR) in cardio- vascular diseases has been shown in various studies. Ascending aortic dilatation (AAD) is a common complication in the patients with bicuspid aortic valve. In this study, we aimed to investigate the relationship between MHR and the presence of aortic dilatation in the patients with bicuspid aortic valve. Methods: The study population included totally 347 patients with bicuspid aortic valve.169 patients with aortic dilatation (ascending aorta diameter ≥ 4.0 cm) and 178 patients with no aortic dilatation. Echocardiographic and laboratory measurement was done and compared between groups. Results: The mean age of the participants was 44.7 ± 15.4 years and average ascending aorta diameter was 3.2 ± 0.3 cm in dilatation negative group and 4.4 ± 0.4 cm in positive group. MHR was significantly increased in in patients with aortic dilatation. MHR and uric acid level was independently associated with the presence of aortic dilatation in the patients with bicuspid aortic valve. Conclusion: We found a significant relationship between MHR and aortic dilatation in the patients with bicuspid aortic valve